Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhao, Fei; Masci, Domiziana; Ferla, Salvatore; Varricchio, Carmine; Brancale, Andrea; Colonna, Serena; Black, Gary W.; Turner, Nicholas J.; Castagnolo, Daniele researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).HPLC of Formula: 2343-22-8.They published the article 《Monoamine Oxidase (MAO-N) Biocatalyzed Synthesis of Indoles from Indolines Prepared via Photocatalytic Cyclization/Arylative Dearomatization》 about this compound( cas:2343-22-8 ) in ACS Catalysis. Keywords: monoamine oxidase indole indoline photocatalytic cyclization dearomatization. We’ll tell you more about this compound (cas:2343-22-8).

The biocatalytic aromatization of indolines into indole derivatives exploiting monoamine oxidase (MAO-N) enzymes is presented. Indoline substrates were prepared via photocatalytic cyclization of arylaniline precursors or via arylative dearomatization of unsubstituted indoles and in turn chemoselectively aromatized by the MAO-N D11 whole cell biocatalyst. Computational docking studies of the indoline substrates in the MAO-N D11 catalytic site allowed for the rationalization of the biocatalytic mechanism and exptl. results of the biotransformation. This methodol. represents an efficient example of biocatalytic synthesis of indole derivatives and offers a facile approach to access these aromatic heterocycles under mild reaction conditions.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application of 54903-09-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Acyl benzoxazolinones. I. Author is Bonte, Jean P.; Lesieur, Daniel; Lespagnol, Charles; Plat, M.; Cazin, Jean C.; Cazin, Micheline.

6-Acylbenzoxazolinones I (R = H, Me, R1 = Me, CH2Cl, Et, Ph, CH2Ph, 2-thienyl) were prepared in 25-75% yield by treating 2-benzoxazolinone or 1-methyl-2-benzoxazolinone with R1CO2H and polyphosphoric acid. I (R = H, Me, R1 = CHO) was similarly prepared with hexamethylenetetramine and polyphosphoric acid. I had analgesic activity comparable to that of benzoxazolinone and aspirin, but lower antiinflammatory activity.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C9H7NO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about “”Fries Like”” Rearrangement: a novel and efficient method for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones. Author is Ucar, Huseyin; Van derpoorten, Kim; Depovere, Paul; Lesieur, Daniel; Isa, Majed; Masereel, Bernard; Delarge, Jacques; Poupaert, Jacques H..

6-Acyl-2(3H)-benzoxazolone and 6-acyl-2(3H)-benzothiazolone derivatives have particularly interesting antiinflammatory, antiepileptic, analgesic and antiviral properties. A method of acylation on the 6-position of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone which consists in a two-step procedure involving migration of the acyl group from the N-position to the 6-position of the heterocycle, at 165° and catalyzed by AlCl3 is reported. This new procedure is more efficient with regard to the consumption of AlCl3 and the yield (76-90%) than other acylation methods previously described.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 2343-22-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Dual-Active-Sites Design of Co@C Catalysts for Ultrahigh Selective Hydrogenation of N-Heteroarenes. Author is Zhang, Sai; Gan, Jie; Xia, Zhaoming; Chen, Xiao; Zou, Yong; Duan, Xuezhi; Qu, Yongquan.

Herein, a general yet powerful strategy to design and fabricate dual-active-sites Co@C core-shell nanoparticle for boosting selective hydrogenation of various N-heteroarenes was reported. It could break the limitation of scaling relation on traditional metal surfaces and thus afford unprecedentedly high selectivity, activity and stability. Combining kinetics anal. and DFT calculations with multiple techniques directly unveil that the critical porous carbon shell with a pore size of 0.53 nm not only allowed H2 diffusion to Co sites for activation and blocked accessibility of N-heteroarenes but also catalyzed hydrogenation of N-heteroarenes via hydrogen spillover from Co sites. In addition, the presence of surface/subsurface carbon at the Co sites showed high anti-sulfur poisoning and anti-oxidant capability. This work was valuable for guiding the design and manipulation of cost-effective and robust hydrogenation catalysts.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Total synthesis of macrosphelide A by way of palladium-catalyzed carbonylative esterification, Author is Kusaka, Shin-ichi; Dohi, Suguru; Doi, Takayuki; Takahashi, Takashi, which mentions a compound: 53562-86-0, SMILESS is C[C@H](O)CC(OC)=O, Molecular C5H10O3, SDS of cas: 53562-86-0.

The total synthesis of macrosphelide A (I) has been achieved with a highly convergent and efficient strategy. Key steps include the preparation of seco-acid II using sequential carbonylative esterification, and subsequent macrolactonization.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. Author is Reader, John C.; Matthews, Thomas P.; Klair, Suki; Cheung, Kwai-Ming J.; Scanlon, Jane; Proisy, Nicolas; Addison, Glynn; Ellard, John; Piton, Nelly; Taylor, Suzanne; Cherry, Michael; Fisher, Martin; Boxall, Kathy; Burns, Samantha; Walton, Michael I.; Westwood, Isaac M.; Hayes, Angela; Eve, Paul; Valenti, Melanie; de Haven Brandon, Alexis; Box, Gary; van Montfort, Rob L. M.; Williams, David H.; Aherne, G. Wynne; Raynaud, Florence I.; Eccles, Suzanne A.; Garrett, Michelle D.; Collins, Ian.

Pyrazolopyridine lead inhibitors with micromolar affinities for the checkpoint kinase CHK1 and selective for CHK1 against CHK2 were refined by fragment-growing and scaffold morphing strategies to generate the isoquinolinylaminopyrazinecarbonitrile I as a potent and selective inhibitor of CHK1 [IC50 (CHK1) = 13 nM, IC50 (CHK2) = > 100 μM] as a potential antitumor agent. Scaffold morphing was used to improve the CHK1 potency and selectivity, synthetic accessibility, and novelty of the inhibitors; the inhibitor core was changed from pyrimido[2,3-b]azaindole to pyrazinylpyrimidinamine to imidazo[4,5-c]pyridine and isoquinoline. The toxicities, lipophilicities, and polar surface areas of selected compounds were determined, while ligand efficiencies were determined for the compounds prepared and tested; the microsomal stability and oral bioavailability of I in mice were determined I potentiated the efficacies of irinotecan and gemcitabine in SW620 human colon carcinoma xenografts in nude mice but had no effect on its own. The structures of six kinase inhibitors including I bound to the CHK1 kinase domain were determined by x-ray crystallog.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 66-71-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Rationalization on high-loading iron and cobalt dual metal single atoms and mechanistic insight into the oxygen reduction reaction. Author is Jiang, Min; Wang, Fei; Yang, Fan; He, Hao; Yang, Jian; Zhang, Wei; Luo, Jiayan; Zhang, Jiao; Fu, Chaopeng.

Rational design of single-atom catalysts (SACs) with high metal loadings is essential to enhance the sluggish kinetics of oxygen reduction reactions in metal-air batteries and proton-exchange membrane fuel cells (PEMFCs). Herein, an effective plasma engineering strategy to construct Fe/Co dual single atoms densely dispersed on porous nitrogen-doped carbon nanofibers (Fe, Co SAs-PNCF) with a high mass loading of 9.8 wt% is proposed without any acid leaching. The electrocatalyst exhibits superior ORR performances in both alk. and acidic media (e.g., Eonset = 1.04 V and E1/2 = 0.93 V). The N3-Fe-Co-N3 moieties are identified to be the main active sites by X-ray absorption spectroscopy (XAS) and d. functional theory calculations The in situ XAS and Raman spectroscopy quantitively reveal the decrease in oxidation states of Fe/Co and the increase in bond lengths of the Fe-N/Co-N in the N3-Fe-Co-N3 during the ORR. Benefitting from the high loading of single atoms and enhanced activity, the Fe, Co SAs-PNCF endows the Al-air batteries and PEMFCs with excellent discharge performances, demonstrating promising practical applications.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ) is researched.COA of Formula: C5H13NO.Gennari, Cesare; Molinari, Francesco; Cozzi, PierGiorgio; Oliva, Ambrogio published the article 《Auxiliary structure and asymmetric induction in the Mukaiyama-aldol reactions of chiral silyl ketene acetals》 about this compound( cas:53636-17-2 ) in Tetrahedron Letters. Keywords: auxiliary structure asym induction Mukaiyama aldol; silyl ketene acetal asym condensation aldehyde. Let’s learn more about this compound (cas:53636-17-2).

A variety of chiral auxiliaries [e.g., (1S,2R-Me2NCHMeCHPhOH, (S)-Me2NCH2CHMeOH] were prepared and tested for levels of asym. induction control in the Mukaiyama-aldol reaction of chiral silyl ketene acetals. Structural features required for high levels of control are discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric synthesis by Ru-BINAP, published in 1995, which mentions a compound: 53636-17-2, mainly applied to ruthenium dinaphthylphosphine complex asym hydrogenation catalyst; phosphinobinaphthyl ruthenium complex asym hydrogenation catalyst, Synthetic Route of C5H13NO.

Chiral compounds were obtained in extremely high enantiomeric excesses by the Ru-BINAP catalysis. The catalysts are capable to hydrogenate numerous unsaturated substrates. The effect of substituents in ketones for enantio- and diastereo-differentiations is discussed. Practical applications in the production of pharmaceuticals and new materials are also described.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity. Author is Krasnov, Victor P.; Zarubaev, Vladimir V.; Gruzdev, Dmitry A.; Vozdvizhenskaya, Olga A.; Vakarov, Sergey A.; Musiyak, Vera V.; Chulakov, Evgeny N.; Volobueva, Alexandrina S.; Sinegubova, Ekaterina O.; Ezhikova, Marina A.; Kodess, Mikhail I.; Levit, Galina L.; Charushin, Valery N..

A number of novel amides were synthesized by coupling of 6-[(9H-purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine is linked to position 6 of purine through a fragment of ω-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro. Purine derivatives showed to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine depend on the length of the linker fragment.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics