Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Phenanthroline-based Ni(II) coordination compounds involving unconventional discrete fumarate-water-nitrate clusters and energetically significant cooperative ternary π-stacked assemblies: Antiproliferative evaluation and theoretical studies.Name: 1,10-Phenanthroline.

Two new Ni(II) coordination complexes involving fumarate and 1,10-phenanthroline viz.; [Ni2(phen)2(μ-fum)(H2O)6](fum)·6H2O (1) and [Ni(phen)2(H2O)2](0.5 fum)(NO3)·4H2O (2) (fum = fumarate, phen = 1,10-phenanthroline) were isolated in aqueous medium at room temperature Crystal structure analyses of the compounds reveal cooperative (π-π)2/(π-π)1/(π-π)2 stacked ternary assemblies which provide stabilities to the layered architectures. The lattice water and the large counteranions in the lattice of the compounds are involved in the formation of unconventional discrete cyclic fumarate-water, fumarate-water-nitrate clusters and infinite nitrate-water 1D chains that are very scarcely reported in the literature. The energetically significant π-stacked dimers observed in the biol. relevant ternary assemblies of the crystal structures were further studied theor. using DFT calculations and NCI plot index computational tools. DFT calculations reveal that the cooperative (π-π)2 binding mode of 1 is energetically more significant than (π-π)1 Moreover, the study also reveals that for the equivalent cooperative (π-π)1 stacking interactions in both the structures, the energy is unexpectedly higher for 2 than that observed for 1. Both the compounds induce significant cytotoxicity in Da’s lymphoma (DL) cancer cells by inducing apoptotic cell death with negligible cytotoxicity in normal cells. Decrease in the mitochondrial membrane potential (MMP) of DL cells after treatment with the compounds also corroborates the apoptotic cell death. The mol. docking and pharmacophore features reveal that the compounds interact and accommodated well with the active sites of anti-apoptotic proteins.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Seebach, Dieter; Zueger, Max researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Quality Control of (S)-Methyl 3-hydroxybutanoate.They published the article 《Depolymerization of poly[(R)-3-hydroxy-butanoate](PHB)》 about this compound( cas:53562-86-0 ) in Helvetica Chimica Acta. Keywords: depolymerization poly hydroxybutanoate; alkyl hydroxybutanoate enantiomeric. We’ll tell you more about this compound (cas:53562-86-0).

Enantiomerically pure Me, Et, Bu, or 2-methoxyethyl (R)-3-hydroxybutanoates were prepared in 75-90% yields by depolymerization of the title compound, or materials containing it, at 80-160° in MeOH, EtOH, BuOH, or MeOCH2CH2OH with or without cosolvent (ClCH2)2 in the presence of either H2SO4 or (EtO)4Ti catalyst. (S)-3-Hydroxybutanoates were also obtained by yeast reduction of acetoacetates; thus 3-hydroxybutyric acid derivatives are among those useful synthons available in both enantiomeric forms.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Frelek, Jadwiga; Klimek, Agata; Ruskowska, Patrycja published an article about the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2,SMILESS:C[C@H](O)CN(C)C ).Quality Control of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53636-17-2) through the article.

A straightforward and versatile method for the determination of the absolute configuration of vic-amino alcs. is proposed. The proposed method involves the in situ formation of chiral complexes of optically active ephedrine- or adrenaline-type vic-amino alcs. with the achiral dimolybdenum tetraacetate [Mo2(OAc)4] acting as an auxiliary chromophore. The resulting CD spectra are suitable for the assignment of absolute configuration, since the observed sign of Cotton effects arising within the d-d absorption bands for the metal cluster depends solely upon the chirality of the amino alc. ligand. An empirically based rule correlating a pos./neg. helicity expressed by the O-C-C-N torsional angle with the sign of Cotton effects occurring in the 400-260 nm spectral range has been formulated.

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Piperazine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called First total synthesis of macrosphelides C and F, published in 2001-04-09, which mentions a compound: 53562-86-0, Name is (S)-Methyl 3-hydroxybutanoate, Molecular C5H10O3, Category: piperazines.

Macrosphelides C and F were synthesized by lactonization of 14-oxo seco acids at the O(10)-C(11) bond followed by reduction and Mitsunobu inversion of the resulting hydroxyl group. The seco acids were prepared from the corresponding furans by furan ring-opening with NBS followed by further oxidation of the 4-oxo-2-alkenals with NaClO2.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Concise Asymmetric Syntheses of Radicicol and Monocillin I》. Authors are Garbaccio, Robert M.; Stachel, Shawn J.; Baeschlin, Daniel K.; Danishefsky, Samuel J..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Safety of (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

Radicicol (I) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the mol. chaperone Hsp90. Recently, we reported the results of a synthetic program targeting I and monocillin I (II), highlighted by the application of ring-closing metathesis to macrolide formation. These efforts resulted in a highly convergent synthesis of radicicol di-Me ether but failed in the removal of the two aryl Me ethers. Simple exchange of these Me ethers with more labile functionalities disabled a key esterification in the initial route. Through extended experimentation, a successful route to both natural products was secured, along with some intriguing results that emphasize the implications of this design on a broad range of fused benzoaliph. targets, including analogs of these natural products.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 53562-86-0, is researched, SMILESS is C[C@H](O)CC(OC)=O, Molecular C5H10O3Journal, Chemistry – A European Journal called Chiral 1,2-bis(phosphetano)benzenes: preparation and use in the Ru-catalyzed hydrogenations of carbonyl derivatives, Author is Marinetti, Angela; Genet, Jean-Pierre; Jus, Sebastien; Blanc, Delphine; Ratovelomanana-Vidal, Virginie, the main research direction is phosphetanobenzene preparation chiral ligand stereoselective hydrogenation carbonyl; alc stereoselective preparation phosphetanobenzene chiral ligand.COA of Formula: C5H10O3.

Chiral 1,2-bis(phosphetano)benzenes are readily prepared from accessible, optically pure 1,3-diol cyclic sulfates. Their ruthenium complexes catalyze the enantioselective hydrogenations of functionalized carbonyls with moderate-to-high enantiomeric excesses. High levels of diastereo- and enantioselectivity are achieved, especially in the hydrogenation of β-diketones to the corresponding anti-1,3-diols.

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Piperazine – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ) is researched.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.Meyers, Marvin J.; Arhancet, Graciela B.; Hockerman, Susan L.; Chen, Xiangyang; Long, Scott A.; Mahoney, Matthew W.; Rico, Joseph R.; Garland, Danny J.; Blinn, James. R.; Collins, Joe T.; Yang, Shengtian; Huang, Horng-Chih; McGee, Kevin F.; Wendling, Jay M.; Dietz, Jessica D.; Payne, Maria A.; Homer, Bruce L.; Heron, Marcia I.; Reitz, David B.; Hu, Xiao published the article 《Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy》 about this compound( cas:54903-09-2 ) in Journal of Medicinal Chemistry. Keywords: mineralocorticoid receptor antagonist benzoindazole derivative hypertension nephropathy. Let’s learn more about this compound (cas:54903-09-2).

We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogs were poorly soluble and had a propensity to inhibit the hERG channel. Remarkably, both of these challenges were overcome by incorporation of a single carboxylate moiety. Structural modification of carboxylate-containing lead R-4g with a wide range of substituents at each position of the pyrazoline ring resulted in R-12o, which shows excellent activity against MR and reasonable pharmacokinetic profile. Introduction of conformational restriction led to a novel series characterized by exquisite potency and favorable steroid receptor selectivity and pharmacokinetic profile. Oral dosing of 3S,3aR-27d (PF-3882845) in the Dahl salt sensitive preclin. model of salt-induced hypertension and nephropathy showed blood pressure attenuation significantly greater than that with eplerenone, reduction in urinary albumin, and renal protection. As a result of these findings, 3S,3aR-27d was advanced to clin. studies.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Asymmetric Hydrogenation of Amino Ketones Using Chiral RuCl2(diphosphine)(1,2-diamine) Complexes.Product Details of 53636-17-2.

Chiral RuCl2(diphosphine)(1,2-diamine) complexes catalyzed the asym. hydrogenation of amino ketones. E.g., hydrogenation of MeCOCH2NMe2 in presence of trans-RuCl2[(R)-xylbinap][(R)-daipen] gave 79% (S)-MeCH(OH)CH2NMe2. Also prepared by this catalytic hydrogenation system were (R)-denopamine, (R)-fluoxetine, and BMS 181100.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Product Details of 53636-17-2. The article 《Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Optimization of P1 and N-aryl》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:2343-22-8).

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.

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Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Zinc(II) complexes of 3,5-dibromo-salicylaldehyde and α-diimines: Synthesis, characterization and in vitro and in silico biological profile. Author is Zianna, Ariadni; Geromichalou, Elena; Geromichalos, George; Fiotaki, Augusta-Maria; Hatzidimitriou, Antonios G.; Kalogiannis, Stavros; Psomas, George.

The synthesis of five neutral zinc(II) complexes of 3,5-dibromo-salicyladehyde (3,5-diBr-saloH) in the presence of nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (neoc), or 2,2′-bipyridylamine (bipyam) was undertaken and complexes [Zn(3,5-diBr-salo)2(H2O)2] (1), [Zn(3,5-diBr-salo)2(bipy)] (2), [Zn(3,5-diBr-salo)2(phen)].3,5-diBr-saloH (3), [Zn(3,5-diBr-salo)2(neoc)] (4) and [Zn(3,5-diBr-salo)2(bipyam)] (5) were characterized by various techniques. The crystal structures of complexes 3 and 5 were determined by x-ray crystallog., revealing the coexistence of two different coordination modes of 3,5-diBr-salo- ligands. The new complexes show selective in vitro antibacterial activity against two Gram-pos. and two Gram-neg. bacterial strains. The complexes may scavenge 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals and reduce H2O2. The complexes may intercalate in-between the calf-thymus DNA-bases and have exhibited low-to-moderate ability to cleave supercoiled circular pBR322 plasmid DNA. The complexes may bind tightly and reversibly to bovine and human serum albumins. In order to explain the in vitro activity of the compounds, mol. docking studies were adopted on the crystal structure of calf-thymus DNA, human and bovine serum albumin, Escherichia coli and Staphylococcus aureus DNA-gyrase, 5-lipoxygenase, and 5-lipoxygenase activating protein. The employed in silico studies aimed to explore the ability of the compounds to bind to these target biomacromols., establishing a possible mechanism of action and were in accordance with the in vitro studies.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics