Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of chalcones condensed with an 1,3-azole ring using a SOCl2/EtOH catalytic system.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

A series of substituted heterocyclic chalcones were synthesized by aldol condensation of corresponding heterocyclic ketones (preparation shown) aromatic aldehydes, in the presence of thionyl chloride-EtOH as a catalyst. The reaction was stereoselective and only trans-isomers were obtained in excellent yields and purity. Three out of 7 prepared chalcones (I, R = H, OH, OMe) were tested in vitro for their antitumor activity. They were found to have IC50 values ranging between 10-15 μM.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structural speciation in chemical reactivity profiling of binary-ternary systems of Ni(II) with iminodialcohol and aromatic chelators, the main research direction is preparation nickel iminodialc bipyridine phenanthroline complex reactivity luminescence dft.Reference of 1,10-Phenanthroline.

The importance of structural speciation in the control of chem. reactivity in Ni(II) binary-ternary systems, involving (O,O,N)-containing substrates (1,1′-iminodi-2-propanol), and aromatic chelators (2,2′-bipyridine, 1,10-phenanthroline), prompted the systematic synthesis of new crystalline materials characterized by elemental anal., FTIR, UV-Visible, Luminescence, magnetic susceptibility, and x-ray crystallog. The structures contain mononuclear octahedral assemblies, the lattice architecture of which exemplifies reaction conditions under which conformational variants and solvent-associated lattice-imposed complexes are assembled. Transformations between complex species denote their association with reactivity pathways, suggesting alternate synthetic methodologies for their isolation. Theor. work (Hirshfeld, Electrostatic Potential, DFT) signifies the impact of crystal structure on energy profiles of the generated species. The arisen physicochem. profiles of all compounds portray a well-configured interwoven network of pathways, projecting strong connection between structural speciation and Ni(II) reactivity patterns in organic-solvent media. The collective results provide well-defined parameterized profiles, poised to influence the synthesis of new Ni(II)-iminodialc. materials with specified structural-magneto-optical properties.

In some applications, this compound(66-71-7)Reference of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Tuning the coordination environment of single-atom catalyst M-N-C towards selective hydrogenation of functionalized nitroarenes. Author is Zhou, Dan; Zhang, Leilei; Liu, Xiaoyan; Qi, Haifeng; Liu, Qinggang; Yang, Ji; Su, Yang; Ma, Jingyuan; Yin, Jianzhong; Wang, Aiqin.

Fine-tuning of the coordination environment of single-atom catalysts (SACs) is effective to optimize their catalytic performances, yet it remains challenging due to the vulnerability of SACs. Herein, we report a new approach to engineering the coordination environment of M-N-C (M = Fe, Co, and Ni) SACs by using glutamic acid as the N/C source and pyrolysis atm. as a regulator. Compared with that in N2, NH3 was able to promote the doping of N at T < 700°C yet etch the N-species at higher temperatures, by which the M-N coordination number (CN) and the electronic structure were delicately tuned. It was found that the electron d. of Ni single atoms increased with the decrease of Ni-N CN. As a consequence, the capability of Ni-N-C to dissociate H2 was greatly enhanced and a higher catalytic activity in chemoselective hydrogenation of functionalized nitroarenes was achieved. Moreover, this modulation method could be applied to other transition metals including Fe and Co. In particular, the as-synthesized Co-N-C SAC afforded a turnover frequency of 152.3 h-1 with 99% selectivity to 3-vinylaniline in the hydrogenation of 3-nitrostyrene, which was the highest ever reported thus far and was at least one order of magnitude more active than state-of-the-art noble-metal-free M-N-C catalysts, demonstrating the great potential of engineering the coordination environment of SACs. In some applications, this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives.

An efficient “”green”” method for facile and rapid N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones by acyl chlorides using solid sodium hydroxide in a solvent mixture of acetone/water is reported. was found to catalyze N-acylation N-acyl derivatives This method was applied to the synthesis of a series of 132 compounds I (R1 = H, O2N, Br, etc.; R2 = Me, Et, Ph, etc.; X = O, S) in excellent yields.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Base catalysis in the Willgerodt-Kindler reaction, the main research direction is Willgerodt Kindler reaction triethylamine solvent; methoxyacetophenone Willgerodt Kindler reaction triethylamine solvent; benzoxazolone acetyl Willgerodt Kindler reaction triethylamine solvent.Category: piperazines.

Yields in Willgerodt-Kindler reactions, e.g., of 4′-methoxyacetophenone with S8 and morpholine or of 6-acetyl-2(3H)-benzoxazolone with S8 and morpholine, piperidine, and piperazines, are improved when Et3N is used as the solvent.

In some applications, this compound(54903-09-2)Category: piperazines is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Preparation, spectroscopic characterization and antitumor-antimicrobial studies of some Schiff base transition and inner transition mixed ligand complexes. Author is Khalil, Eman A. M.; Mohamed, Gehad G..

Mixed ligand complexes of Mn(II), Ni(II), Zn(II), La(III), Er(III) and Yb(III) metal ions were prepared from bidentate Schiff base ligand (L) as a primary ligand, derived from condensation of benzophenone and 1,8-naphthylenediamine, and 1,10-phenanthroline (Phen) as a secondary ligand. The new Schiff base ligand (N1-(diphenylmethylene)naphthalene-1,8-diamine) and its mixed ligand complexes were characterized by using elemental microanal., conductometric measurements, magnetic susceptibility and spectroscopic studies (UV-Vis, mass spectral anal., IR, 1H NMR and SEM). In addition, their thermal anal. (TG and DTG) behavior has been reported. Measurements of the molar conductivity of the complexes in DMF solvent pointed out the electrolytic nature of all complexes except Mn(II) and Zn(II) complexes were non electrolytes. According to the elemental analyses data, it was observed that the mixed ligand chelates had the general formulas [M(L)(Phen)Cl2]Cl.2H2O (M = La(III), Er(III) and Yb(III)), [M(L)(Phen)Cl2].H2O (M = Mn(II) and Zn(II)) and [Ni(L)(Phen)Cl(H2O)]Cl.H2O. Based on these findings, all mixed ligand complexes had octahedral geometry. The SEM image of the Schiff base ligand illustrated its rods like morphol. with and average particle size of 77 nm while, the image of Ni(II) complex showed non-uniform platelets structure with some scattered rods with an average particle size of 54 nm. Considerable applications were done to ensure the biol. significance of Schiff base ligand and its new mixed ligand complexes with Phen against Gram-neg. bacteria (Escherichia coli), Gram-pos. bacteria (Bacillus subtilis) and fungal (Aspergillus flavus and Candida albicans) strains and anti-cancer activities against (MCF7 breast cancer cell line). The results obtained revealed that the complexes exhibited promising biol. and anticancer activity. Moreover, mol. docking studies were applied to determine the probable binding mode among the Schiff base ligand and the active site of the crystal structure of E. coli YcbB acylated with meropenem (PDB ID: 6NTW) and breast cancer estrogen mutant L536S (PDB ID: 6SBO) receptors.

In some applications, this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Enantiomeric separation of β-amino alcohols with a primary or tertiary amine moiety by reversed phase liquid chromatography with a chiral mobile phase containing copper(II) and (R)-mandelic acid, the main research direction is amino alc enantiomer separation liquid chromatog; copper mobile phase amino alc enantiomer; mandelic acid mobile phase aminoalc enantiomer.Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol.

Enantiomeric separation of β-amino alcs. with a primary or tertiary amine moiety was carried out on ODS column with aqueous mobile phase containing Cu(II) and (R)-mandelic acid. The analyte was detected by post-column chemiluminescence using a Ru(III) complex solution prepared from Ru(II) complex by photochem. oxidation The results were satisfactory.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about p-Hydroxymethadone: synthesis, crystal structure and CD properties.Name: (S)-1-(Dimethylamino)propan-2-ol.

Alkylation of 2-chloro-N,N-dimethylpropylamine with the Li salt derived from 2-(p-methoxyphenyl)-2-phenylacetonitrile gave a mixture of p-methoxymethadone nitrile (I) and p-methoxyisomethadone nitrile. The nitriles were separated chromatog. and the aminonitrile (I) was converted subsequently into the diastereomeric p-hydroxymethadone (II) hydrochlorides. Careful recrystallization afforded a separation of the (4RS,6RS)- and (4RS,6SR)-p-hydroxymethadone hydrochlorides. Repetition of the synthesis using (R)-2-chloro-N,N-dimethylpropylamine, derived in 3 steps from (S)-dilactide (III) yielded the (4S,6S)- and (4S,6S)-p-hydroxymethadone hydrochlorides which were also separated by fractional crystallization The absolute configuration of the products was verified by x-ray crystallog. The (4R,6S) salt exhibited a more intense Cotton effect than (S)-methadone hydrochloride while the (4S,6S) salt showed a less intense Cotton effect and less fine structure in the 260-275 nm range.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Asymmetric bioreduction of benzyl acetoacetate to its corresponding alcohol, benzyl (S)-(+)-3-hydroxybutyrate by the yeast Candida schatavii MY 1831, published in 1996-11-25, which mentions a compound: 53562-86-0, mainly applied to benzyl acetoacetate asym reduction hydroxybutyrate Candida, Synthetic Route of C5H10O3.

The screening of 35 microbial strains yielded 13 of them as suitable biocatalysts for the asym. bioreduction of benzyl acetoacetate to its corresponding alc. benzyl (S)-(+)-3-hydroxybutyrate. The production of benzyl (S)-(+)-3-hydroxybutyrate with an elevated optical purity of 93% was achieved when employing the yeast Candida schatavii strain MY 1831.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide, the main research direction is photoacoustic probe imaging nitric oxide.Product Details of 54903-09-2.

Photoacoustic (PA) imaging is an emerging, hybrid imaging modality that uses optical excitation and acoustic detection to enable high resolution at centimeter depths. The development of activatable PA probes can allow for detection of specific stimuli within a variety of live-animal models using this technol. Herein, the authors report the design, development, and evaluation of a series of Acoustogenic Probe(s) for Nitric Oxide (APNO) for the ratiometric, analyte-specific detection of nitric oxide (NO) in vivo. The best probe in this series, APNO-5 (I), responds rapidly to NO to form an N-nitrosylated product that exhibits an absorbance maximum that is 91 nm blue-shifted relative to the probe. This property enables ratiometric PA imaging upon selective irradiation of APNO-5 and the corresponding product. Moreover, APNO-5 displays the requisite photophys. characteristics for in vivo PA imaging (e.g., high absorptivity, low quantum yield) as well as high biocompatibility, stability, and selectivity for NO over a variety of biol. relevant analytes. APNO-5 was successfully applied to the detection of endogenous NO in a murine lipopolysaccharide-induced inflammation model at depths up to 2.5 cm. The authors’ studies show a 1.9-fold increase in PA signal at 680 nm and a 1.3-fold ratiometric turn-on relative to a saline control.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics