Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5317-33-9,3-(4-Methylpiperazin-1-yl)propan-1-ol,as a common compound, the synthetic route is as follows.

170 mg (1.08 mmol) of 3-(4-methylpiperazin-1-yl)propan-1-ol are dissolved in 20 ml of DMF, 64.5 mg (1.61 mmol) of NaH in paraffin oil (60%) are added under nitrogen, and the mixture is stirred at room temperature. After 10 min, 200 mg (0.54 mmol) of 5-[6-oxo-3-(3,4,5-tri-fluorophenyl)-6H-pyridazin-1-ylmethyl]-1,3-dihydrobenzimidazol-2-one are added, and the mixture is stirred at room temperature under a nitrogen atmosphere. The reaction is monitored by means of HPLC. After 3 h, the reaction is terminated. The mixture is neutralised using 1N HCl.The mixture is evaporated to dryness, the residue is dissolved in 100 ml of ethyl acetate and 30 ml of water, the aqueous phase is separated off and neutralised using sodium hydrogencarbonate and subsequently extracted. A precipitate deposits in the process and is separated off. The residue is stirred with methanol, filtered off with suction and dried in vacuo.Yield: 41 mg of ?A56? as white solid; ESI 511; Rt.=1.97 min (method B)., 5317-33-9

5317-33-9 3-(4-Methylpiperazin-1-yl)propan-1-ol 79208, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRAeNKTER HAFTUNG; US2010/179149; (2010); A1;,
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13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted piperazine (10 mmol), 4-uoroben-zaldehyde (10 mmol) and K2CO3 (2 mmol) were reuxed at130 C in DMF for 15-24 h. Thereafter, the reaction mixture waspoured into ice cold water and the precipitate that appeared wasltered and dried to accomplish formyl derivatives (14-25) in ayield of 80-90%

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Mishra, Chandra Bhushan; Manral, Apra; Kumari, Shikha; Saini, Vikas; Tiwari, Manisha; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3829 – 3841;,
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13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 18 To a solution of Compound A (0.25 g, 0.60 mmol) in acetonitrile (6 mL) at room temperature were added diisopropylethylamine (0.42 mL, 2.4 mmol) and 1-acetylpiperazine (0.116 g, 0.90 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 503. An NMR spectrum is provided in FIG. 18.Yield: 0.26 g (85%)., 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.,5271-27-2

(S)-1 -methyl-3-phenylpiperazine.(+)Anicyphos salt 100 g of (R,S)-1-methyl-3-phenylpiperazine (1 ) (567 mmole) and 154.5 g of (+)- Anicyphos (571 mmole) were dissolved in 250 ml of water by heating the mixture to reflux. After cooling down to room temperature a seed crystal was added. After two hours, the white crystals formed were collected by filtration and dried in a vacuum oven at 40 0C for 21 hours. This provided 121 g (48 percent) with an ee of 85.5percent. The crystals were dissolved in water (119 ml) at reflux temperature. After cooling down the crystallization started. After one hour the crystals were collected by filtration and dried in a vacuum oven at 40 0C. The yield of the crystals of (S)-1-methyl-3- phenylpiperazine.Anicyphos salt was 105.8 g (42 percent, ee 99.0percent). The ee was determined by HPLC analysis: Chiralcel OD 250*4.6mmlD (Daicel), 5 percent iso-propylalcohol in hexane, flow rate 1.0 ml.min”1, UV-detector, column temperature 40 0C, retention times 5.6 min, 6.3 min.

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; WO2008/125578; (2008); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

Step 1 A solution of 4-fluoro-2-nitrobenzaldehyde (0.20 g, 1.2 mmol) in DMSO (3.5 mL) was added with 1-methanesulfonylpiperazine (0.71 g, 3.5 mmol), followed by stirring at 100 C for 1 hour. The reaction mixture was added with water and the organic layer was extractd with hexane/ethyl acetate (4/1) to remove impurities. The aqueous layer was extracted with ethyl acetate and the obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to obtain 4-(4-methanesulfonylpiperazin-1-yl)-2-nitrobenzaldehyde (0.36 g, 96%). 1H-NMR (270 MHz, DMSO-d6) delta 2.92 (s, 3H), 3.23 (t, J = 5.1 Hz, 1H), 3.63 (t, J = 5.1 Hz, 1H), 7.31 (dt, J = 8.9 Hz, 2.4 Hz, 1H), 7.49 (d, J = 2.4 Hz, 1H), 7.85 (d, J = 8.9 Hz, 1H), 9.86 (s, 1H). APCI-MS (m/z); 314 [M+H]+, 55276-43-2

The synthetic route of 55276-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1847532; (2007); A1;,
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Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, Di-tert-butyl azodicarboxylate (0.478 g, 2.08 mmol) was added portionwise to a mixture of 4-chloro-7-hydroxy-6-methoxyquinazoline (0.350 g, 1.66 mmol), 3-(4-methyl-piperazin-1-yl)-propan-1-ol (Intermediate 9, 0.276 g, 1.74 mmol), and triphenylphosphine (0.544 g, 2.08 mmol) in dichloromethane (20 mL) at r.t.. If necessary, further alcohol was added. After stirring for 2 h, the solution was concentrated to 10 mL, mounted on silica and chromatographed (gradient, dichloromethane to dichloromethane : methanol = 3:2 within 1 h) to obtain 4-chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline (brownish solid, 0.431 g, 1.23 mmol, 74 %). LC/ESI-MS: m/z = 351 [M(35Cl) +H]+; Rt = 1.88 min. Cf. also WO 04/043472, page 32.

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference£º
Patent; 4SC AG; EP1674466; (2006); A1;,
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Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-chlorophenyl isothiocyanate (8.0 g, 47.17 mmol) in dichloromethane (250 mL) was added dropwise over 30 minutes to an ice cooled solution of 2-methylpiperazine (9.45 g, 94.33 mmol) in dichloromethane (250 mL). Once the addition was complete, the reaction was stirred at room temperature for an hour. The reaction was then washed with water (3¡Á), dried over MgSO4 and concentrated under reduced pressure, to give the title compound as a white solid, 11.8 g. 1H NMR (400 MHz, CDCl3): delta 1.08 (d, 3H), 2.70 (m, 1H), 2.88 (m, 2H), 3.02 (m, 2H), 4.43 (m, 2H), 7.10 (m, 2H), 7.29 (m, 2H). LCMS: m/z ES+270.1 [MH]+

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/154024; (2005); A1;,
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142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,142-64-3

EXAMPLE 27 In a 100-ml. flask was placed 1.59 g. of piperazine dihydrochloride and 3 ml. of water. To the resulting solution was added 3.92 g. of 2,3,4-trimethoxybenzaldehyde dissolved in 15 ml. of methanol. A solution of 0.98 g. of sodium cyanide in 5 ml. of water was added dropwise to the mixture over a period of about 10 minutes with ice cooling. Then the reaction mixture, from which crystalline precipitate separated upon heating, was stirred for 2.5 hours while the external temperature was kept at 40 to 50C. After the mixture was cooled, crystal was collected by filtration, washed with water and methanol, and dried. There was obtained 4.3 g. of crystal having a melting point of 244 – 247C. Recrystallization from chloroform-methanol afforded N,N’-bis-(alpha-cyano-2,3,4-trimethoxybenzyl)piperazine as a crystalline product melting at 245 – 247C.

The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fuji Chemical Industry Co., Ltd.; Nippon Chemiphar Co., Ltd.; US3962247; (1976); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of 2-chloroalkyl/aryl substitutedwith or without N-substitution as well as with or without 5 and/or 6-substituted benzimidazole derivative (1.75g,0.01051mol) and 1-[(4-phenyl)carbonyl]piperazine (3g,0.0105mol) in N, N dimethylformamide was taken in a RBF.K2CO3(2gm,) was added to the reaction mixture. The reaction mixture was stirred for 8h at 80C on a magnetic stirrer (heat + stirring). The progress of the reaction was monitored by thin layer chromatography (TLC).Upon completion of the reaction, water was added to the reaction mixture and the product extracted by shaking the reaction mixture with dichloromethane in a separating funnel.The dichloromethane layer was washed successively with water and brine, dried over anhydrous sodium sulfate. Evaporation of the solvent gave theproduct. 11a-l Recrystallized with various solvent like chloroform, ethanol, methanol., 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Article; Kankate, Rani S.; Gide, Parag S.; Belsare, Deepak P.; Oriental Journal of Chemistry; vol. 30; 4; (2014); p. 1855 – 1863;,
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109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 2 2-(4-methylpiperazin-1-yl)-aniline A mixture of 2-fluoronitrobenzene (6.0 mL, 56.9 mmol) and N-methylpiperazine (8.11 mL, 56.9 mmol) was stirred at 0 C. for 20 minutes, then at room temperature for 3 days. The crude mixture was partitioned between methylene chloride and saturated aqueous sodium bicarbonate and the organic layer was then washed with saturated sodium chloride (NaCl), dried and concentrated in vacuo to provide 2-(4-methylpiperazin-1-yl)-1-nitrobenzene as an orange oil, 12.4 g. 1H-NMR (CDCl3, 300 MHz) delta 7.75 (1H, dd), 7.47 (1 H, dt) 7.15 (1H, dd), 7.03 (1H, dt), 3.09 (1H, dd), 2.56 (1H, dd), 2.36 (3H, s).

109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US6258953; (2001); B1;,
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Piperazines – an overview | ScienceDirect Topics