Tag: 34770-60-0

34770-60-0, 4-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Palladium(ll) acetate (0.020 g, 0.090 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.078 g, 0.135 mmol), 4-methylpiperazin-2-one (0.061 g, 0.540 mmol), cesium carbonate (0.440 g, 1 .350 mmol) and the title compound from Preparative Example 6 (0.120 g, 0.450 mmol) were added to a reaction vial followed by degassed 1 ,4-dioxane (5 ml). The vial was filled with argon gas and sealed and heated at 120 C for 45 minutes. The reaction mixture was cooled to room temperature and the residue was taken up with dichloromethane (40 mL) and water (50 mL), the phases were separated and the aqueous phase was extracted again with dichloromethane (50 mL). The organics were combined, dried over Na2S04 and the crude product was purified on a HP-Sil column (biotage) by employing a dichloromethane/methanol gradient (100/0 -> 90/10) to afford the title compound (83 mg, 54%). MS (ESI); m/z = 345.12 [M+H]+ 1H-NMR (400 MHz, CDCI3) d 9.53 (s, 1 H), 9.04 (d, 1 H), 8.73 (ddd, 1 H), 7.49 (dd, 1 H), 3.98 – 3.83 (m, 2H), 3.22 (s, 2H), 2.87 – 2.66 (m, 2H), 2.33 (s, 3H).

As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.

Reference£º
Patent; AC IMMUNE SA; MOLETTE, Jerome; (0 pag.)WO2019/234243; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

To a solution of 4-methyl-2-piperazinone (26.16 mg, 0.23 mmol) in N,N-dimethylformamide (3mL) was added sodium hydride (18.34 mg, 60% purity, 0.46 mmol) at 0 C. The reaction was stirred for 20 minutes at 0 C. 2-[[8-Chloro-6-(chloromethyl)-7-fluoro-3-isoquinolyl]amino]-6-isopropyl-5,8-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7-one (50 mg, 0.11 mmol) was added and stirred at 25 C. for 1 hour. The reaction was quenched with water, extracted with ethyl acetate, dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum. The residue was purified by reverse phase chromatography ( acetonitrile 0-40/0.1% sodium bicarbonate in water) to afford 2-[[8-chloro-7-fluoro-6-[(4-methyl-2-oxo-piperazin-1-yl)methyl]-3-isoquinolyl]amino]-6-isopropyl-5,8-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7-one (9 mg, 0.018 mmol) as a yellow solid. LCMS (ESI) [M+H]+=514.

As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics