Tag: M.W:100-200

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, A mixture of 2-(4-bromophenyl)-5-methylpyrimidine 78 (250mg, 1.008mmol), palladium acetate (50mg), cesium carbonate (400mgf1.23mmol), (S)-2-methyl piperazine(200mg, 2mmol) and 2-Di-t-butylphosphino)-biphenyl (50mg, 0.167mmol) was stirred in dioxane:water (10ml,v/v 5:1 ) at reflux temperature for 4 hours. The reaction was cooled.diluted with MeCI2 (100ml) and H2O (50ml). The organic layer was separated, dried (MgSO4), filtered and solvent evaporated. The residue was purified by chromatography eluting with 100% EtOAc then with 10% v/v MeOHZEtOAcZIVJH4OH yielding product 79 as a white solid. (220mg.81%) ESMS (MH, 269).

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

5464-12-0, 10.0 g 2-chloro-3-methyl-4-(4,4, 5, 5-tetramethyl-l, 3,2-dioxaborolan-2-yl)phenol (from Step K) (37.2 mmol), 8.7 g 2-(4-methylpiperazin-l-yl)ethanol (60.3 mmol) and 15.8 g PPh3 (60.3 mmol) were dissolved in 100 mL dry toluene and then 27 mL diethyl azodicarboxylate (60.3 mmol, 40 percent solution in toluene) was added dropwise. The mixture was stirred at 50 ¡ãC under argon for 1.5 hours. The volatiles were evaporated under reduced pressure and 100 mL Et20 was added. The precipitated white crystals were filtered off and washed with Et20. The filtrate was concentrated under reduced pressure and purified via flash chromatography using CHC13 and MeOH as eluents. The resulting light brown oil was crystallized from hexane to give l-[2-[2-chloro-3-methyl-4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)phenoxy]ethyl]-4-methyl-piperazine as an off-white solid. 1H NMR (500 MHz, DMSO-d6): 7.56 (d, 1H), 6.99 (d, 1H), 4.15 (t, 2H), 2.72 (t, 2H), 2.51 (s, 3H), 2.50 (br s, 4H), 2.29 (br s, 4H), 2.13 (s, 3H), 1.29 (s, 12H)

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; SZLAVIK, Zoltan; PACZAL, Attila; BALINT, Balazs; KOTSCHY, Andras; CHANRION, Maia; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; SIPOS, Szabolcs; PROSZENYAK, Agnes; (102 pag.)WO2016/207216; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8

At Step 1, obtained 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 80.0 g was in the dimethylformamide 560 ml and the temperature was raised to 70C after the input and the ethylpiperazine 47.29 g and diisopropylethylamine 46.38 g were reacted for 5 hours. The temperature of this reaction solution was cooled to the room temperature and the purified water 560ml was cooled after doing injection to 10C . Here, the generated Decision was filtered to the Nutsche filtration (Buchner funnel, Coors) and the residue was washed with the purified water 250 ml. This Decision was recrystallized as ethanol and it dried in 70C and the white blonanserin 100 g (yield 98.6 %) was obtained.

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SAM-OH PHARMACEUTICAL CO., LTD.; KIM, DAE SIK; HO, CHEOL; (6 pag.)KR2015/117123; (2015); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54699-92-2,4-Methyl-1-piperazineacetic acid,as a common compound, the synthetic route is as follows.

54699-92-2, Example 13; General Method for the Preparation of Active Esters of N-Substituted Piperazine Acetic Acid from Trifluoroacetate Esters; A solution of the trifluoroacetate in THF (0.58 M, 1.2 equiv) was added to a solid sample of N-methyl piperazine acetic acid and mixed in a vortex or shaker until a homogeneous solution was obtained. The reaction of the carboxylic acid with the trifluoroacetate ester was generally complete within 30 min for all cases except N-hydroypyrrolidinone (NHP, 18 h). The progress of conversion to the active ester was monitored by ES-MS. The amount of product and any starting material (N-MPA) could be determined by direct infusion of a sample of the reaction (in ethanol) into the ES-MS. In some cases the active ester product was precipitated as dihydrochloride salt by the addition of a solution by addition of HCl solution in dioxane (4 M, 50% volume of the reaction) followed by washing with THF, ethyl acetate and hexanes. In other cases the product was isolated from the reaction as the mono TFA salt. Addition of TFA could be performed if the bis-TFA salt was desired. Dhbt ester, Calculated MH+ = 304.14 Found = 304.20 NHP ester, Calculated MH+ = 242.15 Found = 242.20 4-NP ester, Calculated MH+ = 280.13 Found = 280.20 1H NMR (400 MHz, CDCl3) d 8.20 (d, 2H, J=9.2 Hz, aromatic protons), 7.25 (d, 2H, J=9.2 Hz, aromatic protons), 3.69-3.40 (broad, 2H, ring protons), 3.57 (s, 2H, -CH2-CO-), 3.15-2.90 (broad, 6H, ring protons), 2.78 (s, 3H, -CH3). Pfp ester, Calculated MH+ = 325.10 Found = 325.10 Pcp ester, Calculated MH+ = 404.95 Found = 405.90 3-NP ester, Calculated MH+ = 280.13 Found = 280.20 NHS ester, Calculated MH+ = 256.13 Found = 256.10

As the paragraph descriping shows that 54699-92-2 is playing an increasingly important role.

Reference£º
Patent; Applera Corporation.; US2005/148771; (2005); A1;; ; Patent; Applera Corporation.; US2005/148774; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5-bromo-2-nitropyridine (18.0 g, 88.7 mmol), N-isopropylpiperazine (17.1 g, 133 mmol) and potassium carbonate (36.9 g, 267 mol) in dimethylsulfoxide (200 mL) was stirred at 100 ¡ãC for 16 h. After this time, the reaction was cooled to room temperature, poured into ice water (500 mL), stirred for 15 min, then extracted with ethyl acetate (2 x 500 mL). The combined organic layers were dried over sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting residue was dried under vacuum to a constant weight to afford l -isopropyl-4-(6-nitropyridin-3-yl)piperazine as a yellow solid: 1H NMR (400 MHz, CDC13) d 8.15 (d, J = 9.2 Hz, 1H), 8.12 (d, J = 2.8 Hz, 1 H), 7.18 (dd, J = 9.2, 2.8 Hz, 1 H), 3.46 (t, J = 4.8 Hz, 4H), 2.78-2.74 (m, 1 H), 2.69 (t, J = 5.2 Hz, 4H), 1.09 (d, J = 10.8 Hz, 6H)., 4318-42-7

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Step 4: A mixture of the chloropyrimidine (200 mg, 0.38 mmol), the piperazine (238 mg, 1.88 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.51 mmol) in DMSO (1.5 mL) was heated in a sealed tube at 1 10 C for 2 h. The reaction was cooled to room temperature and diluted with water. The layer was then extracted with EtOAc (x2). The combined organic layers were washed with water and brine, dried over MgSC>4, filtered and concentrated to leave a residue which was used purified by column chromatography (Si02; elution with 2: 1 hexane:EtOAc) to yield the desired adduct. LCMS 621 [M+H]+.

20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LI, Wei; HARRIS, Joel; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/134772; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

To a solution of EXAMPLE 26B (74 mg, 0.15 mmol) in dichloromethane (10 mL) was added 2-(4-methylpiperazin-l -yl)ethanamine (11 1 mg, 0.78 mmol), 2-(7-aza-lH- benzotriazole-l -yl)-l, l ,3,3-tetramethyluronium (1 18 mg, 0.312 mmol) and triethylamine (79 mg, 0.78 mmol). After stirring at ambient temperature for 2 hours, the mixture was poured into water (30 mL) and extracted with dichloromethane (30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, concentrated and purified by preparative HPLC using a gradient of 10/90 to 90/10 acetronitrile in water (containing 0.1 percent trifluoroacetic acid) to give the title compound. NMR (DMSO-ak, 300 MHz): delta ppm 12.29 (s, 1 H), 1 1.60 (s, 1 H), 8.35 – 8.31 (m, 2 H), 7.58 (d, J = 8.1 Hz, 2 H), 7.42 – 7.38 (m, 3 H), 7.20 (d, J = 8.7 Hz, 1 H), 6.84 (s, 1 H), 6.47 (d, ./ = 7.5 Hz, 1 H), 4.44 (s, 2 H), 3.93 (s, 3 H), 3.00 (s, 3 H), 2.55 (bra, 12 H). MS 595.2 (M + H ).

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97683; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-methylpiperazine (0.10 g, 1 mmol) in CH2CI 2 (2 mL) was added 4- fluorobenzyl bromide (0.125 mL, 1 mmol). The resultant mixture was stirred at ambient temperature. After 15 hours, the mixture was concentrated in vacuo to afford a solid. This solid was dissolved in CH2CI2 and washed sequentially with water, aqueous NaHCO3 solution, then brine. The organic layer was dried over MgS04, filtered, and concentrated to an oil. Purification by flash column chromatography afforded 0.025 g (12% yield) of 1- (4-fluorobenzyl)-3- methylpiperazine, a compound of formula (C), as a colorless oil ; NMR (CDCI 3) 7.3 (m, 2), 7.0 (m, 2), 3.4 (s, 2), 3.0-2. 6 (m, 5), 2.0 (br s, 2), 1.6 (t, 1), 1.0 (d, 3) ppm, 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING AKTIENGESELLSCHAFT; HORUK, Richard; WO2005/79769; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00100] Step 8. To a solution of 2-((lH-indol-3-yl)methyl)-5-amino-3-butylphenol (2 g, 6.8 mmol) and diisopropylethylamine (0.9 g, 6.8 mmol) in 40 mL of THF, was added 4-nitrophenyl chloroformate (1.4 g, 6.8 mmol). The solution was stirred for 30 min and then 2-(4- methylpiperazin-l-yl)ethanamine (1.9 g, 13.6 mmol) was added at room temperature. The reaction mixture was stirred at room temperature for 2 h. After the reaction mixture was concentrated, the residue was purified by preparative HPLC to afford l-(4-((lH-indol-3- yl)methyl)-3-butyl-5-hydroxyphenyl)-3-(2-(4-methylpiperazin-l-yl)ethyl)urea (3.4 g, 36percent, 3 batches) as a white solid. 1H NMR (400 MHz, DMSO) delta: 0.75-0.79 (t, 3H), 1.21 (m, 2H), 1.23 (m, 2H), 2.20 (m, 3H), 2.34-2.43 (m, 10H), 2.47-2.50 (m, 2H), 3.15-3.16 (d, J = 6.0 Hz, 2H), 3.86 (s, 2H), 5.95 (s, 1H), 6.54-6.55 (d, J = 2.0 Hz, 1H), 6.66 (d, J = 2.0 Hz, 1H), 6.90 (s, 1H), 6.95 (d, J = 2.0 Etazeta,IotaEta), 7.00 (s, 1H), 7.26 (d, J = 8.4 Etazeta,IotaEta), 7.55 (d, J = 7.6 Hz, 1H), 8.38 (s, 1H), 9.10 (s, 1H), 10.60 (d, J = 1.6 Hz, 1H).

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; WO2013/148365; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8

To a solution of 1 i (28 mg, 0.089 mmol) in acetonitrile (2 mL) were added DIPEA (48 muIota_, 0.267 mmol), 1j (15 muIota_, 0.107 mmol) and HATU (41 mg, 0.107 mmol). The resulting mixture was stirred at room temperature for 2 h and purified by reversed phase prep HPLC to give title compound 1 as white solid (36 mg, 90% yield). The mass of the compound was obtained by Shimadzu LCMS-2020, MS(ESI) : m/z = 451 [M+H]

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan; WO2012/125521; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics