Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.

5271-27-2, 24. (2,4-bis(allyloxy)-5-isopropylphenyl)(4-methyl-2-phenylpiperazin-1-yl)methanone (16) Compound 14 (0.18 g, 0.66 mmol), 1-methyl-3-phenylpiperazine (0.18 g, 0.99 mmol), 1-ethyl-3-(3-dimethylaminopropyl) (0.25 g, 1.33 mmol), 1-hydroxybenzotriazole (0.09 g, 0.66 mmol) and N,N-diisopropylethylamine (0.09 mL, 0.66 mmol) were dissolved in 4 ml of DMF and stirred at 120¡ã C. for 3 hours under a microwave irradiation (Biotage Initiator). The reaction mixture was diluted with ethyl acetate and the organic layer was washed with 1 N HCl solution. It was dried over Na2SO4, concentrated under pressure and purified by MPLC to obtain Compound 16 in a yield of 92percent. Rf=0.24 (3:7 ethyl acetate:hexane).

The synthetic route of 5271-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY; SEO, Young Ho; (32 pag.)US2019/31620; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

59878-57-8, To a round bottom flask containing Methyl-5-((4-oxo-3-((2-(trimethylsilyl)ethoxy) methyl)- 3,4-dihydrophthalazin-l-yl) methyl)-2-(4,4,5,5-tetramethyl-l,3,2-dioxa borolan-2- yl)benzoate and bis(pinacolato) diboron (2.00 g) was added THF (100 mL) before cooling to 0C. Upon cooling, 2M lithium hydroxide (7 mL, 14 mmol) was added dropwise before allowing to reaction to stir for 30 minutes at 0C. 1M HC1 was then added dropwise to the reaction mixture at 0C until reaching pH 4. The mixture was then extracted with EtOAc (3 x 80 mL) and washed with Brine (3 x 50 mL). The organic phases were combined and the excess solvent removed in vacuo. The crude material (1.4 g) was transferred to a round bottom flask upon which DCM (100 mL), HBTU (2.97 g, 7.84 mmol) and DIPEA (1.36 mL, 7.84 mmol) was added. After stirring at room temperature for 30 minutes, N- cyclopropylcarbonylpiperazine (1.11 mL, 7.85 mmol) was added and the reaction stirred overnight. After stirring for 16 hours, the excess solvent was removed in vacuo and the crude material isolated by flash column chromatography (Pure EtOAc) before purification by reverse phase HPLC was carried out to afford 4-(3-(4-(cyclopropanecarbonyl) piperazine- 1- carbonyl)-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzyl)-2-((2-trimethlsilyl) ethoxy)methyl)phthalazin-l(2/7)-one (419 mg, 0.62 mmol, 22% – three steps) as a white solid in a mixture of rotamers. In each case the shift relating to the minor rotamer has been donated with an asterisk.* *H NMR (400 MHz, CDCb) d = 8.46 (dd, J = 7.8, 1.6 Hz, 1H + 1H*), 7.79 – 7.55 (m, 4H + 4H*), 7.32 – 7.28 (m, 1H + 1H*), 7.14 (bs, 1H + 1H*), 5.59 (s, 2H + 2H*), 4.33 (s, 2H + 2H*), 3.87 – 3.04 (m, 10H + 10H*), 1.28 (s, 12H + 12H*), 1.04 – 0.97 (m, 4H + 4H*), 0.90 – 0.85 (m, 1H + 1H*), 0.83 – 0.71 (m, 2H + 2H*), 0.00 (s, 9H + 9H*); 13C NMR (100 MHz, CDCb) d = 172.3 (1C + 1C*), 171.0 (1C + 1C*), 160.0 (1C + 1C*), 144.7 (1C + 1C*), 142.9 (1C + 1C*), 141.3 (1C + 1C*), 136.3 (1C + 1C*), 133.3 (1C + 1C*), 131.5 (1C + 1C*), 129.2 (1C + 1C*), 128.4 (1C + 1C*), 128.2 (1C + 1C*), 127.7 (1C + 1C*), 125.4 (1C + 1C*), 125.2 (1C + 1C*), 84.1 (2C + 2C*), 79.0 (1C + 1C*), 67.3 (1C + 1C*), 47.3 (1C*), 46.9 (1C), 45.2 (1C*), 44.8 (1C), 41.9 (1C*), 41.7 (2C), 41.4 (1C*), 39.1 (1C + 1C*), 24.9 (4C + 4C*), 18.1 (1C + 1C*), 11.1 (1C + 1C*), 7.66 (2C + 2C*), -1.36 (3C + 3C*) (the carbon bearing the boron substituent is not observed); IR (v, cm 1): 2981, 2889, 2360, 2341, 1641, 1382, 1354, 1146, 1087, 956; HRMS (ESI) for C36H49N4O610B23Na28Si [M+Na]+ requires 694.34429 found 694.34418; Mp: 78 – 80C.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
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109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 7 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid A mixture of 0.75 g (2.68 mmol) of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 1.07 g (10.4 mmol) of 2-methylpiperazine and 30 ml of acetonitrile was refluxed for five hours, then stirred at room temperature overnight. The precipitate was filtered, washed with water/ethanol and acetonitrile, and dried to give 0.42 g of the title compound, mp 189-192 C., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Warner-Lambert Company; US4920120; (1990); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

5464-12-0, a) 1 -(2-Chloroethyl)-4-methylpiperazine (1-96) Thionyl chloride (2.4 mL; 33 mmol; 1.1 eq) was added to a solution of 2- (4- methylpiperazin-l-yl)ethan-l-ol (4 g; 29 mmol; 1 eq) in dry chloroforme (40 mL). The reaction mixture was stirred at reflux for 4 hours, then, concentrated to dryness. 1M sodium hydroxide solution (100 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 150 mL). The combined organic layers were washed with saturated sodium chloride (1 x 50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound, l-(2-chloroethyl)- 4-methylpiperazine in 35percent yield (1.66 g) as an brown oil. 1H NMR (CDC13): 2.36 (s, 3H), 2.59 (m, 8H), 2.79 (t, 2H), 3.64 (t, 2H); MS (ESI+): m/z = 163.1-165.1 [M+H]+.

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 511 2-{[(2-{[3-(4-cyclopentyl-1-piperazinyl)propyl]amino}phenyl)sulfonyl]amino}-8-methyl-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid EXAMPLE 511A 3-(4-cyclopentyl-1-piperazinyl)-1-propanamine [0873] A mixture of N-(3-bromopropyl)phthalimide (0.8 g, 3.0 mmol), 1-cyclopentylpiperazine (0.46 g, 3.0 mmol), and K2CO3 (1.66 g, 12.0 mmol) in CH3CN (30 mL) was heated to reflux for 3 hours, cooled to room temperature, and filtered through diatomaceous earth (Celite). The filtrate was concentrated, treated with 6N HCl (9.0 mL) and acetic acid (18.0 mL), heated to reflux overnight, and concentrated. The residue was treated with potassium carbonate (1.66 g) in CH3CN (30 mL) for 1 hour. After filtration of the solid, the solvent was evaporated to provide the desired product. MS (DCI/NH3) m/e 212 (M+H)+; 1H NMR (300 MHz, DMSO-d6) delta 8.04 (br s, 2H), 3.68 (m, 4H), 3.41 (m, 4H), 3.21 (m, 2H), 2.91 (m, 2H), 2.0 (m, 4H), 1.84-1.73 (m, 4H), 1.55 (m, 2H)., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Patent; Comess, Kenneth M.; Erickson, Scott A.; Henkin, Jack; Kalvin, Douglas M.; Kawai, Megumi; Kim, Ki H.; BaMaung, Nwe Y.; Park, Chang Hoon; Sheppard, George S.; Vasudevan, Anil; Wang, Jieyi; Barnes, David M.; Fidanze, Steve D.; Kolaczkowski, Lawrence; Mantei, Robert A.; Park, David C.; Sanders, William J.; Tedrow, Jason S.; Wang, Gary T.; US2004/167128; (2004); A1;,
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Piperazines – an overview | ScienceDirect Topics

59702-31-7, 1-Ethylpiperazine-2,3-dione is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a four-necked flask was added 4-ethyl-2,3-dioxopiperazine (14.2 g, 0.1 mol)Dichloromethane (60 ml) and trimethylchlorosilane (13.0 g, 0.12 mol) were added. The temperature was controlled to -10 to -20 C. and triethylamine (25.5 g, 0.25 mol) was added dropwise to -5 to 0, Stirring for 12min;Ethyl-2,3-dioxopiperazine chloride (22.4 g, 0.11 mol) was dissolved in 20 ml of methylene chloride,The temperature was controlled at 0 C ~ -5 C for 40min, warmed to 25 C and incubated for 8h. After the reaction was completed, the temperature was lowered to -15 C, filtered and the filter cake was rinsed with precooled dichloromethane (8ml). The mother liquor was combined and concentrated (30 ~ 40 , the degree of vacuum is <0.1MPa) to obtain crude product 0.4g (yield 98.6%, purity 95%)., 59702-31-7

As the paragraph descriping shows that 59702-31-7 is playing an increasingly important role.

Reference£º
Patent; Jiangxi Fuxiang Pharmaceutical Co., Ltd.; Zheng Yuyi; Wu Xiaofeng; Zhou Zhongbo; Xie Yongju; Wang Dongdong; (8 pag.)CN104529914; (2017); B;,
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Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1.Synthesis of 4-Ethyl-1-(4-nitrophenyl)piperazine To 4-fluoro-1-nitrobenzene(1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80 C. for 16 h.Concentrated the resultant mixture and partitioned between ethyl acetate and water.The organic layer was then washed with brine and dried with sodium sulfate and concentrated.Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
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Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

13484-40-7, General Method FFl F2 F3Fl (1 equiv) was dissolved in CH2Cl2 (2 mL) and F2 (1.0-1.1 equiv) was added. The reaction mixture was stirred at room temperature for 3 hours whereafter it was washed with saturated NaHCO3 (2 mL). The organic phase was dried (Na2SO4), filtered and concentrated to afford F3.Example 44(a) l~[(4-Bromophenyl)sulfonyl]-4-(2-methoxyethyl)piperazineThe title compound was prepared in accordance with the general method F using 4- bromobenzenesulfonyl chloride (201.7 mg, 0.789 mmol) and l-(2- methoxyethyl)piperazine (113.8 mg, 0.789 mmol) to give the title compound (277 mg,97%).1H NMR (400 MHz, CDCl3) delta ppm 7.64 – 7.69 (m, 2 H) 7.57 – 7.62 (m, 2 H) 3.47 (t, J=5.2 Hz, 2 H) 3.30 (s, 3 H) 3.08 (s, 4 H) 2.62 (d, J=4.8 Hz, 6 H); MS (ESI) m/z 364 (M + 1).

The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/40440; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27561-62-2, Cyclohexyl(piperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 5.1.5. General procedure 4 (GP4) A halide intermediate (1.0equiv), amine (0.9-10equiv) and optionally a base (2.7equiv) and halogenating agent (0.5equiv) were mixed together in industrial methylated spirits (15mL per g halide) and heated in a microwave at 150C for 1h, repeating if neccesary. Upon completion of the reaction, the mixture was passed through a phase seperation cartridge, concentrated and purified, 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Article; Kelly, Nicholas M.; Wellejus, Anja; Elbr¡ãnd-Bek, Heidi; Weidner, Morten Sloth; J¡ãrgensen, Signe Humle; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3334 – 3347;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Step A: 2-(4-Cyclopropylpiperazin-1-yl)benzothiazole-6-carbonitrile; A suspension of 2-chlorobenzothiazole-6-carbonitrile (3.5 g, 18 mmol), 1-cyclopropyl- piperazine (3.63 g, 28.8 mmol) and ammonium chloride (0.96 g, 18 mmol) in butan-1-ol (1 12 ml.) was heated at reflux for 48 h. The solvent was removed under reduced pressure and the residue was diluted with water (30 ml_). The mixture was made alkaline with potassium carbonate and extracted with CH2CI2 (3 x 20 ml_). The combined organic extracts were concentrated to give a residue which was purified by column chromatography on silica gel (20 % ethyl acetate in petroleum ether) to give 2.2 g (43 5) of 2-(4-cyclopropylpiperazin-1-yl)benzo- thiazole-6-carbonitrile., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics