Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25057-77-6,1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of N-(l-(lH-indol-3-yl)hexan-2-yl)-2-bromothiazole-5- carboxamide (0.20 g, 0.49 mmol) and 1,2-dimethylpiperazine (0.06 g, 0.54 mmol) in CH3CN (4.5 mL) was added K2C03 (0.20 g, 1.47 mmol) and the reaction mixture was heated at 80 C for 16 h. The reaction mixture was concentrated in vacuo. The residue was diluted with H20 (10 mL) and extracted with 10% MeOH in DCM (10 mL). The organic layer was separated, dried over anhydrous Na2S04 and concentrated in vacuo. The crude obtained was purified by column chromatography (silica 230-400 mesh, 0.5 to 3.5% MeOH in DCM) and triturating with pentane (10 mL) to afford N-(l-(lH-indol-3-yl) hexan-2-yl)-2-(3,4-dimethylpiperazin-l- yl)thiazole-5-carboxamide (0.075 g, 34%) as a white solid. HPLC Purity: 99.2%. LC/MS (ESI) m/e [M+H]+/RT (min)/%: 440.00/2.76/99.8%. 1H NMR (400 MHz, DMSO-d6) delta 0.81 (t, = 6.9 Hz, 3H), 1.02 (d, = 6.4 Hz, 3H), 1.18-1.31 (m, 4H), 1.40-1.60 (m, 2H), 2.06-2.18 (m, 2H), 2.20 (s, 3H), 2.69-2.91 (m, 4H), 3.10-3.22 (m, 1H), 3.64-3.77 (m, 2H), 4.11 (d, = 4.4 Hz, 1H), 6.91-6.99 (m, 1H), 7.04 (t, = 7.6 Hz, 1H), 7.09 (brs, 1H), 7.31 (d, = 7.8 Hz, 1H), 7.57 (d, = 7.8 Hz, 1H), 7.80 (s, 1H), 7.93 (d, = 8.3 Hz, 1H), 10.75 (brs, 1H)., 25057-77-6

The synthetic route of 25057-77-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 100 mL 3-necked flask was equipped with a magnetic stirrer bar, nitrogen in- and outlet and septum. The setup was thoroughly dried using a heat gun and allowed to cool to room temperature under a nitrogen flow. Then, 4-nitrobenzoyl chloride (4.64 g, 25.0 mmol) was dissolved in dry dichloromethane (50 mL) and the solution was 10 minutes in an ice-water bath. N-methylpiperazine (2.58 g, 25.8 mmol, 1.03 eq) was added drop wise over a 10 minute time interval while stirring vigorously. The resulting suspension was stirred for 1 hour at 0 C., after which triethylamine (5.01 g, 50.0 mmol, 2.0 eq) was added and stirrring was continued at r.t. for 1 h. The reaction mixture was transferred into a separatory funnel and washed with demineralized water (3¡Á50 mL). The organic layer was dried over Na2SO4, filtered over a paper filter and all volatiles were removed under reduced pressure using a rotary evaporator to give the desired product as a pale orange solid (5.77 g 23.1 mmol, 92%)., 109-01-3

The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEIJIN ARAMID B.V.; VAN DEN HEUVEL, Christiaan J.M.; VELD, Martijn Arnoldus Johannes; QUAIJTAAL, Joannes H.M.; VERHOEF, Rene P.; DE JONG, Jorrit; NIJENHUIS, Wido; (12 pag.)US2018/223077; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

(General Procedure 16)4-Cyclopentyl-piperazine-1-carboxylic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and N-cyclopentylpiperazine applying the general procedure 16. The crude product was purified by preparative HPLC (water-acetonitrile-0.1% TFA) (34%, salt with TFA). 1H NMR (300 MHz; CDCl3): delta 1.45-2.01 (m, 8H), 2.70 (bs, 4H), 2.92 (bs, 1H), 3.55 (bt, 1H), 3.63 (bs, 2H), 3.77 (bs, 2H), 6.31 (t, 1H), 7.38 (dd, 1H), 7.41 (dd, 1H); HPLC-MS: m/z=265.1 (M+1); Rt=0.54 min., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

59878-57-8, (e) Library Synthesis (10a-m)To a solution of 2-fluoro-5-(4-oxo-3,4,5,6,7,8-hexahydro-phthalazin-1-ylmethyl)-benzoic acid (22 mg, 0.07 mmol), in DMA (1 ml) was added HBTU (53 mg, 0.140 mmol), triethylamine (20 muL, 0.140 mol) and amine (0.140 mmol). The crude reaction mixture was stirred for 18 hours at room temperature and then submitted for preparative HPLC purification.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Javaid, Muhammad Hashim; Menear, Keith Allan; Martin, Niall Morrison Barr; Smith, Graeme Cameron Murray; Rudge, David Alan; Roberts, Craig Anthony; US2009/23727; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh 2,4-dichlorobenzoic acid 9.6g (0.05mol) was dissolved in 20ml of dry tetrahydrofuran was slowly added CDI8.9g (0.055mol), at room temperature for 4hAfter the reaction solution through a dropping funnel was added dropwise to a solution of constant piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of an aqueous solution of sodium chloride, 14g, and reacted for 5 hours at room temperature .After completion of the reaction by suction, the filtrate evaporated to remove THF, 10ml ethyl acetate again, NaOH saturated solution was adjusted to pH = 10, and the combined organic phase was extracted 3 times with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate overnight, pumping filtered, spin dry ethyl acetate, the resulting white crystals is 1- (2,4-dichloro-benzoyl) piperazine crude product 5.8g, 45% yield.

142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xi’an Jiaotong University; Zhang, Jie; Lu, Wen; Dong, Jinyun; Pan, Xiaoyan; He, Langchong; Zhang, Tao; Wang, Sicen; Shen, Xiuxiu; (16 pag.)CN104262238; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,57260-71-6

EXAMPLE 125 N-Boc-N-bromoacetyl-piperazine The title compound was prepared as described above for N-bromoacetyl-N(bis-Boc-guanidinyl)piperazine from N-Boc-piperazine (prepared as per the procedure of Carpino, L.A., et al., J. Org. Chem., 1983, 48, 661-665) (23.0 g, 123 mmol), bromoacetyl bromide (25.0 g, 123 mmol), and diisopropyletyhl amine (21 mL, 156 g, 120 mmol) in 240 mL of CH2Cl2. Flash chromatographic purification afforded 25.0 g of the title compound as pale yellow crystals, yield 66%. Silica gel TLC Rf 0.34 (1:1 hexanes-EtOAc). 1H NMR delta1.37 (s, 9H), 3.30-3.56 (m, 8H), 3.80 (s, 2H). 13C NMR delta25.8, 28.2, 28.5, 41.9, 43.2, 46.5, 80.3, 154.4, 165.4. MS (FAB) m/z 331 (M+Na)+. HRMS (FAB) m/z 307.066 (M+H)+(C11H20BrN2O3 requires 307.065). Anal. Calcd. for C:LHlgBrN2O3: C, 43.01; H, 6.22; N, 9.12. Found: C, 43.24; H, 6.22; N, 9.37.

The synthetic route of 57260-71-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ISIS Pharmaceuticals, Inc.; US6329523; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

5mmol N,N-dimethylglycine,2mmol CuI,20mmol 4,6-dichloro-2-methylpyrimidine is soluble100 mL of N,N-dimethylformamide (DMF),22 mmol of N-hydroxyethylpiperazine was added with stirring.40mmol K3PO4, stir at room temperature for 40min,22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide was added with stirring.Passing N2 and reacting at 120 C for 6 h,The copper salt was dissolved in 50 mL of aqueous ammonia, and extracted with 50 mL of EtOAc (EtOAc).The crude product was added to 100 mL of an 80% aqueous ethanol solution, and stirred.2 g of activated carbon was added, refluxed for 30 min, filtered while hot, and the filtrate was recrystallized overnight, filtered, and the filter cake was washed with ice-cold 80% aqueous ethanol solution and dried.That is, 8.64 g of a white solid was obtained, the yield was 88.41%, and the purity was 99.92%.

103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Ren Qingwei; Zhang Qingdong; (12 pag.)CN109879869; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

109-01-3, 1-METHYLPIPERAZINE (13.49 g, 135 mmol) and triethylamine (16.4 g, 162 mmol) were added to 200 mL OF CHC13 in a 500 mL round-bottomed flask equipped with a 250 mL addition funnel under argon with a magnetic stirring bar. 4-nitrobenzoyl chloride (25.00 g, 135 mmol) was dissolved in 200 mL OF GHCI3 with slight warming. The solution of benzoyl chloride was placed in the addition funnel and was added slowly to the solution of piperazine. The solution warmed slightly and was allowed to stir 1 hour after the addition was complete. The reaction was concentrated until the product began to precipitate. The product was isolated by vacuum filtration and rinsed with two 25 mL portions of cold diethyl ether. After recrystallization from 95% ethanol, the product, 4-METHYL-1- (4- nitrobenzoyl) piperazine, was pure by standard analytical techniques.

As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.

Reference£º
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2004/63195; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of intermediate 7 (500 mg, 1.3 mmol), EDC¡¤HCl (300 mg, 1.5 mmol) and HOBt (210 mg, 1.5 mmol)) in dried CH2Cl2 was added appropriate amine (1.5 mmol), and stirred at rt for overnight. After complete reaction, the reaction mixture was concentrated in vacuo and purified via column chromatography to afford appropriate 2-(2-(tritylamino)thiazol-4-yl)acete amide. The above product was dissolved in the mixture of 5 mL of acetic acid and 0.1 mL of water. The solution was heated under argon at 60 C for 1 h, and then allowed to cool to rt. The resulted dark solution was diluted with 20 mL of water, the triphenylmethanol was removed by extraction with Et2O. The watery phase was adjusted to pH8 with saturated Na2CO3 solution, and extracted with CH2Cl2. The organic extract was dried over anhydrous MgSO4, evaporated to dryness in vacuo. The resulting brown oil was purified via column chromatography with CH2Cl2-MeOH as eluent to afford appropriate 2-(2-(amino)thiazol-4-yl)acete amide 8a-f., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sang, Chun-Yan; Tian, Heng-Zhi; Chen, Yue; Liu, Jian-Fei; Chen, Shi-Wu; Hui, Ling; Bioorganic and Medicinal Chemistry Letters; vol. 28; 2; (2018); p. 71 – 76;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo [1 ,2-b]pyridazin-6-yl)pyrido [1,2- a]pyrimidin-4-one (Intermediate 3; 250 mg, 0.808 mmol), and (S)-2-methylpiperazine (405 mg,4.04 mmol, 5.0 eq.) were stuffed in DMSO (6 mL) and heated at 130C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2C12 and washed with an aqueous saturated solution of NaHCO3. The organic layer was separated and dried over Na2504 and concentrated in vacuo. The crude was purified by column chromatography (5i02, CH2C12/MeOH=95/5 to 85/15) to afford the title product (135 mg, 43%) as a light yellow solid.MS m/z 390.3 [M+H?i.

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALSENZ, Jochem; GRASSMANN, Olaf; KUEHL, Peter; METZGER, Friedrich; MCCARTHY, Kathleen Dorothy; MORAWSKI VIANNA, Eduardo Paulo; WOODHOUSE, Marvin Lloyd; (130 pag.)WO2017/80967; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics