Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

For the N-boc protection of amines, to solution of diboc (1 mmol) in ethanol (5 ml) was added {K*18-crown-6]Br3}n (0.001 mmol). The solution was stirred at room temperature for 1 min. The amine (1 mmol) was then added and solution as stirred at room temperature for an appropriate time (table 1). After completion of the reaction, the solvent was removed by water bath distillation. To the residue was added ethyl acetate (5 ml) and the mixture was filtered (the catalyst is insoluble in n-hexane and ethyl acetate). The solid was washed with ethyl acetate ()10 ml*2) amd combined filtrates were reduced to dryness to yield the pure products.

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Chehardoli, Gholamabbas; Zolfigol, Mohammad Ali; Derakhshanpanah, Fateme; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 9; (2013); p. 1730 – 1733;,
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109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(ira^-4-(3-Chloropyrazin-2-yloxy)cyclohexyl)benzo[JJthiazol-2-amine (0.080 g, 0.22 mmol), 1 -methylpiperazin-2-one hydrochloride (0.10 g, 0.67 mmol), and triethylamine (0.093 mL, 0.67 mmol) were mixed in DMSO (2 mL) under an argon atmosphere. The reaction mixture was stirred at 80 C for 24 h. The reaction mixture was then warmed to 120 C and stirred for an additional 72 h. The reaction mixture was cooled to T, diluted with water, and extracted with EtOAc (2x). The organic extracts were combined, washed with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated. The resulting crude product was purified via silica gel chromatography to give 4-(3-(ira?s-4-(benzo[J]thiazol-2- ylamino)cyclohexyloxy)pyrazin-2-yl)-l-methylpiperazin-2-one as a light orange solid. [M+l] 439.2. ICso (uM): 0.5369., 109384-27-2

109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8

General procedure: A solution of compound 2 (0.55 mmol), 1-substituted piperazine (0.83 mmol) and pyridine (0.8 mmol) in 10 mL THF (tetrahydrofuran) was stirred at room temperature overnight. When the reaction was completed, the solvent was evaporated under reduced pressure. The residues were dissolved in ethyl acetate and washed with water and saturated sodium chloride solution. After drying over anhydrous Na2SO4, the solvent was removed under reduced pressure to get crude product. The pure products were obtained by recrystallizing from ethanol.

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Zhilin; Ding, Na; Tang, Yuting; Ye, Jiao; Peng, Junmei; Hu, Aixi; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4833 – 4850;,
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13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction of1-bromo-4-nitrobenzene (0.20 g, 1.0 mmol), 1-(piperazin-1-yl)ethan-1-one (0.190 g,1.5 mmol), copper powder (0.0064 g, 0.1 mmol), MI (0.036 g, 0.2 mmol), Cs2CO35(0.720 g, 2.2 mmol), TBAHS (0.068 g, 0.2 mmol) produced 0.238 g (96%) of1-(4-(4-nitrophenyl)piperazin-1-yl)ethan-1-one as a yellow solid., 13889-98-0

The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang; Tetrahedron Letters; vol. 60; 29; (2019); p. 1938 – 1941;,
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50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, PREPARATION 8: Preparation of piperazine-1-carboxylic acid methylamide 11 g (59 mmol) of N-butyloxycarbonylpiperazine was dissolved in 250 ml of anhydrous tetrahydrofuran, and then 20.6 ml (118 mmol) of N,N-diisopropylethylamine and 13.1 g (64.9 mmol) of 4-nitrophenylchloroformate were added thereto, followed by stirring under reflux for 1 hour. 177 ml of methylamine (2 M tetrahydrofuran solution) was added to the reaction, followed by stirring under reflux for 30 minutes. After completion of the reaction, the reaction solution was concentrated, after addition of 100 ml of water, and then extracted twice with 100 ml of dichloromethane. 30 ml of 4 N hydrochloric acid/l,4-dioxane solution was added thereto, followed by stirring for 5 hours at room temperature. A solid, which was produced from completion of the reaction, was filtered off and dried to obtain 9.53 g (53 mmol, yield of 90%) of the title compound as hydrochloride salt.1H NMR (DMSOd6, ppm); delta 9.28 (IH, bs), 7.94 (IH, bs), 3.52 (4H, m), 3.01 (4H, m), 2.57 (3H, s)FAB MS(m/e) = 144 [M+l]

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG LIFE SCIENCES, LTD.; WO2007/58482; (2007); A1;,
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13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of 1-(4-(3-methoxy-4-nitrophenyl)piperazin-1-yl)ethanone The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80C overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid. 1H-NMR(300 MHz, CDCl3) delta 8.00(d, J = 9.1 Hz, 1H), 6.42(d, J = 9.1 Hz, 1H), 6.32(s, 1H), 3.96(s, 3H), 3.80-3.79(m, 2H), 3.67-3.65(m, 2H), 3.47-3.40(m, 4H), 2.15(s, 3H); Mass (M+H+) calcd for C13H17N3O4 279.12, found 279.20, 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Korea Research Institute of Chemical Technology; LEE, Kwangho; KIM, Hyoung Rae; PARK, Chi Hoon; LEE, Chong Ock; LEE, Jong Kook; JUNG, Hee Jung; CHO, Sung Yun; CHAE, Chong Hak; CHOI, Sang Un; HA, Jae Du; EP2883875; (2015); A1;,
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4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7

N, N -CARBONYLDIIMIDAZOLE (11. 0G, 67.5 mmol) was added to a solution of D8 (14.9 g, 32.2 mmol) in DMAC (100 mL) at room temp. Vigorous gas evolution was evident. The reaction mixture was stirred for 1 hour forming a yellow ppt after 15 min. Additional DMAC (50 mL) was added to aid stirring. i-Propylpiperazine (9.5 g, 74.0 mmol) was added and the reaction mixture became homogeneous. The reaction mixture was stirred overnight, forming a yellow ppt, then poured into H20 (1000 mL). The solid was collected by filtration, suspended in ETOH (300 mL) and heated to boiling. After cooling slightly, the solid was collected by filtration, rinsed with ETOH (50 mL), then Et2O (100 mL), and dried under vacuum to give D9 (17.4 g, 94 percent yield) as a yellow solid.

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GPC BIOTECH, INC.; WO2004/92139; (2004); A2;,
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Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5308-25-8

5-Ch.oro-2-nitroaniline (3g, 17.4mmol), 1-ethylpiperazine (4.42ml, 34.9mmol) and potassium carbonate (2.4g, 17.4mmol) in DMF (8ml) were heated at 130C for 2h in a Smithcreator microwave. The mixture was diluted with water and ethyl acetate. A yellow solid formed, it was filtered off and dried to give 1.3g of the title compound. LC/MS Rt = 1.21 , [MH+] 251.2, 252.2

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/114272; (2006); A1;,
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Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 3-methyl-1-thiazol-2-ylpiperazine 30.06 g (300.0 mmol) of 2-methylpiperazine were combined with 4.51 ml (50.0 mmol) of 2-bromothiazole. This mixture was fused and refluxed 5 min. The reaction mixture was cooled and taken up in 10% strength hydrochloric acid and washed with EA. The aqueous phase was set to pH>12 with a 10% strength aq. NaOH solution and then extracted with EA. The organic phase was dried over MgSO4 and conc. in vacuo. There were obtained 8.26 g (45.1 mmol, 90%) of 3-methyl-1-thiazol-2-ylpiperazine., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: Methane sulfonyl chloride (58 muL, 0.7 mmol) and triethylamine (238 muL) was added to a solution of compound 2 (180 mg, 0.6 mmol) in dichloromethane (5 mL) and stirred at room temperature for 1 h. After completion of the reaction by TLC, ice water was added to quench the reaction. The mixture was extracted with dichloromethane (20 mL¡Á3). The organic layer was washed with brine and dried over Na2SO4. The solid was filtered off, and the filtrate was concentrated under reduced pressure to give the methylsulfonylated product (210 mg, yield 93%). To a solution of the methylsulfonylated product (210mg, 0.6 mmol) in DMF (5 mL) was added K2CO3 (111 mg, 0.8 mmol), morpholine (93 muL, 1.0 mmol). The mixture was stirred at 90 C for 2 h. After completion of the reaction by TLC, The mixture was extracted with dichloromethane (20 mL¡Á3). The organic layer was washed with brine and dried over Na2SO4. The solid was filtered off, and the filtrate was concentrated under reduced pressure. The residues were separated by silica gel column chromatography (V petroleum ether: V ethyl acetate = 8:1) to give CH-H-1 (108 mg, yield 53%). Under the same conditions, compounds CH-H-2 to CH-H-16 were obtained., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Duan, Zhe; Liu, Jingqiu; Niu, Liping; Wang, Jun; Feng, Mingqian; Chen, Hua; Luo; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3229 – 3236;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics