Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of compounds 21a, b (0.5mmol) in anhydrous DCM (20mL) was added BOP-Cl (0.6mmol), Et3N (1.5mmol) and the amino parts (3, 4, 8a-l, 9a-d, 13a,b, 14a,b, 16a-i, 18, 22a,b and 23) at room temperature. The mixture was stirred overnight at the same temperature, and washed by H3PO4 solution (1%), saturated NaHCO3 solution and brine, dried over anhydrous MgSO4, filtered, and concentrated. The residue was purified by Flash column chromatography (DCM/MeOH, 0-10%) to afford the crude target compounds as yellow solids. The solid was further purified by treating with EtOAc and hexane (11mL, 1: 10) to yield the target compounds (24, 25, 26a-l, 27a-g, 28a,b, 29a,b, 30a-i, 31, 32a,b, 33).

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference£º
Article; Lv, Kai; Li, Linhu; Wang, Bo; Liu, Mingliang; Wang, Bin; Shen, Weiyi; Guo, Huiyuan; Lu, Yu; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 117 – 125;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, To a stirred solution of Ethyl piperazine (11.06 g, 96.8 mmol, 2.0 eq) and triethylamine (24.46 g, 242 mmol, 5.0 eq) in CH2Cl2 (150 ml) at 0C was added a solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(chlorocarbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate (25 g, 48.4 mmol, 1.0 eq) in CH2Cl2 (150 ml). The reaction mixture was allowed to stir at room temperature for overnight. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was quenched with water and extracted with CH2Cl2 (3×200 ml). The combined organic layers were dried over Na2S04, filtered and evaporated under reduced pressure. The crude residue was purified by silicagel column chromatography by using 2% methanol: dichloromethane as an eluent to obtain the desired product (26 g, 90% yield) as a white solid. 1H NMR (300 MHz, CDCl3): delta ppm 4.72 (s, 1H), 4.57 (s, 1H), 4.50-4.42 (m, 1H), 3.68-3.56 (m, 4H), 3.03-2.82 (m, 2H), 2.48-2.32 (m, 6H), 2.04 (s, 3H), 1.68 (s, 3H), 1.10 (t, J= 7.2 Hz, 3H), 0.95 (s, 3H), 0.94 (s, 3H), 0.84 (s, 3H), 0.836 (s, 3H), 0.83 (s, 3H), 2.15-0.75 (m, 23H); ES MS: [M+H]+ 595.4 (100%).

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi; WO2013/160810; (2013); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6,75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 4-fluoronitrobenzene (2.0 g, 0.014 mol, 1.0 eq) in DMF (50 mL) at rt, (R)-2-methylpiperazine (1.1 eq) and K2CO3 (3.0 eq) were added and stirred at rt for 16 h. After TLC showed completion of starting material, the mixture was diluted with water (100 mL) and extracted with EtOAc (3 x 150 mL). The organic layer was washed with brine solution (50 mL), dried over anhydrous sodium sulphate, and concentrated to provide crude residue. The crude was triturated with n-hexane and filtered to obtain (R)-3-methyl-l-(4-nitrophenyl)piperazine (2.6 g, 84percent) as yellow solid. 1H NMR (400 MHz, DMSO-d6): delta 8.028 (d, 2H), 7.002 (d, 2H), 3.860 (m, 2 H), 2.952 (d, 1H), 2.887 (t, 1H), 2.790 (m, 2H), 2.450 (m, 1H), 2.331 (s, 1H), 1.023 (d, 3H).

The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASANA BIOSCIENCES, LLC; VENKATESAN, Aranapakam M.; SMITH, Roger A.; THOMPSON, Scott K.; LAPING, Nicholas; KULKARNI, Bheemashankar; HALLUR, Gurulingappa; VISWANADHAN, Vellarkad N.; PENDYALA, Muralidhar; KETHIRI, Raghava Reddy; TYAGI, Rajiv; SIVANANDHAN, Dhanalakshmi; BAKTHAVATCHALAM, Rajagopal; WO2015/38417; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 : 4-(4-Acetylpiperazin-l-yl)benzaldehyde To a solution of 4-fluorobenzaldehyde (5 g, 40.2 mmol) in N,N-dimethylformamide (130 mL) was added potassium carbonate (8.35 g, 60.4 mmol) and 1-piperazin-l-ylethanone (10.3 g, 80.5 mmol) and the reaction was stirred at 130 C for 16 hours. The reaction was then cooled to ambient temperature, diluted with EtOAc and washed with water (x2) and brine. The organic layer was then dried with MgSC>4, concentrated and purified by silica gel column chromatography (0-10% methanol in dichloromethane) to give 4-(4- acetylpiperazin-l-yl)benzaldehyde (5.96 g, 64% yield). LCMS (m/z) ES+ 233 [M+l]+.

13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; FAUBER, Benjamin; RENE, Olivier; WO2013/92941; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 10 (0.17mmol, 1.0eq.), TEA (10.0eq.) and corresponding amine (5.0eq.) in ethanol (5mL) was stirred at reflux overnight. The reaction solution was evaporated. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=50/1/1) to give the desired product

20327-23-5, As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Article; Lin, Yu; Li, Zhanhui; Xu, Chen; Xia, Kaijiang; Wu, Shuwei; Hao, Yongjin; Yang, Qing; Ma, Haikuo; Zheng, Jiyue; Luo, Lusong; Zhu, Fang; He, Sudan; Zhang, Xiaohu; Bioorganic Chemistry; vol. 99; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1. A solution of N-cyclopentylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90 C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=291.4., 21043-40-3

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 0C was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give (R)-3-methyl-piperazine-l- carboxylic acid tert-butyl ester as a white solid (669 mg, 84%).

As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; GENENTECH, INC.; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; OXENFORD, Sally; WAN, Nan, Chi; CASTANEDO, Georgette; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel, P.; ZHU, Bing-Yan; WO2008/70740; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 1: Ninety grams of L-CYCLOPROPYL-6, 7-DIFLUORO-1, 4-DIHYDRO-8-METHOXY-4-OXO-3- quinoline carboxylic acid and 64g (2.1 eq) of 2-methyl piperazine were put in suspension in 1.8 liter of DMSO under nitrogen atmosphere. The mixture was heated to 55 C during 24 hours. Subsequently, the mixture was heated to 70 C and half of the amount of DMSO was distilled-off at reduced pressure (1-5 mm Hg). At the end of the distillation, the reaction mixture was cooled to 20 C and left at this temperature overnight. The solution was then filtered under vacuum and the wet cake washed twice with n-butanol (300 ml). The collected solid was then dried under vacuum to obtain 94 g. The calculated yield, after assay, was 84%.

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2004/69825; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (3-bromophenyl)methanol (570 mg, 3.05 mmol) in THF (5 mL) was added LHMDS (7.43 mL, 7.43 mmol) and the mixture was stirred at RT for 30 minutes. Ru-phos precatalyst (97 mg, 0.133 mmol), dicyclohexyl(2′,6′-diisopropoxy-[l,l’- biphenyl]-2-yl)phosphine (61.9 mg, 0.133 mmol), and 1-methylpiperazine (0.441 mL, 3.98 mmol) were added, the mixture was degassed with a stream of nitrogen and heated to 75 C for 1 h. The mixture was then diluted with DCM and washed with water. The organic layer was concentrated under reduced pressure and the residue was purified by Si02gel chromatography (0-20% MeOH in DCM) to give the title compound (506 mg, 80%). MS(ES+) C12H18N20 requires: 206, found: 207 [M+H]+.

109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; MARSZALEK, Joe; LIU, Gang; KANG, Zhijun; CARROLL, Christopher, L.; MCAFOOS, Timothy; CZAKO, Barbara; WO2014/31928; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics