Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

A 250 mL round bottom flask was charged with 20 mmol of compound (4), 80 mL of 1,4-dioxane,20 mmol of compound (2) (R is methyl) was added dropwise at 20 C under stirring for 1 hour. The mixture was heated to reflux for further stirring. After about 6 hours, the solid was no longer increased but changed to distilled. The methanol was distilled off to recover the compound (2) (R is methyl), cooled to below 30 , 40mmol sodium methylate in methanol 30% sodium methoxide was added dropwise over about 1 hour and then stirred for 1 hour, the temperature was rectified methanol were recovered, 1 , 4-dioxane and piperazine (3). The product was distilled off under reduced pressure to give a pale yellow transparent liquid to obtain piperazine methylmethyldimethoxysilane (R is methyl) represented by the formula (1) a, the yield of 95% (as (2) dollars), high performance liquid chromatography analysis content of 98.7%.

142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Yancheng Technology College; Sun Guoxiang; (6 pag.)CN106046041; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,74879-18-8

(2S)-2-methylpiperazine (15 g, 150 mmol) was dissolved in tetrahydrofuran (300 mL) and the solution was cooled down to 0 C. Sodium hydroxide (150 mL, 449 mmol) was added, then 4-(trifluoromethyl)benzenesulfonyl chloride (40 g, 164 mmol) (dissolved in 200 ml THF) was added dropwise and the resulting mixture was stirred for 1 h. Further 4-(trifluoromethyl)benzenesulfonyl chloride (0.06 eq, 2.2 g) was added and mixture stirred for 10 min. The mixture was diluted with DCM (500 ml) and water (500 ml) and stirred for 5 min. The phases were separated, the aqueous layer was extracted with DCM (1000 ml) and the organic phases concentrated under reduced pressure. The residue was taken-up with 1 M HCl (500 ml) and washed with DCM in order to extracted impurities. The aqueous phase was basified to pH=9 with NaOH 3M, extracted with DCM (3×500 ml) and the combined organic phases dried over Na2SO4 before the solvent was removed under reduced pressure to give the title compound (30 g).m/z (API-ES) 309 [M+H]+ 1H NMR (400 MHz, CDCl3) delta ppm 1.06 (d, J=7.2 Hz, 3H), 1.94 (t, J=10.4 Hz, 1H), (td, J=11.2, 4.0 Hz, 1H), 2.88-3.07 (m, 3H), 3.66 (m, 2H), 7.83 (d, J=8.4 Hz, 2H), 7.90 (d, J=8.4 Hz, 2H).

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Beswick, Paul John; Campbell, Alister; Cridland, Andrew; Gleave, Robert James; Heer, Jag Paul; Nicholson, Neville Hubert; Page, Lee William; Vile, Sadie; US2010/22555; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

(iii) 3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfinyl)phenyl)ureido)naphthalen-1- yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamideHATU (150 mg, 0.394 mmol) was added to a solution of the product from step (ii) above (200 mg, 0.284 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (60 mg, 0.419 mmol) and diisopropylethylamine (150 L, 0.859 mmol) in DMF (2 mL). The reaction mixture was stirred at rt for 72h. Water (10 mL) added and the resulting solid filtered off, washed with water (2 mL) and dried to afford the title compound (0.19 g). 1H NMR (400 MHz, DMSO-ds) delta 9.41 (s, 1 H), 9.07 (s, 1 H), 8.96 (s, 1 H), 8.51 (d, 1 H), 8.28 (d, 1 H), 8.21 (t, 1 H), 8.12 (d, 1 H), 8.10 (d, 1 H), 7.88 (d, 1 H), 7.77-7.67 (m, 1 H), 7.66-7.58 (m, 1 H), 7.56 (t, 1 H), 7.50 (t, 1 H), 7.40 (d, 1 H), 7.36 (d, 1 H), 6.86 (dd, 1 H), 6.58 (dd, 1 H), 6.14 (d, 1 H), 3.87 (s, 3H), 3.74 (s, 3H), 2.79 (s, 3H), 2.43 (t, 2H), 2.32 (s, br, 10H), 2.15 (s, 3H), 1.32 (s, 9H). LCMS m/z 794 (M+H)+(ES+)

934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-(l-(lH-indol-3-yl)hexan-2-yl)-2-bromothiazole-5- carboxamide (0.20 g, 0.49 mmol) and 1-cyclopropylpiperazine (0.07 g, 0.54 mmol) in CH3CN (4.5 mL) was added K2CO3 (0.20 g, 1.47 mmol) and the reaction mixture was heated at 80 C for 16 h. The reaction mixture was concentrated in vacuo. The residue was diluted with H20 (10 mL) and extracted with 10% MeOH in DCM (10 mL). The organic layer was separated, dried over anhydrous Na2S04 and concentrated in vacuo. The crude obtained was purified by column chromatography (silica 230-400 mesh, 0 to 10% MeOH in DCM) and then triturating with petroleum ether (6 mL), pentane (10 mL) and DCM (2 mL) to afford N-(l-(lH-indol-3- yl)hexan-2-yl)-2-(4-cyclopropylpiperazin-l-yl)thiazole-5-carboxamide (0.14 g, 63%) as an off- white solid. HPLC Purity: 99.0%. LC/MS (ESI) m/e [M+H]+/RT (min)/%: (0271) 452.00/2.91/98.8%. 1H NMR (400 MHz, DMSO- 6) delta 0.35-0.44 (m, 4H), 0.82 (t, = 6.9 Hz, 3H), 1.16-1.37 (m, 4H), 1.40-1.60 (m, 2H), 1.62-1.68 (m, 1H), 2.60-2.68 (m, 4H), 2.73-2.98 (m, 2H), 3.40-3.48 (m, 4H), 4.04-4.18 (m, 1H), 6.92-6.99 (m, 1H), 7.04 (t, = 7.6 Hz, 1H), 7.09 (s, 1H), 7.31 (d, = 8.3 Hz, 1H), 7.57 (d, = 7.8 Hz, 1H), 7.80 (s, 1H), 7.94 (d, = 8.8 Hz, 1H), 10.75 (brs, 1H).

20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

To a stirring solution of piperazin-2-one 16 (500 mg, 5.00 mmol) in CH2C12 (5 mL) under argon atmosphere were added triethylamine (1.5 mL, 10.00 mmol) and Boc- anhydride (1.3 mL, 6.00 mmol) at 0 C; warmed to RT and stirred for 18 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo. The crude was purified through silica gel flash column chromatography using 2% MeOH/ CH2C12 to afford compound 17 (450 mg, 45%) as pale yellow solid. TLC: 10% MeOH/ CH2C12 (R/. 0.6); 1H-NMR (DMSO-i/tf, 400 MHz): delta 8.02 (br s, IH), 3.81 (s, 2H), 3.48-3.45 (m, 2H), 3.19-3.14 (m, 2H), 1.41 (s, 9H)., 5625-67-2

As the paragraph descriping shows that 5625-67-2 is playing an increasingly important role.

Reference：
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ARNOLD, Lee Daniel; MAAG, Hans; TURNER, JR., William W.; (274 pag.)WO2016/168619; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, General procedure: A mixture of celastrol (45mg, 0.1mmol), BOP (53mg, 0.12mmol), DIEA (53muL, 0.3mmol) and 2-dimethylaminoethylamine (28muL, 0.3mmol) in DCM (5.0mL) was stirred at room temperature overnight. Then the mixture was concentrated and purified by normal phase column chromatography (DCM/MeOH=30:1) to afford the target compound as a red solid (35mg, 75.6percent).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Jiang, Fen; Wang, Hui-Jie; Bao, Qi-Chao; Wang, Lei; Jin, Yu-Hui; Zhang, Qiong; Jiang, Di; You, Qi-Dong; Xu, Xiao-Li; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5431 – 5439;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.,59702-31-7

(2)–To a suspension of 0.71 g of the abovementioned 1-ethyl-2,3-dioxo-piperazine in 15 ml of anhydrous dioxane were added with stirring 0.70 g of trimethylsilyl chloride and 0.83 ml of triethylamine. The resulting mixture was stirred at room temperature for 20 hours to deposit triethylamine hydrochloride. This hydrochloride was separated by filtration, and the filtrate was dropped at 5 to 10 C. into a solution of 0.70 g of phosgene in 10 ml of anhydrous tetrahydrofuran. Subsequently, the resulting mixture was reacted at 5 to 10 C. for 30 minutes and at room temperature for 2 hours, and then the solvent was removed by distillation under reduced pressure to obtain 1.0 g of pale yellow crystals of 4-ethyl-2,3-dioxo-1-piperazinocarbonyl chloride. IR (KBr) cm-1: — nuC=O 1780, 1660

59702-31-7 1-Ethylpiperazine-2,3-dione 108812, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Toyama Chemical Co., Ltd.; US4112090; (1978); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 28 2-(Phenoxy)ethyl 3-(3-methyl-1-piperazinyl)-2-pyrazinyl Ether The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2-phenoxyethoxy)pyrazine (150 mg, 0.54 mmol; from Example 1, Step 1) and 2-methylpiperazine (250 mg, 2.5 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 138 mg (73%) of the title product. Anal. (C17H22N4O2) C, H, N. *Prepared according to the procedure described in Example 4, Step 1., 109-07-9

As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference：
Patent; Biovitrum AB; US6465467; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 13 N-[6-(4-Allyl-3-methylpiperazin-1-yl)pyridin-3-yl]-4-isopropylbenzenesulfonamide hydrochloride 13.1 3-Methyl-1-(5-nitropyridin-2-yl)piperazine 872 mg (6.31 mmol) of potassium carbonate were added to a solution of 500 mg (3.15 mmol) of 2-chloro-5-nitropyridine in 7 ml of dimethylformamide. After that, a solution of 350 mg (3.32 mmol) of 2-methylpiperazine in 3 ml of dimethylformamide was slowly added dropwise to the reaction mixture while cooling with ice (exothermic reaction). The reaction mixture was stirred for 1 hour while cooling with ice and then stirred overnight at room temperature. After the solvent had been evaporated to dryness, the residue was taken up in water and this mixture was extracted three times with diethyl ether. The combined organic phases were dried over sodium sulfate, filtered and evaporated to dryness, with 3-methyl-1-(5-nitropyridin-2-yl)piperazine (Yield: 650 mg, 89% of theory) being obtained. 1H-NMR (500 MHz, CDCl3): delta [ppm] 9.0 (s, 1H); 8.2 (d, 1H); 6.6 (d, 1H), 4.4 (m, 2H); 3.2 (m, 1H); 3.1 (m, 1H); 2.9 (m, 2H); 2.7 (m, 1H); 1.2 (m, 3H). 13C-NMR (125 MHz, CDCl3): 160.4 (C); 146.5 (CH); 134.9 (C); 133.0 (C); 104.5 (CH); 52.2 (CH2); 50.6 (CH); 45.7 (CH2); 45.4 (CH2); 19.6 (CH3).

109-07-9, 109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Abbott GmbH & Co. KG.; US2006/160809; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: General procedure: a suspension of the indenoquinoline 20 or 23(1.67 mmol) and the appropriated amine (3.33 mmol) in 7 ml ofdry pyridine was heated at 100 C for 20 h. The reaction mixturewas poured into iced water (150?200 ml) and when it was possible,the precipitate was filtered, otherwise it was extracted withethyl acetate or dichloromethane. The organic layer was dried withanhydrous Na2SO4 and evaporated to dryness. The residue waspurified by CC (silica gel; CH2Cl2/MeOH or cyclohexane/ethyl acetatein gradient as indicated for each compound).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics