Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of 5- and 6-haloindoles from indoline》. Authors are Ikan, R.; Hoffmann, E.; Bergmann, E. D.; Galun, A..The article about the compound:5-Fluoroindolinecas:2343-22-8,SMILESS:FC1=CC2=C(NCC2)C=C1).Quality Control of 5-Fluoroindoline. Through the article, more information about this compound (cas:2343-22-8) is conveyed.

cf. Terent’ev, et al., CA 54, 10991c. A mixture of 240 g. indoline and 2 1. concentrated H2SO4 stirred 1 hr. below 0° with a mixture of 90 ml. HNO3 and 2 h H2SO4 gave 95% 6-nitroindoline, m. 66-7° (BuOH); NAc derivative (I) m. 156-7°. I (250 g.) suspended in 600 ml. isoPrOH and hydrogenated over 10% Pd-C at 70°/80 lb./in.2 gave 85% 6-amino-1-acetyfindole (II), m. 181°. II (500 g.) suspended in a mixture of 760 ml. H2O and 760 ml. concentrated HCl and diazotized at 0-5° by a solution of 208 g. NaNO2 in 420 H2O, gave on stirring 1 hr. at 0-5° with a solution of 580 g. NaBF4 in 1 1. H2O a diazonium salt, which, filtered and washed successively with aqueous NaBF4 solution, cold EtOH, and Et2O and then dried, was extracted with iso-PrOH to give 55% 6-fluoro-1-acetylindole (III), b1 180°, b0.5 165°, m. 79-80°. III refluxed 1 hr. with 10 parts concentrated HCl gave quant. 6-fluoroindoline (IV), b0.3 70-2°, n29D 1.5533, also obtained directly by adding 1.5 moles NaOH/mole II to the iso-PrOH extract of the decomposition product of the diazonium fluoborate, and subsequent distillation A mixture of 7 1. xylene, 470 g. chloranil, and 194 g. IV refluxed 5 hrs. gave 60% 6-fluoroindole (V), m. 74.5-5.5°. IV (50 g.) dehydrogenated by 20-min. treatment at 180-200° with 3 g. 10% Pd-C gave 35% V. Dropwise addition of 170 ml. fuming HNO3 to 220 g. indoline in 3 1. Ac2O at 10-12° gave 350 g. orange solid when the product was poured on ice. After removing the small amount of dinitroacetylindoline by refluxing the product with 10 parts concentrated HCl 1 hr. and then filtering off the more acidic dinitroindole which precipitated, the filtrate was made alk. to aqueous NaOH solution and the precipitate refluxed 3 hrs. with Ac2O to give 73% 5-nitro-1-acetylindoline, m. 175-6° (AcOH), which hydrogenated over 10% Pd-C at 70° gave 85% the 5-amino analog (VI), m. 185-6° (aqueous EtOH). VI, diazotized and subjected to a Schiemann reaction, gave 55% 5-fluoro-1-acetylindoline, b8 170°, m. 110-11°, which was deacetylated quant. to 5-fluoroindoline, b15 116-18°, n24D 1.5559, and converted into 5-fluoroindole, m. 45-6°, by the above method. II (176 g.) was suspended in a mixture of 250 ml. H2O and 250 ml. concentrated HCl and diazotized at 0° with a solution of 70 g. NaNO2 in 150 ml. H2O, and the resulting diazonium solution added slowly at 0° to a Cu2Cl2. solution prepared from 310 g. CuSO4.5H2O and 81 g. NaCl in 1 1. H2O, 66 g. NaHSO3 and 44 g. NaOH in 0.5 1. H2O, and 500 ml. concentrated HCl, and the mixture heated to 45° slowly, stirred 2 hrs., cooled to 0°, and filtered gave 56% 6-chloro-1-acetylindoline, m. 127-8°, 85 g. of which refluxed 1 hr. with 850 ml. concentrated HCl gave 6-chloroindoline-HCl, m. 210°; the free base (VII) b28 156-8°, n29D 1.5984. Dehydrogenated with chloranil VII gave 60% 6-chloroindole, m. 89-90°. Similarly, 5-amino-1-acetylindoline gave 60%, the 5-chloro analog, m. 115-16° (EtOH), which was deacetylated to 94% 5-chloroindoline, b20 132-5°, n24D 1.5996, and in turn dehydrogenated to 62% 5-chloroindole, m. 69-70°, by chloranil. Ultraviolet data for these compounds were given.

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Application of 2343-22-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors. Author is Yamane, Masayoshi; Sawada, Jun-ichi; Ogo, Naohisa; Ohba, Mai; Ando, Takayuki; Asai, Akira.

Kinesin centromere-associated protein E (CENP-E) has emerged as a potential target for the development of anticancer drugs due to its involvement in the mitotic progression of the cell cycle. Although several CENP-E inhibitors have been reported, more knowledge of chem. structures and inhibitory mechanisms is necessary for developing CENP-E inhibitors. Here, we describe the identification of new CENP-E inhibitors. Screening of a small-mol. chem. library identified benzo[d]pyrrolo[2,1-b]thiazole derivatives, including 1, as compounds with inhibitory activity against the microtubule-stimulated ATPase of the CENP-E motor domain. Among the mitotic kinesins examined, 1 selectively inhibited the kinesin ATPase activity of CENP-E. In a steady-state ATPase assay, 1 exhibited ATP-competitive behavior, which was different from the CENP-E inhibitor GSK923295. Compound 1 inhibited the proliferation of tumor-derived HeLa and HCT116 cells more efficiently than that of non-cancerous WI-38 cells. The inhibition of cell proliferation was attributed to the ability of 1 to induce apoptotic cell death. The compound showed antimitotic activity, which caused cell cycle arrest at mitosis via interference with proper chromosome alignment. We identified 1 and its derivatives as the lead compounds that target CENP-E, thus providing a new opportunity for the development of anticancer agents targeting kinesins.

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Madec, J.; Pfister, X.; Phansavath, P.; Ratovelomanana-Vidal, V.; Genet, J.-P. published the article 《Asymmetric hydrogenation reactions using a practical in situ generation of chiral ruthenium-diphosphine catalysts from anhydrous RuCl3》. Keywords: asym hydrogenation catalyst ruthenium diphosphine.They researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Name: (S)-Methyl 3-hydroxybutanoate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53562-86-0) here.

A very simple in situ preparation of chiral ruthenium-diphosphine catalysts from anhydrous RuCl3 is reported. Prochiral C:O and C:C bonds have been reduced with high enantioselectivities via ruthenium-catalyzed hydrogenation.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones.SDS of cas: 54903-09-2.

A series of 12 new Mannich bases with chalcone core structure were synthesized as potential antineoplastic agents, via N-aminomethylation of two parent 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. The newly synthesized compounds as well as the chalcone prototypes were evaluated for cytotoxicity in the human pre-B-cell leukemia cell line BV-173 using the MTT-dye reduction assay. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations Ten of the Mannich bases characterized by significant activity in BV-173 were further evaluated against the chronic myeloid leukemia cell line K-562 and were found to suppress the growth of these cells at relatively higher concentrations as compared to the former tumor model. Selected Mannich bases induced programmed cell death in BV-173 at a concentration of 2.5 μM as evidenced by the encountered DNA-laddering. Taken together our data suggest that the presented heterocyclic chalcone derived Mannich bases necessitate detailed pharmacol. evaluation in order to define further the structure activity relationships, in a larger spectrum of tumor models and to elucidate the mechanisms implicated in the observed cytotoxic effects.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dirhodium tetraacetate as an auxiliary chromophore in a circular dichroic study on vic-amino alcohols, published in 2005-07-18, which mentions a compound: 53636-17-2, Name is (S)-1-(Dimethylamino)propan-2-ol, Molecular C5H13NO, Category: piperazines.

The dirhodium method proposed herein, involves the in situ formation of chiral complexes of optically active vic-amino alcs. with the achiral dirhodium tetraacetate [Rh2(OAc)4] acting as an auxiliary chromophore. The resulting CD spectra are suitable for stereochem. studies, since the observed sign of Cotton effects arising within the d-d absorption bands of the metal core is determined by the chirality of the amino alc. ligand. In MeCN and CHCl3 solutions, chiral complexes are formed by axial ligation of the ligand to the metal atom(s) of the dirhodium core. This axial binding occurs through the N atom of the 1,2-amino alc. unit independently of the ligand-to-metal molar ratio, as shown from the 15N and low-temperature NMR experiments In agreement with NMR results, ESI MS experiments indicate that in solution, a mixture of chiral complexes with ligand-to-metal molar ratios 1:1 and 2:1 is present. An empirically based rule correlating the sign of Cotton effect occurring >600 nm with the stereochem. of ligand was formulated.

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COA of Formula: C5H13NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols. Author is Noyori, R.; Suga, S.; Kawai, K.; Okada, S.; Kitamura, M.; Oguni, N.; Hayashi, M.; Kaneko, T.; Matsuda, Y..

Nucleophilic addition of dialkylzincs to aldehydes in hydrocarbon solvents is markedly accelerated by the presence of a catalytic amount of a β-dialkylamino alc. Use of certain sterically constrained chiral amino alcs. such as 3-exo-(dimethylamino)isoborneol or 1-tert-butyl-2-piperidinoethanol effects highly enantioselective catalysis, giving secondary alcs. in up to 99% ee. Dimethyl-, diethyl-, di-n-butyl-, and di-n-pentylzincs have been employed for the alkylation of substituted benzaldehydes and some olefinic or aliphatic aldehydes. Configurational correlation between the chiral auxiliary and alkylation products is discussed.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Egg white protein polymer: an affinity matrix for protease enrichment and isolation, the main research direction is egg white protein polymer affinity matrix protease enrichment isolation.Quality Control of 1,10-Phenanthroline.

Egg white was precipitated with acetone and crosslinked with glutaraldehyde. Protease specificity of the polymer was investigated with different types of proteases and non-protease proteins. Protein polymer effectively bound trypsin, papain and the different proteases from pancreatin. SDS-PAGE results and diffusion agar plate tests supported the protease-binding efficiency of the polymer. In conclusion, egg white protein polymer can specifically bind proteases and it is a convenient and cost-effective material for enrichment, isolation, and removal of proteases.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Structure called Synthesis, molecular modeling, and docking studies of a new pyridazinone-acid hydrazone ligand, and its nano metal complexes. Spectroscopy, thermal analysis, electrical properties, DNA cleavage, antitumor, and antimicrobial activities, Author is Abdelrahman, Maha S. A.; Omar, Fouz M.; Saleh, Akila A.; El-ghamry, Mosad A., which mentions a compound: 66-71-7, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2, Related Products of 66-71-7.

New nano Co(II), Ni(II), Cu(II), Zn(II), Fe(III) complexes, and oxovanadium(IV), dioxouranium(VI) complexes of pyridazinone-acid hydrazone ligand, DCNHP (H2L), in addition of new mixed-ligand complexes using 8-HQ/or 1,10-phen as an auxiliary ligand (L’), were synthesized and characterized by different techniques. The ligand, H2L, acted as tridentate towards the metal ions in a mono-, and bis- deprotonated form. The complexes exhibited a variety of geometrical structures including octahedral, square pyramidal, and tetrahedral configurations. The results of TGA confirmed the thermal stability of the metal complexes. The X-ray diffractograms and TEM images confirmed that the particles of the studied compounds were situated in nano-range with spherical and stick-shaped. Mol. modeling studies indicated that the theor. data agree well with the exptl. results. The antimicrobial activity study showed enhancement in activity of the free ligand upon complexation. The results of antitumor screening indicated that all examined compounds displayed inhibition of Hepatocellular carcinoma cell line (HepG-2) viability. The ligand, H2L, and its nano Cu(II) complex 7 displayed strong antitumor activity with IC50 = 3.80 and 3.81μg/mL, resp. The DNA cleavage study revealed that no ability for the screened compounds to cleavage DNA, and they may be able to induce cellular death in cancer cells through the apoptosis pathway. The docking results suggesting strong interactions of both the ligand, H2L, and its Cu(II) complex 7 with the VEGFR-2 enzyme, these interactions are very similar to that of the known hepatocellular carcinoma (HCC) inhibitor, sorafenib (Nexavar) with the target enzyme, and indicating the effective inhibition of the studied compounds towards hepatocellular carcinoma. Moreover, the elec. conductivity study in solid-state revealed that the nano Cu(II) complex 7 displayed higher σac values than that for the free ligand, H2L, and the studied compounds act as semiconductors.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Science of the Total Environment called Efficient degradation of aqueous organic contaminants in manganese(II)/peroxymonosulfate system assisted by pyridine organic ligands, Author is Hu, Youyou; Sun, Siyu; Xu, Mengshan; Guo, Jialin; Li, Zhengkui, which mentions a compound: 66-71-7, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2, Quality Control of 1,10-Phenanthroline.

Although manganese(II) is known to have no role in peroxymonosulfate (PMS) activation, through a series of sulfamethoxazole (SMX) oxidation experiments, we found that the addition of pyridine organic ligands can improve the catalytic activity and accelerate SMX oxidation For the organic ligands to be effective: the stability constant of the Mn(III) complex should be higher than that of the Mn(II) complex. A pos. correlation was observed between the SMX oxidation rate and Mn(II) concentration, and the maximum PMS utilization efficiency was achieved. Many shreds of evidence verified that neither •SO-4 nor •OH was associated with SMX oxidation The enhanced effect of phenanthroline on the Mn(II)/PMS system was attributed to the highly oxidative intermediate manganese species (Mn(V)), originating from the two-electron transfer reaction of complexed Mn(III) and PMS. Notably, the main oxidizing species did not change (η-(PMSO2) ∼ 100%) regardless of the initial PMSO concentration or pH value. Addnl., the anal. of SMX degradation products revealed that the oxygen transfer oxidation pathway was dominant in the Mn(II)/phenanthroline/PMS system, while the N radical coupling pathway also contributed significantly to SMX oxidation This work offers new insights into the formation of high-valent manganese species and provides a potential strategy for applying low-concentration Mn(II) to wastewater treatment.

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Recommanded Product: 5-Fluoroindoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about B(C6F5)3-promoted hydrogenations of N-heterocycles with ammonia borane. Author is Ding, Fangwei; Zhang, Yiliang; Zhao, Rong; Jiang, Yanqiu; Bao, Robert Li-Yuan; Lin, Kaifeng; Shi, Lei.

A transition-metal-free method for the B(C6F5)3-promoted hydrogenations of N-heterocycles using ammonia borane under mild reaction conditions was developed. The reaction afforded a broad range of hydrogenated products in moderate to good yields. The enantioselective versions for the corresponding products were also investigated via our approach, showing good feasibility.

Here is just a brief introduction to this compound(2343-22-8)Recommanded Product: 5-Fluoroindoline, more information about the compound(5-Fluoroindoline) is in the article, you can click the link below.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics