Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

5308-25-8, 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene (34 g, 120 mmol) obtained in above was dissolved in dichloromethane (300 mL), followed by stirring. The reaction solution was added with 1-ethylpiperazine (15.97 mL, 126 mmol) and DIPEA (27.2 mL, 156 mmol), followed by further stirring for about 3 hours at room temperature. The reaction mixture was diluted with dichloromethane, and washed with a saturated aqueous solution of sodium bicarbonate and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the title compound (21.7 g, 57%). -NMR Spectrum (300 MHz, DMSO-MS(ESI+, m/z): 318 [M+H]+

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun; WO2013/100632; (2013); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 7 6-chloro-2-(4-cyclopropyl-1-piperazinyl)-pyrazine hydrochloride Crude N-cyclopropylpiperazine (2.8 g) and 2,6-dichloropyrazine (3.0 g) are combined in 5 ml 2,2,2-trifluoroethanol and the mixture refluxed 4 hours under N2. The mixture is concentrated under vacuum and the residue partitioned between aqueous sodium carbonate and methylene chloride. The combined methylene chloride extracts are extracted with dilute hydrochloric acid which is made basic with sodium hydroxide. The crude base is extracted with methylene chloride and chromatographed on silica gel. Elution with CHCl3 gives fractions containing 2.4 g pure title base which is treated with hydrogen chloride in ethanol-isopropanol to give 2.0 g of the title salt, mp greater than 340 C. with decomposition at 245 C., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4163849; (1979); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) (S)-(+)-3-methyl-1-(2-nitrophenyl)piperazine. To a solution of 2-bromo-1-nitrobenzene (0.6 g, 3.0 mmol) in 1,4-dioxane (15 mL) was added (S)-(+)-2-methylpiperazine (0.5 g, 0.5 mmol) and powdered K2CO3 (15.0 mmol, 1.5 g) and the resulting suspension was heated at reflux for 10 h. After the suspension was cooled, it was filtered through a sintered glass funnel and the solvent was evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (1:1 hexane/EtOAc followed by 4:1 EtOAc/MeOH) to yield (S)-(+)-3-methyl-1-(2-nitrophenyl)-piperazine as an orange oil (0.53 g, 80%).

74879-18-8, The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Synaptic Pharmaceutical Corporation; US6245773; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Example 71] 1-[5-(5-Methylpyridin-2-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carbonyl]-4-methyl-3-oxopiperazine Triethylamine (0.330 mL) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (179 mg) were added at room temperature to a solution of 5-(5-methyl-2-pyridyl)-1-(3-pyridyl)-1H-pyrazole-3-carboxylic acid (0.218 g) obtained from Referential Example 9, 1-methyl-2-piperazinone hydrochloride (176 mg) obtained from Referential Example 15, and 1-hydroxybenzotriazole (143 mg) in N,N-dimethylformamide (15 mL), and the mixture was stirred at room temperature for 15.5 hours. The reaction solvent was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogencarbonate. The aqueous layer was further extracted with ethyl acetate four times. The organic layers were combined, and the combined organic layer was dried over sodium sulfate anhydrate. After a filtration step, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel flash column chromatography (dichloromethane – methanol), to thereby give the title compound (231 mg, 78%) as a solid product. 1H-NMR(400MHz,CDCl3)delta:2.34(3H,s), 3.03(3H,s), 3.46-3.50(2H,m), 4.03-4.07(1H,m), 4.41-4.45(2H,m), 4.85(1H,brs), 7.16-7.20(1H,m), 7.34-7.40(2H,m), 7.52-7.56(1H,m), 7.68-7.83(1H,m), 8.30(1H,s), 8.47(1H,brs), 8.59(1H,brs). ESI-MS m/z:377(M+H)+. Elementary analysis: as C20H20N6O2 Calculated: C,63.82;H,5.36;N,22.33. Found: C,63.65;H,5.28;N,22.24.

109384-27-2, 109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

D. Amination Reaction In one experiment, (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (41.73 g, 94.35 mmol) and triethylamine (88 mL, 630 mmol) were added to a mixture of (R)-2-(1-hydroxycyclohexyl)-2-(3-(trifluoromethoxy)phenyl)acetic acid (20.0 g, 62.9 mmol) and cis-2,6-dimethylpiperazine (7.17 g, 62.9 mmol) in methylene chloride (150 mL) at RT. After stirring for 18 h, the mixture was concentrated in vacuo. The residue was purified by flash chromatography on silica gel (50 to 100percent ethyl acetate in heptane) to afford 1-(3,5-Dimethyl-piperazin-1-yl)-2-(R)-(1-hydroxy-cyclohexyl)-2-(3-trifluoromethoxy-phenyl)-ethanone (24.3g, 93percent).

21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2007/135449; (2007); A1;,
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934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15-chloro-3-(3-fury)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole-2-carboxamideA DMF solution (340 mL) containing the compound obtained in Production example 1-3 (11.6 g), 2-(4-methylpiperazin-1-yl)ethylamine (7.0 g) and HATU (18.5 g) was ice-cooled to 15¡ã C., and diisopropylethylamine (23.2 mL) was added thereto and the resulting solution was stirred overnight at room temperature.The reaction solution was poured into water (1.5 L), and the mixture was stirred at room temperature for 5 minutes.A precipitate was collected by filtration and washed with water and then dissolved in chloroform (600 mL).The chloroform layer was washed with a saturated aqueous sodium hydrogen carbonate solution and then dried over anhydrous magnesium sulfate.The solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3), whereby the title compound (8.8 g) was obtained as a pale yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.30 (3H, s), 2.32-2.50 (8H, m), 2.47 (2H, t, J=5.8 Hz), 3.51 (2H, dt, J=5.8 Hz, 5.8 Hz), 6.63 (1H, dd, J=1.9, 0.9 Hz), 7.03 (1H, br s), 7.25 (1H, m), 7.39 (1H, dd, J=8.8 Hz, 0.6 Hz), 7.49 (1H, m), 7.66 (1H, m), 7.70 (1H, m), 9.78 (1H, s).ESI-MS Found: m/z 387[M+H]+

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure for 10-(amino)-6,ll-dihydro-5H-indeno[l,2- h]ll,6]naphthyridin-5-one (51): A mixture of 10-bromo compound (50) (94 mg, 0.3 mmol), amine (64 mg, 0.45 mmol), Pd2(dba)3 (5.5 mg, 0.006 mmol), S-X-Phos (7.2 mg, 0.015 mmol), sodium tert-butoxide (72 mg, 0.75 mmol) in DMF (4 ml) was degassed and then purged with nitrogen. The mixture was irradiated under microwave at 130 0C for 20 min. It was concentrated and purified on the silica gel column using 0 to 7% methanol and DCM. The residue obtained was further purified on the reverse phase column to provide final product (51).; 5.3 Examples; The following examples were prepared according to the methods, schemes and experimental described above.; Example 49: 10-(4-(2-methoxyethyl)piperazin-l-yl)-6,ll-dihydro-5H-indeno[l,2- h] [l,6]naphthyridin-5~one; MS: m/z 377.2 (M-H+)., 13484-40-7

The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INOTEK PHARMACEUTICALS CORPORATION; JAGTAP, Prakash; PHAM-HUU, Duy-Phong; COHEN, Frederick; HU, Huiyong; WANG, Xiaojing; WO2010/77663; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(4-Methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate To a stirred solution of 1-(2-hydroxyethyl)piperazine (26.0 g, 0.2 mol) in DMF (200 mL) was added formic acid (752 mL, 0.2 mol) and formaldehyde (16.2 g, 0.2 mol, 37percent solution in water) The reaction mixture was cautiously heated at 100¡ã C. for 2 hours then stirred overnight at room temperature. The solvent was removed in vacuo. This procedure was repeated 3 further times to give ~100 g of product. The crude products were combined and distilled under vacuum to give, at 74¡ã C., 2-(4-methylpiperazin-1-yl)ethanol (51 g, 44percent) as a colourless liquid. Analytical LCMS: (System C, RT=0.70 min), ES+: 145.1 [MH]+. 4-Nitrophenyl chloroformate (9.85 g, 49 mmol) was dissolved in DCM (200 mL), and cooled to 0¡ã C. 2-(4-methylpiperazin-1-yl)ethanol (7.2 g, 50 mmol) and NMM (6 mL) were added, and the reaction mixture was allowed to warm gradually to room temperature over 16 hours. The reaction mixture was washed with 1M aq Na2CO3 solution until the yellow colour extracted into the aqueous layer had disappeared. The organic phase was dried (MgSO4), filtered and concentrated in vacuo to give 2-(4-methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate (10.7 g, 71percent) as a yellow oil which solidified on standing. Analytical LCMS: purity ~80percent (System C, RT=1.70 min), ES+: 310.4 [MH]+., 5464-12-0

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US2009/281087; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i (+-)-N-(2,6-Dimethylphenyl)-2-(3-methylpiperazin-1-yl)acetamide The subtitle compound was prepared from 2-chloro-N-(2,6-dimethylphenyl)acetamide (7 g) and (+-)-2-methyl-piperazine (3.55 g) by the method of Example 15 step (ii) as a white solid. Yield 7 g. MS: ES(+ve) 262(M+1, 100%), 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Meghani, Premji; Bennion, Colin; US2003/13721; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59702-07-7

General procedure: The following exemplary compounds were prepared analogously to Example 127.1 from Example 129A and the appropriate commercially available amines. In many cases, under the reaction conditions, mixtures of mono- and di-aminated products were obtained, and were separated by chromatography. Under argon, 1.30 g (3.01 mmol) of (4S)-1-(4-bromophenyl)-7,8-dimethoxy-N,4-dimethyl-4,5-dihydro-3H-2,3-benzodiazepine-3-carboxamide (Example 49.2A) were initially charged in 65 ml of degassed toluene. 0.37 ml (331 mg, 3.31 mmol) of 1-methylpiperazine, 405 mg (4.21 mmol) of sodium tert-butoxide and 118 mg (0.15 mmol) of chloro-(2-dicyclohexylphosphino-2,4,6-triisopropyl-1,1-biphenyl) [2-(2-amino-1,1-biphenyl)]palladium(II) (CAS [1310584-14-5]) were added. The mixture was degassed again, saturated with argon and then stirred at 80¡ã C. for 12 hours. After cooling, the mixture was added to sat. sodium bicarbonate solution and extracted with ethyl acetate. The combined organic phases were washed with sat. sodium chloride solution and dried with sodium sulphate. The solvents were removed on a rotary evaporator and the residue (1.5 g orange foam) was purified by flash chromatography (SiO2, dichloromethane/methanol 0-3-10percent). This gave 850 mg (63percent of theory) of the desired product as a yellow solid.

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SIEGEL, STEPHAN; BAURLE, STEFAN; CLEVE, ARWED; HAENDLER, BERNARD; FERNANDEZ-MONTALVAN, AMAURY ERNESTO; MONNING, URSULA; KRAUSE, SABINE; LEJEUNE, PASCALE; SCHMEES, NORBERT; BUSEMANN, MATTHIAS; HOLTON, SIMON; KUHNKE, JOACHIM; (434 pag.)JP2015/529192; (2015); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics