Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of l-(2-hydroxyethyl)piperazine (51.7 g, 398 mmol) in DCM (500 mL) was added NEt3 (70.0 mL, 526 mmol) and dicarbonate (80.0 g, 367 mmol). The reaction mixture was stirred overnight at r.t. and then washed with IM aq Na2CO3 solution (2 x 300 mL). The organic phase was dried (MgSO4) and concentrated in vacuo to give tert-bvXy 4-(2-hydroxyethyl)piperazine-l-carboxylate (66.0 g, 72%) as a colourless oil.

103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference：
Patent; BIOVITRUM AB (publ); WO2009/147221; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

General procedure: To a solution of 6-amino-4-anilinoquinazoline or 4-(1-phenylethyl)quinazoline-4,6-diamine (0.23 mmol) in acetonitrile(5 mL), CDI (0.11 g, 0.69 mmol) was added. The reaction mixture was stirred at room temperature for 8 h when lots of solidproduced. To this suspension, the solution of 2-(4-methylpiperazin-1-yl)ethylamine in 5 mL of acetonitrile was added. Then, the mixture was stirred at room temperature for 2 h, refluxed for another 2 h, cooled to room temperature and concentrated under reduced pressure. The residue was added water (20 mL) and the mixture was extracted with dichloromethane (20 mL 3). The organic layer was combined, washed with brine (20 mL), dried(Na2SO4), concentrated under reduced pressure and purified bychromatography on silica gel (dichloromethane/methanol = 15:1,v/v) to give compounds 4a or 4b as yellow powder. 4.1.60. 1-(2-(4-Methylpiperazin-1-yl)ethyl)-3-(4-((3-(trifluoromethyl)phenyl)amino)quinazolin-6-yl)urea (4a)Yield 45.5percent. Mp: 169.8?170.5 C. 1H NMR (DMSO-d6): d 9.96 (s,1H, N-H), 9.03 (s, 1H, N-H), 8.54 (s, 1H, N-H), 8.46 (d, 1H, Ar-H,J = 2.0 Hz), 8.29 (s, 1H, Ar-H), 8.21 (d, 1H, Ar-H, J = 8.0 Hz), 7.83(dd, 1H, Ar-H, J1 = 2.0 Hz, J2 = 8.8 Hz), 7.74 (d, 1H, Ar-H,J = 8.8 Hz), 7.62 (t, 1H, Ar-H, J = 8.0 Hz), 7.44 (d, 1H, Ar-H,J = 7.6 Hz), 6.35 (t, 1H, Ar-H, J = 5.2 Hz), 3.20?3.29 (m, 4H,2 CH2), 2.41?2.49 (m, 8H, 4 N-CH2), 2.27 (s, 3H, N-CH3). 13CNMR (DMSO-d6): d 157.4, 155.6, 152.5, 145.9, 141.0, 139.2, 130.0,129.5, 128.8, 126.7, 124.7 (d, JC?F = 261 Hz), 126.0, 119.8, 118.4,116.2, 109.3, 57.6, 54.7 (2 CH2), 52.4 (2 CH2), 45.5, 36.9. ESIHRMSm/z: calcd for C23H27F3N7O [M+H]+: 474.2229; found:474.2224.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Zuo, Sai-Jie; Zhang, Sai; Mao, Shuai; Xie, Xiao-Xiao; Xiao, Xue; Xin, Min-Hnag; Xuan, Wei; He, Yuan-Yuan; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 179 – 190;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Synthesis of (IS, 2R) and (1R, 2S)-2-(4-chlorophenyl)-l’-(2-(4-isopropylpiperazin-l- yl)ethyl)spiro[cyclopropane-l,3′-indolin]-2′-one; A mixture of (1R, 2S) and (I S, 2R)-2-(2-(4-chlorophenyl)-2′-oxospiro[cyclopropane-l,3′- indoline]-l’-yl)acetaldehyde (0.1 mmol), (l-Isopropyl)piperazine (0.15 mmol) and acetic acid (catalytic amount) in DCM (2 ml) was stirred for 20 minutes at room temperature. The mixture was cooled to 0 °C and NaBH(OAc)3 (2 mmol) was added carefully. The mixture was warmed to room temperature and stirred for 14 hours at room temperature. The mixture was concentrated under reduced pressure and dissolved in DMF. Purification by preparative HPLC gave the title product as colorless oil (35 mg). LC/MS m/e calcd. for C25H3oClN30: 423, observed (M+H)+: 424.1 1HNMR(400 MHz, MeOD-d4) 5ppm 1.37 (d, J=6.57 Hz, 6 H) 2.18 (dd, J=8.46, 5.94 Hz, 2 H) 2.46 – 2.64 (m, 1H) 2.85 (d, J=3.54 Hz, 2 H) 3.22 (s, 2 H) 3.50 (d, J=6.57 Hz, 2 H) 3.90 – 4.27 (m, 2 H) 6.09 (d, J=7.58 Hz, 1H) 6.76 (s, 1 H) 7.10 (d, J=7.83 Hz, 1 H) 7.16 – 7.25 (m, 3 H) 7.33 (d, J=8.59 Hz, 2 H).

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HUANG, Mengwei; FENG, Lichun; HE, Yun; YUN, Hongying; WO2011/69298; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,13889-98-0

(0452) 1-(Piperazin-1-yl)ethan-1-one (2.56 g, 20 mmol) and 4-fluoro-2-methoxy-1-nitrobenzene (3.42 g, 20 mmol) were dissolved in N,N-dimethylformamide (30 mL), and potassium carbonate (5.52 g, 40 mmol) was added. The reaction was carried out at 70 C. for 16 h. The reaction solution was cooled to room temperature, and poured into water (150 mL). The mixture was extracted with ethyl acetate (150 mL×4), and the water phase and the organic phase was separated. The organic phases were combined, washed with saturated saline solution, dried with anhydrous sodium sulfate, and concentrated. The crude product was purified by silica gel column chromatography (ethyl acetate: petroleum ether=1:10-2:1) to get the title compound as a light yellow solid (4.8 g, yield: 86.0%).

The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; (117 pag.)US2017/112833; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 4 (100 mg, 0.23 mmol) in acetonitrile (CH3CN, 10 mL) was added the corresponding arylpiperazines (1.2 equiv) and potassium carbonate (6.0 equiv). The reaction mixture was stirred at reflux for 16 h. After cooling to ambient temperature, the reaction mixture was filtered through a Buchner funnel. After filtration the filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:4, v/v) as eluent to afford the corresponding products, and all compounds were recrystallized from trichloromethane and n-hexane., 115761-79-0

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Xu, Fang; Chen, Hong; Xu, Jingyi; Liang, Xue; He, Xuelan; Shao, Binhao; Sun, Xianqiang; Li, Bing; Deng, Xiaoliang; Yuan, Mu; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7735 – 7742;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

A mixture of 97 (0.30 g, 0.88 mmol), EDC.HCl (0.25 g, 1.32 mmol), HOBt (0.14 g, 1.06 mmol), NMM (0.23 ml, 2.11 mmol) and DMF (2.5 ml) was stirred for a while, to which was then added 2-(4-methylpiperazin-1-yl)ethylamine (0.16 ml, 1.06 mmol) at room temperature and stirred overnight. The residue was purified by flash column over silica gel (dichloromethane: methanol = 9:1, Rf = 0.19) to afford 49 (0.08 g, 19.47 percent) as a red solid. 1H-NMR (300 MHz, DMSO-d6): delta 2.13 (s, 3H), 2.36-2.42 (br, 12H), 4.91 (d, J= 6.3 Hz, 2H), 7.29 (d, J= 7.8 Hz, 2H), 7.67-7.77 (m, 4H), 7.88 (d, J= 6.9 Hz, 2H), 7.98 (br, 1H), 8.25 (br, 1H)., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (44 pag.)WO2017/20030; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27561-62-2, Cyclohexyl(piperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of compound 3 (1g, 4.6mmol) and 95% ethanol (30ml) was added to morpholine (0.4g, 4.6mmol).The mixture was stirred at room temperature for 30min, then warmed up to 60C. After the starting 3 was completely consumed (the reaction courses was monitored by TLC), evaporation of the ethanol, the crude yellow compound 4j was obtained and purified by preparative thin-layer chromatography over silica gel PF 254 (2mm, ethyl acetate: petroleum ether=1:1). Yield: 78%.

27561-62-2, 27561-62-2 Cyclohexyl(piperazin-1-yl)methanone 3437502, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Xu, Feng; Yang, Zhen-Zhen; Jiang, Jun-Rong; Pan, Wan-Gui; Yang, Xiao-Le; Wu, Jian-Yong; Zhu, Yan; Wang, John; Shou, Qi-Yang; Wu, Han-Gui; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 3042 – 3047;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 211 N-{[1,6-Diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-N’-[(3′-{[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl}-6-fluoro-3-biphenylyl)methyl]-2,6-pyridinedicarboxamide N-{[1,6-Diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-N’-[(6-fluoro-3′-formyl-3-biphenylyl)methyl]-2,6-pyridinedicarboxamide (0.059 mmol) was diluted in DMSO (1.5 mL) and dispensed into a 1 dram vial containing (2R,6S)-2,6-dimethylpiperazine (0.177 mmol, 3.0 eq) and acetic acid (3.55 mg, 0.059 mmol) and fitted a magnetic stir bar. The resulting solution was stirred at room temperature for 4 h. MP-B(OAc)3H (0.591 mmol, 138 mg, 10.0 eq) was added and the solution was stirred for another 12 h. The polymer reagent was filtered. Purification was completed via a Gilson HPLC (acidic conditions). The product was dissolved in 3 mL of MeOH and passed through 0.5 g amine columns (washed with 8 mL of MeOH) to afford 29.9 mg of the title compound (66.5percent). LC-MS m/z 763 (M+H)+, 1.31 min (ret time).

21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5271-27-2, To a 1000 ml three-necked flask, 600 ml of N, N-dimethylformamide and 2-chloronicotinamide (153 g, 0.98 mol) were added.1-methyl-3-phenylpiperazine (172 g, 0.98 mol) and potassium fluoride (114 g, 1.96 mol) were added and the mixture was heated to 140 ° C and stirred for 16 hours. The crude product was added to 1000 ml of ice water, stirred for 1 hour, Isolated by filtration to give a white solid. The white solid was further dried by blowing with air at 50 ° C to give 261 g of 2-(4-methyl-2-phenyl-1-piperazinyl)nicotinamide as a white solid in a yield of 90percent.

The synthetic route of 5271-27-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Liu Jinai; Li Yuanzhen; Ning Ruibo; Wang Mingxin; (8 pag.)CN105367571; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

5308-25-8, 2-Chloro-5-nitropyridine (800 mg, 5.05 mmol) was dissolved in dioxane (20 mL) and then 1-ethylpiperazine (1.7 g, 15.15 mmol) and N,N-diisopropylethylamine (927 mL, 5.05 mmol) were added. The reaction mixture solution was stirred at 70 C for a day. The reaction solution was cooled to room temperature, diluted with ethyl acetate, and then washed with brine. The organic layer was concentrated by drying with magnesium sulfate. The target compound (1.05 g, 87% yield) was used in the following reaction without purification.MS m/z: 237.51 [M+1].

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; HAH, Jung Mi; CHOI, Hwan Geun; HAM, Young Jin; LEE, Jung Hun; PARK, Dong Sik; KIM, Hwan; WO2011/62372; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics