Tag: M.W:100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Methyl 3-hydroxybutanoate(SMILESS: C[C@H](O)CC(OC)=O,cas:53562-86-0) is researched.Application of 54903-09-2. The article 《New chiral phospholanes; synthesis, characterization, and use in asymmetric hydrogenation reactions》 in relation to this compound, is published in Tetrahedron: Asymmetry. Let’s take a look at the latest research on this compound (cas:53562-86-0).

The practical synthesis of enantiomerically pure trans-2,5-disubstituted-1-phenylphospholanes, e.g., I, which are then employed in the preparation of a new series of C2-sym. bis-, e.g., II, and C3-sym. tris(phospholane) ligands, is described. A versatile three-step route to the important chiral 1,4-diol intermediates, e.g., III, used in the phosphine syntheses, is outlined. Rhodium complexes bearing the new phosphine ligands were prepared and shown to act as efficient catalyst precursors for the enantioselective hydrogenation of various unsaturated substrates. The crystal structure of 3 of the prepared Rh complexes were determined

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Piperazine – Wikipedia,
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Safety of 5-Fluoroindoline. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about The use of IR studies to investigate substituent effects: geometry changes in substituted anilines. Author is Butt, G. L.; Topsom, R. D..

The frequencies and intensities of the νNH mode of p-XC6H4NHMe (X = NMe2, OMe, F, Cl, Me, H, CO2Me, CN, NO2) were recorded. The frequencies followed σ values whereas the intensities correlated with σ- values, as a result of changing geometry in the mols. Results for 5-substituted indolines supported this explanation.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about 5-Hydroxytryptamine (5-HT3) receptor antagonists. 2. 1-Indolinecarboxamides. Author is Bermudez, Jose; Dabbs, Steven; Joiner, Karen A.; King, Frank D..

Indazole I is a potent and selective 5-HT3 receptor antagonist. A novel series of potent 5-HT3 receptor antagonists, 1-indoline- and 1-indolecarboxamides II [R = H , F, Cl, MeO, O2N; R1 = H, Me, Et, Ph; R2 = H, Me; R1R2 = (CH2)2, (CH2)4, (CH2)5; R3 = H, Me; n = 2,3] and III (R1 = H, Me, Et, Ph), resp., is described. The activity of II suggests that aromaticity of the 5-membered ring is not an essential requirement for potency provided that an in plane orientation of the CO group is favored. On the basis of this hypothesis indene IV was prepared In IV the in plane orientation of the CO group is maintained by conjugation with the aromatic ring through the sp2-hybridized C. IV is also a potent 5-HT3 receptor antagonist.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Carboline and phenothiazine derivatives as potent SIGMA-1 protein ligands. Author is Donnier-Marechal, Marion; Larchanche, Paul-Emmanuel; Le Broc, Delphine; Furman, Christophe; Carato, Pascal; Melnyk, Patricia.

Sigma 1 receptors are associated with neurodegenerative and psychiatric disorders. These receptors, via their chaperoning functions that counteract endoplasmic reticulum stress and block neurodegeneration, may serve as a target for a new generation of antidepressants or neuroprotective agents. The involvement of these receptors has also been observed in neuropathic pain and cancer. Only a few ligands, such as Igmesine and Anavex 2-73, have been involved in clin. trials. Thus the development of sigma 1 ligands is of interest to a new generation of drugs. Previous work in the laboratory underlined the potency of benzannulated bicyclic compounds as interesting ligands. Herein the work was extended to a series of novel tricyclic compounds Carboline and phenothiazine derivatives were designed and synthesized. In vitro competition binding assays for sigma 1 and 2 receptors showed that most of them have high affinity for sigma 1 receptor (Ki = 2.5-18 nM), and selectivity toward sigma 2 receptor, without cytotoxic effects on SY5Y cells.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chen, Qing-An; Chen, Zhiwei; Dong, Vy M. published an article about the compound: 5-Fluoroindoline( cas:2343-22-8,SMILESS:FC1=CC2=C(NCC2)C=C1 ).HPLC of Formula: 2343-22-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2343-22-8) through the article.

The hydroamination of internal alkynes via tandem rhodium catalysis gives branched N-allylic indolines with high regio- and enantioselectivity. An acid switch provides access to the linear isomer in preference to the branched isomer by an isomerization mechanism. Mechanistic studies suggest formation of an allene intermediate, which undergoes hydroamination to generate allylic amines instead of the enamine or imine products typically observed in alkyne hydroaminations.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jara, Yoselin; Araujo, Mary Lorena; Madden, Waleska; Lubes, Vito; Hernandez, Lino published the article 《Ternary complex formation of the nickel(II), 2,2′-bipyridine, 1,10′-Phenanthroline and some aminoacids》. Keywords: nickel bipyridine phenanthroline amino acid ternary complex formation speciation.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Electric Literature of C12H8N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

In this work we report the results of a speciation study on the ternary complexes present in the ternary Ni(II)-1,10 phenanthroline (Phen)-amino acids and Ni(II)-2,2-bipyridine (Bipy)-amino acids, with amino acids = aspartic acid (H2Asp), glutamic acid (H2Glu), histidine (H2His) and cysteine (H2Cys). The anal. involved the use of potentiometric data in 1 M NaCl aqueous solution at 25°C and a least-squares method (LETAGROP). The relative stability of the ternary complexes were compared with the corresponding binary complexes. The concentration distribution of various species formed in aqueous solution were evaluated as a function of pH. The binary complexes in the Ni(II) – Phe and Ni(II) – Bipy systems in 1 M NaCl aqueous solution at 25°C were also studied.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Rh(III)-Catalyzed Carbocyclization of 3-(Indolin-1-yl)-3-oxopropanenitriles with Alkynes and Alkenes through C-H Activation》. Authors are Zhou, Tao; Wang, Yanwei; Li, Bin; Wang, Baiquan.The article about the compound:5-Fluoroindolinecas:2343-22-8,SMILESS:FC1=CC2=C(NCC2)C=C1).Recommanded Product: 2343-22-8. Through the article, more information about this compound (cas:2343-22-8) is conveyed.

Rh(III)-catalyzed carbocyclization reactions of 3-(indolin-1-yl)-3-oxopropanenitriles with alkynes and alkenes have been developed to form 1,7-fused indolines through C-H activation. These reactions have a broad range of substrates and high yields. Unsym. aryl-alkyl substituted alkynes proceeded smoothly with high regioselectivity. Electron-rich alkynes could undergo further oxidative coupling reaction to form polycyclic compounds For alkenes, 1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-ones were formed via C(sp2)-H bond alkenylation and C(sp2)-H, C(sp3)-H oxidative coupling reactions.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Recommanded Product: 2343-22-8.Yang, Guoqiang; Lindovska, Petra; Zhu, Dajian; Kim, Justin; Wang, Peng; Tang, Ri-Yuan; Movassaghi, Mohammad; Yu, Jin-Quan published the article 《Pd(II)-Catalyzed meta-C-H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template》 about this compound( cas:2343-22-8 ) in Journal of the American Chemical Society. Keywords: regioselective meta carbon hydrogen bond olefination indoline palladium catalyst; acetoxylation indoline palladium catalyst; arylation indoline palladium catalyst. Let’s learn more about this compound (cas:2343-22-8).

Meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are otherwise highly reactive toward electrophilic palladation at the para-positions. A wide range of synthetically important and advanced indoline analogs are selectively functionalized at the meta-positions.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Metal-Organic Layers Hierarchically Integrate Three Synergistic Active Sites for Tandem Catalysis. Author is Quan, Yangjian; Lan, Guangxu; Shi, Wenjie; Xu, Ziwan; Fan, Yingjie; You, Eric; Jiang, Xiaomin; Wang, Cheng; Lin, Wenbin.

We report the design of a bifunctional metal-organic layer (MOL), Hf12-Ru-Co, composed of [Ru(DBB)(bpy)2]2+ [DBB-Ru, DBB=4,4′-di(4-benzoato)-2,2′-bipyridine; bpy=2,2′-bipyridine] connecting ligand as a photosensitizer and Co(dmgH)2(PPA)Cl (PPA-Co, dmgH=dimethylglyoxime; PPA=4-pyridinepropionic acid) on the Hf12 secondary building unit (SBU) as a hydrogen-transfer catalyst. Hf12-Ru-Co efficiently catalyzed acceptorless dehydrogenation of indolines and tetrahydroquinolines to afford indoles and quinolones. We extended this strategy to prepare Hf12-Ru-Co-OTf MOL with a [Ru(DBB)(bpy)2]2+ photosensitizer and Hf12 SBU capped with triflate as strong Lewis acids and PPA-Co as a hydrogen transfer catalyst. With three synergistic active sites, Hf12-Ru-Co-OTf competently catalyzed dehydrogenative tandem transformations of indolines with alkenes or aldehydes to afford 3-alkylindoles and bisindolylmethanes with turnover numbers of up to 500 and 460, resp., illustrating the potential use of MOLs in constructing novel multifunctional heterogeneous catalysts.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-1-(Dimethylamino)propan-2-ol(SMILESS: C[C@H](O)CN(C)C,cas:53636-17-2) is researched.Category: piperazines. The article 《Relative potencies of the stereoisomers of bethanechol on muscarinic receptors》 in relation to this compound, is published in Farmaco, Edizione Scientifica. Let’s take a look at the latest research on this compound (cas:53636-17-2).

The stereoisomers S(+)-bethanechol iodide  [86941-71-1] and R(-)-bethanechol iodide  [86941-72-2], as well as the racemate [86919-69-9], were prepared from the corresponding S(+)-, R(-)-, or RS-forms of 1-amino-2-propranol by refluxing the primary amine with a mixture of HCO2H and H2CO to produce the corresponding tertiary amines, which in turn were reacted with ClSO2NCO, the product being hydrolyzed with aqueous K2CO3 and the quaternary ammonium salts isolated by reacting the tertiary amines with excess MeI. The resulting bethanechol enantiomers and racemate were tested for their muscarinic receptor affinity (pD2) in an isolated rat ileum preparation As was previously reported for the enantiomers of acetyl-β-methylcholine, the highest activity was associated with the S configuration. The more active enantiomer had twice the affinity of the racemate, as would be the case if the R form had almost no affinity at all. It is concluded that acetyl-β-methylcholine and bethanechol satisfy the steric requirements of a common receptor site.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics