Tag: M.W:100-200

5625-67-2, Piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4) Preparation of benzyl 3-oxopiperazine-1-carboxylate 1.4; 10 g of piperazin-2-one and 90 g of sodium carbonate were dissolved in 250 ml of water; 500 ml of ethyl acetate were added to this solution, and 20.45 g of benzyl chloroformate were added dropwise with vigorous stirring. After the addition had ended, the mixture was stirred at room temperature overnight. For workup, the organic phase was removed, dried over magnesium sulfate, filtered and concentrated under reduced pressure. This afforded benzyl 3-oxopiperazine-1-carboxylate 1.4. Molecular weight 234.10 (C12H14N2O3); retention time Rt=1.18 min. [B]; MS (ESI): 235.11 (MH+)., 5625-67-2

As the paragraph descriping shows that 5625-67-2 is playing an increasingly important role.

Reference：
Patent; SANOFI-AVENTIS; US2011/46105; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-cyclopropylpiperazine, yield 62%. Recrystallisation from 0.2 M HCl gave white crystals, m.p. 238-239 C.; 1H NMR (DMSO-d6): delta 11.51 (br s, 1H), 8.61-8.55 (m, 1H), 8.30-8.20 (m, dd, 1H), 7.32-7.19 (m, d+s, 5H), 4.44-4.00 (br, 2H), 3.80-3.40 (br m, 4H), 3.29-2.93 (br m, 4H), 1.28-1.05 (br m, 1H), 0.75-0.58 (m, 2H), 0.50-0.35 (m, 2H).IR (KBr): nu 1730, 1713 (C=O) cm-1.

20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,75336-86-6

Example 1] Synthesis of compound (I-40) a) Synthesis compound 3 [Show Image] [Show Image] Under the nitrogen atmosphere, toluene (7.5 ml) was added to a commercially available compound 2 (1.50 g, 7.30 mmol), a commercially available compound 1 (1.50 g, 7-30 mmol), and sodium tert-butoxide (842 mg, 8.76 mmol) were added, and the system was degassed, and replaced with nitrogen. Xantphos (127 mg, 0.22 mmol) and Pd2(dba)3 (67 mg, 0.67 mmol) were added to react them at 100°C for 1 hour. Toluene (8 ml) was added to dilute the reaction, and this was filtered using Celite. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (chloroform-methanol) to obtain a compound 3 (1.27 g, yield 77percent). 1H-NMR (CDCl3 / TMS) deltappm: 1.13 (d, J = 6.2Hz, 3H), 1.57 (s, 1H), 2.28-2.37 (m, 1H), 2.35 (s, 3H), 2.67 (dt, J = 3.5, 11.6Hz, 1H), 2.92-3.15 (m, 3H), 3.46 (d, J = 11.6Hz, 2H), 6.69 (dd, J = 8.9, 2.7Hz, 1H), 6.78 (d, J = 2.7Hz, 1H), 7.19 (d, J = 8.9Hz, 1H).

As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.

Reference：
Patent; Shionogi&Co., Ltd.; EP2184272; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

59702-07-7, Example 16. Preparation of Compound Nos. 136. 136a and 136b To a solution of l-[4-[(3-cyclopentyl-lH-pyrazol-5-yl)amino]-6,7-dihydro-5H- cyclopenta[d]pyrimidin-2-yl]pyrrolidine-2-carboxylic acid hydrochloride (500 mg, 1.19 mmol) in DMF (6 mL) was added l-methylpiperazin-2-one (205 mg, 1.79 mmol), HOBt (16 mg, 0.11 mmol), EDC’HCl (320 mg, 1.67 mmol), and DIPEA (618 mg, 4.79 mmol), and the reaction mixture was stirred at RT for 18 h. The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (2×50 mL). The combined organic layers were washed with water (8×50 mL) and dried over anhydrous sodium sulfate. Removal of solvent under reduced pressure gave a crude product that was purified by reverse phase HPLC followed by chiral HPLC to afford 20 mg of 4-[(2S)-l-[4-[(3-cyclopentyl-lH-pyrazol-5-yl)amino]-6,7- dihydro-5H-cyclopenta[d]pyrirmdin-2-yl]pyrrolidine-2-carbonyl]-l-methyl-piperazin-2-one (Compound No. 136b). 1H NMR (CD3OD, 400 MHz) 1.60-1.90 (m, 8H), 1.92-2.20 (m, 8H), 2.30-2.42 (m, 1H), 2.60-2.80 (m, 6H), 2.97-3.12 (m, 1H), 3.22-3.56 (m, 3.61-4.30 (m, 4H), 5.02 (brs, 1H), 5.75 (brs, 1H).

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference：
Patent; MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; RAI, Roopa; GREEN, Michael, John; ANSARI, Amantullah; AGARWAL, Anil, Kumar; (216 pag.)WO2016/3827; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

68104-63-2, 4-(Piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

68104-63-2, Preparation 23 tert-butyl 4-(4-cyanophenyl)piperazine-1-carboxylate 4-(piperazin-1-yl)benzonitrile (0.7g, 3.74mmol) was dissolved in a mixture of dioxane/water (15ml/7ml), then 1 N solution of NaOH was added (5.2ml) and finally BOC2O (0.82g, 3.78mmol). The reaction mixture was stirred at r.t. for 2h. The solvent was concentrated and the residue redissolved in water and the pH adjusted to 7 by adding 2N HCl. The aqueous layer was extracted with chloroform and the organic layer washed with brine, dried over magnesium sulphate and evaporated under reduced pressure to give 1 g of the desired compound (yield=93%) as a white solid. LRMS: m/z 288 (M+1)+ Retention time: 6.33 min (Method B) 1H NMR (300 MHz, CDCl3) delta ppm: 1.49 (s, 9H), 3.33-3.35 (m, 2H), 3.57-3.59 (m, 2H), 6.84-6.87 (m, 2H), 7.50-7.53 (m, 2H).

68104-63-2 4-(Piperazin-1-yl)benzonitrile 2733995, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Laboratorios Almirall, S.A.; EP2202232; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21655-48-1, To a stirring suspension of 2?fluoro?5?nitrobenzaldehyde (2.69 g, 15.9 mmol) and potassium carbonate (8.80 g, 63.7 mmol) in anhydrous DMF (10 mL) was added (25,6R)?2,6?dimethylpiperazine (2 g, 17.51 mmol) and the mixture washeated at 90 °C for 16 h. After cooling the mixture was partitioned between brine/water (100 mL) and ethyl acetate (25 mL) . The aqueous layer was separated and extracted with ethyl acetate (3 x 25 mL) . The combinedethyl acetate fractions were washed with brine/water (1:1, 4 x 25 mL), dried (anhydrous sodium sulfate), filtered and reduced in vacuo. The resulting residue was chromatographed (gradient 20?100percent ethyl acetate in cyclohexane) to afford the title compound (2.77 g, 66.1 percent) . ?H NMR (400 MHz, CDC13) : 3 10.07 (s, 1H), 8.62 (d,1H), 8.28 (dd, 1H), 7.06 (d, 1H), 3.35 (d, 2H), 3.14?3.17 (m, 2H) , 2.72 (dd, 2H) , 1.13 (d, 6H) . LCMS (Method C) := 0.43 mi m/z = 264 [M+H].

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

59878-57-8, To the reaction flask was added compound 6 (prepared in Example 3-2, 256.5g,0.86mol), CDI (139.45g, 0.86mol), 1.6LTHF, after stirring for 0.5h Compound 7 (138.8g,0.90mol) at room temperature The reaction 3h, after completion of the reaction, water was added to quench the reaction, of THF was distilled off under reduced pressure, theresidue was dissolved in ethyl acetate was added, the organic phase was separated,washed with water three times, the organic phase was dried over anhydrous Na 2SO 4Dried,filtered and concentrated to give Ola Trapani (356.3g, 0.82mol), yield 95%, HPLC purity 99.8%.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Shandong Luoxin Pharmaceutical Group Heng Xin Pharmaceutical Co. Ltd.; Li, Hua; Wang, Chunyan; Liu, Shuxin; (8 pag.)CN105820126; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-cyclopentyl Piperazine(507 mg, 0.003 mmol) was added to a stirred solution of 6 (1 g, 0.0029 mmol) in dry 1,4-Dioxaneand DIPEA (0.7 mL,0.005 mmol). The solution was stirred for 4 h at room temperature. After adding water a precipitate was formed which was filtered to give compound 7 (1.1g, 86% yield) as white solid (m.p-156-159 C).1H NMR (300 MHz, CDCl3) ^ 1.39 – 1.50 (m, 2H), 1.58 (dd, J=7.72, 4.71 Hz, 2H), 1.68 – 1.75 (m, 2H), 1.88 (br. s, 2H), 2.51 – 2.60 (m, 1H), 2.64 – 2.70 (m, 4H), 3.66 – 3.71 (m, 1H), 3.76 – 3.82 (m, 4H), 3.96 (s, 3H), 5.25 (s, 2H), 7.06 (s, 1H), 7.18 (s, 1H), 7.31 – 7.41 (m, 3H), 7.42 – 7.48 (m, 2H).ESI [M+H]+:453.40., 21043-40-3

21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; TALUKDAR, Arindam; GANGULY, Dipyaman; PAUL, Barnali; MUKHERJEE, Ayan; ROY, Shounak; ROY, Swarnali; GHOSH, Amrit Raj; BHATTACHARYA, Roopkatha; RAHAMAN, Oindrila; KUNDU, Biswajit; (89 pag.)WO2017/163264; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57260-71-6, To a solution of thiocarbonyldiimidazole (2.1 g, 11.8 mmol) in tetrahydrofuran (30 mL) at room temperature, was added 1,1 -dimethylethyl 1-piperazinecarboxylate (2.0 g, 10.7 mmol). The reaction mixture was stirred at room temperature for 2 h and then heated to 55 C for additional 2 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure until approximately 20 mL of tetrahydrofuran remained. The residue was then treated with a 2 M solution of ammonia in methanol (10 mL) and stirred at room temperature for 24 h. The reaction mixture was concentrated under reduced pressure, and the residue was triturated with diethyl ether (25 mL) to give a white precipitate. The precipitate was filtered and dried to give 1.5 g of the title compound as a white solid..H NMR (CDCI3) delta 1.39 (s, 9H), 3.32 (m, 4H), 3.73 (m, 4H), 7.49 (br s, 2H).

As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.

Reference：
Patent; E. I. du Pont de Nemours and Company; DUNG, Mei H.; PASTERIS, Robert, James; WO2011/72207; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh Trifluoromethyl acid 9.5g (0.05mol) was dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI8.9g (0.055mol),At room temperature for 4hAfter the reaction solution through a dropping funnel was added dropwise to a solution of constant piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of an aqueous solution of sodium chloride, 14g, and reacted for 5 hours at room temperature .After completion of the reaction by suction, the filtrate evaporated removal of THF, treated 10ml ethyl acetate again, and then a saturated solution of NaOH was adjusted to pH = 10, extracted with ethyl acetate three times and the combined organic phases, the organic phase was dried over anhydrous sodium sulfate overnight, filtration, spin dry ethyl acetate, the resulting white crystals is 1- [3- (trifluoromethyl) benzoyl] crude 6.5g, 50% yield.

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference：
Patent; Xi’an Jiaotong University; Zhang, Jie; Lu, Wen; Dong, Jinyun; Pan, Xiaoyan; He, Langchong; Zhang, Tao; Wang, Sicen; Shen, Xiuxiu; (16 pag.)CN104262238; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics