Tag: M.W:100-200

25057-77-6, 1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 65: tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1- yl)methyl)phenyl)ethyl carbamateA solution of (S)-tert-butyl 1 -(4-formylphenyl)ethylcarbamate (84.1 mg, 0.337 mmol) [obtained from (S)-1-(4-bromophenyl)ethanamine following the procedure of Hashihayata, Takashi PCT Int. Appl., 2008081910, 10 Jul 2008] and 1 ,2- dimethylpiperazine (86.3 mg, 0.756 mmol, 2.24 equiv) in THF (1.5 mL) was stirred at room temperature for 65 min and treated with sodium triacetoxyborohydride (277.2 mg, 1 .308 mmol, 3.88 equiv). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with saturated aqueous solution of NaHCO-3(15 mL) and extracted with EtOAc (5 x 15 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (MeOH/CH2Cl2 0 to 20%) provided tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)ethyl carbamate (90.7 mg) in 34.5% yield. 1 H NMR (400 MHz, CD3OD) delta 7.29 (s, 4 H), 4.68 (br s, 1 H), 3.54 – 3.47 (m, 2 H), 3.37 (s, 1 H), 2.84 – 2.74 (m, 3 H), 2.38 (td, J = 12, 2.5 Hz, 1 H), 2.31 (s, 3 H), 2.28 – 2.22 (m, 2 H), 1.94 – 1.89 (m, 1 H), 1.40 (br s, 9 H), 1.38 (d, J = 6.9 Hz, 3 H), 1 .06 (d, J = 6.3 Hz, 3 H); MS m/z 348.2 (M + H)

25057-77-6, As the paragraph descriping shows that 25057-77-6 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; TOURE, Bakary-Barry; YANG, Fan; CAFERRO, Thomas; LEI, Huangshu; LENOIR, Francois; LIU, Gang; PALERMO, Mark G.; SHULTZ, Michael David; SMITH, Troy; COSTALES, Abran Q.; PFISTER, Keith Bruce; SENDZIK, Martin; SHAFER, Cynthia; SUTTON, James; ZHAO, Qian; WO2013/46136; (2013); A1;,
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21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Palladium(II) acetate (0.225 g, 1.00 mmol) was added to ethyl 5-bromothiophene-2-carboxylate (2.351 g, 10 mmol), (2S,6R)-2,6-dimethylpiperazine (1.142 g, 10.00 mmol), rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.623 g, 1.00 mmol) and cesium carbonate (4.56 g, 14.00 mmol) in dioxane (100 ml) at 20¡ã C. under nitrogen. The resulting suspension was stirred at 105¡ã C. for 23 h. The mixture was evaporated to dryness to give a brown oil. This crude product was purified by ion exchange chromatography, using a SCX2 column. The crude material was dissolved in methanol and then applied to the column. The desired product was eluted from the column using 2M NH3 in methanol and pure fractions were evaporated to dryness to afford the crude product as a brown solid.This material was further purified by silica column chromatography, eluting with a gradient of 0 to 5percent MeOH in DCM. Pure fractions were evaporated to dryness to afford ethyl 5-((3S,5R)-3,5-dimethylpiperazin-1-yl)thiophene-2-carboxylate (1.600 g, 59.6percent) as a white solid. 1H NMR (399.9 MHz, CDCl3) delta 1.12-1.14 (6H, m), 1.33 (3H, t), 2.46-2.56 (2H, m), 2.98-3.07 (2H, m), 3.42-3.46 (2H, m), 4.28 (2H, q), 6.00 (1H, d), 7.55 (1H, d) MS: m/z 269 (MH+)

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
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57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Boc-pyridazine (compound F-1, 0.558 g, 3 mmol) was weighed in 10 mL of anhydrous CH2Cl2 in a 25 mL beaker and anhydrous Na2CO3 (0.848 g, 8 mmol) was weighed into 7 mL of deionized water. Pour into a 100 mL single-mouth bottle and stir it in an ice bath for 20 min. Dissolve bromoacetyl bromide (0.568 mL, 6.6 mmol) in 10 mL of anhydrous CH2C12 and quickly drip into a single-mouth flask. Add DMAP (36.7 mg) after the addition. 0.3 mmol), stirring continued, TLC traces until starting material conversion, transfer to room temperature reaction 1 h. Extract with CH2C12 (3 X 30 mL). Combine the organic layers and dry over anhydrous Na2SO4. Chromatographic separation of CH2Cl2/MeOH=60:1, v/ nu) 598 mg (Compound G-1) was obtained as a milky white solid, yield 65%.

57260-71-6, 57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; East China University of Science and Technology; Qian Xuhong; Xu Yufang; Jia Xiaotong; Zhu Weiping; Yang Youjun; (14 pag.)CN107619397; (2018); A;,
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20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

11311] 1-Cyclopropylpiperazine (268, 1.76 g, 14.0 mmol) was dissolved in 15 mE DMF. To it were added 1 -fluoro-4- nitrobenzene (1.00 g, 7.0 mmol) and DIEA (1.24 mE, 7.0 mmol). The mixture was stirred at 90 C. for overnight, cooled to RT, diluted with EtOAc, washed with water x2, dried, concentrated in vacuo, subjected to silica flash colunm using 0 to 40% EtOAc in DCM to isolate 1-cyclopropyl-4- (4-nitrophenyl)piperazine (269). It was dissolved in 2:1 EtOAc/MeOR (80 mE/40 mE), and to it were added 40 IL 6N HC1 and 10% Pd/C (0.5 g). The mixture was stirred at RT for overnight under a hydrogen balloon. It was filtered through celite, concentrated in vacuo to dryness to afford 4-(4-cyclo- propylpiperazin-1 -yl)aniline hydrochloride (270, 1.30 g, 73% overall) as an off-white solid., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
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75336-86-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Solid K2CO3 (10 g, 72.4 mmol, 1.8 eq) is added to a solution of (R)-2-methyl-piperazine (4.00 g, 40 mmol, 1 eq) and 3,6-dichloro-4,5-dimethyl-pyridazine (8 g, 45.2 mml, 1.1 eq) in DMF (50 mL), and the resulting solution is stirred at 60¡ã C. for 48 h. The reaction mixture is concentrated to 1/2 volume under reduced pressure and the minimum water (ca. 15 mL) required to dissolve the solid salts is added, followed by the addition of dichloromethane (100 mL). The organic layer is separated, dried over sodium sulfate and concentrated under reduced pressure, then purified by silica gel column chromatography (2percent-20percent MeOH/CH2Cl2) to yield the desired compound as a white solid (4.7 g, 49percent).1H NMR (400 MHz, CDCl3) delta=3.08-3.21 (m, 2H), 2.73-2.92 (m, 4H,) 2.47 (dd, J=12.4 Hz, 10.2 Hz, 1H), 2.13 (s, 3H), 2.07 (s, 3H), 0.93 (d, J=6.3 Hz, 3H).HR MS (m/z, MH+): meas. 241.1218.

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

13484-40-7, Preparation of 2-Chloro-6-[4-(2-methoxy-ethyI)-piperazin-l-yl]-pyrimidine-4- carboxylic acid methyl ester:; To a solution of 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (580 mg, 2.8 mmol) in DCM (6 mL) at 0 C was added triethylamine (0.39 mL, 2.8 mmol), followed by a solution of l-(2-methoxyethyl)piperazine (406 mg, 2.8 mmol) in DCM (6 mL). The resulting solution was stirred at 0 C for 30 min. The reaction mixture was diluted with water and extracted with DCM (3×80 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated to afford 870 mg (99%) of the title compound as a pale yellow solid.

13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/61453; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH)., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Step B: 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-fluoro-2H-chromen-2-one hydrobromide (100 mg, 0.25 mmol) was stirred with (R)-2-methylpiperazine (52 mg, 0.52 mmol) in DMSO (0.5 mL) with K2CO3 (0.14 g, 1.0 mmol) at 120¡ã C. for 2 h. The mixture was cooled to room temperature and diluted with water to produce a precipitate. The solid was collected by vacuum filtration and purified by silica gel chromatography (10percent MeOH in CH2Cl2) to give the title compound (64 mg, 64percent) as a yellow solid. MS m/z 390.2 [M+H]+; 1H NMR (500 MHz, CDCl3): delta 8.74 (1H, s), 8.45 (1H, s), 7.77 (1H, s), 7.51 (1H, d, J=8.8 Hz), 6.88 (1H, dd, J=8.8 Hz, 2.5 Hz), 6.77 (1H, d, J=2.5 Hz), 3.77-3.67 (2H, m), 3.21-3.14 (2H, m), 3.06-2.92 (3H, m), 2.91 (3H, s), 2.64-2.56 (1H, m), 2.48 (3H, s), 1.20 (3H, d, J=6.3 Hz)., 75336-86-6

The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PTC Therapeutics, Inc.; F. Hoffmann-La Roche AG; Woll, Matthew G.; Chen, Guangming; Choi, Soongyu; Dakka, Amal; Huang, Song; Karp, Gary Mitchell; Lee, Chang-Sun; Li, Chunshi; Narasimhan, Jana; Naryshkin, Nikolai; Paushkin, Sergey; Qi, Hongyan; Turpoff, Anthony A.; Weetall, Marla L.; Welch, Ellen; Yang, Tianle; Zhang, Nanjing; Zhang, Xiaoyan; Zhao, Xin; Pinard, Emmanuel; Ratni, Hasane; (317 pag.)US9617268; (2017); B2;,
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55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55112-42-0, EXAMPLE 107: 4-(4-(l,3-BenzothiazoI-6-ylamino)-7fl-pyrrolo[2,3-rf|-pyrimidin-6-yl)methylpiperazinyI-3,6-dihydropyridine-l(2fl)-yI)-carboxamide.; [342] To a suspension of benzothiazol-6-yl-[6-(l ,2,3,6-tetrahydropyridin-4-yl)-7^-pyrrolo[2,3-J]pyrimidin-4-yl]-amine tris-hydrochloride (200mg, 0.44mmol) in NJJ-dimethylformamide (6mL) was added AfAf-diisopropylethylamine (O.SmL, 3mmol). Thereaction mixture was stirred at 0C for 5min prior to the addition of 4-methylpiperazine-l-carbonyl chloride hydrochloride (87mg, 0.44mmol). The resulting mixture was stirred at 0Cfor Ih, diluted with water (50mL), and the resulting precipitate was collected by filtration,washed with EtOAc (5mL), and dried in vacua to give the title compound. LC-MS (ES,Pos.): 474 [MH+], and ‘H NMR (DMSO-d6, 400 MHz): 5 = 1.99 (s, 3H), 2.24 (m, 4H), 2.50(m, 2H), 3.18 (m, 4H), 3.41 (m, 2H), 3.93 (m, 2H), 6.41 (s, IH), 6.82 (s, IH), 7.87 (d, J= 8.8Hz, IH), 8.04 (d, J= 8.8 Hz, IH), 8.34 (s, IH), 8.91 (s, IH), 9.23 (s, IH), 9.59 (s, IH), 11.99(s, IH).

The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OSI PHARMACEUTICALS, INC.; WO2006/17443; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31321-68-3, (R)-Piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (R)-piperazine-2-carboxylic acid (70 g, 344.71 mmol, 1.0 equiv, 2HCl) in dioxane (1120 mL) and H2O (700 mL) was added 50% aq. NaOH until the solution was pH=11. Benzyl chloroformate (156.82 mL, 1.10 mol, 3.2 equiv) was added and the reaction mixture was stirred at room temperature for 12 h. To the solution was then added H2O (1200 mL) and the aqueous layer was washed with MTBE (3 x 800 mL). The aqueous layer was adjusted to pH=2 with concentrated HCl (12N) and extracted with EtOAc (2 x 1000 mL). The combined organic extracts were dried, filtered and the filtrate was (1187) concentrated under reduced pressure to afford the desired product (137 g, 99.8% yield) as a yellow solid. LCMS (ESI) m/z: [M + H] calcd for C21H22N2O6: 399.16; found 399.2.

31321-68-3, The synthetic route of 31321-68-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; SEMKO, Christopher Michael; WANG, Gang; BURNETT, G. Leslie; AGGEN, James Bradley; KISS, Gert; CREGG, James Joseph; GLIEDT, Micah James Evans; PITZEN, Jennifer; LEE, Julie Chu-Li; WON, Walter; THOTTUMKARA, Arun P.; GILL, Adrian Liam; (356 pag.)WO2019/212991; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics