Tag: M.W:100-200

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2- (5-amino-2- (furan-2-yl) -8H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-8-yl) pentanoic acid (50 mg, 0.15 mmol) , 1- (2, 4-difluorophenyl) piperazine (32 mg, 0.16 mmol) , HATU (69 mg, 0.18 mmol) and DIEA (39 mg, 0.3 mmol) in DMF (5 mL) was stirred at rt for 2 hrs. The solution was added with water (5 mL) , extracted with ethyl acetate (10 mL) and washed with brine (10 mL) . The organic layer was dried, concentrated and purified by column chromatography (PE: EA = 1: 1) to get the desired product (49 mg, 64%) .1H NMR (400 MHz, DMSO-d6) delta 8.76 (s, 1H) , 7.95 (s, 1H) , 7.66 (br. s, 2H) , , 7.19-6.96 (m, 4H) , 6.74-6.73 (m, 1H) , 5.71-5.67 (m, 1H) , 3.78-3.65 (m, 4H) , 2.94-2.83 (m, 4H) , 2.19-1.99 (m, 2H) , 1.33-1.17 (m, 2H) , 0.92 (t, J = 8.0 Hz, 3H) ppm. MS: M/e 522 (M+1)+

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, The 4-(2-hydroxyethyl)-l-methylpiperazin-2-one used as starting material was prepared as follows :-2-Bromoethanol (5.60 mL, 78.85 mmol) was added to 1 -methylpiperazin-2-one (1.80 g, 15.77 mmol) and potassium carbonate (6.54 g, 47.31 mmol) in THF (20 mL). The resulting mixture was stirred at 65¡ãC for 16 hours. The mixture was cooled to room temperature, fltered and the solvents evaporated to give crude product. The crude product was purified by flash silica chromatography, elution gradient 0 to 8percent MeOH in DCM. Pure fractions were evaporated to dryness to give 4-(2-hydroxyethyl)-l-methylpiperazin-2-one (1.870 g, 75.0percent). IH NMR (399.9 MHz, CDC13) delta 2.55 (2H, t), 2.71 (2H, t), 2.90 (3H, s), 3.15 (2H, s), 3.28 (2H, t), 3.60 (2H, t)

59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; RABOW, Alfred, Arthur; WO2010/131022; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6,57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 121: tert-Butyl 4-(3-hvdroxypropyr)piperazine-l -carboxylate A mixture of tert-butyl piperazine-1 -carboxylate (2.75 g, 14.8 mmol), l-bromo-3- propanol (1.43 mL, 16.2 mmol) and potassium carbonate (2.25 mL, 27.5 mmol) in acetonitrile (75 mL) was heated at 950C for 4 hours. The solvent was removed under reduced pressure, and the residue was taken up in dichloromethane (300 mL) and washed with water, brine, EPO dried over sodium sulfate and concentrated under reduced pressure. Chromatography on silica gel with methanol in dichloromethane (0-10%) gave a tan solid 2.88 g (80% yield). MS (ESV 245 (MH+) for C12H24N2O3,1H-NMR TCDCl1) delta: 1.44 (m, 9H); 1.70-1.82 (m, 2H); 2.40-2.53 (m, 2H); 2.62-2.65 (m, 2H); 3.43-3.50 (m, 4H); 2.77 (m, 2H); 3.73-3.82 (m, 2H).

57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/134378; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67455-41-8

Add 2-chloro-4-(cyclopentylamino) pyrimidine-5-carboxylic acid ethyl ester (1.3 g, 4.82 mmol) to an eggplant-shaped bottle containing 20 mL of isopropanol, and add Et3N (0.49 g, 4.82 mmol), 4-Piperazinyl aniline (1.11 g, 6.27 mmol), refluxed after the addition, after 6.0 hours TLC showed that the reaction was complete, and concentrated under reduced pressure to give the target crude product (1.31 g), CH2Cl2: MeOH = 20:1 to obtain pure product (1.06 g, 51.7%).

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Patent; FIRST AFFILIATED HOSPITAL ZHENGZHOU UNIV; Zhengzhou University The First Affiliated Hospital; KAN QUANCHENG; Kan Quancheng; TIAN XIN; Tian Xin; ZHANG XIAOJIAN; Zhang Xiaojian; YANG ZHIHENG; Yang Zhiheng; DU YUE; Du Yue; CHENG WEIYAN; Cheng Weiyan; YUAN YONGLIANG; Yuan Yongliang; WANG SUHUA; Wang Suhua; (29 pag.)CN108299312; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

34770-60-0, 4-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0209] Step 1. To a solution of N-(l-(lH-indol-3-yl)hexan-2-yl)-2-bromothiazole-5- carboxamide (0.10 g, 0.24 mmol) and 4-methylpiperazin-2-one (0.03 g, 0.29 mmol) in dioxane (7 mL), Cs2C03 (0.23 g, 0.72 mmol) and 2-(dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′- triisopropyl-l,l’-biphenyl (BrettPhos precatalyst; 0.02 g, 0.02 mmol) were added. The reaction vessel was purged with argon for 20 min and the mixture was then heated at 110 C for 16 h. The reaction mixture was filtered through diatomaceous earth, washing with 5% MeOH in DCM (2 x 10 mL). The filtrate was concentrated, and the crude obtained was purified by column chromatography (silica, 100-200 mesh, 1 to 4% MeOH in DCM) and preparative HPLC to afford the title compound (0.03 g, 14%) as a white solid. HPLC Purity: 99.4%; MS (ESI) m/e [M+H]+/Rt/%: 440.00/2.69/98.0%; 1H NMR (400 MHz, DMSO-d6) delta 0.81 (t, 7 = 6.8 Hz, 3H), 1.19-1.35 (m, 4H), 1.47-1.63 (m, 2H), 2.31 (s, 3H), 2.81 (t, 7 = 5.4 Hz, 2H), 2.85-2.97 (m, 2H), 3.34 (s, 2H), 4.03 (t, 7 = 5.6 Hz, 2H), 4.16 (m, 1H), 6.92-6.98 (m, 1H), 7.04 (t, 7 = 7.6 Hz, 1H), 7.11 (d, 7 = 1.5 Hz, 1H), 7.31 (d, 7 = 8.3 Hz, 1H), 7.58 (d, 7 = 7.8 Hz, 1H), 8.13 (s, 1H), 8.24 (d, 7 = 8.8 Hz, 1H), 10.75 (brs, 1H).

34770-60-0, The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of intermediate 47 (0.49 g; 0.85 mmol) and cis 2,6-dimethylpiperazine (0.2 g; 1.7 mmol) in MeOH (6 mL) was stirred at room temperature overnight. Sodium triacetoxyborohydride (0.54 g; 2.6 mmol) was added to the reaction mixture and stirred 3 hours at room temperature. The solution was poured into cooled water and basified with K2CO3 powder and the product was extracted with EtOAc. The organic layer was separated, dried over MgSC , filtered and evaporated to dryness. The residue (0.625 g) was purified by chromatography over silica gel (Irregular SiOH, 15-40 muiotaeta, gradient from 97percent DCM 3percent CH3OH 0.1percent NH4OH to 85percent DCM 15percent CH3OH 0.1percent NH4OH). The fractions containing the product were collected and evaporated to dryness to afford 0.347 g (61percent) of intermediate 49., 21655-48-1

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; MEVELLEC, Laurence, Anne; MEERPOEL, Lieven; COUPA, Sophie; PONCELET, Virginie, Sophie; PILATTE, Isabelle, Noelle, Constance; PASQUIER, Elisabeth, Therese, Jeanne; BERTHELOT, Didier, Jean-Claude; QUEROLLE, Olivier, Alexis, Georges; MEYER, Christophe; ANGIBAUD, Patrick, Rene; DEMESTRE, Christophe, Gabriel, Marcel; MERCEY, Guillaume, Jean, Maurice; (203 pag.)WO2016/97359; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

25057-77-6, 1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide (388 mg, 1.00 mmol) was added in one portion to 1,2-dimethyl-piperazine (228 mg, 2.00 mmol) in anhydrous dimethylsulfoxide (2.00 ml) at 25 C. The resulting solution was stirred at ambient temperature for 2 h. The residue was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH to afford impure material. The concentrated eluent was purified by silica column chromatography, eluting with a gradient of 0 to 10% 7M NH3/MeOH in DCM. Pure fractions were evaporated to dryness to afford the title compound (375 mg, 81%) as a yellow solid. 1H NMR (399.9 MHz, DMSO-d6) delta 1.07-1.09 (3H, d), 2.06-2.20 (2H, m), 2.23 (3H, s), 2.76-2.86 (2H, m), 2.87 (4H, s), 3.13-3.19 (1H, m), 3.72 (6H, s), 4.27-4.30 (2H, m), 6.33 (1H, t), 6.42 (2H, d), 6.46 (1H, s), 8.35 (1H, d), 8.70 (1H, d), 9.75 (1H, s), 12.18 (1H, s). MS: m/z 466 (MH+). Mean of n=1, FGFR Kinase assay-Caliper Echo Dosing, IC50 0.0022 muM., 25057-77-6

25057-77-6 1,2-Dimethylpiperazine 198037, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59878-57-8, To a round bottom flask containing 2-(4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)benzoic acid (1.00 g, 4.03 mmol) was added DCM (40 mL), diisopropylethylamine (1.05 mL, 6.04 mmol) and HBTU (2.29 g, 6.04 mmol). The reaction mixture was stirred for 30 min before adding cyclopropylpiperazine-l-ylmethanone (0.86 mL, 6.04 mmol). The reaction was stirred overnight before the excess solvent with removed in vacuo and the crude material purified via flash column chromatography (EtOAc:MeOH 10:1) affording (4- (Cyclopropanecarbonyl)piperazin-l-yl)(2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)methanone as a white solid (1.08 g, 2.82 mmol, 70%) in a mixture of rotamers (2:1). The shifts relating to the minor rotamer has been donated with an asterisk.* *H NMR (400 MHz, CDCh) d = 7.81 (d, J = 7.4 Hz, 1H + 1H*), 7.45 (td, J = 7.6, 1.5 Hz, 1H + 1H*), 7.35 (td, / = 7.5, 1.3 Hz, 1H + 1H*), 7.22 (d, J = 7.5 Hz, 1H + 1H*), 3.86 – 3.69 (m, 4H, 4H*), 3.67 – 3.50 (m, 2H, 2H*), 3.34 – 3.07 (m, 2H, 2H*), 1.81 – 1.52 (m, 1H + 1H*), 1.29 (s, 12H + 12H*), 1.04 – 0.95 (m, 2H + 2H*), 0.67 – 0.87 (m, 2H + 2H*); 13C NMR (100 MHz, CDCh) d = 172.3 (1C + 1C*), 171.3 (1C + 1C*), 142.3 (1C + 1C*), 135.7 (1C + 1C*), 131.2 (1C + 1C*), 128.2 (1C + 1C*), 125.4 (1C + 1C*), 84.1 (2C + 2C*), 47.3 (1C*), 47.0, 45.2 (1C*), 44.9, 41.9 (2C), 41.6 (2C*) 24.9 (4C + 4C*), 11.0 (1C + 1C*), 7.65 (2C + 2C*) (the carbon bearing the boron substituent is not observed); IR (v, cm 1): 2970, 1634, 1467, 1213, 1014, 741; HRMS (ESI) for C2iH3o10BN204 [M+H]+ requires 384.2220 found 384.2218; Mp: 85 – 87C.

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 9 In a 100 ml four-neck flask, 5.06 g (= 0.0505 mole) of racemic 2-methylpiperazine was placed, and 50.00 g of 1-butanol (water content 0.05 wtpercent) was added for dissolution. After cooling down to 0¡ãC, 10.91 g (= 0.0500 mole, 0.99 molar time) of di-tert-butyl dicarbonate was added dropwise with the liquid temperature kept in a range from 5 to 15¡ãC. Then, stirring was carried out at 5 to 10¡ãC for 2 hours. The reaction solution was analyzed, and as a result, the conversion of 2-methylpiperazine was 94.7percent, while the selectivity of 1-tert-butoxycarbonyl-3-methylpiperazine was 89.3percent (reaction yield 84.6percent).Example 10 An experiment was carried out as described for Example 9, except that the amount of di-tert-butyl dicarbonate used was changed to 11.97 g (= 0.0548 mole, 1.10 molar times). As a result, the conversion of 2-methylpiperazine was 100.0percent, and the selectivity of 1-tert-butoxycarbonyl-3-methylpiperazine was 81.5percent (reaction yield 81.5percent)., 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Toray Fine Chemicals Co., Ltd.; EP1548010; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 14;: 5-fluoro-2-[(3R)-3-methylpiperazin-l-yl]pyrimidine; HN,A solution of 2-chloro-5-fluoropyrimidine (239 mg, 1.80 mmol) and (R)-2-methylpiperazine (271 mg, 2.71mmol) in iPrOH (1 mL) and DIEA (617 uL) was heated in MW at 130¡ãC for 30 min. Solvent was removed under reduced pressure and the crude (600 mg) was purified by chromatography on silica using DCM/methanol (9/1) as eluent to afford The title compound as a white solid (416 mg, quantitative). TLC- DCM / MeOH(8/2); R/ 0.3. JH NMR (DMSO-d6) 5 8.14 (s, 2H), 4.48 (d, J = 13.2 Hz, 2H), 4.33 (bra,1H), 2.98-3.13 (m, 2H), 2.83 (m, 2H), 2.67 (t, J = 12.7 Hz, 1H), 1.20 (m, 3H)., 75336-86-6

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Applied Research Systems ARS Holding N.V.; WO2006/10751; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics