Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

A solution of 4S-(3,5-bis-trifluoromethyl-benzloxy)-3R-2-tolyl-piperidine (Example 1) 100 mg (0.220 mmol) was dissolved in CH2Cl2 under nitrogen. 4-methyl-piperazine carbonyl chloride (purchased from Aldrich Chemical Company or Aztec Chemical Company) 46 mg (0.231 mmol), and diisopropylethylamine 0.4 mL (2.20 mmol) were added, and the reaction mixture was stirred at room temperature under nitrogen. The reaction mixture was diluted with EtOAc (100 ml) and washed with water three times. The organic layer was dried with MgSO4. Evaporation of most of the solvent gave 120 mg of oil. This oil was dissolved in about 10 mL of ether and a solution of HCl gas in ether was added drop by drop. The HCl salt was dried under nitrogen on high vacuum for one hour to give 125 mg of [4S-(3,5-bis-trifluoromethyl-benzyloxy)-3R-2-tolyl-piperidine-1-yl]-(4-methyl-piperazine-1-yl)-methanone. Fab/MS m/e 544 (M+1)

39539-66-7, The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/256164; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-cyclopentylpiperazine (1.27 mL, 10 mmole) was added to 10 mL DMF containing 0.3 g of 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one (TC-XCl-1)(1 mmol). The mixture was heated while stirring at 150 C. for 4 hours and added pyridine (0.5 mL, 6.21 mmole) as the catalyst. Pour the mixture into ice water after the reaction is completed and filter to get the crude product. Recrystallized from hot EtOH to get compound SJ-14 (0.16 g). [0141] Mol. Wt.: 417.9306 (C25H24ClN3O); Rf: 0.46 (Dichloromethane:Hexane:Methanol=2:1:0.5); Yield: 37.3%; Mp.: 183-184 C. (EtOH); IR (KBr) cm-1: 1716 (C?O); HRMS (ESI) m/z calcd for C25H24ClN3O+[M]+: 417.1608. Found: [M+H]+=418.1689 (error1H-NMR (300 MHz, CDCl3) delta (ppm): 1.19 (t, 3H, J=7.2 Hz, -CH3), 2.57 (q, 2H, J=7.4 Hz, N-CH2-), 3.03 (br, 4H, -CH2-), 3.46 (br, 4H, -CH2-), 7.43-7.48 (m, 2H, Ar-H8,10), 7.57-7.63 (m, 3H, Ar-H2,3,4), 7.85 (d, J=8.7 Hz, 1H, Ar-H7), 8.69 (d, J=8.1 Hz, 1H, Ar-H1); 13C-NMR (300 MHz, CDCl3) delta (ppm): 24.32, 30.67, 50.12, 52.36, 67.87, 120.99, 124.28, 124.61, 125.05, 127.31, 128.50, 130.40, 131.56, 134.36, 135.19, 135.32, 136.58, 141.94, 149.85, 157.48, 194.40 (CO).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; National Defense Medical Center; Huang, Hsu-Shan; Chen, Tsung-Chih; Chen, Shiang-Jiun; Chen, Chun-Liang; Lee, Chia-Chung; US2015/197492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, A solution of 5 – ((2,4-dioxo-3,4-dihydroquinazolin-1 (211) -yl) methyl) -2-fluorobenzoic acid, EDC (123 mg, 0.64 mmol ), H0Bt (86 mg, 0.64 mmol) and DIEA (125 mg, 0.96 mmol)In a flask, about 3 mL of anhydrous DMF was added, stirred at room temperature for 15 min, followed by the dropwise addition of 1-methyl-niazin-2-one (225 mg,1.97 mmol) in DMF was added to the reaction solution, stirred overnight at r.t. The reaction was poured into 100 mL of water and treated with 100 mL of DCMThe organic layer was washed successively with water (100 mL), saturated NaCl (100 mL) and water (100 mL), concentrated under reduced pressure and subjected to column chromatography to give the title compound.

59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Zhou Jie; Ji Ming; Yao Haiping; Zhou Qin; (57 pag.)CN107098886; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, EXAMPLE 6 General Procedure: Nucleophilic Displacement with 2-Chloro-3-NitroPyridine Piperazine (2-5 mmol) and 2-chloro-3-nitro-pyridine (1 mmol) were dissolved in DMF or acetonitrile (2-3 mL) and stirred for 5 min at room temperature. A slight exotherm was observed shortly after addition of the solvent. When TLC analysis showed that the reaction was complete, the mixture was diluted with dichloromethane, and washed with water. The organic layer was dried, filtered and concentrated, then chromatographed in 10% methanol in dichloromethane to yield the desired product.; In this manner the following compounds were synthesized: Example Structure Name Yield 6.1 (3S)-3-methyl-1-(3-nitropyridin-2-yl) piperazine 92%1H 1.11(d, J=6.3 Hz, 3H); 2.74(dd, J=12.8, 10.4 Hz, 1H); 2.99(m, 4H); 3.72(m, 2H); NMR 6.74(dd, J=8.1, 4.5 Hz, 1H); 8.14(dd, J=8.1, 1.8 Hz, 1H); 8.34(dd, J=4.5, 1.8 Hz, 1H).

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca AB; NPS PHARMACEUTICALS; US2007/49578; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

54699-92-2, 4-Methyl-1-piperazineacetic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54699-92-2, Example 13; General Method for the Preparation of Active Esters of N-Substituted Piperazine Acetic Acid from Trifluoroacetate Esters; A solution of the trifluoroacetate in THF (0.58 M, 1.2 equiv) was added to a solid sample of N-methyl piperazine acetic acid and mixed in a vortex or shaker until a homogeneous solution was obtained. The reaction of the carboxylic acid with the trifluoroacetate ester was generally complete within 30 min for all cases except N-hydroypyrrolidinone (NHP, 18 h). The progress of conversion to the active ester was monitored by ES-MS. The amount of product and any starting material (N-MPA) could be determined by direct infusion of a sample of the reaction (in ethanol) into the ES-MS. In some cases the active ester product was precipitated as dihydrochloride salt by the addition of a solution by addition of HCl solution in dioxane (4 M, 50% volume of the reaction) followed by washing with THF, ethyl acetate and hexanes. In other cases the product was isolated from the reaction as the mono TFA salt. Addition of TFA could be performed if the bis-TFA salt was desired. Dhbt ester, Calculated MH+ = 304.14 Found = 304.20 NHP ester, Calculated MH+ = 242.15 Found = 242.20 4-NP ester, Calculated MH+ = 280.13 Found = 280.20 1H NMR (400 MHz, CDCl3) d 8.20 (d, 2H, J=9.2 Hz, aromatic protons), 7.25 (d, 2H, J=9.2 Hz, aromatic protons), 3.69-3.40 (broad, 2H, ring protons), 3.57 (s, 2H, -CH2-CO-), 3.15-2.90 (broad, 6H, ring protons), 2.78 (s, 3H, -CH3). Pfp ester, Calculated MH+ = 325.10 Found = 325.10 Pcp ester, Calculated MH+ = 404.95 Found = 405.90 3-NP ester, Calculated MH+ = 280.13 Found = 280.20 NHS ester, Calculated MH+ = 256.13 Found = 256.10

54699-92-2 4-Methyl-1-piperazineacetic acid 2762732, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Applera Corporation.; US2005/148771; (2005); A1;; ; Patent; Applera Corporation.; US2005/148774; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100-ml flask, 500 mg (2.68 mmol) of t-butyl piperazine-1-carboxylate was dissolved in 5 ml of water, followed by stirring. 1.6 ml of acetic acid and 1.09 g (13.4 mmol, 5.0 eq) of potassium cyanate dissolved in water were added, followed by stirring at room temperature for 4 hours. After completion of the reaction, a solid was obtained by filtration while washing with water. The solid thus obtained was dissolved in dichloromethane, and then washed with water. An organic layer was separated and washed with a NaCl aqueous solution, dehydrated and dried over MgSO4, and concentrated under reduced pressure to obtain 282 mg (46%) of a title compound., 57260-71-6

57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Dong-A ST Co., Ltd.; CHOI, Sung Pil; CHOI, Seul Min; SON, Byoung Hwa; KIM, Hyun Jung; KIM, Ju Mi; JANG, Byung Jun; SUNG, Ji Hyun; LEE, Ji Hye; KIM, Eunjin; KANG, Kyung Koo; KIM, Soon-Hoe; (142 pag.)EP3135669; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

889939-92-8, 2-(1-Methylpiperazin-2-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

889939-92-8, 974 mg of Nu,Nu-diisopropylethylamine and 724 mg of 2-(1 -methylpiperazin-2-yl)ethanol are added to a suspension of 1 g of 4-fluoro-1 -nitro-2-(propan-2-yloxy)benzene in 10 ml of acetonitrile. The reaction medium is microwave-heated at 1 10C for 6 hours and then concentrated to dryness under reduced pressure. Purification is carried out by flash chromatography on silica gel (40-63 microns), elution being carried out with a mixture of dichloromethane and methanol (100/0) to (90/10). 1 .15 g of 2-{1 -methyl-4-[4-nitro-3- (propan-2-yloxy)phenyl]piperazin-2-yl}ethanol are obtained in the form of a yellow oil.

The synthetic route of 889939-92-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stephanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice; WO2013/150036; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Palladium() acetate (6mg, 0.22mmol) 2-dicyclohexylphosphino-2?,6? -di-i-porpoxy-1,1?-biphenyl (22mg, 0.044mmol), and cesium carbonate (0.22g, 0.68mmol) were weighted out and the vial was purged with nitrogen, the bromo-contained intermediate 8d (0.44mmol) and a series of N-containing heterocyclic compounds (0.68mmol) solved in 1,4-dioxane (15mL) were added. The mixture was stirred at 100C for 16h. The reaction was filtered, concentrated and purified by silica gel column chromatography to give 18a-38a.

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Article; Cao, Zhonglian; Fu, Wei; Ma, Xiaojun; Sun, Nannan; Wang, Yonghui; Xu, Jun; Zhou, Kaifeng; Zhu, Chen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-chloro-5-nitropyridine (200 mg, 1.26 mmol) in DMFF (5.0 mL) were added l-cyclopropylpiperazine (191 mg, 1.57 mmol) and DIPEA (0.54 mF, 3.09 mmol) and the mixture was stirred at 80 C for 5 h. The mixture was cooled to RT and diluted with water. The solid was filtered and washed with pet ether to yield 250 mg of the desired product. JH NMR (400 MHz, DMSO-ESI-MS ( m/z ) 249 (M+H)+.

20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ICHNOS SCIENCES S.A.; CHAUDHARI, Sachin, Sundarlal; GHARAT, Laxmikant, Atmaram; IYER, Pravin; DHONE, Sachin, Vasantrao; ADIK, Bharat, Gangadhar; WADEKAR, Prashant, Dilip; GOWDA, Nagaraj; BAJPAI, Malini; (233 pag.)WO2020/70331; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The starting material was ptepared as follows: 2-Bromoethanol (2.36 g, 19 mmol) was added dropwise to a mixture of 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol) in absolute ethanol (150 ml) and the mixture heated at reflux for 18 hours. The mixture was allowed to cool and the precipitates were removed by filtration and the solvent volatiles were removed by evaporation. The residue was treated with acetone/methylene chloride, the insolubles were removed by filtration and the solvent was removed from the filtrate by evaporation to give 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48percent) as a light brown oil. 1H NMR Spectrum: (CDCl3) 2.1 8(s, 3H); 2.3-2.7(br m, 8H); 2.56(t, 2H); 3.61 (t, 2H) MS-ESI: 145 [MH]+, 109-01-3

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US6291455; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics