Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Into a reactor with a working volume of 1000 mL equipped with a thermometer, a reflux condenser and a mechanical stirrer, DMSO (480 mL), l-cyclopropyl-6,7-difluoro-l,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid (138.0 g; 0.4675 mole) and 2-methylpiperazine (94.0 g; 0.9387 mole) were put at 25C (20C-30C). The reaction mixture was stirred for 30 minutes at 25C (20C-30C). Then it was heated in 50 minutes (45-60 minutes) to the temperature of 73C. The reaction mixture was stirred at this temperature for 12 hours. After 12 hours at 73C, the reaction mixture was cooled to 25C in 45 minutes (40-50 minutes). The pH of the suspension was measured and adjusted to the pH value of 10.2 with a 15% HC1 solution (27.5 mL of 15% HC1) and the suspension was stirred for 24 hours. The pHof the suspension was periodically checked and adjusted to the desired value of 10.2 if necessary. When adjusting the pH vapours were formed, which were sucked off by underpressure and led through a trap with a solution of calcium hydroxide, which irreversibly bound fluoride ions. The product was then filtered over a filter MN 640 (black ribbon) and washed with methanol (165 mL). The product was thoroughly sucked off and the humidity was determined. Estimated yield of the dry gatifloxacin base: 52.0-54.7%., 109-07-9

As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference：
Patent; KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; WO2006/4561; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 1-substituted piperazines (1.5mmol), carbon disulfide (0.45mL, 7.5mmol) and finely powered anhydrous potassium phosphate (0.32g, 1.5mmol) in DMF (7.5mL) was stirred at room temperature for 30min. 6-(Bromomethyl)-2,4-diaminoquinazoline (7) (0.38g, 1.5mmol) was added to the solution, and stirring was continued at room temperature for 4h. After poured into water (100mL), the resulting precipitate was collected by filtration, which was purified by column chromatography (CC) on silica gel or recrystallization from appropriate solvent to give compounds 8a-u., 115761-79-0

115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Cao, Sheng-Li; Han, Ying; Yuan, Chong-Zhen; Wang, Yao; Xiahou, Zhi-Kai; Liao, Ji; Gao, Rui-Ting; Mao, Bei-Bei; Zhao, Bao-Li; Li, Zhong-Feng; Xu, Xingzhi; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 401 – 409;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

To the 25 ml round-bottom flask by adding 69A (159mul, 1mmol) and dichloromethane, after stirring to dissolve by adding 69B (270 mg, 1mmol), then adding STAB (254 mg, 1 . 2mmol) stirring overnight, TLC detection reaction is complete, water washing, the water layer is extracted with ethyl acetate, combined with the phase, saturated salt water washing, dry anhydrous sodium sulfate, concentrated after the silica gel to obtain the product 69 (217 mg, 56%).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Chengdu Biological Technology Co., Ltd. Kerry Bass; Li, Dequn; (92 pag.)CN105777632; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Substituted amine (1.2 equiv) was added to a mixture of 4-fluoronitrobenzene (1 equiv) and K2CO3 (2.0 equiv) in DMF (7mL/g). The reaction mixture was stirred at 40C and followed by TLC. After completion of the reaction, the mixture was poured into stirring ice-water. The resulting precipitate was filtered and dried to obtain compounds 11 as a yellow solid., 21043-40-3

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

HATU (184 mg, 0.48 mmol) was added to a stirred mixture of 4-(6-mefhyl-7-oxo-6,7-dihydro- lH-pyrrolo[2,3-c]pyridin-4-yl)benzoic acid (Intermediate D) (100 mg, 0.37 mmol), 1 – mefhylpiperazin-2-one (63 mg, 0.56 mmol), and diisopropylethylamine (168 mg, 1.30 mmol) in DMF (5 mL). The reaction mixture was stirred at room temperature for 8 h, at which time (0597) LCMS indicated that the reaction had gone to completion. The reaction mixture was partitioned between ethyl acetate (20 mL) and water (15 mL). The separated organic solution was washed with brine (2 x 10 mL), dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by preparative HPLC, acetonitrile : water (10 nM ammonia bicarbonate) 35percent-65percent, to afford the title compound (47.9 mg, 15.8percent yield) as a white solid. 1H NMR (400 MHz, DMSC 5): 3 12.14 (s, 1 H), 7.66 (d, J= 8.4 Hz, 2 H), 7.52 (d, J- 8.4 Hz, 2 H), 7.45 (s, 1 H), 7.35 (s, 1 H), 6.47 (d, J= 2.0 Hz, 1 H), 4.12-4.09 (m, 4 H), 3.56-3.50 (m, 2 H), 3.47 (s, 3 H), 2.85 (s, 3 H). LCMS M/Z (M+H) 365.1. The following compounds were prepared in a similar fashion to Example 26: Examples 27-38, 59702-07-7

59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BELLON, Steven, F.; BURDICK, Daniel, J.; COTE, Alexandre; CRAWFORD, Terry; DAKIN, Les, A.; HEWITT, Michael, Charles; HSIAO-WEI TSUI, Vickie; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F. Anthony; TANG, Yong; TAYLOR, Alexander, M.; WANG, Shumei; (128 pag.)WO2016/77380; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.,21043-40-3

1-Cyclopentyl piperazine (700?mg, 4.5?mmol) was added to a stirred solution of 1 (1?g, 3.0?mmol) in 15?mL dry 1,4-dioxane and DIPEA (0.8?mL, 4.5?mmol). The solution was stirred for 6?h?at room temperature. The reaction mixture was concentrated under reduced pressure and poured into ice water and extracted with ethyl acetate (3?*?50?mL). The combined organic part was washed with water followed by brine, dried over sodium sulphate and concentrated under reduced pressure. The crude residue was purified by flash column chromatography, eluting with 2-5% methanol in chloroform to provide pure compound 36 as white solid (940?mg, 86% yield, m.p- 156-160?C). 1H NMR (300?MHz, CDCl3) delta 7.47-7.44 (m, 2H), 7.41-7.32 (m, 3H), 7.18 (s, 1H), 7.06 (s, 1H), 5.25 (s, 2H), 3.96 (s, 3H), 3.79 (t, J?=?4.8?Hz, 4H), 2.67 (t, J?=?4.8?Hz, 4H), 2.58-2.53 (m, 1H), 1.94-1.85 (m, 2H), 1.76-1.66 (m, 2H), 1.60-1.53 (m, 2H), 1.47-1.40 (m, 2H). 13C NMR (75?MHz, CDCl3) delta 164.3, 154.8, 154.1, 150.5, 148.6, 135.4, 128.7, 128.3, 127.4, 109.1, 108.4, 103.6, 70.8, 67.6, 56.2, 51.8, 48.9, 30.0, 24.0. HRMS (EI) calcd for C25H29ClN4O2 (m/z) [M]+ 452.1979; found 452.1987.

As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference：
Article; Paul, Barnali; Rahaman, Oindrila; Roy, Swarnali; Pal, Sourav; Satish, Sohal; Mukherjee, Ayan; Ghosh, Amrit R.; Raychaudhuri, Deblina; Bhattacharya, Roopkatha; Goon, Sunny; Ganguly, Dipyaman; Talukdar, Arindam; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 187 – 205;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

A solution of DIPEA (690 mul, 3.97 mmol) and 1-cyclopropylpiperazine (500 mg, 3.97 mmol) in acetonitrile (5 ml) was added to a solution of 2-chloro-5-nitropyridine (631 mg, 3.97 mmol) in acetonitrile (10 ml). The mixture was stirred at rt for 4 hours and then concentrated to dryness. The residue was diluted with DCM and 2M sodium carbonate solution (aq). The organic phase was dried and concentrated to give a yellow solid (912 mg, 93%). 1H NMR (400 MHz, DMSO-cfe) delta ppm 0.31 – 0.49 (m, 4 H), 1.65 (it, ./=6.70, 3.38 Hz, 1 H), 2.52 – 2.69 (m, 4 H), 3.61 – 3.82 (m, 4 H), 6.95 (d, 7=9.62 Hz, 1 H), 8.21 (dd, 7=9.62, 2.75 Hz, 1 H), 8.95 (d, 7=2.75 Hz, 1 H); m/z (ES+APCI)+: 249 [M+H]+., 20327-23-5

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference：
Patent; MEDICAL RESEARCH COUNCIL; WO2009/122180; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.

-Methyl-3-phenylpiperazine (17.6 g; 0.1 mol) was dissolved in 100 dichloromethane.Triethylamine (5 ml; ca 0.03 mol) was added. A solution of methyl chlorooxalate (10 ml; 0.10 mol) in dichloromethane was slowly added under cooling. After the total addition, 5271-27-2

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference：
Patent; N.V. ORGANON; WO2007/144409; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

In a 5 ml_ glass microwave vial equipped with a magnetic stirring bar and nitrogen flow at room temperature was placed the methyl 4-bromo-1-(4-bromo-5- (isopropylthio)thiazol-2-yl)-3-methyl-1 H-pyrazole-5-carboxylate prepared as described above with respect to Compound 1 (150 mg, 0.330 mmol), the 1-cyclopropylpiperazine (42 mg, 0.33 mmol), Cs2C03(537 mg, 1.65 mmol), XantPhos (19 mg, 0.033 mmol) and dioxane (3 ml_). Nitrogen was bubbled in the solvent for 10 minutes followed by the addition of the catalyst RuPhos Pd G1 (27 mg, 0.033 mmol). The vial was capped and placed in an oil bath at 105 C for 16 h. The product was purified by flash chromatography (dry packing) on silica gel using a gradient 0 to 10% EtOAc in hexanes to give the title compound (28 mg, 0.055 mmol, 17%) as a yellow oil. MS (m/z): 500.0 [M+1]+., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; BANTAM PHARMACEUTICAL, LLC; SIDDIQUI, Arshad, M.; CIBLAT, Stephane; DERY, Martin; CONSTANTINEUA-FORGET, Lea; GRAND-MAITRE, Chantal; BRUNEAU-LATOUR, Nicolas; SHIPPS, Gerald, W.; COOPER, Alan, B.; OZA, Vibha; KOSTURA, Matthew, W.; LUTHER, Michael; LEVINE, Jedd; (174 pag.)WO2018/102453; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of intermediate4a or 4b (1mmol), corresponding aliphatic amine (2mmol), K2CO3 (2mmol) in DMF was stirred at room temperature overnight. DMF was removed in vacuo and then H2O was added. The layer was extracted with CH2Cl2 (15mL×3). Organic layers were dried on Na2SO4 and the solvent was removed under pressure. Compounds were purified by column chromatography using dichloromethane/methanol as an eluent to give 5a-11a and 12b-21b.

21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Yu; Chen, Shaowei; Hu, Gang; Wang, Jiao; Gou, Wenfeng; Zuo, Daiying; Gu, Yucheng; Gong, Ping; Zhai, Xin; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 123 – 136;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics