Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

To a mixture of 4-aminobenzoic acid (5g, 36.5 mmol), 1-methylpiperazine (3.7 mL, 32.8 mmol) and TEA (16.0 mL, 114.8 mmol) in DCM (100 mL) was added EDC.HCl (10.5 g, 54.8 mmol) and the mixture was stirred at room temperature overnight. The sovent was removed and the residue was purified by silica flash chromatography with 0 to 10% MeOH in DCM. The light yellow oil obtained was dissolved in DCM and filtered. The yellow solid obtained was dissolved in DCM washed with brine then with Na2CO32M. The organic phase was dried and evaporated to give 4-(4-methylpiperazine-1-carbonyl)aniline (3 g, 42% yield). MS found for C12H17N3O as (M+H)+ 220.2., 109-01-3

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMACYCLICS LLC.; ATALLAH, Gordana, Babic; CHEN, Wei; JIA, Zhaozhong, J.; POZZAN, Alfonso; RAVEGLIA, Lucal, Francesco; ZANALETTI, Riccardo; (815 pag.)WO2016/196776; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.60787-05-5,1-(4-Methylpiperazin-1-yl)ethanone,as a common compound, the synthetic route is as follows.,60787-05-5

To a solution of 1 -(4-methylpiperazin-1 -yl)ethanone (1 .68 g, 1 1 .8 mmol) in THF (25 mL) cooled to -78 C, a solution of LDA (1 .5 M in THF, 9.8 mL, 14.75 mmol) was added, and the resulting mixture was stirred at -78 ^ for 1 h under argon atmosphere. Finally, a solution of 4-bromoindan-1 -one (1 .25 g, 5.9 mmol) in THF (50 mL) was added, and the resulting mixture was kept at -78 ‘ for 4 h. The reaction mixture was diluted with water and extracted with EtOAc. The organic extracts were dried over Na2S04 and evaporated to dryness. A solution of the previous residue in AcOH:H2S04:H20 (79 mL, 85:10:5) was stirred for 6 h. The reaction mixture was poured into water, basified with 50% NaOH and extracted with EtOAc. The organic extract, after being dried over Na2S04, was evaporated to dryness. To a solution of the previous residue in THF (75 mL) cooled to 0 C, AIH3- NMe2Et (0.5 M in toluene, 20 mL, 10.34 mmol) was added and the resulting mixture was stirred for 5 h. EtOAc:H20 (90 mL, 1 :1 ) was added to the reaction mixture and the resulting suspension was filtered through Celite. The layers were separated and the aqueous phase was extracted with EtOAc. The organic extract was dried over Na2S04 and evaporated to dryness. A solution of the previous residue in 37% HCLEtOH (150 mL, 1 :1 ) was refluxed overnight. The reaction mixture was evaporated to dryness. Purification of the residue by silica gel column chromatography (EtOAc/NH3:MeOH mixtures of increasing polarity as eluent) afforded the desired product (981 mg, 51 %). 1 H-NMR (CDCI3, 300 MHz) delta: 7.32 (m, 2H), 7.18 (t, J= 7.6 Hz, 1 H), 6.30 (s, 1 H), 3.31 (d, J= 1 .8 Hz, 2H), 2.72 (m, 4H), 2.60 (m, 4H), 2.51 (m, 4H), 2.30 (s, 3H) ppm. EI-MS m/z: 320.1 (M).

As the paragraph descriping shows that 60787-05-5 is playing an increasingly important role.

Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALCALDE-PAIS, Maria, de las Ermitas; ALMANSA-ROSALES, Carmen; DIAZ-FERNANDEZ, Jose-Luis; MESQUIDA-ESTEVEZ, Maria, de les Neus; PALOMA-ROMEU, Laura; WO2014/6071; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.,5464-12-0

Example 43 2-(4-Methylpiperazin-1-yl)ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate 2-(4-Methyl-piperazin-1-yl)-ethanol (0.86 g, 6 mmol) and NMM (0.58 mL, 6 mmol) were dissolved in DCM (8 mL) and the reaction mixture was cooled to 0¡ã C. 4-Nitrophenyl chloroformate (1.29 g, 6 mmol) was added and stirred for 1 h. To the reaction mixture was added a solution of 1-(4-chloro-benzyl)-piperazine (1.05 g, 5 mmol) and DIPEA (6.0 mL, excess) in DMF (20 mL). The reaction mixture was stirred at room temperature overnight and then concentrated in vacuo. The residue was dissolved in EtOAc (150 mL), washed with sat aq Na2CO3 solution (6*100 mL), dried (MgSO4) and dried in vacuo. The residue was initially purified by column chromatography (normal phase, 20 g, Strata SI-1, silica gigatube, 20 mL/min, gradient 0percent to 15percent MeOH in DCM) and then further purified by reverse phase column chromatography (LiChroprep RP-18, 40-63 mum, 460*26 mm (100 g), 30 mL/min, gradient 0percent to 30percent (over 40 min) MeOH in water with 1percent formic acid). The residue was stirred for 2 h in DCM (10 mL) with K2CO3 (~0.20 g), filtered and then dried in a vacuum oven overnight to give 2-(4-methylpiperazin-1-yl)ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate (0.51 g, 28percent) as a pale yellow oil. Analytical HPLC: purity 99.7percent (System A, RT=3.39 min); Analytical LCMS: purity 100percent (System A, RT=3.83 min), ES+: 381.5 [MH]; HRMS calcd for C19H29ClN4O2: 380.1979, found 380.1996.

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US2009/281087; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Step B tert-Butyl (3S)-3-methylpiperazine-1-carboxylate To a solution of (2S)-2-methylpiperazine (20.0 g, 0.200 mol) in methylene chloride (300 mL) and triethylamine (20.4 g, 0.202 mol) was added dropwise a solution of di-tert-butyl dicarbonate (44.0 g, 0.202 mol) in CH2Cl2 (100 mL) over 5 hrs. The mixture was washed with water, brine, and then dried over MgSO4 and concentrated. Column chromatography on silica (10-20% MeOH in EtOAc) afforded 32.0 g (80%) of the title compound as an oil. Step C tert-Butyl (3S)-4-(5-bromo-2,3-dihydro-1H-inden-1-yl)-3-methylpiperazine-1-carboxylate, 74879-18-8

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xue, Chu-Biao; Cao, Ganfeng; Huang, Taisheng; Chen, Lihua; Zhang, Ke; Wang, Anlai; Meloni, David; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.; US2005/261310; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Chloro-5-nitropyridine (800 mg, 5.05 mmol) was dissolved in dioxane (20 mL) and then 1-ethylpiperazine (1.7 g, 15.15 mmol) and N,N-diisopropylethylamine (927 mL, 5.05 mmol) were added. The reaction mixture solution was stirred at 70 C for a day. The reaction solution was cooled to room temperature, diluted with ethyl acetate, and then washed with brine. The organic layer was concentrated by drying with magnesium sulfate. The target compound (1.05 g, 87% yield) was used in the following reaction without purification. [0166] MS m/z: 237.51 [M+1].

5308-25-8, The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; CHOI, Hwan Geun; HAH, Jung Mi; HAM, Young Jin; JUN, Eun Jin; LEE, Jung Hun; KIM, Hwan; WO2011/49332; (2011); A2;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 1a-c (1.93 g, 10 mmol), 4 (1.76 g, 10mmol) and KF (18 mmol) were heated at 120-130 ¡ãC inDMF (30 mL) for 16 – 18 h. At the end of this period, thereaction mixture was cooled to room temperature and dilutedwith water (30 mL). The separated solid was filtered, washedand dried to obtain crude 5a-i. The obtained crude productwas then purified by recrystallization using ethanol

5271-27-2, The synthetic route of 5271-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Darsi, S.S. Praveen Kumar; Kumar, K. Shiva; Devi, B. Rama; Naidu; Dubey; Letters in Organic Chemistry; vol. 11; 8; (2014); p. 551 – 555;,
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Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 55-chloro-N-[2-(4-methylpiperazin-1-yl)ethyl]-3-phenyl-1H-indole-2-carboxamideTo a DMF solution (1 mL) containing commercially available 5-chloro-3-phenyl-1H-indole-2-carboxylic acid (100 mg), 2-(4-methylpiperazin-1-yl)ethylamine (52 mg) and HATU (141 mg), diisopropylethylamine (0.2 mL) was added and the resulting solution was stirred overnight at room temperature.Water was added to the reaction solution and the solution was extracted with chloroform.After the chloroform layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=1:1), whereby the title compound (100 mg) was obtained as a yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.22-2.32 (8H, m), 2.23 (3H, s), 2.36 (2H, t, J=5.8 Hz), 3.44 (2H, dt, J=5.8, 5.8 Hz), 6.52 (1H, br s), 7.25 (1H, m), 7.41 (2H, m), 7.51 (5H, m), 9.89 (1H, s).ESI-MS Found: m/z 397[M+H]+

934-98-5, 934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

2-(piperazin-1-yl)ethan-1-ol (5 g, 38.41 mmol, 1.00 equiv) was dissolved inDCM (100 mL), and a solution of di-tert-butyl dicarbonate (8.38 g,38.40 mmol, 1.00 equiv) in DCM (20 mL) was added drop-wise. The reaction was left under agitation overnight at ambient temperature. The reaction was evaporated to dryness and the residue dissolved in 200 mL of AcOEt, washed 5 times with NaC1 (sat.), dried over sodium sulfate, filtered and concentrated under reduced pressure toyield 8.5 g (96 %) of compound 45A in the form of a white solid., 103-76-4

103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; PEREZ, Michel; RILATT, Ian; LAMOTHE, Marie; WO2014/174062; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-bromobenzonitrile 12 (1.5 g, 8.24 mmol) in toluene, N-methylpiperazine (1.4mL, 12.36 mmol), sodium tert-butoxide(1.19 g, 12.36 mmol), Tris(dibenzylideneacetone)dipalladium(0) (0.023 g, 0.02mmol), and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) (0.036 g, 0.05mmol) were added. The reaction mixture was heated at 80 C for 16 hours andthen filtered on celite pad. The organic phase was evaporated under reducedpressure. The brown oil was purified by flash chromatography on silica gel(Eluent: CH2Cl2:MeOH 9:1). Compound 13 was obtained as a yellow oil (60%). 1H NMR (400 MHz,CDCl3): delta(ppm) 2.25(s, 3H); 2.46(t, J=8, 4H); 3.25-3.23(t, J=8, 4H);6.76(d, J=8, 2H); 7.39(d, J=8, 2H). Anal. Calcd. for C12H15N3:C, 71.61; H, 7.51; N, 20.88; found: C, 71.21; H, 7.21; N, 20.78

109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Radi, Marco; Bernardo, Vincenzo; Vignaroli, Giulia; Brai, Annalaura; Biava, Mariangela; Schenone, Silvia; Botta, Maurizio; Tetrahedron Letters; vol. 54; 38; (2013); p. 5204 – 5206;,
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Piperazines – an overview | ScienceDirect Topics

57184-23-3, 1-(Cyclohexylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Die nachfolgenden Verbindungen der Beispiele 8 bis 65 wurden nach einem automatisierten Herstellungsverfahren hergestellt.Hierzu wurde pro Ansatz eine Loesung von 0,03 mmol (2R)-1-[3,5- Bis(trifluormethyl)benzoyl]-2-(1H-indol-3-ylmethyl)-4-(4-azido-2-butin-1-yl)piperazin der Formel IV (Herstellung siehe Beispiel 1/Syntheseweg 1B)) in 1 ml Ethylacetat jeweils mit einer Loesung von 0,03 mmol des als Reaktionspartner vorgesehenen sekundaeren Amins der Formel V in 1 ml Ethylacetat umgesetzt und anschliessend mit 3 ml Ethylacetat verduennt. Auf das Reaktionsgemische wurde Stickstoffgas gegeben und es wurde jeweils 6 Stunden lang bei 70 C geruehrt. Der Reaktionsendpunkt wurde Duennschicht-chromatographisch bestimmt. Nach vollendeter Umsetzung wurden die einzelnen Reaktionsgemische jeweils im Vakuum zur Trockene eingedampft. Aus dem Rueckstand wurde ohne weitere Aufreinigung jeweils eine Probe fuer die Hochleistungs-Fluessigkeitschromatographie (= HPLC) und fuer die automatische Massenspektroskopie zur Bestimmung der Reinheit bzw. zur Strukturbestaetigung entnommen., 57184-23-3

The synthetic route of 57184-23-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Solvay Pharmaceuticals GmbH; EP1176144; (2002); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics