Tag: M.W:100-200

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 1-Ethylpiperazine5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a article, author is Hu, Zhi, introduce new discover of the category.

Flame retardancy, thermal properties, and combustion behaviors of intumescent flame-retardant polypropylene containing (poly) piperazine pyrophosphate and melamine polyphosphate

A (poly) piperazine pyrophosphate (PIPP) was synthesized and its chemical structure was confirmed via Fourier transform infrared spectroscopy,H-1 nuclear magnetic resonance, and(31)P nuclear magnetic resonance. PIPP was used together with melamine polyphosphate (MPP) as an ammonium polyphosphate (APP)-free intumescent flame retardant (IFR) to prepare several flame-retardant polypropylene (FRPP) composites. The flame retardancy and burning behaviors of the composites were investigated via limiting oxygen index (LOI) determination, vertical burning tests (UL-94), and cone calorimeter tests. The thermal properties were investigated by means of thermogravimetric analysis under nitrogen and air atmosphere. Use of PIPP and MPP together yielded an increase in the LOI value, a UL-94 V-0 rating, and a decrease in both the values of PHRR and THR in cone calorimetric analysis. Visual observations and scanning electronic microscopy confirmed the occurrence of char formation, which acted as a heat and fire barrier in the condense phase.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5308-25-8. Application In Synthesis of 1-Ethylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Kettle, Jason G., once mentioned the application of 5308-25-8, Application In Synthesis of 1-Ethylpiperazine, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, molecular weight is 114.1888, MDL number is MFCD00059912, category is piperazines. Now introduce a scientific discovery about this category.

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS(G12C)

Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS(G12)C mutant represents an Achilles heel and has recently yielded to covalent targeting with small molecules that bind the mutant cysteine and create an allosteric pocket on GDP-bound RAS, locking it in an inactive state. A weak inhibitor at this site was optimized through conformational locking of a piperazine-quinazoline motif and linker modification. Subsequent introduction of a key methyl group to the piperazine resulted in enhancements in potency, permeability, clearance, and reactivity, leading to identification of a potent KRAS(G12C) inhibitor with high selectivity and excellent cross-species pharmacokinetic parameters and in vivo efficacy.

If you are interested in 5308-25-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-Ethylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of C11H17N3, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Okhlopkova, L. S., introduce the new discover.

Mononuclear Antimony(V) Catecholate Complexes with Additional Pyridine Ligands

A series of triarylantimony(V) complexes withp-dimethylaminopyridine andp-cyanopyridine of the general formulas [(Cat)SbAr3(p-Me2N-Py)] (complexesI-IV) and [(Cat)SbAr3(p-CN-Py)] (complexesV-VII) has been synthesized. Their molecular structures and electrochemical properties have been studied. 3,6-Di-tert-butyl-o-benzoquinone, 4,5-piperazine-1,4-diyl-3,6-di-tert-butyl-o-benzoquinone, and 4,5-dichloro-3,6-di-tert-butyl-o-benzoquinone are used as redox-active ligands. The molecular structures of several complexes in the crystalline state are determined by X-ray diffraction analysis (CIF files CCDC nos. 1974173 (I. 0.5toluene), 1974174 (II. 2toluene), 1974175 (V), 1974176 (VI. hexane), and 1974177 (VII)). All complexes have a distorted octahedral structure, and an additional neutral pyridine ligand occupies one of the apical positions. Electrochemical transformations of the complexes are studied by cyclic voltammetry in a dichloromethane solution. The introduction of substituted pyridine into the molecule of the complex does not change the electrooxidation mechanism of the complexes. For all complexes withp-dimethylaminopyridine, both oxidation potentials are shifted to the cathodic region (0.13-0.21 V for the potential of the first oxidation process and to 0.3-0.4 V for the potential of the second oxidation process). A similar shift for the complex withp-cyanopyridine is less pronounced (0.05 V for the potential of the first oxidation process of complexVas compared to that of complexI).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. Computed Properties of C11H17N3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Chen, Zhuoyao, introduce the new discover, Computed Properties of C5H12N2.

Anodic oxidation of ciprofloxacin using different graphite felt anodes: Kinetics and degradation pathways

Ciprofloxacin (CIP) is ubiquitous in the environment which poses a certain threat to human and ecology. In this investigation, the physical and electrochemical properties of graphite felt (GF) anodes which affected the anodic oxidation (AO) performance, and the CIP removal effect of GF were evaluated. The GFs were used as anodes for detection of center dot OH with coumarin (COU) as molecule probe and removal of CIP in a 150 mL electrolytic cell with Pt cathode (AO-GF/Pt system). The results showed that hydrophilic GF (B-GF) owned higher sp(3)/sp(2) and more oxygen-containing and nitrogen-containing functional groups than the hydrophobic GF (A-GF). Moreover, B-GF possessed higher oxygen evolution potential (1.12 V), more active sites and stronger center dot OH generation capacity. Above mentioned caused that B-GF exhibited more superior properties for CIP removal. The best efficiencies (96.95%, 99.83%) were obtained in the AO-B-GF/Pt system at 6.25 mA cm(-2) after 10 min (k(1), 0.356 min(-1)) and 60 min (k(2), 0.224 min(-1)), respectively. Furthermore, nine degradation pathways of CIP in AO-B-GF/Pt system were summarized as the cleavage of the piperazine ring, cyclopropyl group, quinolone ring and F atom by center dot OH. It provides new insights into the removal and degradation pathways of CIP with GF in AO system.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 109-01-3 is helpful to your research. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2. In an article, author is Waltemate, Jana,once mentioned of 109-01-3, SDS of cas: 109-01-3.

10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

As part of our continuing search for potent inhibitors of tubulin polymerization, two novel series of 42 10-(4-phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and N-benzoylated acridones were synthesized on the basis of a retrosynthetic approach. All newly synthesized compounds were tested for antiproliferative activity and interaction with tubulin. Several analogs potently inhibited tumor cell growth. Among the compounds tested, 10-(4-(3-methoxyphenyl)piperazine-1-carbonyl)acridin-9(10H)-one (17c) exhibited excellent growth inhibitory effects on 93 tumor cell lines, with an average GI(50) value of 5.4 nM. We were able to show that the strong cytotoxic effects are caused by disruption of tubulin polymerization, as supported by the EBI (N,N’-Ethylenebis(iodoacetamide)) assay and the fact that the most potent inhibitors of cancer cell growth turned out to be the most efficacious tubulin polymerization inhibitors. Potencies were nearly comparable or superior to those of the antimitotic reference compounds. Closely related to this, the most active analogs inhibited cell cycling at the G2/M phase at concentrations down to 30 nM and induced apoptosis in K562 leukemia cells. We believe that our work not only proves the excellent suitability of the acridone scaffold for the design of potent tubulin polymerization inhibitors but also enables synthetic access to further potentially interesting N-acylated acridones.

If you¡¯re interested in learning more about 109-01-3. The above is the message from the blog manager. SDS of cas: 109-01-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2. In an article, author is Liu, Fei,once mentioned of 109-01-3, Application In Synthesis of 1-Methylpiperazine.

CO2 absorption rate in biphasic solvent of aminoethylethanolamine and diethylethanolamine

Amine scrubbing is currently the most promising technology for CO2 capture from gas turbine and coal-fired flue gas. It is hindered by high regeneration energy and high capital cost. Biphasic solvent of 25% aminoethylethanolamine (AEEA)/50% diethylethanolamine (DEEA) could be a potential solution as it may achieve significant reduction in regeneration energy. A fast CO2 absorption rate is preferred to reduce the capital cost of the absorber. In this work, the CO2 absorption rate (k g’) of the biphasic solvent was measured in a wetted wall column at 40 degrees C and at the loading conditions in the absorber. At CO2 equilibrium partial pressure (P-CO2*) lower than 100 Pa, 25% AEEA/50% DEEA is homogeneous. The CO2 absorption rate, kg, is as fast as 30% PZ (3 times faster than 30% MEA). When P-CO2* is greater than 100 Pa, 25% AEEA/50% DEEA forms aqueous and organic phases after CO2 absorption. It was first found that the organic phase of 25% AEEA/50% DEEA absorbs CO2 2-7 times faster than the aqueous phase because of greater physical CO2 solubility at the same P-CO2* and physical mass transfer coefficient. The kg’ of the organic phase is much faster than 30% MEA and 25% AEEA at lean and rich loading and even greater than 30% PZ at lean loading. The instantaneous reaction mechanism fits the kinetics of CO2 absorption in the organic phase at low P-CO2*. The slow kg’ of the aqueous phase results from greater viscosity which significantly reduces the physical mass transfer coefficient. The CO2 capacity of the aqueous phase is 2.9 times, 1.8 times, and 5.3 times greater than that of 30% MEA, 30% PZ, and the organic phase, respectively.

If you¡¯re interested in learning more about 109-01-3. The above is the message from the blog manager. Application In Synthesis of 1-Methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, belongs to piperazines compound. In a document, author is Wang, Fang, introduce the new discover, Product Details of 109-01-3.

Multi-Stimuli Responsive Luminescent beta-Diketones and Difluoroboron Complexes with Heterocyclic Substituents

Emissive beta-diketones (bdks) and difluoroboron complexes (BF(2)bdks) exhibit multi-stimuli responsive luminescence, including solvatochromism, viscochromism, aggregation induced emission, thermal and mechanochromic luminescence, halochromism and pH sensing. In this study, a series of six-membered heterocycle-substituted (piperidine, morpholine, 1-methyl piperazine) bdk ligands and boron complexes were synthesized, and their luminescent properties were investigated. All the compounds exhibited red-shifted emission in more polar solvents due to intramolecular charge transfer as well as higher emission intensity in more viscous environments. In response to solubility changes in water/tetrahydrofuran mixtures, while the piperazine bdk ligand showed aggregation caused quenching, the piperidine and morpholine bdks displayed enhanced emission upon aggregation. In the solid state, all ligands exhibited mechanochromism. More dramatic halochromism was observed for the piperidine boron dye spin cast film. In solution, for the boron dyes under varying pH values (1-13), different protonated and deprotonated forms were analyzed according to the measured emission spectra.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 109-01-3. Product Details of 109-01-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 16153-81-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Muresan-Pop, M., introduce new discover of the category.

Structural characterization of 5-fluorouracil & piperazine new solid forms and evaluation of their antitumor activity

A salt (FP-S) and two co-crystals (FP-C1 and FP-C2) of fluorouracil (FU) with piperazine (PZ) were investigated in terms of bioavailability and their effect on endothelial cells. From structural point of view, the best stability was observed for FP-C2 sample obtained by storage of FP-C1 sample under extreme conditions of temperature and humidity. This result was explained by the strong intermolecular interactions between 5-fluorouracil, piperazine and water, as denoted by the crystallographic analysis of FP-C2 form. Dissolution measurements in water indicate that the most soluble form is the salt, with a dissolution rate about 3 times greater than for the fluorouracil pure compound, while the solubility for co-crystals decreases compared to FU. Toxicity and antitumoral effect of the synthesized compounds were checked on three different cell lines: normal cells (HUVEC endothelial cells) and tumor cells (DLD-1 and HT29, both colorectal adenocarcinoma) and cytotoxicity by the MTT assay and cell proliferation assay. It has been found that the FP-C1 exerts a selective cytotoxic effect on HT29 cells and FP-C2 on DLD-1 cells in contrast to normal endothelial cell line resistance. For FU and FP-S salt, the effect on normal and tumoral cells is similar. The comparative study of the three fluorouracil forms shows that the best antitumor selective response was obtained for the co-crystal forms. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, belongs to piperazines compound, is a common compound. In a patnet, author is Kurutos, Atanas, once mentioned the new application about 109-01-3, Safety of 1-Methylpiperazine.

Near-infrared pH responsive heptamethine cyanine platforms: Modulating the proton acceptor

In this report, we wish to present the rational design, synthesis, and study of optical characteristics of near-infrared (NIR) molecular probes emitting over 800 nm. The title pH sensing platforms consist of a piperazine moiety serving as a hydronium ion receptor, coupled with a rigidified symmetric heptamethine backbone. The spectrally fine-tuned response of the fluorophores was studied in both organic solvents and aqueous buffer solutions, employing combined UV-Vis and steady state fluorimetric techniques. In parallel, computational approach and optical spectroscopy were employed aiming to ascribe the origin of spectral behavior of the amino-substituted heptamethines. Herein, we also investigated the halochromic effect of the differently substituted piperazines on the spectral properties of the NIR cyanine dyes. Under acidic conditions, the protonation of the piperazine moiety promoted a gradual bathochromic shift in the absorption spectra. The Delta lambda between the neutral and the protonated forms are indirectly related to the modifications applied to the proton acceptor. The calculated pK(a) values (5.13-7.06) were found to be dependent on the dye chemical structure. A good linear correlation was established between the pK(a) of the newly synthesized dyes and that of the reported piperazine moieties. This aspect allows the future expansion of the current facile strategy since sensing chromophores with predicted pH response could readily be designed based on pK(a) databases for substituted piperazine derivatives. A detailed literature study along with NMR and computational methods were found to be in agreement with our assumption, that both nitrogen atoms of the 1,4-disubstituted amine are involved in the sensing process. The covered pK(a) range allows us to recommend the title fluorophores as promising potential candidates for qualitative analysis of biological samples. A cytotoxicity study by the MTT assay showed that the NIR dyes are safe and applicable for bioanalytical purposes at dye concentrations up to 10 mu M. Fluorescence imaging and cellular applications, including staining and visualization of HeLa cervical cancer cells was successfully demonstrated.

If you¡¯re interested in learning more about 109-01-3. The above is the message from the blog manager. Safety of 1-Methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 109-01-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a article, author is Lee, Yi-Tzu, introduce new discover of the category.

AdeABC Efflux Pump Controlled by AdeRS Two Component System Conferring Resistance to Tigecycline, Omadacycline and Eravacycline in Clinical Carbapenem Resistant Acinetobacter nosocomialis

Carbapenem-resistant Acinetobacter nosocomialis (CRAn) is a significant public health concern. Tigecycline non-susceptible CRAn (Tn-CRAn) isolates have emerged worldwide. Tigecycline resistance is mainly related to the overexpression of AdeABC efflux pump controlled by AdeRS two-component system (TCS). Two novel tetracycline derivatives, omadacycline and eravacycline, may present a treatment option for CRAn. This study investigated the in vitro antimicrobial activity of tigecycline, omadacycline and eravacycline against clinical CRAn isolates and the contribution of efflux pumps in their resistance. Eighty-nine clinical CRAn isolates, including 57 Tn-CRAn isolates were evaluated for minimum inhibitory concentrations (MICs) by the broth microdilution. The relationship between the antimicrobial resistance and efflux pump expression was assessed by their responses to the efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine (NMP). The contribution of the AdeABC efflux pump in their resistance was determined by the complementation of the AdeRS two-component system in wild-type, adeRS operon and adeB gene knockout strains. Among the 89 isolates, omadacycline and eravacycline MICs were correlated closely with those of tigecycline. They demonstrated improved potency, based on MIC90 values, by showing a 4 to 8-fold greater potency than tigecycline. The synergetic effects of tigecycline, omadacycline and eravacycline with NMP were observed in 57 (100%), 13 (22.8%), and 51 (89.5%) of Tn-CRAn isolates, respectively. Further analysis showed that the laboratory strain carrying the Type 1 adeRS operon increased the tigecycline, omadacycline and eravacycline MICs by 4-8-folds, respectively. Eravacycline demonstrated improved potency over tigecycline against populations of CRAn, including Tn-CRAn isolates. The over-expression of AdeABC efflux pumps was directly activated by the AdeRS two-component system and simultaneously reduced the susceptibilities of tigecycline, eravacycline, and omadacycline. Omadacycline and eravacycline MICs were correlated closely with those of eravacycline.

Reference of 109-01-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 109-01-3 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics