Tag: 630125-91-6

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,630125-91-6

General procedure: To a solution of 76 45 (30mg, 0.07mmol) in 77 DMF (5mL) were added 78 methylamine hydrochloride (5.4mg, 0.08mmol), 79 HATU (41.8mg, 0.11mmol) and DIEPA (18.1mg, 0.14mmol). The resulting mixture was stirred at room temperature for 2h. Then it was diluted with EtOAc (50mL), washed with water (100mL¡Á3) and brine (100mL). The organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was diluted with DCM (1mL) and CF3COOH (0.5mL). The reaction mixture was stirred at room temperature for 4h and then the pH value was adjusted to 12 with saturated sodium bicarbonate. The mixture was extracted by 80 EtOAc (50mL) and washed with water (50mL¡Á2) followed by brine (50mL). The organic layers were dried over sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (eluting with 0-5% MeOH in 81 DCM) to afford 82 9 (12.9mg, 52%) as a yellow solid.

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Article; Liu, Xuesong; Wang, Beilei; Chen, Cheng; Jiang, Zongru; Hu, Chen; Wu, Hong; Zhang, Yicong; Liu, Xiaochuan; Wang, Wenliang; Wang, Junjie; Hu, Zhenquan; Wang, Aoli; Huang, Tao; Liu, Qingwang; Wang, Wei; Wang, Li; Wang, Wenchao; Ren, Tao; Li, Lili; Xia, Ruixiang; Ge, Jian; Liu, Qingsong; Liu, Jing; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 61 – 81;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

A mixture of 4-((4-ethylpiperazin- 1 -yl)methyl)-3-(trifluoromethyl)aniline (Intermediate Cl)(500 g, 1.74 mmol) and methyl 3-hydroxybenzoate (Intermediate B2) (317 mg, 1.91 mmol)in anhydrous THF (5.0 mL) was cooled to -20 C and added potassium tert-butoxide (1M, 10 mL, 10.44 mmol). The mixture was stirred at RT for 3 h. The reaction mixture was cooled to-20 C and quenched with saturated sodium bicarbonate solution. The aqueous mixture was extracted twice with ethyl acetate and the combined organic layers were washed with waterfollowed by brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to yield 220 mg of the desired product. ?H NMR (400 MHz, DMSO-d6) oe 0.98 (t, J = 6.8 Hz, 3H), 2.31-2.50 (m, 8H), 2.51 (br s, 2H), 3.56 (s, 2H), 6.98-7.01 (br d, 1H), 7.3 1-7.35 (m, 2H), 7.39 (d, J = 6.4 Hz, 1H), 7.69 (d, J = 8.8 Hz, 1H), 8.03 (d, J = 8.4 Hz, 1H), 8.21 (s, 1H), 9.79 (s, 1H), 10.42 (s, 1H); ESI-MS (m/z) 408 (M+H).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; PATEL, Vinod; REDDY, Venkateshwar; GHARAT, Laxmikant Atmaram; CHAUDHARI, Sachin Sundarlal; DAS, Sanjib; VELGALETI, Ranganadh; SHAH, Daisy Manish; BAJPAI, Malini; (262 pag.)WO2018/215668; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics