Tag: M.W:100-200

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 1-(2-hydroxyethyl)piperazine (26 g, 0.2 mol) in DMF (200 mL) was added formic acid (752 mL, 0.2 mol) and formaldehyde (16.2 g, 0.2 mol, 37% solution in water). The reaction mixture was cautiously heated at 100 C. for 2 hours then stirred overnight at room temperature. The solvent was removed in vacuo. This procedure was repeated 3 further times to give 100 g of product. The crude products were combined and distilled under vacuum to give, at 74 C., 2-(4-methylpiperazin-1-yl)ethanol (51 g, 44%) as a colourless liquid.Analytical LCMS: (System B, RT=0.70 min), ES+: 145.1 [MH]+., 103-76-4

103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Biovitrum AB; US2009/203695; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

Example 121-(2-(2-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea [Show Image] To a solution of 1-(2-(2-chloropyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea (227 mg) in ethanol (1.0 mL), 1-(2-methoxyethyl)piperazine (80 mg) and N,N-diisopropylethylamine (0.5 mL) were added, and the resulting mixture was stirred at room temperature for 4 days. Saturated aqueous sodium bicarbonate solution was added to the reaction mixture, which was then extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous sodium sulfate, and then evaporated under reduced pressure. The obtained residue was purified by amine-silica gel column chromatography (ethyl acetate/n-hexane = 1/1 – 2/1) to obtain the desired product (212 mg, yield: 76.5%). 1H-NMR (CDCl3):delta 8.13 (d 1H J = 5.6 Hz) 7.34-7.06 (m 8H) 6.20 (s 1H) 5.99 (s 1H) 5.90 (d 1H J = 5.6 Hz) 5.28 (t 1 H J = 5.9 Hz) 4.34 (d 2H J = 5.9 Hz) 3.68 (br 4H) 3.51 (t 2H J = 5.6 Hz) 3.35 (s 3H) 2.57 (t 2H J = 5.6 Hz) 2.46-2.44 (m 4H) 2.37 (s 3H) 1.32 (s 9H) MS (ESI):599 (M+H+)

13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TORAY INDUSTRIES, INC.; EP1970375; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, General procedure: General Procedure 5: [000565] The compounds of the application with the general formula shown below can be prepared according to the synthetic scheme shown in Scheme 5. Scheme 5 [000566] To a solution of compound (II) or (II?) (1 equivalent) in N,N-dimethyl-formamide (DMF) is added 2 equivalents of N,N-diisopropylethylamine (DIPEA) and 2.2 equivalent of 2-(4- methylpiperazin-1-yl)ethanamine (VIa). The reaction mixture is stirred at about 15 oC to about 28 oC for about 6 hours to about 24 hours. The reaction mixture is diluted with water, washed with ethyl acetate, washed with brine, dried over Mg2SO4, filtered and evaporated to give a crude compound which is then purified by silica gel column using a mixture of Chloroform:Methanol (9:1) as eluent. The product is collected under reduced pressure to provide the compound with the general formula shown in Scheme 5. [000567] Compounds 47-65, 101, 107-110, and 114-117 were prepared according to General Procedure 5 substituting (II) or (II?) with the appropriate substituted compound. Example 116: [000568] Synthesis of 2-benzamido-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamide (47) [000569] Compound 47 was obtained as a white powder in 88percent yield. 1H-NMR (500MHz, CDCl3): delta 12.28 (s, 1H, ArNHCO), 8.86 (dd, J = 8.5, 0.8 1H, CONHCH2), 8.07 (dd, J = 8.2, 1.3, 2H), 7.58-7.51 (m, 5H), 7.16 (td, J = 7.6, 0.9, 1H), 7.07 (s, 1H), 3.57 (q, J = 5.45, 2H, NHCH2CH2), 2.66 (t, J = 5.45, 2H, NHCH2CH2), 2.64-2.38 (m, 8H), 2.34 (s, 3H, CH3). 13C- NMR (126 MHz, CDCl3): delta 169.11 (ArC=O), 165.57 (ArC=O), 140.17 (ArC), 134.92 (ArC), 132.69 (ArCH), 131.78 (ArCH), 128.75 (ArCH), 127.41 (ArCH), 126.56 (ArCH), 122.84 (ArCH), 121.62 (ArCH), 120.42 (ArC), 55.90 (CH2), 55.10 (CH2), 52.66 (CH2), 45.92 (CH3), 36.27 (CH2). MS (ESI): 367.2 [M+1]. m.p. (from ethanol/water): 80 oC.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; WESTWELL, Andrew, David; BRANCALE, Andrea; CLARKSON, Richard, William Ernest; (247 pag.)WO2016/16728; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

100 mg of intermediate I-24 was dissolved in resulfured dry DMF,Twelve mg of palladium acetate and 36 mg of DPPP (1,3-bis(diphenylphosphino)propane) were added under nitrogen protection.After stirring for 5 minutes,Withdrawal of nitrogen,Charge CO,After multiple replacements,400 mul of triethylamine and 186 mg of 2-(4-methylpiperazin-1-yl)ethanamine are added,Stir overnight at 80 °C in an oil bath.TLC showed that after the reaction,Take CO,Evaporate the reaction solution under reduced pressureTo the residue was added 30 ml of ethyl acetate and 20 ml of water.Insoluble material was removed by filtration.The filtrate is extracted and separated from the organic layer.dry,Column chromatography after concentration gave 83 mg of compound C-4 (oil, yield 61percent).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Xing Weiqiang; Ding Jian; Ai Jing; (86 pag.)CN103664895; (2018); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

The intermediate N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]- 4-quinazolinamine 10 (9.26 g, 1.13 mol) was mixed with 4-methyl-1-piperazinyl-ethanol 11 (10.5 g, 1.5 mol), mixed and stirred in the presence of 80percent concentrated sulfuric acid (100 ml) and rapidly heat to 140°C, an intermolecular dehydration reaction occurs to produce N-(5-chloro-1,3-benzodioxolane-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(4- Hydrogen-2H-pyran-4-yl)oxy]-4-quinazolinamine 12 (16.1 g, 1.86 mol)., 5464-12-0

Big data shows that 5464-12-0 is playing an increasingly important role.

Reference：
Patent; Hu Zhangyan; (10 pag.)CN107814793; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a N-(tert-Butoxycarbonyl)-1-(2-hydroxyethyl)piperazine To a solution of 1-(2-hydroxyethyl)piperazine (5.20 g, 40 mmol) and triethylamine (6 mL) in 1,4-dioxane (100 mL) was added slowly di-tert-butyl dicarbonate (8.72 g, 40 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was removed in vacuo and the residue was purified by flash column chromatography (ethyl acetate to 2% methanol in ethyl acetate) to give the title compound as a colorless oil (8.32 g, 90%). 1 H-NMR (300 MHz, CDCl3) delta 1.46 (s, 9H), 2.46 (t, 4H), 2.55 (t, 2H), 2.75 (bs, 1H), 3.44 (t, 4H), 3.63 (t, 2H)., 103-76-4

103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; 3-Dimensional Pharmaceuticals, Inc.; US5792769; (1998); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The appropriate piperazine derivative (1.34mmol) and K2CO3 (180mg, 1.34mmol) were added to a solution of the appropriate 3-(4-(n-iodoalkoxy)phenyl)thiazolidine-2,4-dione (11, 0.67mmol) in MeCN (6mL). The reaction mixture was stirred at room temperature for 9h. The mixture was quenched by addition of water and extracted with DCM. The organic layer was dried over anhydrous MgSO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography (SiO2, DCM/MeOH= 15/1 v/v including 1% of NH4OH).

59878-57-8, As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference：
Article; Elkamhawy, Ahmed; Kim, Nam youn; Hassan, Ahmed H.E.; Park, Jung-eun; Yang, Jeong-Eun; Oh, Kwang-Seok; Lee, Byung Ho; Lee, Mi Young; Shin, Kye Jung; Lee, Kyung-Tae; Hur, Wooyoung; Roh, Eun Joo; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 691 – 704;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

Part II – Synthesis of [(S)-4-(3-chloro-benzenesulfonyl)-2-(4-methyl-3-oxo-piperazin-l- ylmethyl)-3,4-dihydro-2H-benzo[l,4]oxazin-6-yl]-carbamic acid tert-butyl ester [0340] A suspension of 3-chloro-benzenesulfonic acid (i?)-6-tert-butoxycarbonylamino-4-(3- chloro-benzenesulfonyl)-3,4-dihydro-2H-benzo[l,4]oxazin-2-yl methyl ester (63 mg, 0.1 mmol), N, N-diisopropylethylamine (0.2 mmol), l-methyl-piperazin-2-one, hydrochloride salt (30 mg, 0.2 mmol) and potassium iodide (5 mg) in THF (0.5 mL) and N-methyl pyrrolidinone (0.5 mL) was heated in a sealed tube for 12 hours at 80 C. After cooling, the mixture was partitioned between water and ethyl acetate. The organic layer was separated, washed with brine, saturated aqueous NaHC03 and concentrated. The residue was purified by column chromatography on silica gel to provide [(5)-4-(3-chloro-benzenesulfonyl)-2-(4- methyl-3-oxo-piperazin-l-ylmethyl)-3,4-dihydro-2H-benzo[l,4]oxazin-6-yl]-carbamic acid tert-butyl ester. LCMS (ESI) m/z 551., 109384-27-2

The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine; WO2013/169704; (2013); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54699-92-2,4-Methyl-1-piperazineacetic acid,as a common compound, the synthetic route is as follows.,54699-92-2

Example 13; General Method For The Preparation Of Active Esters Of N-Substituted Piperazine Acetic Acid From Trifluoroacetate Esters; A solution of the trifluoroacetate in THF (0.58 M, 1.2 equiv) was added to a solid sample of N-methyl piperazine acetic acid and mixed in a vortex or shaker until a homogeneous solution was obtained. The reaction of the carboxylic acid with the trifluoroacetate ester was generally complete within 30 min for all cases except N-hydroypyrrolidinone (NHP, 18 h). The progress of conversion to the active ester was monitored by ES-MS. The amount of product and any starting material (N-MPA) could be determined by direct infusion of a sample of the reaction (in ethanol) into the ES-MS. In some cases the active ester product was precipitated as dihydrochloride salt by the addition of a solution by addition of HCl solution in dioxane (4 M, 50% volume of the reaction) followed by washing with THF, ethyl acetate and hexanes. In other cases the product was isolated from the reaction as the mono TFA salt. Addition of TFA could be performed if the bis-TFA salt was desired. Dhbt ester, Calculated MH+ = 304.14 Found = 304.20 NHP ester, Calculated MH+ = 242.15 Found = 242.20 4-NP ester, Calculated MH+ = 280.13 Found = 280.20 1H NMR (400 MHz, CDCl3) d 8.20 (d, 2H, J=9.2 Hz, aromatic protons), 7.25 (d, 2H, J=9.2 Hz, aromatic protons), 3.69-3.40 (broad, 2H, ring protons), 3.57 (s, 2H, -CH-CO-), 3.15-2.90 (broad, 6H, ring protons), 2.78 (s, 3H, -CH3). Pfp ester, Calculated MH+ = 325.10 Found = 325.10 Pcp ester, Calculated MH+ = 404.95 Found = 405.90 3-NP ester, Calculated MH+ = 280.13 Found = 280.20 NHS ester, Calculated MH+ = 256.13 Found = 256.10

The synthetic route of 54699-92-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Applera Corporation.; US2005/148773; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

A solution of 2,4-dichloro-5,7-difluoro-3-nitroquinoline (5.58 gm, 2.0×10?2 moles) in 2-methyl tetrahydrofuran (50 mL) is stirred as diisopropylethylamine (2.84 gm, 2.2×10?2 moles) and N-2-aminoethyl-N? methylpiperazine (3.15 gm, 2.2×10?2 moles) are added. This solution is stirred at room temperature overnight. The yellow reaction mixture is diluted with more 2-methyl-tetrahydrofuran (50 mL) and this is washed with water (100 mL) followed by brine (50 mL). After being dried over magnesium sulfate, the solution is filtered and the solvent is removed under reduced pressure. The oily residue is stirred with diethyl ether (25 mL) and this is cooled on ice causing the product to crystallize. The solid yellow product is isolated by filtration, washed with ether and dried. The yield is about 4.32 gm.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANUS BIOTHERAPEUTICS, INC.; Lipford, Grayson B.; Zepp, Charles M.; (72 pag.)US9873694; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics