Tag: M.W:100-200

Related Products of 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Achieving host-free near-ultraviolet electroluminescence via electronic state engineering with phosphine oxide. Author is Chen, Shuo; Zhang, Chunying; Xu, Hui.

Developing near-UV (NUV) emitters with board band gap and high photoluminescence quantum efficiency (PLQY) is a formidable challenge for organic light-emitting diode (OLED) applications. Herein, two NUV emitters PhImPOCz and PhImPOtBuCz were designed on the basis of phosphine oxide (PO) modification. It is showed that based on crescent phenanthrene (Phen) fused with acceptor imidazole (Im) as NUV chromophore, carbazole (Cz) or 3,6-di-tertbutyl carbazole (tBuCz) donors make the mol. bipolar character to balance carrier recombination in emissive layer (EML). More significantly, besides steric hindrance for aggregation suppression, the introduction of triphenylphosphine enhances localized excited feature of the electronic states, and prevents the red shift induced by intra- and inter- mol. charge transfer, which establishes the basis for fabricating host-free NUV OLEDs. The non-doped devices based on the PhImPOCz and PhImPOtBuCz emitters achieved the low turn-on voltages of 4.2 V and 4.4 V, and the state-of-the-art external quantum efficiency (EQE) up to 2.81% and 3.42%, resp. This work demonstrates the significance of electronic state engineering for high-energy OLED applications.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about The role of acid in accelerating the asymmetric reduction of methyl acetoacetate with BINAP-chloro-(p-cymene)-Ru chloride complex.Category: piperazines.

The effect of addition of catalytic amounts of organic and inorganic acid on the asym. hydrogenation of Me acetoacetate with Ru-BINAP complex was studied. An increased activity was observed which was found to be dependent on the strength and the amount of acid added up to saturation It was proposed that the added acids protonate the carbonyl bond and hence facilitate the hydride transfer.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Name: 5-Fluoroindoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Ruthenium-catalyzed C7 amidation of indoline C-H bonds with sulfonyl azides. Author is Pan, Changduo; Abdukader, Ablimit; Han, Jie; Cheng, Yixiang; Zhu, Chengjian.

A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jo, Donghyun; Lee, Jae Sung; Lee, Kyung Hee researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).COA of Formula: C5H10O3.They published the article 《Enantio-differentiating hydrogenation of methyl acetoacetate over modified nickel catalysts: Effects of nickel dispersion on the enantio-selectivity of catalysts》 about this compound( cas:53562-86-0 ) in Research on Chemical Intermediates. Keywords: nickel silica hydrogenation catalyst enantioselectivity tartaric acid reduction temperature; methyl acetoacetate hydrogenation enantioselectivity catalyst malic acid sorption. We’ll tell you more about this compound (cas:53562-86-0).

Enantio-differentiating hydrogenation of Me acetoacetate was performed over fumed silica-supported Ni catalysts modified with solution of (R,R)-tartaric acid or (S)-malic acid and NaBr. The reduction temperature of supported Ni was the most important factor determining the enantioselectivity of catalysts. The reduction temperature affected Ni dispersion, quantity, and coverage by the agent. The enantioselectivity (ee) of (R,R)-tartaric acid and (S)-malic acid was compared at various reduction temperatures (R,R)-tartaric acid, with two hydroxyl groups, showed optimum coverage on Ni surface and maximum ee of 72% at reduction temperature of 973 K. In contrast, (S)-malic acid with one hydroxyl group showed monotonous decrease in ee and decreasing adsorbed amount with increasing reduction temperature

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Abdel-Rahman, Laila H.; Basha, Maram T.; Al-Farhan, Badriah Saad; Ismael, Mohamed published an article about the compound: 1,10-Phenanthroline( cas:66-71-7,SMILESS:C1=CC3=C(C2=NC=CC=C12)N=CC=C3 ).Quality Control of 1,10-Phenanthroline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:66-71-7) through the article.

The emergence of drug-resistant pathogens has greatly limited the use of antibiotics in treating microbial infections. Therefore, Cu complexes have emerged as potential alternatives to ordinary antibiotics. Ternary Cu(II) complexes with N-benzoyl-DL-phenylalanine (Bzphe) and imidazole (Imi), methylimidazole (Mimi), 2,2′-bipyridine (Bipy), and 1,10-phenanthroline (Phen) ligands were prepared and investigated for antimicrobial efficacy against two Gram-pos. bacteria (Bacillus subtilis and Micrococcus luteus), one Gram-neg. bacteria (Escherichia coli), and three fungal cultures (Aspergillus niger, Candida glabrata, and Saccharomyces cerevisiae). The new complexes were characterized by elemental anal., IR spectroscopy, electronic spectroscopy, thermogravimetry, and measurements of their molar conductivity and m.p. The formulas of the new complexes were Cu(Bzphe)2(Imi)2(OH2)2, [Cu(Bzphe)2(Mimi)2(OH2)2], Cu(Bzphe)2(Bipy)(OH2)2, and Cu(Bzphe)2(Phen)(OH2)2. The obtained data revealed that the Bzphe invariably coordinates to the Cu(II) ions through carboxylic oxygen as a monobasic ligand. The addition of secondary ligands such as amines does not affect the unidentate coordination behavior of the Bzphe. The new compounds were screened for antimicrobial activity against different strains of bacteria and fungi. The results for the Bzphe ligand and its mixed-ligand Cu(II) complexes showed that the ligands exhibit low potency to inhibit the growth of both Gram-pos. bacteria (B. subtilis and M. luteus) and Gram-neg. bacteria (E. coli). However, the new ternary complexes greatly suppressed the growth of these pathogens according to the order CuBipyBzphe > CuPhenBzphe > CuMimiBzphe > CuImiBzphe. In addition, computational studies using d. functional theory calculations and mol. docking experiments were carried out to characterize the mol. properties of the new complexes and provide insights into their role in inhibiting the growth of bacterial and fungal strains.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Quality Control of 1,10-Phenanthroline. The article 《Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors》 in relation to this compound, is published in ACS Chemical Neuroscience. Let’s take a look at the latest research on this compound (cas:2343-22-8).

Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkinson’s diseases. Screening a library of CNS-targeted drugs using novel reporters for HIF-1α and Nrf2 elevation in neuronal cells revealed histone deacetylase (HDAC) inhibitors as potential activators of these pathways. We report the identification of phenylhydroxamates as single agents exhibiting tripartite inhibition of HDAC6, inhibition of HIF-1 prolyl hydroxylase (PHD), and activation of Nrf2. Two superior tripartite agents, ING-6 and ING-66, showed neuroprotection against various cellular insults, associated with stabilization of both Nrf2 and HIF-1, and expression of their resp. target genes in vitro and in vivo. Discovery of the innate ability of phenylhydroxamate HDAC inhibitors to activate Nrf2 and HIF provides a novel route to multifunctional neuroprotective agents and cautions against HDAC6 selective inhibitors as chem. probes of specific HDAC isoform function.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres.Quality Control of (S)-1-(Dimethylamino)propan-2-ol.

The synthesis and chiral resolution of a dissym. tetraurea-calix[4]pyrrole/tetraurea-calix[4]arene mol. capsule with two hemispheres mech. locked is described. The assembly features a bis-[2]catenated topol. and shows reversible mol. co-encapsulation of two different neutral mols. or two oppositely charged ions.

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Piperazine – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Phenanthroline bridging graphitic carbon nitride framework and Fe (II) ions to promote transfer of photogenerated electrons for selective photocatalytic reduction of Nitrophenols, the main research direction is phenanthroline graphitic carbon nitride nitrophenol photocatalytic reduction; Fe (II); Graphitic carbon nitride; Nitrophenols; Phenanthroline; Selective reduction.Formula: C12H8N2.

Nitrophenols (NPs) are widely used in industries and highly toxic to ecol. environment and human health. Because aminophenols (APs) are important chems., catalytic reduction of NPs via efficient and environment-friendly strategies is of great importance. Herein, we developed a green photocatalysis route to efficiently convert NPs to APs using a Fe (II) modified graphitic carbon nitride (g-C3N4) photocatalyst, where phenanthroline units were employed to bridge Fe (II) and carbon nitride framework. The optimized sample P-CN-8-Fe presented significantly improved absorption of visible light, separation of photogenerated charges and carrier transportation in comparison with the pristine g-C3N4 and the modified samples of CN-Fe and P-CN-8. Accordingly, the P-CN-8-Fe showed a high conversion (97%) of p-nitrophenol (p-NP) to p-aminophenol (p-AP) under 2 h visible light irradiation, and meanwhile possessed high photocatalytic durability. Its high activity was also demonstrated through photocatalytic reduction of other NPs and nitrobenzene compounds Finally, a possible mechanism was proposed for the photocatalytic reduction of p-NP by P-CN-8-Fe. This work provides an effective approach to prepare Fe (II) modified g-C3N4 through the bridging effect of phenanthroline group, which is a potential visible light driven photocatalyst for reduction of nitrobenzene derivatives

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 66-71-7, is researched, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2Journal, Article, International Journal of Biological Macromolecules called Lignin-based fluorescence-switchable graphene quantum dots for Fe3+ and ascorbic acid detection, Author is Zhu, Lingyan; Li, Dongbing; Lu, Heng; Zhang, Shangkun; Gao, Hao, the main research direction is lignin fluorescence graphene quantum dot ascorbic acid detection; Alkali lignin; Fluorescence sensing; Graphene quantum dots.Quality Control of 1,10-Phenanthroline.

The synthesis of lignin-based graphene quantum dots (GQDs) with excellent fluorescence stability, quantum yield, and biocompatibility for sensitive and selective detection of Fe3+ and ascorbic acid (AA) has remained a challenging endeavor. Using an acidolysis process with 17.5% nitric acid followed by hydrothermal treatment at 200 °C, this study provided an improved synthesis route for the production of high-quality GQDs from alkali lignin. The nitrogen-doped GQDs exhibit remarkable fluorescence stability under a wide range of pH (3-10), duration (1-12 h), and [NaCl] (0-1000 mM) conditions, and have a high quantum yield of 28%. The GQDs or GQDs/Fe3+ sensing systems ([GQDs] at 50 mg L-1, [Fe3+] at 500 °mol L-1, and UV excitation at 370 nm) for fluorescence sensing of Fe3+ or AA have excellent sensitivity, selectivity, and reproducibility. For Fe3+ and AA, the limit of detection is 1.49 and 1.62 °mol L-1, resp. Mechanism investigation shows that photoluminescence quenching is caused by the formation of GQDs-Fe3+ complexes, whereas fluorescence recovery is due to Fe3+ reduction by AA.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 66-71-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Heteroleptic copper(II) complexes of prenylated flavonoid osajin behave as selective and effective antiproliferative and anti-inflammatory agents. Author is Vanco, Jan; Travnicek, Zdenek; Hosek, Jan; Dvorak, Zdenek.

Heteroleptic copper(II) complexes, containing prenylated flavonoid osajin isolated from the fruits of Maclura pomifera Schneid., were prepared and thoroughly characterized, including single crystal X-ray anal. Some of the following complexes of the general composition [Cu(L)(bpy)]NO3 (1), [Cu(L)(dimebpy)]NO3·2MeOH (2) [Cu(L)(phen)]NO3·H2O (3), [Cu(L)(bphen)]NO3 (4) and [Cu(L)(dppz)]NO3 (5), where HL stands for 3-(4-hydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one (osajin), bpy = 2,2′-bipyridine, dimebpy = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine, were also monitored for their solution stability and interactions with cysteine and glutathione by mass spectrometry. The in vitro cytotoxicity of the complexes was evaluated against a panel of eight human cancer cell lines: (MCF-7, HOS, A549, PC-3, A2780, A2780R, Caco-2, and THP-1). The results revealed high antiproliferative activity of the complexes with the best IC50 values of 0.5-3.4 μM for complexes (4) and (5), containing the bulkier N,N′-donor ligands (bphen, and dppz, resp.). The complexes also revealed a relatively low toxicity towards human hepatocytes (IC50 values are higher than 100 μM in some cases), and thus proved to be highly selective towards the cancer cells. On the other hand, the complexes showed a strong in vitro nuclease effect using the model pUC-19 plasmid. In the model of lipopolysaccharide-stimulated (LPS) THP-1 monocytes, the complexes revealed ability to lower the activity of nuclear factor kappa-B/activator protein 1 (NF-κB /AP-1) system and decrease the secretion of tumor necrosis factor alpha (TNF-α). Thus, the complexes have been identified as strong antiproliferative and anti-inflammatory compounds

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics