Tag: M.W:100-200

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A:6-Bromo-2-(4-cyclopentylpiperazin-1-yl)benzothiazole; To a solution of 6-bromo-2-chlorobenzothiazole (3 g, 12.1 mmol) in ethanol (50 mL) was added triethylamine (5.04 mL, 36.3 mmol) and 1-cyclopentylpiperazine (1.86 g, 12.1 mmol). The reaction mixture was heated at reflux for 16 h and then concentrated under reduced pressure. The residue was extracted with ethyl acetate and the combined organic extracts were washed with brine, dried (Na2SO4) and concentrated under reduced pressure to afford 4.3 g (99 %) of 6-bromo-2-(4-cyclopentylpiperazin-1-yl)benzothiazole., 21043-40-3

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

15g of compound 6,150 ml of dichloromethane was added to the reaction flask.Cool down to 0 ¡ã C,Dissolve in 100 mL of dichloromethane16.5g of Boc-anhydride was added to the reaction flask and stirred for 1 hour.Point plate monitoring, after the reaction, filtering,The filtrate was spun dry, added with 100 mL of water, stirred, filtered, and the filtrate was added with saturated 10 g of potassium carbonate and stirred with methyl tert-butyl ether ether.Extract, dry over sodium sulfate, spin dry,Adding petroleum ether, stirring and crystallizing under cooling to obtain 25 g of compound 7;, 75336-86-6

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Tonghua Normal College; Geng Xiaoyu; Xue Mingxing; Zang Hao; Liu Xuekun; Sun Renshuang; Xue Changsong; Zhang Haifeng; (13 pag.)CN109438423; (2019); A;,
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Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dissolve 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE (0. 057 moles) and (R)- (-)-2- methylpiperazine (5. 75 g, 0. 057 moles) in DMA (125. 0 mL) under nitrogen atmosphere. Add anhydrous powdered K2CO3 (23. 75 g, 0. 172 moles) to this mixture and stir at 135-140¡ãC for 48 hours. Cool the reaction mixture to room temperature, dilute with water (400 mL), extract with EtOAc (3 x 200 mL) and wash the combined organic extract with brine (2 x 150 mL). Dry over MGS04, concentrate under vacuum to afford crude product as orange yellow liquid. Distil the crude under high vacuum to afford the title compound., 75336-86-6

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
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Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution containing 2 7g (18 9 mmol) of 1-[2-(methyloxy)ethyl]piotaperaziotane and 20 mL of THF at O0C was added 0 9 g (23 mmol) of a 60% suspension of sodium hydride in mineral oil The reaction mixture was allowed to stir for 15 mm and 3 O g (18 9 mmol) of 2-chloro-5-niotatropyriotadiotane was added The reaction mixture was heated at 60 0C overnight and then quenched by the addition of H2O and extracted with EtOAc The combined organic layers were dried over MgSO4 and the solvents were removed under reduced pressure The residue was subjected to silica gel chromatography to give 2 7g (54%) of 1-[2-(methyloxy)ethyl]-4-(5-niotatro-2- pyriotadiotanyl)piotaperaziotane as a yellow solid 1 H-NMR (400 MHz, DMSO-cfe) delta 8 95 (d, J = 2 8 Hz, 1 H), 8 21 (dd, J = 9 6 and 2 8 Hz, 1 H), 6 94 (d, J = 9 7 Hz, 2 H), 3 71 – 3 78 (m, 4 H), 3 46 (t, J = 5 7 Hz, 2 H), 3 24 (s, 3 H), and 2 50 – 2 53 (m, 6 H)

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory; WO2010/104899; (2010); A1;,
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74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,74879-18-8

(S)-2-Methylpiperazine (CAS No 74879-18-8) (420mg) is added to a solution ofIntermediate 7 (1g) in a mixture of NMP (10ml) and TEA (0.5 ml). The mixture is stirred for 1h at room temperature and then added to water (40ml). The mixture is stirred for 30 min, then the product is collected by filtration and washed with water (2 x 20ml) to give the title compound as colourless solid (H Og1 92 %). LCMS 402/404 [M+H]+, RT 2.64 mins (pH 5.8). 1 H NMR 300 MHz (d6-DMSO) (delta ppm): 9.65 (1 H, br s), 7.95 (1 H, m), 7.85 (1 H, d), 7.68 (1 H, dd), 4.75 (2H, m), 3.00-3.15 (2H, m), 2.70-2.82 (3H, m), 2.50 (1H, br s), 1.23 (9H, s), 1.07 (3H1 d)

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA, S.A.; WO2008/74445; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Compound 9 (10g, 82.6mmol) placed in 500mL single-port flask, 200mLDMSO. At room temperature was added (2R, 6S) -2,6-dimethylpiperazine (14g, 124mmol) and K2CO3 (28.5g, 206.5mmol), and mix well. Then heated to 130 , reaction 8h. After completion of the reaction was poured into 1L of water. (150mL * 3) and extracted three times with ethyl acetate. The organic phase was washed with 100mL saturated brine, dried over anhydrous sodium sulfate, the solvent spin dried to give a yellowish solid 15g, yield 85%.

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ShangHai HaiHe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica Chinese Academy of Sciences; Geng, Meiyu; Liu, Lei; Jiang, Lei; Huang, Min; Chua, Chuantao; Ai, Jing; Wang, Lei; Cao, Jianhua; Ding, Jian; (58 pag.)CN105524048; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-({3-Chloro-4-[(1-ethyl-4,5-dimethyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-methoxy-3-quinolinecarbonitrile To a stirred solution of 4-[3-chloro-4-(1-ethyl-4,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile (0.300 g, 0.539 mmol) in DMF (2 mL) was added 1-ethyl-piperazine (0.137 mL, 1.08 mmol) and NaI (0.008 g, 0.0539 mmol). The solution was heated to 100 C., maintaining the temperature overnight. The solution was cooled to room temperature and then diluted with brine (2 mL) and H2O (2 mL). The precipitate was collected via vacuum filtration and washed with H2O and Et2O to afford the product (0.290 g, 85%) as a solid, mp. 229-230 C.; 1H NMR (DMSO-d6) delta 0.93 (t, J=7.2 Hz, 3H), 1.04 (t, J=7.1 Hz, 3H), 1.85-1.95 (m, 2H), 2.07 (s, 3H), 2.15 (s, 3H), 2.22-2.43 (m, 12H), 3.86 (s, 3H), 3.90 (dd, J=7.1, 14.4 Hz, 2H), 4.14 (t, J=6.4 Hz, 2H), 6.58 (d, J=8.6 Hz, 1H), 7.06 (dd, J=2.3, 8.7 Hz, 1H), 7.29 (s, 1H), 7.30 (d, J=2.3 Hz, 1H), 7.61 (s, 1H), 8.45 (s, 1H), 9.46 (s, 1H); mass spectrum [(+) ESI], m/z 634/636 (M+H)., 5308-25-8

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/264427; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Compound P42: 5-(Morpholin-4-yl)-2-nitroaniline To the flask 2-amino-3-nitro-6-chloropyridine (1.50 g, 8.47 mmol), potassium carbonate (1.30 g, 9.32 mmol) and morpholine (10.5 ml, 119 mmol) were added. The reaction was carried out under argon flow at 130¡ãC overnight. The progress of the reaction was monitored by TLC (system: heptane/ethyl acetate, 1 /1 ). The mixture was cooled to room temperature and poured into the ice-water. A precipitated yellow solid was filtered and dried. 1.789 g of the title product were obtained (yield 94.2percent). Compound P48: 5-[(3R,5S)-3,5-dimethylpiperazin-1 -yl]-2-nitroaniline; The compound was obtained by the method analogous to that described for Compound P42. Starting from 5-chloro-2-nitroaniline (0.800 g, 4.64 mmol), potassium carbonate (0.705 g, 5.10 mmol) and cis-2,6-dimethylpiperazine (1.620 g, 13.9 mmol) in 5 ml of DMF, 1.144 g of the title product in the form of a yellow solid were obtained (yield 98.6percent). MS-ESI: (m/z) calculated for C12H19N4O2 [ + H]+: 251.15, found 251.1.

21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CELON PHARMA S.A.; ZDZALIK, Daria; LIPNER, Joanna; WIECZOREK, Maciej; DZWONEK, Karolina; YAMANI, Abdellah; DUBIEL, Krzysztof; LAMPARSKA-PRZYBYSZ, Monika; GRYGIELEWICZ, Paulina; STANCZAK, Aleksandra; WO2014/141015; (2014); A1;,
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Piperazines – an overview | ScienceDirect Topics

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh between methoxybenzoate 7.6g (0.05mol) was dissolved in 20ml of dry tetrahydrofuran was slowly added CDI8.9g (0.055mol), at room temperature for 4hAfter the reaction solution through a dropping funnel was added dropwise to a solution of constant piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of an aqueous solution of sodium chloride, 14g, and reacted for 5 hours at room temperature .After completion of the reaction by suction, the filtrate evaporated to remove THF, 10ml ethyl acetate again, NaOH saturated solution was adjusted to pH = 10, and the combined organic phase was extracted 3 times with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate overnight, pumping filtered, spin dry ethyl acetate, the resulting white crystals is 1- (3-methoxybenzoyl) piperazine crude product 6.5g, 59% yield.

142-64-3, 142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Xi’an Jiaotong University; Zhang, Jie; Lu, Wen; Dong, Jinyun; Pan, Xiaoyan; He, Langchong; Zhang, Tao; Wang, Sicen; Shen, Xiuxiu; (16 pag.)CN104262238; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Description 146(S)-tert-butyl 3-methylpiperazine-1-carboxylate (1)146)NHBocTo a solution of (S)-2-methylpiperazine (500 mg) in DCM (5 mL) was added Et3N (1010 mg) and(Boc)20 (1198 mg) in DCM (3 mL) dropwise. The mixture was stirred at 0C for 2 hours. DCM(10 mL), water (5 mL) and 30% NaHSO4 (10 mL) aqueous solution were added to the reactionmixture. The resulted mixture was stirred for 10 mm, and to the aqueous layer was added saturatedNa2CO3 solution until pH = 8, extracted with isopropyl alcohol: chlorofonn1: 3 (5 x20 mL). The combined organic layer was washed with brine (5 mL), dried over Na2SO4, filtered and concentrated to afford the title compound (562 mg) as pale yellow oil, MS (ESI): C10H20N202 requires 200; found 201 [M+H]., 74879-18-8

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics