Tag: M.W:100-200

39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5,6-dimethyl-2-(3-fluorophenyl)-3-hydroxyisoindolin-1-one (83 mg, 0.31 mmol) in anhydrous dimethylformamide (3 ml) was added to a suspension of 65% sodium hydride (13 mg, 0.34 mmol) in anhydrous dimethylformamide (3 ml), and stirred at 25C for 35 minutes. Then, a solution of 1-chlorocarbonyl-4-methylpiperazine (50 mg, 0.31 mmol) in anhydrous dimethylformamide was added thereto, and stirred with heating at 70C for 5 hrs. The reaction solution was concentrated under reduced pressure, and water was added to the residue, followed by extracting with chloroform. The extract was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform: methanol = 20: 1). The resulting crystals were washed with petroleum ether to give 21 mg of the title compound. melting point: 146-148C 1H-NMR (CDCl3) delta: 2.38 (3H, s, CH3), 2.40 (3H, s, CH3), 2.73 (3H, s, NCH3), 3.01-3.14 (6H, m, piperazine), 3.18-3.24 (1H, m, piperazine), 3.32-3.38 (1H, m, piperazine), 6.43 (1H, s, CH), 6.85-6.91 (1H, m, PhH), 7.33-7.39 (1H, m, PhH), 7.36 (1H, s, C4-H), 7.66 (1H, s, C7-H), 7.66-7.76 (2H, m, PhH), 39539-66-7

39539-66-7 4-Methylpiperazine-1-carbonyl chloride 3016935, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Maruishi Pharmaceutical Co., Ltd.; EP1566378; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

54699-92-2, 4-Methyl-1-piperazineacetic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54699-92-2, Example 13; General Method for the Preparation of Active Esters of N-Substituted Piperazine Acetic Acid from Trifluoroacetate Esters; A solution of the trifluoroacetate in THF (0.58 M, 1.2 equiv) was added to a solid sample of N-methyl piperazine acetic acid and mixed in a vortex or shaker until a homogeneous solution was obtained. The reaction of the carboxylic acid with the trifluoroacetate ester was generally complete within 30 min for all cases except N-hydroypyrrolidinone (NHP, 18 h). The progress of conversion to the active ester was monitored by ES-MS. The amount of product and any starting material (N-MPA) could be determined by direct infusion of a sample of the reaction (in ethanol) into the ES-MS. In some cases the active ester product was precipitated as dihydrochloride salt by the addition of a solution by addition of HCl solution in dioxane (4 M, 50% volume of the reaction) followed by washing with THF, ethyl acetate and hexanes. In other cases the product was isolated from the reaction as the mono TFA salt. Addition of TFA could be performed if the bis-TFA salt was desired. Dhbt ester, Calculated MH+ = 304.14 Found = 304.20 NHP ester, Calculated MH+ = 242.15 Found = 242.20 4-NP ester, Calculated MH+ = 280.13 Found = 280.20 1H NMR (400 MHz, CDCl3) d 8.20 (d, 2H, J=9.2 Hz, aromatic protons), 7.25 (d, 2H, J=9.2 Hz, aromatic protons), 3.69-3.40 (broad, 2H, ring protons), 3.57 (s, 2H, -CH2-CO-), 3.15-2.90 (broad, 6H, ring protons), 2.78 (s, 3H, -CH3). Pfp ester, Calculated MH+ = 325.10 Found = 325.10 Pcp ester, Calculated MH+ = 404.95 Found = 405.90 3-NP ester, Calculated MH+ = 280.13 Found = 280.20 NHS ester, Calculated MH+ = 256.13 Found = 256.10

54699-92-2 4-Methyl-1-piperazineacetic acid 2762732, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Applera Corporation.; US2005/148771; (2005); A1;; ; Patent; Applera Corporation.; US2005/148774; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 81fert-ButvK^-l-(2-rr35l.5i?V3.5-dimethvbiperazin-l-yll-7-fluoro-8-methylquinolin-3- yl } ethylcarbamateTo a solution of Intermediate 27 (500 mg, 1.48 mmol) in NMP (6 mL) were added (25′,6i?)-2,6-drmethylpiperazine (340 mg, 3.00 mmol) and DIPEA (1.3 mL) and the resulting solution was heated at 14O0C for 16 h. The reaction mixture was taken up in EtOAc (150 mL) and washed with water (2 x 50 mL) and brine (50 mL). The organic phase was separated, dried (MgSO4), filtered and the solvent removed in vacuo. Purification by column chromatography (SiO2, 0-5percent MeOH in EtOAc) gave the title compound (530 mg, 86percent) as a beige solid. deltaH (CDCl3) 7.90 (IH, s), 7.49 (IH, dd, J 8.87, 6.12 Hz), 7.12 (IH, t, .78.98 Hz)5 5.04 (2H, d, J38.75 Hz), 3.65 (IH, d, J 12.33 Hz), 3.43 (IH, d, J 12.40 Hz), 3.26 (IH, s), 3.14-3.09 (IH, m), 2.79 (IH5 1, J 11.35 Hz)5 2.60 (3H, d, J2.40 Hz)5 2.43 (IH51, J 11.28 Hz)5 1.48-1.42 (13H5 m), 1.15 (6H, dd5 J 14.95, 6.35 Hz).

21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
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Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 45A: tert-but l 4-(2-hydroxyethyl)piperazine-l-carboxylate 2-(piperazin-l-yl)ethan-l-ol (5 g, 38.41 mmol, 1.00 equiv) was dissolved in DCM (100 mL), and a solution of di-tert-butyl dicarbonate (8.38 g, 38.40 mmol, 1.00 equiv) in DCM (20 mL) was added drop-wise. The reaction was left under agitation overnight at ambient temperature. The reaction was evaporated to dryness and the residue dissolved in 200 mL of AcOEt, washed 5 times with NaCl (sat.), dried over sodium sulfate, filtered and concentrated under reduced pressure to yield 8.5 g (96 %) of compound 45 A in the form of a white solid.

103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; RILATT, Ian; PEREZ, Michel; GOETSCH, Liliane; BROUSSAS, Matthieu; BEAU-LARVOR, Charlotte; HAEUW, Jean-Francois; WO2015/162293; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) Put the solvent ethanol into the reactor, add piperazine, and stir to dissolve all the piperazine. Hydrochloric acid is added dropwise under the condition of 20 C to make the reaction solution PH = 2 as an end point; after reacting for 1 hour and cooling to 20 C,Pipette rejection by centrifugation to give piperazine dihydrochloride, the mother liquor can continue to be concentrated to give piperazine dihydrochloride;(2) The ethanol into the reaction vessel was added with stirring 42g piperazine dihydrochloride and 21g of piperazine,Reaction at 68 C for 3 hours;(3) cooling to 45 C dropwise cinnamyl chloride 36g, after the dropwise addition was warmed to 60 incubated for 4 hours,And then cooled to 10 C, centrifuged, the solid filter cake was recovered to give piperazine dihydrochloride recycling, the mother liquor drawn into the distillation reactor;(4) heat distillation mother liquor recovery solvent,The solvent is no longer out when adding purified water,Dropping lye to adjust PH to 12,The mixture was extracted with chloroform twice, the organic phases were combined and the organic phase was washed twice with water. The organic phase was separated and dried over anhydrous sodium sulfate overnight. The chloroform was then recovered by distillation and the product was still hot while still in the still pot to give cinnamylpiperazine., 142-64-3

As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference£º
Patent; Zhengzhou Ruikang Pharmaceutical Co., Ltd.; Zhang Jie; Zhang Guoyong; Li Mingxuan; Liu Yuanyuan; (6 pag.)CN106366051; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.,4318-42-7

Step B/lntermediate B62: 1-[2-fluoro-5-(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; To 5-bromo-4-fluoro-2-nitrophenyl methyl ether (4.0 g, 16.0 mmol) in dioxane (150 ml.) was added 1-(1-methylethyl)piperazine (4.1 g, 32.0 mmol), XANTPHOS (0.9 g, 1.6 mmol), and Cs2CO3 (10.4 g, 32.0 mmol). The mixture was bubbled with N2 for 15 min prior to the addition of Pd2(dba)3 (0.7 g, 0.8 mmol). The reaction was stirred at 100 0C for 18 h. Ethyl acetate (100 ml.) was used to dilute the reaction mixture, followed by the addition of water (80 ml_). After partitioning, extraction with Ethyl acetate (2 x 75 ml_), drying (Na2SO4), filtration and concentration, silica gel chromatography afforded 1-[2-fluoro-5-(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine as a yellow solid (3.3 g, 70percent yield). 1 H NMR (400 MHz,DMSO-de) delta ppm 0.98 (d, J=6.6 Hz, 6 H), 2.54 – 2.61 (m, 4 H), 2.68 (dt, J=13.2, 6.6 Hz, 1 H), 3.24 – 3.31 (m, 4 H), 3.91 (s, 3 H), 6.64 (d, J=I .1 Hz, 1 H), 7.82 (d, J=13.6 Hz, 1 H).

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(piperazin-1-yl)ethan-1-ol (5 g, 38.41 mmol, 1.00 equiv) was dissolved inDCM (100 mL), and a solution of di-tert-butyl dicarbonate (8.38 g,38.40 mmol, 1.00 equiv) in DCM (20 mL) was added drop-wise. The reaction was left under agitation overnight at ambient temperature. The reaction was evaporated to dryness and the residue dissolved in 200 mL of AcOEt, washed 5 times with NaC1 (sat.), dried over sodium sulfate, filtered and concentrated under reduced pressure toyield 8.5 g (96 %) of compound 45A in the form of a white solid., 103-76-4

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; PEREZ, Michel; RILATT, Ian; LAMOTHE, Marie; WO2014/174060; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148546-99-0,3-(4-Methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 132 Naphthalene-2-sulfonic Acid [3-(4-Methylpiperazin-1-yl)phenyl]amide (E132) The title compound (E132) was prepared from 3-(4-methylpiperazin-1-yl)benzenamine and naphthalene-2-sulfonyl chloride according to the method of Example 1 MH+=382.

148546-99-0, 148546-99-0 3-(4-Methylpiperazin-1-yl)aniline 11564613, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SmithKline Beecham p.l.c.; US6423717; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 35; (4-Cyclopentyl-piperazin-1-yl)-[4-(2-fluoro-phenylamino)-cyclohexyl]-methanone; A mixture of 86 mg (0.5 mmol) 4-oxo-cyclohexanecarboxylic acid ethyl ester (commercially available), 100 mg (0.6 mmol) 2-fluoro-phenylamine and 300 mg (5 mmol) acetic acid in 5 mL THF was stirred for 1 h at 60 C. Afterwards 159 mg (0.75 mmol) sodium triacetoxyborohydride were added and the mixture was heated to 65 C. for 16 h. After evaporation of the volatiles 10 mL 1N NaHCO3 aq. was added and the mixture was extracted with DCM. The combined organic layers were evaporated and methanol and DMF were added and the mixture was subjected to preparative HPLC purification on reversed phase eluting with a gradient of acetonitrile/water (0.1% NEt3). The combined product fractions were evaporated to dryness to yield the intermediate 3-(2-fluoro-phenylamino)-cyclohexanecarboxylic acid ethyl ester. MS(m/e): 266.2 (MH+). A mixture of 21 mg (0.08 mmol) 4-(2-fluoro-phenylamino)-cyclohexanecarboxylic acid ethyl ester, 17 mg (0.4 mmol) LiOH.H2O in a mixture of 2 mL THF/methanol/water was heated to 45 C. for 2 h and subsequently evaporated. The intermediately built acid was dissolved in 2 mL DMF and treated with 30 mg (0.096 mmol) TBTU, 24 mg (0.24) NEt3 and 13.5 mg (0.88 mmol) 1-cyclopentyl-piperazine (commercially available) and stirred for 16 h at room temperature. The mixture was directly subjected to preparative HPLC purification on reversed phase eluting with a gradient of acetonitrile/water (0.1% NEt3). The combined product fractions were evaporated to dryness to yield 6.4 mg (21%) of the title compound. MS(m/e): 374.4 (MH+)., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Patent; Nettekoven, Matthias; Plancher, Jean-Marc; Roche, Olivier; Takahashi, Tadakatsu; Taylor, Sven; US2007/167436; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,74879-18-8

Example 24 2-(2,8-dimethylimidazo[l,2-b]pyridazin-6-yl)-9-methyl-7-[(3S)-3-methylpiperazin-l- yl]pyrido[l,2-a]pyrimidin-4-one In a sealed tube, 2-(2,8-dimethylimidazo[l,2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[l,2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol) and (S)-2-methylpiperazine (62 mg, 0.619 mmol, 4.0 eq.) were stirred in DMSO (2 mL) at 125C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2CI2 and washed with an aqueous saturated solution of NaHC03. The organic layer was separated and dried over Na2S04 and concentrated in vacuo. The crude was purified by column chromatography (S1O2, CH2Cl2/MeOH=95/5 to 90/10) to afford the title product (45 mg, 72%) as a light yellow solid. MS m/z 404.3 [M+H+].

As the paragraph descriping shows that 74879-18-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; RATNI, Hasane; GREEN, Luke; NARYSHKIN, Nikolai A.; WEETALL, Marla L.; (80 pag.)WO2015/173181; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics