Tag: M.W:100-200

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59878-57-8

INTERMEDIATE 48(S)-tert~BvLtyl 1 – { 8-chloro-2- F4-C cvclopropanecarbonvDpiperazin- 1 -yl] quinolin-3- vDethylcarbamateIntermediate 11 (150 mg, 0.44 mmol), cyclopropyl(piperazin-l-yl)methanone (0.16 mL, 1.1 mmol), NMP (2 mL) and DIPEA (0.38 mL, 2.2 mmol) were combined in a sealed tube and heated to 14O0C for 36 h. After cooling, Et2O was added to the reaction mixture. The organic layer was washed with water and brine. The organic layer was dried (MgSO4), filtered and the solvent was removed in vacuo. Purification by column chromatography on silica, eluting with 0-5% MeOH in EtOAc, gave the title compound (175 mg, 86%) as a yellow gum. deltaH (CDCl3) 8.00 (IH, s), 7.71 (IH, dd, J7.5, 1.3 Hz), 7.62 (IH, dd, J8.1, 1.3 Hz), 7.34-7.28 (IH, m), 5.15 (IH, br s), 4.95 (IH, br s), 3.86 (4H, br s), 3.60 (2H, br s), 3.34 (2H, br s), 1.85-1.77 (IH, m), 1.46 (3H, s), 1.44 (9H, s), 1.05- 1.00 (2H, m), 0.80 (2H, dd, J 7.8, 3.5 Hz). LCMS (ES+) 459 (M+H)+.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
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115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Intermediate?A? (200 mg, 0.55 mmol), l-(2,4-difluorophenyl)- piperazine (328 mg, 1.65 mmol), and Et3N (170 mg) in CH2CI2 (5 g) was stirred for 16 h at rt, then extracted with 2×30 mL of CH2CI2. The combined organic layers were concentrated under vacuum and purified with silica gel column chromatography using EtOAc / hexane (1:1) to afford 240 mg (97%) of the title compound as an off-white solid. LC-MS: (ES, m/z): 449.

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference£º
Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
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Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, Intermediate 62 : 2-f3-f4-Methyl-3-oxopiperazin-l-vnpropynisoindoline-l,3- dione (0595) To a mixture of 3-(l,3-dioxoisoindolin-2-yl)propanal (515 mg, 2.53 mmol, commercially available from Fluorochem) and Na(OAc)3BH (815.9 mg, 3.85 mmol) in 2-MeTHF (20 mL) was added l-methylpiperazin-2-one (0.420 mL, 3.82 mmol, commercially available from Fluorochem). The mixture was stirred at rt for 4 h 45 min. To the reaction mixture was added aqueous 2M Na2C03 (10 mL) and this mixture stirred at rt for 10 min giving an aqueous phase at approximately pH 10. The layers were separated and the aqueous layer washed with EtOAc (2 x 10 mL). The organic layers were filtered through a cartridge fitted with a hydrophobic frit and the filtrate evaporated in vacuo to give a pale yellow crystalline solid. 2-(3-(4-methyl-3-oxopiperazin-l-yl)propyl)isoindoline-l,3-dione (660.5 mg, 2.192 mmol, 86 percent yield). (0596) LCMS (2 min high pH); Rt = 0.74 min, m/z = 302 for [MH]+

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LEVERNIER, Etienne; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (225 pag.)WO2017/174621; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

General procedure: To a solution of 2 (0.6 mmol) in MeOH/H2O/DMSO=2:1:1(4 mL)was added sodium hydroxide (6 mmol). The solution was warmed to 45 C, after being stirred for overnight, the mixture allowed to cool, and the MeOH was removed by rotary evaporation. To the resultant slurry 1M HCl was added, and the pH was adjusted to 4. Subsequently, the mixture was filtered and washed thoroughly with water, dried to afford a white solid, which was used without additional purification. A mixture of above acid (0.3 mmol), HOBt (0.36 mmol), EDCI (0.36 mmol)were dissolved in dry DMF(3 mL), and stirred for 20 min. Then, amine(0.6 mmol) were added, the mixture was stirred for overnight, diluted with EtOAc, washed with water (30 mL¡Á5), dried over anhydrous Na2SO4, filtered and evaporated under-reduced pressure. The crude product was purified by silica gel column chromatography to afford the corresponding product 3-26.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Xiao; Xu, Mei; Yang, Chao; Yao, Yao; Liang, Li-na; ED Chung, Philip; Long, Qun; Zacksenhaus, Eldad; He, Zhixu; Liu, Sheng; Ben-David, Yaacov; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6096 – 6104;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

Example 1; This Example illustrates the preparation of N- (3-phenyl-3- [4- METHANESULPHONYLPIPERAZIN-1-YL] PROPYL)-4- [2- (4-METHANESULPHONYLPHENYLSULPHONYL) ethyl] – piperidine (Compound No. 8, Table I). N- (3-Phenyl-3-chloropropyl)-4- [2- (4-methanesulphonylphenylsulphonyl) ethyl] – piperidine (prepared according to Method D; 180mg) was added to a solution of N- methanesulphonylpiperazine (61mg) and triethylamine (0. 102ML) in dichloromethane (10ML) and the mixture was allowed to stand at room temperature for 16 hours. The reaction mixture was poured onto a 20g silica Bond Elut eluted with a solvent gradient (ethyl acetate-25% methanol/ethyl acetate). The title compound was obtained, yield 67mg, MHF 612. NMR (CDC13) : 1.6-1. 8 (m, 7H), 2.2-2. 6 (m, 9H), 2.7 (m, 1H), 2.75 (s, 3H), 3.2 (m, 11H), 3.45 (m, 1H), 7.2 (d, 2H), 7.3 (m, 3H), 8.2 (m, 4H)., 55276-43-2

55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2004/56773; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

General procedure: I-c (0.6 g, 2.8 mM), 2-methoxyethanol (1.3 g, 17 mM) and sodium hydride (0.1 g, 2.8 mM, 60percent) in ethanol were heated to reflux for 5 h. The mixture was evaporated in vacuo and purified by silica gel column chromatography to get I-d-02 (0.6 g, 78.5percent) as a white solid., 934-98-5

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Lu; Zhang, Qing; Zhu, Gaoyuan; Zhang, Zhimin; Zhi, Yanle; Zhang, Li; Mao, Tianxiao; Zhou, Xiang; Chen, Yadong; Lu, Tao; Tang, Weifang; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 86 – 106;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: 10mM sulfochloride hydrochloride was suspendedin 50 ml ethylacetate and 11mM amine component wasadded with stirring. 2.8 ml triethylamine dissolved in 10 ml ethylacetatewas dropped in with stirring and kept stirring overnight atambient temperature. The reaction mixture was extracted threetimes with water, the organic phase was dried over sodium sulfatefiltered, and then evaporated to dryness. For cases in which an oilyproduct was obtained, the residue was treated with diisopropylether., 27561-62-2

As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.

Reference£º
Article; Singh, Vinayak; Pacitto, Angela; Donini, Stefano; Ferraris, Davide M.; Boros, Sandor; Illyes, Eszter; Szokol, Balint; Rizzi, Menico; Blundell, Tom L.; Ascher, David B.; Pato, Janos; Mizrahi, Valerie; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 309 – 329;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The starting material was prepared as follows: 3-Bromopropan-1-ol (20 ml, 20 mmol) was added dropwise to a solution of 1-methylpiperazine (29 ml, 26 mmol) in ethanol (200 ml). Potasium carbonate (83 gr, 60 mmol) was added and the mixture was refluxed for 20 hours. After cooling, the solid was filtered and the filtrate was evaporated. The residue was triturated with ether, filtrate and evaporated. The residue was distilled at about 60-70 C. under about 0.2 mm Hg to give 1-(3-hydroxypropyl)-4-methylpiperazine (17 g, 53%). 1H NMR Spectrum: (CDCl3) 1.72 (m, 2H); 2.3 (s, 3H); 2.2-2.8 (in, 8H); 2.6 (t, 2H); 3.8 (t, 2H); 5.3 (br s, 11H)

109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hennequin, Laurent Francois Andre; US2003/212055; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5625-67-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

To a stirred solution of W-l (20.0 g, 0.200 mol) in DCM, is added Boc anhydride (43.6 g, 0.200 mol), and TEA (40.4 g, 0.400 mol). The mixture is stirred at about 25 C for about 18 hours. The mixture is concentrated and the residue dissolved in EtOAc then extracted with water. The organic layer is concentrated and the residue is purified by silica gel chromatography to give W-2.

As the paragraph descriping shows that 5625-67-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRUNETTE, Steven, Richard; ABEYWARDANE, Asitha; BURKE, Michael, J.; KAPADIA, Suresh, R.; KIRRANE, Thomas, Martin, Jr.; NETHERTON, Matthew, Russell; RAZAVI, Hossein; RODRIGUEZ, Sonia; SAHA, Anjan; SIBLEY, Robert; SMITH KEENAN, Lana, Louise; TAKAHASHI, Hidenori; TURNER, Michael, Robert; WU, Jiang-Ping; YOUNG, Erick, Richard, Roush; ZHANG, Qiang; ZHANG, Qing; ZINDELL, Renee, M.; WO2013/134226; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (2i?,65)-2,6-dimethylpiperazine (8.0 g, 70.1 mmol) in DCM (70 niL) was added triethylamine (9.78 niL, 70.1 mmol). The reaction mixture was cooled to 0 0C and benzyl chlorocarbonate (9.86 mL, 70.1 mmol) was added. After stirring at 0 0C for 1 hour, the reaction was warmed to rt. The reaction mixture was washed with brine, dried (Na2SO4), concentrated and the residue purified with silica chromatography (Hex:EtOAc 1 :1 to EtOAc to EtOAc:MeOH 10:1) to give 13.48g (77 percent) of a colorless oil

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/136191; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics