Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 49; l-{2-[(2R)-4-benzhydryl-2-methylpiperazin-l-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2- one; Example 49A; (R)-l-benzhydryl-3-methylpiperazine; A solution of the dihydrochloride of i?-methylpiperazine (Tetrahedron Lett. 1994, 35, 16, 2533-2536)(0.42 g, 2.42 mmol) in N,JV-dimethylformamide (3 mL) was treated with bromodiphenylmethane (0.6 g, 2.42 mmol), potassium carbonate (1.17 g, 8.5 mmol), and a catalytic amount of potassium iodide. The resultant reaction mixture was then stirred at ambient temperature overnight. Then the reaction mixture was concentrated and partitioned between water/methylene chloride. The organic layer was dried over magnesium sulfate, concentrated and the residue was purified by preparative HPLC on a Waters Nova-Pak.(R). HR Cl 8 6um 6psiA Prep-Pak.(R). cartridge column (40mm x 100mm) using a gradient of 10percent to 100percent acetonitrile in 10 mM aqueous ammonium acetate over 12 minutes at a flow rate of 70 mL/min to provide the title compound., 75336-86-6

The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
Piperazine – Wikipedia
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103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 145 Synthesis of 2-(4-{6-[7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-2-methyl-pyrimidin-4-yl}-piperazin-1-yl)-ethanol To synthesize the title compound (CLXIX), two intermediate compounds 62 (2-[4-(6-chloro-2-methyl-pyrimidin-4-yl)-piperazin-1-yl]-ethanol) and 63 (7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamine) shown below were used. To synthesize compound 62, to a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2-piperazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DIPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The reaulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford compound 62 as a brown liquid (2.1 g, 39%). MS (ESI+): m/z 257.

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TargeGen, Inc.; US2005/245524; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

75336-86-6, Step 1: 3-(R)-Methyl-piperazine-1-carboxylic Acid Tert-Butyl Ester Triethylamine (3 g, 4.2 mL, 30 mmol) was added to a solution of (R)-2-methyl piperazine (2 g, 20 mmol) in dichloromethane (40 mL) followed by di-tert-butyl-dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 20 h. The mixture was diluted with dichloromethane and washed with saturated aqueous sodium bicarbonate and brine and dried over sodium sulfate. The crude product was purified using a short plug of silica gel using hexane/ethyl acetate (1:1). 1H-NMR (CDCl3) delta: 1.05 (3H, d), 1.45 (9H, s), 2.11 (1H, s), 2.37-2.44 (1H, m), 2.66-2.79 (3H, m), 2.93-2.96 (1H, m), 3.93 (2H, br s). ESI-MS m/z: 201(M+1).

As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.

Reference£º
Patent; Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.; US2005/70549; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

A solution of anhydrous piperazine (1, 9.4 g, 0.11 mol) and piperazine dihydrochloride (2, 31.8 g, 0.20 mol) in ethanol (80 mL) was placed in a three-necked flask equipped with a magnetic stir bar and reflux condenser and was heated with vigorous stirring at 65 C for 3 h. Then benzyl chloride (12.6 g, 0.10 mol) was added dropwise over a period of 45 min to the reaction mixture, which was then refluxed for another 2h. The progress of the reaction was monitored by TLC. The mixture was cooled and the precipitated piperazine dihydrochloride (2) was recovered. The combined filtrate was concentrated under reduced pressure to give the N-benzylpiperazine hydrochloride, which was then treated with 4 M NaOH to pH > 12. The aqueous layer of crude N-benzylpiperazine was extracted with CHCl3 (3 ¡Á 50 mL). The combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (1:5 MeOH-CH2Cl2) to give 4: Yield 18.3 g (95%); 1H NMR (500 MHz, CDCl3): delta 7.34-7.28 (m, 5H),3.57 (s, 2H), 3.23 (s, 4H), 2.77 (s, 4H); MS (ESI) m/z: 177 [M + H]+.Spectroscopic data are according to the literature.13, 142-64-3

142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Hu, Xiao; Chen, Hui; Wu, Wei-Jun; Wang, Wen-Ling; Wang, Jin; Journal of Chemical Research; vol. 40; 9; (2016); p. 519 – 520;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-5-nitropyridine (2.5g, 15.7mmol) in THF (25mL), are added1 -isopropylpiperazine (2.01g, 15.7mmol) and K2CO3 (3.25g, 23.6mmol). The reaction mixture is stirred at 5O0C for 4 hours and then at 7O0C overnight. The solvent is removed in vacuo and the resultant orange solid is triturated using 10:1 petroleum ether-diethyl ether. The isolated compound (3.7g, 94percent) is used in the next step without further purification.

4318-42-7, As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57260-71-6

Synthesis of 4-(4-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (1). A mixture of 4-(tert-butyl-l -piperazinecarboxylate (556 mg, 3.0 mmol), 4- fluoro-benzaldehyde (315 mul, 3.0 mmol) and K2CO3 (514 mg, 3.7 mmol) in DMF (5 ml) was stirred at ambient temperature overnight. Reaction was diluted with water (30 ml) and extracted with EtOAc (50 ml x 2). Organic layer was washed with water (20 ml), 1 M aq. HCl (20 ml), water (20 ml x 2) and brine (20 ml) and dried over MgSO4 (anh.). Solvent was evaporated in vacuum. Residue was triturated with hexane. Formed precipitate was filtrated and dried in vacuum overnight to provide target compound (1) (342 mg, 39%) as off-white solid. LC-MS [M+H] 291.2 (C16H22N2O3+H, requires 291.38).

The synthetic route of 57260-71-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACHAOGEN, INC.; WO2008/154642; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55112-42-0, [0218] To a suspension of tert-butyl 5-(2-(3-aminophenyl)quinazolin-4-ylamino)- lH-indazole-1 -carboxylate (100 mg, 0.22 mmol) and 4-methylpiperazine-l-carbonyl chloride hydrochloride (88 mg, 0.44 mmol,) in CH2Cl2 (2 mL) was added Et3N (92 muL, 0.66 mmol) and catalytic amount of DMAP. The reaction mixture was stirred at RT for 2 h after which 2 equivalents each of 4-methylrhoiperazine-l-carbonyl chloride hydrochloride and 3 equivalents OfEt3N were added. Continued to stir at ambient temperature for 16 hours. The reaction was concentrated in vacuo and the residue was purified by flash chromatography on silica (8:1 CH2Cl2MeOH). The product tert-butyl 5-(2-(3-(l- methylpiperazine-4-carboxamido)phenyl)-quinazolin-4-ylamino)-lH-indazole-l- carboxylate was isolated. (160 mg, 100%)

As the paragraph descriping shows that 55112-42-0 is playing an increasingly important role.

Reference£º
Patent; SURFACE LOGIX, INC.; BARTOLOZZI, Alessandra; SWEETNAM, Paul; WO2006/105081; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-31-7, 1-Ethylpiperazine-2,3-dione is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-31-7, EXAMPLE 6 1-Ethyl-4-(mercaptomethyl)-Piperazine-2,3-dione To a solution of 1-ethylpiperazine-2,3-dione (2.13 g, 15 mmol) in 30% aqueous (methanol free) formaldehyde (15 mmol) potassium hydroxide (150 mg, 2.7 mmol) was added and the mixture stirred at 50 C. for 7 days. It was neutralized with 5 N aqueous hydrochloric acid (50 mul) to pH=7. The mixture was evaporated at 15 mm and then dried in high vacuo (0.0013 mbar) (0.001 mm) to give 1-ethyl-4-(hydroxymethyl)-piperazine-2,3-dione as a colourless solid (100%). NMR-spectrum in CDCl3: 1.15 (broad signal, 1H), 1.15 (t, 3H, J=7 Hz), 3.47 (q, 2H, J=7 Hz), 3.54 (m, 2H), 3.68 (m, 2H), 4.88 (s, 2H) ppm.

The synthetic route of 59702-31-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfaendler, Hans Rudolf; US2001/31749; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2,5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20. (5-chloro-2,4-dihydroxyphenyl)(4-methyl-2-phenylpiperazin-1-yl)methanone (11j) Compound 18 (0.20 g, 1.05 mmol), 1-methyl-3-phenylpiperazine (0.28 g, 1.58 mmol), 1-ethyl-3-(3-dimethylaminopropyl) (0.40 g, 2.10 mmol), 1-hydroxybenzotriazole (0.14 g, 1.05 mmol) and N,N-diisopropylethylamine (0.19 mL, 1.05 mmol) were dissolved in 4 ml of DMF and stirred at 120¡ã C. for 3 hours under a microwave irradiation (Biotage Initiator). The reaction mixture was diluted with ethyl acetate and the organic layer was washed with 1 N HCl solution. It was dried over Na2SO4, concentrated under pressure and purified by MPLC to obtain Compound 11j in a yield of 23percent. Rf=0.21 (8:2 ethyl acetate:hexane). 1H NMR (400 MHz, CDCl3) delta 7.46 (d, J=4.4 Hz, 2H), 7.37 (t, J=7.2 Hz, 7.2 Hz, 2H), 7.27 (t, J=7.2 Hz, 6.8 Hz, 1H), 7.17 (s, 1H), 6.61 (s, 1H), 5.58 (s, 1H), 4.24 (s, 1H), 3.24 (d, J=12.0 Hz, 1H), 3.22 (t, J=12.4 Hz, 10.4 Hz, 1H), 2.81 (d, J=10.8 Hz, 1H), 2.50 (dd, J=12.0 Hz, 4.0 Hz, 1H), 2.32 (s, 3H), 2.21-2.14 (m, 1H).

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY; SEO, Young Ho; (32 pag.)US2019/31620; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

74879-18-8, To a solution of 2-(S)-methylpiperazine (3.79 g, 37.9 mmol) in CHCl3 (100 ML) was trityl chloride (10.56 g, 37.9 mmol) added in one portion.The exothermic reaction was stirred at ambient temperature for two hours, the organic phase was washed three times with water, dried (MgSO4) and the solvent was evaporated at reduced pressure to give 12.5 g (96%) of a colorless foam that solidified to a crisp over night. 1H NMR (CDCl3) delta1.06 (d, J=5.5 Hz, 3 H), 1.35 (m, 1 H), 1.61 (m, 1 H), 3.01 (m, 3 H), 3.14 (m, 1 H), 3.31 (m, 1 H), 7.08 (m, 3 H), 7.16 (m, 6 H), 7.35 (m, 6 H).13C NMR (CDCl3) delta18.17, 44.46, 46.68, 51.59, 54.03, 126.26, 127.13, 127.68, 129.07 br. The racemate of the title compound is reported in Bioorg. Med. Chem. Lett. 2000, 10, 2643-2646.

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Nilsson, Bjorn M.; Ringberg, Erik; US2003/232814; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics