Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

To a solution of (5R)-9-[2-(3-bromophenyl)-3,3,3-trifluoro-2-methoxypropanoyl]-5-(4- fluorophenyl)-3,9-diazaspiro[5.5]undecan-2-one (Example 1 14) (100.0 mg, 179 pmol) and 4- methylpiperazin-2-one (CAS-RN: 34770-60-0) (41 .0 mg, 359 pmol) in 1 ,4-dioxane (1 mL) was added caesiumcarbonat (146 mg, 449 pmol), Dipalladium- tris(dibenzylideneacetone)chloroform complex (CAS-RN: 52522-40-4) (9.29 mg, 8.97 pmol) and 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, CAS-RN: 161265-03-8). The mixture was stirred at 900 for 8 h. The reac tion mixture was diluted with water and extracted with dichloromethane. The combined organic layer was dried with sodium sulfate, filtered and concentrated in vacuo. The residue was purified via preparative HPLC (method 6) to give the title compound 9.60 mg (90 % purity, 8 % yield).LC-MS (Method): Rt= 1 .04 min; MS (ESIpos): m/z = 591 [M+H]+1H-NMR (400 MHz, DMSO-d6) d [ppm]: 0.243 (0.68), 0.266 (0.45), 0.540 (0.91 ), 0.570 (0.76), 1 .022 (0.74), 1 .056 (1 .20), 1 .145 (0.52), 1 .170 (0.58), 1.279 (1.50), 1 .432 (0.95), 1.463 (0.82), 1 .646 (0.41 ), 1 .898 (0.99), 1 .942 (1 .30), 2.169 (1 .55), 2.219 (2.82), 2.235 (2.31 ), 2.272 (10.52), 2.293 (16.00), 2.331 (0.85), 2.338 (0.64), 2.518 (4.14), 2.523 (2.99), 2.539 (2.14), 2.699 (1 .1 1 ), 2.712 (1 .94), 2.728 (3.32), 2.744 (4.02), 2.757 (2.47), 2.777 (1.05), 2.793 (1 .83), 2.810 (1 .03),2.844 (0.66), 2.876 (1 .09), 2.907 (0.62), 3.027 (0.60), 3.062 (1.38), 3.080 (1 .48), 3.094 (1 .34),3.1 14 (6.29), 3.140 (9.75), 3.240 (2.06), 3.372 (6.95), 3.577 (10.91 ), 3.595 (2.47), 3.606 (2.31 ), 3.623 (1 .30), 3.662 (0.85), 3.676 (1.51 ), 3.690 (1 .67), 3.704 (1.44), 3.714 (1 .15), 3.726 (0.52),3.970 (0.56), 4.004 (0.52), 4.168 (0.85), 4.200 (0.80), 6.944 (1.96), 6.958 (2.39), 6.966 (2.89),6.980 (2.47), 7.035 (1 .05), 7.054 (1.13), 7.1 19 (2.68), 7.134 (2.47), 7.141 (4.97), 7.155 (3.90),7.162 (2.68), 7.177 (1 .96), 7.243 (1.05), 7.266 (2.66), 7.280 (2.17), 7.288 (1 .84), 7.296 (2.25),7.302 (1.88), 7.316 (4.17), 7.336 (1.55), 7.403 (0.99), 7.425 (1.61 ), 7.445 (2.83), 7.466 (1 .92),7.486 (2.41 ), 7.505 (2.66), 7.524 (1.65), 7.565 (0.41 ), 7.573 (0.43), 7.606 (3.05), 7.633 (2.04)., 34770-60-0

The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; WITTROCK, Sven; HEINRICH, Tobias; BRAeUER, Nico; KUHNKE, Lara, Patricia; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; STEUBER, Holger; (754 pag.)WO2020/48831; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

Maleic anhydride (501.9 mg, 5.11 mmol) was dissolved in CHC13 (25 mL) and 2-(4- methylpiperazin-l-yl)ethan-l -amine (767 mu^, 5.11 mmol) was then added. The reaction was stirred at room temperature for 2 hours. The solvent was removed in vacuo and the crude solid was resuspended in acetic anhydride (25 mL). To the reaction was then added sodium acetate (250 mg). The reaction was heated to reflux under N2 for 3 hours. After reflux, the reaction was cooled to room temperature and washed with hexanes to obtain 3 (crude) as a dark brown/black oil. MS: m/z (M+l) +: 224.28, 934-98-5

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James E.; QI, Jun; FEDERATION, Alexander; JACOBSON, Zoe; VARCA, Anthony; (125 pag.)WO2018/58029; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

00106] Step 6. To a solution of 4-((lH-indol-3-yl)methyl)-3-ethylaniline (0.8 g, 3.2 mmol) and 4-nitrophenyl carbonochloridate (0.64 g, 3.2 mmol) in THF was added diisopropylethylamine (0.4 g, 3.2 mmol) (16 mL) at 20 ¡ãC and the resulting solution was stirred for 30 min. Then 2-(4-methylpiperazin-l-yl)ethanamine (0.9 g, 6.4 mmol) was added to the solution. After the addition was complete, the mixture was stirred at 20 ¡ãC for 12 h. The mixture was concentrated and purified by preparative HPLC to give l-(4-((lH-indol-3- yl)methyl)-3-ethylphenyl)-3-(2-(4-methylpiperazin-l-yl)ethyl)urea (0.33 g, 26percent) as a yellow solid. 1H NMR (400 MHz, MeOD) delta: 1.13-1.17 (t, 3H), 2.25 (s, 3H), 2.48-2.71 (m, 10H), 3.29- 3.32 (m, 2H), 4.01 (s, 2H), 6.73 (s, 1H), 6.92-6.96 (m, 1H), 7.02-7.08 (m, 3H), 7.18 (s, 1H), 7.29-7.31 (d, J = 8.0 Hz, 1H), 7.39-7.41 (d, J = 7.6 Hz, 1H); MS (M+l+): 220.3.

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; WO2013/148365; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

A solution of methyl 4-((N-phenylvinylsulfonamido)methyl)benzoate (0.300 g, 0.905 mmol), (2S,6R)-2,6-dimethylpiperazine (0.207 g, 1.811 mmol) and N,N-Diisopropylethylamine (0.189 mL, 1.086 mmol) in tetrahydrofuran (5 mL) was stilTed at the room temperature for 5 hr. Then, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated ammonium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (Si02, 4 g cartridge; methanol / dichloromethane =0 percent to 10 percent) to give methyl4-(((2-((3S,5R)-3 ,5-dimethylpiperazin- 1 -yl)-N-phenylethyl) sulfonamido)methyl)benzo ate as white solid (0.403 g, 99.9 percent).

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

To a stirring solution of 2-methylpiperazine 7 (3 g, 30.00 mmol) in CH2C12 (100 mL) under argon atmosphere were added triethylamine (9 mL, 90.00 mmol) and Boc-anhydride (7.2 mL, 33.00 mmol) at 0 ¡ãC; warmed to RT and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo. The crude was washed with -pentane (2 x 20 mL) and dried in vacuo to afford compound 9 (5 g, 83percent) as off- white solid. TLC: 5percent MeOH/ CH2C12 (R/. 0.4); 1H-NMR (OMSO-d6, 400 MHz): delta 3.80- 3.62 (m, 2H), 3.27-3.09 (m, 2H), 2.83-2.71 (m, 2H), 2.37-2.17 (m, 1H), 1.39 (s, 9H), 0.92 (d, J= 6.3 Hz, 3H)., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ARNOLD, Lee Daniel; MAAG, Hans; TURNER, JR., William W.; (274 pag.)WO2016/168619; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of 2a (1.9 g, 8.8 mM), morpholine (1.1 mL, 13.2 mM) and triethylamine (1.8 mL, 13.2 mM) were heated to reflux in THF for 2 h. The mixture was partitioned between ethyl acetate (60¡Á2 mL) and water (40¡Á2 mL), the organic layer was evaporated. The oily residue 3a utilized as materials without further purification., 109-01-3

As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.

Reference£º
Article; Wang, Lu; Zhang, Qing; Zhu, Gaoyuan; Zhang, Zhimin; Zhi, Yanle; Zhang, Li; Mao, Tianxiao; Zhou, Xiang; Chen, Yadong; Lu, Tao; Tang, Weifang; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 86 – 106;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

A suspension of 2-chloro-/V-methyl-/V-(4-nitrophenyl)acetamide (1.0 g, 4.37 mmol) in ethyl acetate (10 mL) was heated to 40 C for 30 min and added l-methylpiperazine (1.2 mL, 10.9 mmol) at the same temperature. The mixture was stirred at 50 C for 2 h. The reaction mixture was cooled to RT and diluted with ethyl acetate. The solution was washed with water and dried over anhydrous sodium sulfate. The solution was filtered, concentrated and diluted with methanol. The solution was subjected to hydrogenation in the presence of palladium on carbon as catalyst under 25 bar of hydrogen pressure at 25 C for 2 h. The catalyst was removed by filtration and the solvent was evaporated at 60 C to yield 400 mg of the desired compound. 1 H NMR (400 MHz, DMSO-de) d 1.88 (s, 3H), 2.14-2.19 (m, 4H), 2.63-2.68 (m, 4H), 2.80 (s, 2H), 3.01 (s, 3H), 5.20 (br s, 2H), 6.53 (d, J= 8.1 Hz, 2H), 6.88 (d, J= 8.7 Hz, 2H)., 109-01-3

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ICHNOS SCIENCES S.A.; CHAUDHARI, Sachin, Sundarlal; GHARAT, Laxmikant, Atmaram; IYER, Pravin; DHONE, Sachin, Vasantrao; ADIK, Bharat, Gangadhar; WADEKAR, Prashant, Dilip; GOWDA, Nagaraj; BAJPAI, Malini; (233 pag.)WO2020/70331; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A suitable commercial phenylpiperazine (2.00-5.10 mmol), K2CO3 (0.9-2.00 g) and acetone (7-16 mL) were stirred and refluxed for 30 min. Then, correspondingly substituted bromopentyl 3-benzyl-5,5-hydantoin derivatives 37-39 (2.20-5.70 mmol) in acetone (9-20 mL) were added and the mixture was refluxed for 6 h, left at room temperature overnight and separated from the inorganic precipitate by filtration. The solvent was evaporated from the filtrate. The pure product (14a-24a) was obtained from the residue using method C or D.

115761-79-0, 115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Handzlik, Jadwiga; Bojarski, Andrzej J.; Sata?a, Grzegorz; Kubacka, Monika; Sadek, Bassem; Ashoor, Abrar; Siwek, Agata; Wi?cek, Ma?gorzata; Kucwaj, Katarzyna; Filipek, Barbara; Kie?-Kononowicz, Katarzyna; European Journal of Medicinal Chemistry; vol. 78; (2014); p. 324 – 339;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

A Schlenk flask backfilled with N2 was charged with cw-2,6-dimethylpiperazine (0.11 g, 0.96 mmol), NaO-i-Bu (0.17 g, 1.8 mmol, (rac)-BINAP (8 mg, 0.01 mmol), Pd2(dba)3 (8 mg, 0.009 mmol), and degassed toluene (4 mL). The 2-bromotoluene (0.15 g, 0.88 mmol) was then added, and the mixture was heated under N2 at 110 ¡ãC for 24 h, cooled to rt, diluted with CH2CI2, filtered over Celite, and concentrated. The crude mixture was purified by chromatography on SiO2 (CH2Cl2 MeOH 95:5) to give the product as clear, yellow oil (140 mg, 78percent): NMR (500 MHz, CDCI3) delta 7.19-7.15 (m, 2 H), 7.02-6.98 (m, 2 H), 3.13-3.10 (m, 2 H), 3.01 (d, 7 = 10.5 Hz, 2 H), 2.35-2.31 (m, 5 H), 6 H)., 21655-48-1

The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; SKODA, Erin, M.; WANG, Zhou; WO2015/42297; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, A mixture of 4-(piperazin-l-yl)aniline (348 mg, 1.968 mmol), (E)-methyl 3-(2-(2-chloropyrimidin-5-yl)vinyl)-5-methoxybenzoate (600 mg, 1.968 mmol) and TFA (672 mg, 5.904 mmol) in propan-2-ol (30 mL) was stirred at 150 C for 40 min under microwave. The resulting mixture was concentrated, basified with ammonia water, purified via ISCO (DCM/MeOH) to afford the title compound as a yellow solid (320 mg, 36.6% yield). MS (m/z): 446.3(M+H)+.

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; ZHANG, Weihan; LI, Jinshui; WO2014/139145; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics