Tag: M.W:100-200

75336-86-6,75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(6-Chloro-4,5-dimethyl-pyridazin-3-yl)-pyridin-3-yl-methanone (1.2 g, 4.84 mmol) and (R)-2-methyl-piperazine (485 mg, 4.84 mmol) are added to a microwave vial followed by NMP (17 mL) and triethylamine (2.01 mL, 14.49 mmol). The vial is sealed and irradiated in the microwave at 170¡ã C. for 30 min. The crude material is directly purified via flash chromatography on silica gel (0-20percent methanol in CH2Cl2). The resulting oil is co-evaporated with CH2Cl2 and heptane to afford the title compound as a powder (1350 mg, 90percent). 1H NMR (400 MHz, DMSO-d6) delta=9.56 (br s, 1H), 8.96 (s, 1H), 8.84-8.86 (m, 1H), 8.21-8.24 (m, 1H), 7.60-7.63 (m, 1H), 3.72 (s, 1H), 3.69 (s, 1H), 3.45-3.50 (m, 1H), 3.26-3.31 (m, 4H), 2.30 (s, 6H), 1.32 (d, J=6.5 Hz, 3H).

As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.

Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

To a solution of 4-(3-(4-cyanophenyl)imidazo[l,2-a]pyridin-6-yl)benzoic acid (70 mg, 0.206 mmol) in DMF (1.0 mL) were added HATU (1 17 mg, 0.309 mmol), N-methyl morpholine (90 iL, 0.824 mmol) and l-methylpiperazin-2-one (37 mg, 0.247 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h, then it was diluted with water (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layer was dried over Na2S04 and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent CHCl3 MeOH 96:4) to afford 4-(6-(4-(4-methyl-3- oxopiperazine-l-carbonyl)phenyl)imidazo[l,2-a]pyridin-3-yl)benzonitrile (64 mg, 57percent, AUC HPLC 98percent) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.76 (bs, 1H), 7.97-7.89 (m, 4H), 7.88 (s, 1H), 7.84-7.78 (m, 2H), 7.77 (d, J= 1.2 Hz, 2H), 7.64-7.57 (m, 2H), 4.40- 4.10 (m, 2H), 4.10-3.60 (m, 2H), 3.57-3.42 (m, 2H), 3.01 (s, 3H); 13C NMR (100 MHz, CD3OD): delta 171.72, 147.44, 140.53, 135.51, 134.81 , 134.72, 134.38, 129.42, 129.27, 128.56, 128.52, 127.79, 126.58, 122.93, 119.50, 1 18.47, 112.70, 34.68; MS (ESI) m/z 436 [C26H21N502 + H] +.

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-[(S)-1 -(6-chloro-imidazo[1 ,2-b]pyridazin-3-yl)-ethyl]-5,7-difluoro-quinoline (Intermediate B, 3.0 g, 8.58 mmol), KF (2.52 g, 42.9 mmol), 1-methylpiperazine-2-one hydrochloride (3.88 g, 25.7 mmol), N-ethyldiisopropylamine (5.99 ml_, 35 mmol) were suspended in NMP (60 mL). The RM was stirred at 180 0C for 8.5 h. The mixture was diluted with EtOAc and washed with 1M Na2CO3 (1 x) and water (2 x). The aqueous was further extracted with EtOAc (2 x). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography and then crystallized in EtOAc to afford the title compound as a white solid (tR 3.19 min (conditions 1), (tR 8.84 min (conditions 2), MH+ = 423.2, 1H-NMR in DMSO-d6: 8.94 (d, 1H); 8.45 (d, 1 H); 7.84 (d, 1 H); 7.63 (s, 1H); 7.59 (m, 2H); 7.08 (d, 1H); 4.98 (m, 1H); 4.02 (d, 1 H); 3.73 (d, 1H); 3.60 (m, 2H); 3.31 (m, 1H); 3.25 (m, 1H); 2.80 (s, 3H); 1.88 (d, 3H))., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; FURET, Pascal; McCARTHY, Clive; SCHOEPFER, Joseph; STUTZ, Stefan; WO2011/15652; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example of preparation. Preparing form I gatifloxacin for seeding; 10 g (0.0339 moles, 1 equivalent) of 1- cyclopropyl-6, 7-difluoro-1, 4-dihydrc-8-methoxy-4-oXo-3- quinolinecarboxylic acid (CAS no.: 112811-72-0) is placed in a flask, 30 mL of acetonitryl (3 volumes) is added and the solution is heated to a temperature of 76-80 C. Once reflux has been attained, 3.28 g (0.0203 moles, 0.6 equivalents) of hexamethyldisilazane (HMDS) is added using a compensated addition funnel, maintaining the temperature. Once the addition is completed, the reaction is maintained with stirring for 1 hour at a temperature of 76-80 C. Once this period has elapsed, the reaction mixture is cooled to a temperature between 0 and 15 C, and 5.78 g (0.0407 moles, 1.2 equivalents) of boron trifluoride ethyletherate is added, keeping the temperature below 15 C. Once the addition has finished, the temperature is allowed to rise to 15-25 C and :-t is kept under these conditions for approximately 2 hour : :. The pH of the mixture is then adjusted to an approximate value of 9 with triethylamine (approximately 2 mL). To the resulting suspension : s added a solution of 10.19 g (0.1017 moles, 3 equivalents) of 2-methylpiperazine in 28 mL of acetonitryl, keeping the temperature between 15 and 25 C. The resulting amber solution is kept with stirring under these conditions for approximately 3 hours. Once the reaction has beer : completed, the mixture is distilled at low pressure unti : a stirrable paste is obtained. At this point, 50 mL of methanol is added, the resulting suspension is raised to a temperature of 63-67 C and kept under these conditions for approximately 5 hours. Once the reaction has been completed the mixture is cooled to a temperature of 25-35 C over a water bath and then to a temperature of 0-5 C over a water/ice bath for a further 1 hour. The resulting precipitate is filtered, washed with cold methanol (2 x 10 mL) and dried at 40 C in an oven in vacuo to constant weight. 10.70 g of crude gatifloxacin is obtained, with a water content of 2. 95% by weight. The yield of the process is 81.8%. The crude product obtained is used for the seeding in Example 1. The crude product is crystallised in methanol by dissolving-20 g of crude gatifloxacin in 1 1 of methanol (50 volumes) at a temperature of D3-67 C. Once all the product has been dissolved it is placed to cool to a temperature of 30-40 C, and then to a temperature of 0-5 C over a water/ice bath, maintaining it under these conditions for 1 hour. The resulting suspension is filtered and the solid retained is washed with 20 mL (1 volume) of cold methanol. The solid obtained is dried at 40 C in a vacuum oven to obtain 18.65 g of gatifloxacin with a water content of 2. 36% by weight.

109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; QUIMICA SINTETICA, S.A.; WO2005/47262; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

a N-(tert-Butoxycarbonyl)-1-(2-hydroxyethyl)piperazine To a solution of 1-(2-hydroxyethyl)piperazine (5.20 g, 40 mmol) and triethylamine (6 mL 43 mmol), in 1,4-dioxane (100 mL) was added slowly di-tert-butyl dicarbonate (8.72 g, 40 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was removed in vacuo and the residue was purified by flash column chromatography (ethyl acetate to 2% methanol in ethyl acetate) to give the title compound as colorless oil (8.32 g, 90%). 1 H-NMR (300 MHz, CDCl3) delta 1.46 (s, 9H), 2.46 (t, 4H), 2.55 (t, 2H), 2.75 (br s, 1H), 3.44 (t, 4H), and 3.63 (t, 2H)., 103-76-4

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; 3-Dimensional Pharmaceuticals, Inc.; US6034127; (2000); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C5H12N2, 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, in an article , author is Lin, Yuqing, once mentioned of 109-01-3.

Custom-tailoring metal-organic framework in thin-film nanocomposite nanofiltration membrane with enhanced internal polarity and amplified surface crosslinking for elevated separation property

A polyamide (PA) thin-film nanocomposite (TFN) membrane embedded with post-synthetically functionalized metal-organic framework (MOF) nanofillers of imidazole-2-carbaldehyde (ICA) decorated UiO-66-NH2 nano fillers (ICA_d_UiO-66-NH2) was developed using the interfacial polymerization method. The ICA_d_UiO-66-NH2 nanofiller couples a surface water-capturing ICA decoration, facilitating the rapid transport of water molecules owing to the enhanced internal polarity, while achieving an amplified crosslinking between the terminal amine groups of ICA and trimesoyl chloride, enabling the perfect incorporation of MOF nanofillers within the PA matrix. The resultant ICA_d_UiO-66-NH2@PA TFN membrane with elevated separation property performed comparably high water permeance of 9.4 l m(-2) h(-1) bar(-1) (achieving a nearly 2-fold increase from the initial value of the thin-film composite membrane), and a favorable rejection ratio of 97.4% (Na2SO4). Owing to the unique hierarchical surface microstructure embedded with the intrinsically hydrophilic ICA_d_UiO-66-NH2 nanofillers, the newly-developed TFN membrane exhibited superior antifouling properties. Furthermore, the ICA_d_UiO-66-NH2@PA TFN membrane also retained excellent reusability and durability without significant compromise even after long-term salt, and acid/alkali treatments. Overall, this work provides an insight into the embedding of different functionalized nanofillers inside TFN membranes with elevated separation properties.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 109-01-3, you can contact me at any time and look forward to more communication. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Oa, Seyeon, introduce the new discover, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Effects of carbonation on carbon dioxide capture and the mechanical properties of concrete with amine sorbents

Carbon dioxide (CO2) uptake and the mechanical strength of concrete with and without carbon-dioxide-philic (CDP) amine sorbents were assessed in this study. Cement pastes with three amine-based sorbents (5-amino-1 pentanol, piperazine and 3-amino-1-propanesulfonic acid) were hydrated for 28 d. They were then assessed for carbon dioxide uptake and compressive/bending strength. The carbon dioxide in the atmosphere was sequestrated into the concrete as simulated carbonation weathering occurred, and the carbon dioxide uptake was measured using thermogravimetric analysis. Carbon dioxide uptake increased when CDP amine sorbents were mixed into the concrete specimens, with 5-amino-1-pentanol and piperazine showing the best efficiency, with carbon dioxide uptakes of 2.44% and 2.24%, respectively. The compressive and bending strengths also increased with carbonation. The strengths of the concretes with CDP sorbents were higher than that of ordinary concrete due to the microstructurel densification, indicating that urban carbon dioxide sequestration can be performed using concrete structures without damaging their structural strength.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, belongs to piperazines compound, is a common compound. In a patnet, author is Giancola, JoLynn B., once mentioned the new application about 5308-25-8, Recommanded Product: 1-Ethylpiperazine.

Structure-activity relationships for a series of (Bis(4-fluorophenyl) methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability

Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effective, leaving an underserved patient population and unanswered questions as to what mechanism(s) of action should be targeted for developing pharmacotherapies. Atypical dopamine transporter (DAT) inhibitors, based on (+/-)modafinil, have shown therapeutic potential in preclinical models of psychostimulant abuse. However, metabolic instability among other limitations to piperazine analogues 1-3 have impeded further development. Herein, bioisosteric substitutions of the piperazine ring were explored with a series of aminopiperidines (A) and piperidine amines (B) wherein compounds with either a terminal tertiary amine or amide were synthesized. Several lead compounds showed high to moderate DAT affinities and metabolic stability in rat liver microsomes. Aminopiperidines 7 (DAT K-i = 50.6 nM), 21b (DAT K-i = 77.2 nM) and 33 (DAT K(i)Elsevier = 30.0 nM) produced only minimal stimulation of ambulatory activity in mice, compared to cocaine, suggesting an atypical DAT inhibitor profile. (C) 2020 Elsevier Masson SAS. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 5308-25-8. The above is the message from the blog manager. Recommanded Product: 1-Ethylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, belongs to piperazines compound, is a common compound. In a patnet, author is O’Rourke, Catherine E., once mentioned the new application about 109-01-3, Application In Synthesis of 1-Methylpiperazine.

Occurrence and Mass Loading of Synthetic Opioids, Synthetic Cathinones, and Synthetic Cannabinoids in Wastewater Treatment Plants in Four US Communities

A few new psychoactive substances (NPS) that mimic the effects of controlled neuropsychiatric and illicit drugs have been forensically identified in the U.S. Wastewater-based epidemiology (WBE) can provide a comprehensive and more cost- and time-effective method of determining the prevalence of NPSs in communities. In this study, an analytical method capable of simultaneous determination of trace-level 40 NPS residues (synthetic opioids, synthetic cannabinoids, synthetic cathinones, piperazines, indole, and amphetamine) in wastewater was developed and validated. The developed analytical method was utilized to determine the occurrence of NPSs in four rural communities in southern Illinois. Nine NPSs (carfentanil, furanyl fentanyl, methoxyacetyl fentanyl, MAB-CHMINACA, methcathinone, 4-methyl pentedrone, 2-methyl-4′-(methylthio)-2-morpholinopropiophenone (MMMP), 1-(3-chlorophenyl) piperazine (mCPP), and 5-(2- Aminopropyl) Indole (SIT) were quantified. Methcathinone was the most frequently detected NPS (detection frequency, df = 100%) followed closely by the MMMP and mCPP (df = 91%). The mass loading of methcathinone, mCPP, and S-IT using ammoniacal nitrogen-based population were up to 21.1 +/- 1.3 mg/d/1000 people, 15.0 +/- 0.5 mg/d/1000 people, and 9.75 +/- 2.72 mg/d/1000 people, respectively. This is the first study to determine the occurrence of NPSs including synthetic opioids, synthetic cannabinoids, synthetic cathinones, and piperazines in the U.S. communities.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 109-01-3. The above is the message from the blog manager. Application In Synthesis of 1-Methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, belongs to piperazines compound. In a document, author is Abbasabadi, Masoud Khaleghi, introduce the new discover, Recommanded Product: 1-Ethylpiperazine.

Covalent modification of reduced graphene oxide with piperazine as a novel nanoadsorbent for removal of H2S gas

In the present research, piperazine grafted-reduced graphene oxide RGO-N-(piperazine) was synthesized through a three-step reaction and employed as a highly efficient nanoadsorbent for H2S gas removal. Temperature optimization within the range of 30-90 degrees C was set which significantly improved the adsorption capacity of the nanoadsorbent. The operational conditions including the initial concentration of H2S (60,000 ppm) with CH4 (15 vol%), H2O (10 vol%), O-2 (3 vol%) and the rest by helium gas and gas hour space velocity (GHSV) 4000-6000 h(-1) were examined on adsorption capacity. The results of the removal of H2S after 180 min by RGO-N-(piperazine), reduced graphene oxide (RGO), and graphene oxide (GO) were reported as 99.71, 99.18, and 99.38, respectively. Also, the output concentration of H2S after 180 min by RGO-N-(piperazine), RGO, and GO was found to be 170, 488, and 369 ppm, respectively. Both chemisorption and physisorption are suggested as mechanism in which the chemisorption is based on an acid-base reaction between H2S and amine, epoxy, hydroxyl functional groups on the surface of RGO-N-(piperazine), GO, and RGO. The piperazine augmentation of removal percentage can be attributed to the presence of amine functional groups in the case of RGO-N-(piperazine) versus RGO and GO. Finally, analyses of the equilibrium models used to describe the experimental data showed that the three-parameter isotherm equations Toth and Sips provided slightly better fits compared to the three-parameter isotherms. [GRAPHICS] .

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5308-25-8. Recommanded Product: 1-Ethylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics