Tag: M.W:100-200

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 5 – ((2,4-dioxo -3,4-dihydrochinazolines having antiviral properties -1 (2H)-yl) methyl) – 2-fluoro-benzoic acid (50 mg, 0 . 16mmol), EDCI (62 mg, 0 . 32mmol), HOBT (44 mg, 0 . 32mmol) and TEA (33 mg, 0 . 32mmol) into the reaction bottle in, addition of about 2 ml of the dissolution of water-free DMF, r.t. The lower stirring 60 min, then dropwise (2S, 6R) – 2,6-dimethyl piperazine (28 mg, 0 . 24mmol) in the DMF solution to the reaction solution, r.t. The lower stirring overnight, the reaction solution is poured into 100 ml water, using 100mLDCM extraction, an organic layer for sequentially 1MHCl (100 ml), saturated NaCl (100 ml) and water (100 ml) washing, concentrating under reduced pressure, column chromatography, to obtain 40 mg solid, yield 61.3percent.

21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2- (5-amino-2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-7-yl) -2-phenylpropanoic acid (50 mg, 0.13 mmol) , 1- (2, 4-difluorophenyl) piperazine (25 mg, 0.13 mmol) , HATU (59 mg, 0.16 mmol) and DIEA (33 mg, 0.26 mmol) in DMF (5 mL) was stirred at rt for 2 hrs. The solution was added with water (10 mL) , extracted with ethyl acetate (10 mL) and washed with brine (10 mL) . The organic layer was dried, concentrated and purified by column chromatography (PE: EA = 2: 1) and preparative TLC (DCM: MeOH = 20: 1) to get the desired product (20 mg, 28%) .1H NMR (400 MHz, DMSO-d6) delta 8.31 (s, 1H) , 8.08 (br. s, 2H) , 7.95 (d, J = 4.0Hz, 1H) , 7.30-7.11 (m, 7H) , 6.92-6.86 (m, 2H) , 6.74 (d, J = 4.0Hz, 1H) , 3.71 (br. s, 2H) , 3.45-3.40 (m, 2H) , 3.16-2.90 (m, 4H) , 2.35 (s, 3H) ppm. MS: M/e 570 (M+1)+

115761-79-0, The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

75336-86-6, In a nitrogen atmosphere, 115 mL of di-tert-butyl dicarbonate was dropwise added to chloroform (500 mL) solution of 50.0 g of (R)-2-methylpiperazine, over 1 hour. The reaction liquid was washed with water, and dried with anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was separated and purified through silica gel column chromatography (hexane/ethyl acetate = 2/1) to obtain 63.5 g of the entitled compound as a colorless oily substance.

The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1726590; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

Example-4; Preparation of o-CS-chloropyridin-Z-ylJ-S^-methylpiperazin-l-ylJ-carbonyloxy -7- oxo-5,6-dihydropy rrolo- [3,4-b] -pyrazine (Zopiclone).Mixture of 400 ml dichloromethane, 100 ml dimethyl formamide, 6-(5-chloropyridin-2- yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo-[3,4-b]-pyrazine (10Og) and N-methyl piperazine carbomoyl chloride hydrochloride (106.Ig) was cooled to 10-15 C. Calcium oxide (42.66g) and dimethyl amino pyridine (2.5g) were added to the mixture. Reaction mixture was warmed to 25-30 C and stirred till completion of reaction. After completion of reaction, mixture was filtered and washed with 400 ml dichloromethane. The dichloromethane layer was concentrated at atmospheric pressure till dryness. 400 ml of methanol was added to residual solid and stirred for 60 min at 25-30 C. Slurry was cooled to 0-5 C and stirred for 60 min at same temperature. Solid was filtered, washed with chilled methanol 2X25 ml and dried at 50-60 C to obtain 126 g of racemic Zopiclone, 55112-42-0

As the paragraph descriping shows that 55112-42-0 is playing an increasingly important role.

Reference£º
Patent; MATRIX LABORATORIES LTD; WO2008/126105; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

STARTING MATERIAL SYNTHETIC EXAMPLE 8 5-amino-2-(4-methylpiperazin-1-yl)benzonitrile By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (15 g) and methylpiperazine (9.8 g), the title compound (11.1 g) was obtained. melting point: 45-46¡ã C., 109-01-3

The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ushio, Hiroyuki; Naito, Youichiro; Sugiyama, Naoki; Kawaguchi, Takafumi; Ohtsuki, Makio; Chiba, Kenji; US2003/203909; (2003); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

5625-67-2, Di-tert-butyl dicarbonate (3.92 g, 17.98 mmol) was added to a suspension of 2-piperazinone (1.50 g, 14.98 mmol) in dichloromethane (15 mL). The mixture was stirred at room temperature for 5 hours. The solvent was evaporated to afford 1 ,1- dimethylethyl 3-oxo-1-piperazinecarboxylate (2.99 g, quantitative) as an off-white solid.

As the paragraph descriping shows that 5625-67-2 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3 -Bromo-5 -nitro-toluene, (7.7 8g, 36.0 mmol) and 1 -cyclopropylpiperazine (5 .0g, 39.6 mmol) were dissolved in 100 mL of dry t-BuOH and purged with N2 for 10 minutes. During the purge added t-BuXphos Palladacycle (620mg, 0.9Ommol) followed by sodium t-butoxide, (5.20g, 54.0 mmol) and reaction was allowed to stir at 30C under N2 for two hours. Solvent was removed under reduced pressure and the residue partitioned between EtOAc and water, then the organic phase washed with brine, dried (Na2504) and solvent removed under reduced pressure. The crude material was Isco purified on 5i02 with DCM changing to isocratic 10%/EtOAc/DCM as eluent to afford 6.75 g (64%) of JW-8a as a dark yellow, waxy solid. ?H NMR (400 MHz, Acetone-d6) oe 7.51 (t, J = 2.1 Hz, 1H), 7.43 (d, J = 0.6 Hz, 1H), 7.21 (s, 1H), 3.35 – 3.18 (m, 4H), 2.83 – 2.67 (m, 4H), 2.40 (s, 3H), 1.75 – 1.59 (m, 1H), 0.57 – 0.41 (m, 2H),0.38 (dt, J = 3.8, 2.5 Hz, 2H) ppm. ESI-MS m/z calc. 261.14774, found 262.0 (M+1)+; Retention time: 0.58 minutes., 20327-23-5

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; DAVIES, Robert, J.; CAO, Jingrong; COCKERILL, Meghan, Elise; COLLIER, Philip, Noel; DENINNO, Michael, Paul; DOYLE, Elisabeth; FRANTZ, James, Daniel; GAO, Huai; GOLDMAN, Brian, Anthony; GREY, Ronald, Lee; GRILLOT, Anne-laure; GU, Wenxin; HENDERSON, James, A.; IRARRAZAVAL, Raul Eduardo, Krauss; KOLPAK, Adrianne, Lynn; LIAO, Yusheng; MAGAVI, Sanjay Shivayogi; MALTAIS, Francois; MESSERSMITH, David; PIERCE, Albert, Charles; PEROLA, Emanuele; RYU, Elizabeth Jin-Sun; SYKEN, Joshua; WANG, Jian; (706 pag.)WO2016/197009; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,74879-18-8

In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo[l,2-b]pyridazin-6-yl)pyrido[l,2- a]pyrimidin-4-one (Intermediate 3; 250 mg, 0.808 mmol), and (S)-2-methylpiperazine (405 mg, 4.04 mmol, 5.0 eq.) were stirred in DMSO (6 mL) and heated at 130C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2C12and washed with an aqueous saturated solution of NaHC03. The organic layer was separated and dried over Na2S04and concentrated in vacuo. The crude was purified by column chromatography (Si02,CH2Cl2/MeOH=95/5 to 85/15) to afford the title product (135 mg, 43%) as a light yellow solid. MS m/z 390.3 [M+H+].

As the paragraph descriping shows that 74879-18-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; MCCARTHY, Kathleen Dorothy; METZGER, Friedrich; RATNI, Hasane; (76 pag.)WO2017/81111; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

A solution of 5-fluoro-2-nitroanisole (200 g, 1 eq) and piperazine (302 g, 3 eq) in DMF was stirred for 30 minutes and heated for 12 hours. Acetic anhydride (358 g, 3 eq) was slowly added to the reaction solution, and the reaction solution was stirred at room temperature for 12 hours. Water was added to the reaction solution for dilution, and the solid was filtered and washed twice with water. After drying at 50 C, the product was obtained as a yellow solid (284 g, 87%)., 13889-98-0

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Anqing Yuanqi Pharmaceutical Technology Co., Ltd.; Jin Wei; Liu Jinlun; Wang Jianbing; (6 pag.)CN110294721; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

To a solution of methyl 2-[1-(3-ethylphenyl)cyclopentyl]ethanimidate hydrochloride (2.0 g) and 1-methylpiperazin-2-one (1.62 g) in THE (150 ml) was added at 22¡ãC diisopropylethyl amine (1.83 g) and after 5 mm acetic acid (426 mg) and stirring was continued at 22¡ãC for 16 h. The mixture can be further processed as described below or the intermediate 4-[2-[1-(3- ethylphenyl)cyclopentyl]ethanimidoyl]-1 -methyl-piperazin-2-one hydrochloride can be isolated by dilution with ethyl ether followed by filtration and drying of the residue.The mixture containing the intermediate was cooled down to -30¡ãC, a solution of lithium hexamethyldisilazide in THF (1M, 50 ml) was added followed by diethyl oxalate (4.15 g) and stirring was continued at -30¡ãC. In case of incomplete conversion a further portion of lithium hexamethyldisilazide and diethyl oxalate has to be added. The mixture was warmed to 22¡ãC, partitioned between aqueous hydrochloric acid (1 N) and dichloromethane, the organic layerwas dried, evaporated, the residue triturated with diethyl ether, filtered and the residue dried to give example 1 (1.40 g) as a white powder. Alternatively, the crude material can purified by preparative HPLC (RP-18, MeCN/H20 containing 0.23percent of HCOOH).MS (ESI, mlz): 382.3 [(M+H)]

59702-07-7, As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference£º
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; LERNER, Christian; KREIS, Lukas; WEIKERT, Robert James; NEIDHART, Werner; HILPERT, Hans; (97 pag.)WO2017/158147; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics