Tag: M.W:100-200

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Name: 4-(4-Methylpiperazin-1-yl)phenylamine, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, in an article , author is Park, Hee Min, once mentioned of 16153-81-4.

Preparation and characterization of TFC NF membrane with improved acid resistance behavior

In this study, we prepared the novel acid-resistant thin-film composite (TFC) piperazine(PIP)-based nanofiltration (NF) membrane using melamine (Mel), sulfonated-melamine formaldehyde (SMF), and sulfanilamide (SA) through interfacial polymerization on a polysulfone (PSf) support layer. A long-term acid-resistant experiment for divalent salt was carried out with static immersion tests in a 15 wt% sulfuric acid solution. The divalent rejection of the PIP1-SMF0.3-SA(0.05) in a 15 wt% sulfuric acid solution was maintained at over 96% after 10 days, and then slightly decreased to 94% for 20 days, and finally was maintained over 90% for 30 days. The flux was maintained at about 20 GFD even after 30 days of immersion in acid. In order to confirm the degree of hydrolysis in amide, the bond dissociation energy (BDE) was calculated using the density functional theory (DFT). BDE values of PIP-TMC, Mel-TMC, and SA-TMC were 79.34, 83.78, and 93.91 kcal/mol. Consequently, PIP1-SMF0.3-SA(0.05) having s-triazine and sulfonyl amide group exhibited acid-stable performance because the C-N bond is more stable and the slow hydrolysis reaction in acid. Our research for preparing high perm-selectivity and long-term acid stability membrane can extend NF technology in many industries, particularly in the recovery of rare metals from acidic solutions.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 16153-81-4, you can contact me at any time and look forward to more communication. Name: 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, in an article , author is Hakobyan, N. Z., once mentioned of 5308-25-8, Application In Synthesis of 1-Ethylpiperazine.

Synthesis and Antitumor Activity of Piperazine-Based Tertiary Amino Alcohols and Their Dihydrochlorides

Aminomethylation of 1-(4-alkoxyphenyl)-2-phenyl(chlorophenyl)ethanones with paraformaldehyde and substituted piperazines in ethanol furnished 1-(4-alkoxyphenyl)-3-(4-R-piperazin-1-yl)-2-phenyl (chlorophenyl)propan-1-ones. Reaction of the latter with alkyl (aryl) magnesium halides resulted in the formation of tertiary amino alcohols of piperazine series, which were further converted to dihydrochlorides. The effect of synthesized compounds on the processes of tumor DNA methylationin vitrowas studied.

Interested yet? Read on for other articles about 5308-25-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-Ethylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Related Products of 16153-81-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Mahmoud, Mohamed E., introduce new discover of the category.

Water-stable metal-organic framework/amine-modified silica/poly (piperazine-cresol) hybrids for efficient uptake of La(III) ions

Hybrid nanocomposites of polymers and metal organic frameworks (MOFs) are characterized by distinctive surface activity due to high surface area of MOFs, excellent carrier nature and good thermal stability polymers. The combined two materials are expected to perform unusual performance in adsorptive removal and extraction processes. Therefore, microporous MOFs/polymer hybrid nanocomposite, Zn(Glu)-SiNH/PPC, has been synthesized by direct linking between silica-amine modified MOFs (Zn(Glu)-SiNH2) with poly(piperazine-cresol) (PPC) via microwave irradiation heating. Characterizations of Zn(Glu)-SiNH/PPC hybrid nanocomposite were explored by various techniques as XRD, surface area, SEM, TEM, and FT-IR. Lanthanum (III) ion was chosen as an example of the lanthanides series to investigate its adsorption activity by Zn(Glu)-SiNH/PPC hybrid nanocomposite. The maximum uptake capacity (15023.0 mu mol g(-1)) was established under the optimum conditions (pH 7.0, 20 min and 5 mg of Zn(Glu)-SiNH/PPC). The recognized equilibrium data of La(III) adsorption onto Zn(Glu)-SiNH/PPC hybrid nanocomposite were well explained by the Langmuir model. Additionally, the kinetics study was fitted satisfactorily with the pseudo-second order model. The recovery of La(III) ions from water samples (tap, sea and waste) were recognized as 98.23, 98.28 and 99.66%, respectively.

Related Products of 16153-81-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Application of 16153-81-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Wieczorek, Dorota, introduce new discover of the category.

Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans

Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin(R) (Tavaborole) and Eucrisa(R) (Crisaborole) currently in clinical practice as antifungal and anti-inflammatory drugs, respectively. Over a dozen of 3-amino benzoxaboroles, including Tavaborole’s derivatives, have been synthetized and characterized in terms of their activity against Candida albicans as a model pathogenic fungus. The studied compounds broaden considerably the structural diversity of reported benzoxaboroles, enabling determination of the influence of the introduction of a heterocyclic amine, a fluorine substituent as well as the formyl group on antifungal activity of those compounds. The determined zones of the growth inhibition of examined microorganism indicate high diffusion of majority of the studied compounds within the applied media as well as their reasonable activity. The Minimum Inhibitory Concentration (MIC) values show that the introduction of an amine substituent in position 3 of the benzoxaborole heterocyclic ring results in a considerable drop in activity in comparison with Tavaborole (AN2690) as well as unsubstituted benzoxaborole (AN2679). In all studied cases the presence of a fluorine substituent at position para to the boron atom results in lower MIC values (higher activity). Interestingly, introduction of a fluorine substituent in the more distant piperazine phenyl ring does not influence MIC values. As determined by X-ray studies, introduction of a formyl group in proximity of the boron atom results in a considerable change of the boronic group geometry. The presence of a formyl group next to the benzoxaborole unit is also detrimental for activity against Candida albicans.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 5308-25-8, Name is 1-Ethylpiperazine, formurla is C6H14N2. In a document, author is Zhang, Gang, introducing its new discovery. Safety of 1-Ethylpiperazine.

Molecular Insight into the Discrepancy of Antitubercular Activity between 8-Nitro and 8-Cyano Benzothiazinones

Benzothiazinones with 8-NO2 group is a novel class of compounds with potent antitubercular activity, especially BTZ043 and PBTZ169, which covalently inhibit DprE1. 8-CN benzothiazinones is reported as another type of benzothiazinones with potent antitubercular activity. Taking this as the starting point, a series of 8-CN benzothiazinones are synthesized and evaluated for their antitubercular activity. To better understand the antitubercular activity of this series of benzothiazinones, the difference between the molecular structures of CN01 and PBTZ169 in crystal are analyzed. CN01 and PBTZ169 show completely different conformations of the piperazine ring. Density functional theory analysis (DFT) and molecular dynamics (MD) simulation are performed to provide more details to explain the different antitubercular activity. All the analysis based on crystallography, quantum chemistry, and molecular modeling lay a foundation for the subsequent structural optimization of 8-CN benzothiazinones.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Kim, Joo-Won, introduce the new discover, Name: 1-Methylpiperazine.

Anti-biofilm activity of N-Mannich bases of berberine linking piperazine against Listeria monocytogenes

In the food processing environment, Listeria monocytogenes has the ability to persist on the surfaces, resulting in serious safety concerns. This study aimed to determine the anti-biofilm activity of N-Mannich bases of berberine linking piperazine (MBP) against L. monocytogenes. Among the MBPs used in this study, MBP5 and MBP6 (200 mu g/mL) showed a significant decrease in the L. monocytogenes biofilm on the surface of polystyrene at low (4 degrees C) and high (37 degrees C) temperatures (approximately > 50% reduction). Both MBPs also reduced the L. monocytogenes biofilm on the surface of stainless steel at low and high temperatures (approximately > 1 log CFU/cm(2) reduction). According to fluorescence and scanning electron microscopic analyses, both MBPs prevented the clustered and aggregated forms of L. monocytogenes, which are typical biofilm characteristics; thus, suggesting that both MBPs effectively reduced the L. monocytogenes biofilm. In addition, XTT reduction and ATP production clearly showed that the viability of L. monocytogenes was obviously decreased in the presence of MBP5 and MBP6. Collectively, these results suggest that MBP5 and MBP6 might be used as promising anti-biofilm agents to prevent the L. monocytogenes biofilm.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 109-01-3 is helpful to your research. Name: 1-Methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, Name: 1-Methylpiperazine, belongs to piperazines compound, is a common compound. In a patnet, author is Zhang, Guang-Yu, once mentioned the new application about 109-01-3.

Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker

A series of novel pleuromutilin derivatives containing piperazine ring, 1, 2, 3-triazoles and secondary amines on the side chain of C14 were synthesized under mild conditions via click reaction. The in vitro antibacterial activities of the synthesized derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, ATCC 29213,144 and AD3) and one strain of Escherichia coli (ATCC 25922) were evaluated by the broth dilution method. Among these derivatives, 22-[2-(4-((4-nitrophenyl piperazine)methyl)-1,2,3-triazol-1-yl)-1-(piperazine-1-yl) ethyl-1-one] deoxy pleuromutilin (compound 59) showed the most prominent in vitro antibacterial effect against MRSA (MIC = 1 mu g/mL). Furthermore, compound 59 displayed more rapid bactericidal kinetic than tiamulin time-kill studies and possessed a longer PAE than tiamulin against MRSA in vitro. In addition, in vivo antibacterial activities of compound 59 against MRSA were further evaluated employing thigh infection model. And compound 59 (-8.89 log(10) CFU/mL) displayed superior activities than tiamulin. Compound 59 was further evaluated in CYP450 inhibition assay and the results showed that it exhibited low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6 and CYP3A4 enzymes. The PK properties of compound 59 were then measured. The half-life (t(1/2)), clearance rate (Cl) and the area under the plasma concentration time curve (AUC(0 -> 8)) of compound 59 were 0.74 h, 0.29 L/h/kg and 46.28 mu g.h/mL, respectively.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, belongs to piperazines compound, is a common compound. In a patnet, author is Qin, Yitian, once mentioned the new application about 5308-25-8, Product Details of 5308-25-8.

Performance enhancement of nanofiltration membranes via surface modification with a novel acylation reagent

Acyl chloride monomers have been serving as the dominant acylation reagent for preparing thin-film composite (TFC) nanofiltration (NF) membranes over the past few decades. Herein, a novel acylation reagent (trimellitic anhydride, TMA) was exploited in conjunction with trimesoyl chloride (TMC) to undergo interfacial polymerization with piperazine (PIP) on the polysulfone substrate membranes. The introduction of TMA enabled the deeper diffusion of PIP monomers into the organic phase, resulting in the creation of novel circular-shaped protuberances on the top surface of the polyamide layer and the significant increase in the effective membrane area. Besides, abundant in-situ carboxylic groups were generated in the polyamide layer, conducive to both the surface hydrophilicity and negative charge density. Consequently, with an addition of 0.03 wt% TMA, pure water flux reached up to 15.3 L m(-2) hour(-1) bar(-1), almost 2.2 times that of the pristine membrane, and high rejection of Na2SO4 (97.3%) was maintained, evincing the superior desalination performance of the TMA-modified membranes. The interaction mechanism between TMA, TMC, and PIP was described in detail. Furthermore, the TMA-modified membranes exhibited a stable separation performance over the long-running process.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a document, author is Chitikina, Satya Sri, introduce the new discover, Recommanded Product: 5308-25-8.

Synthesis and anthelmintic activity of some novel (E)-2-methyl/propyl-4-(2-(substitutedbenzylidene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines

A series of some novel (E)-2-methyl/propyl-4-[(2-(substitutedbenzylidene)hydrazinyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines was synthesized and characterized by adopting an appropriate synthetic scheme. The effect of electron withdrawing and electron donating groups at the aromatic ring in presence of methyl and propyl substituents at the 2-position of the scaffold was evaluated for anthelmintic activity against adult Indian earthworms (Pheretima posthuma). Among 2-methyl-thieno[2,3-d]pyrimidine analogs, compounds with electron donating methoxy group either atpara-position or atmetaandpara-positions of the aromatic ring showed potent anthelmintic activity at 100 mu g/ml (284 and 261.8 mu M concentrations) for compounds5gand5hwith a mean paralytic time of 2.32, 2.22 min, and helminthicidal time of 22.38, 19.43 min, respectively. In contrast, the presence of electron withdrawing chloro group atorthoandpara-position of the aromatic ring was found to be favorable for the anthelminthic activity of the compounds5nand5o(at concentration of 259.7 mu M) with propyl group at the 2-position of the thieno[2,3-d]pyrimidine scaffold, exhibiting mean paralytic time of 2.5 min, 2.81 min and helminthicidal time of 21, 20.03 min, respectively. Anthelmintic activities of these four compounds5g,5h,5n, and5o(at the concentrations of 284, 261.8, 259.7, and 259.7 mu M, respectively) were found to be on par with the standard drug piperazine adipate (time for paralysis and death at 6.25 and 24.5 min, respectively) at concentration of 100 mu g/ml (431.03 mu M). Overall, the potency of these compounds (5g,5h,5n, and5o) is better than standard drug as they exhibited the same activity at 259.7-284 mu M as that of a standard drug (which has shown the same activity at 431.03 mu M). Further, the predicted ADME properties of all the synthesized compounds were found to be in the satisfactory ranges as predicted by SwissADME software and found to have drug-like properties. Thus, further modification of these compounds might lead to the discovery of more potent analogs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5308-25-8 is helpful to your research. Recommanded Product: 5308-25-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 8benzyl 2-(4-isopropylpiperazine-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate Oxalyl chloride (2.39 mL, 27.3 mmol) was slowly added to a solution of Intermediate 5 (2.77 g, 9.13 mmol) in DCM (70 mL) at 0¡ã C. under N2. One drop of DMF was added and the reaction mixture was stirred for 2 h. Oxalyl chloride (1.59 mL, 18.2 mmol) was added and the reaction mixture was stirred for 1 more hour. The solvent was concentrated under vacuum and the residue was recovered in DCM (30 mL). The resulting solution was added to a solution of 1-isopropylpiperazine (1.171 g, 9.13 mmol) and Et3N (6.36 mL, 45.66 mmol) in DCM (150 mL) at 0¡ã C. The reaction mixture was stirred for 1 h. The solvent was concentrated and the product was purified on silica gel by MPLC using 3percent-5percent MeOH in DCM as eluent to provide title compound (1.810 g, 47.9percent) as a gum. 1H NMR (400 MHz, CDCl3) delta ppm 1.03 (d, J=6.25 Hz, 6H) 1.52 (br. s., 2H) 1.61 (br. s., 2H) 1.94-2.07 (m, 2H) 2.08-2.18 (m, 2H) 2.39-2.52 (m, 4H) 2.70 (quintet, J=6.54 Hz, 1H) 3.18 (qd, J=8.66, 8.40 Hz, 1H) 3.29-3.40 (m, 4H) 3.40-3.49 (m, 2H) 3.57-3.65 (m, 2H) 5.11 (s, 2H) 7.28-7.42 (m, 5H); MS m/z 414.3 [M+H]+ (ESI).

4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2010/130477; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics