Tag: 300-400

Renau, Thomas E.’s team published research in Antimicrobial Agents and Chemotherapy in 1996 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

SDS of cas: 182868-72-0On October 31, 1996 ,《Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position》 appeared in Antimicrobial Agents and Chemotherapy. The author of the article were Renau, Thomas E.; Gage, Jeffrey W.; Dever, Julie A.; Roland, Gregory E.; Joannides, E. Themis; Shapiro, Martin A.; Sanchez, Joseph P.; Gracheck, Stephen J.; Domagala, John M.. The article conveys some information:

A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relation between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedures described in the literature and were evaluated for their activities against Mycobacterium fortuitum and Mycobacterium smegmatis. The activities of the compounds against these two organisms were used as a measure of Mycobacterium tuberculosis activity. The results demonstrate that the contribution of the 8 position to antimycobacterial activity was dependent on the substituent at N-1 and was in the order (i) COMe ≈ CBr > CCl > CH ≈ CF ≈ COEt > N > CCF3 when N-1 was cyclopropyl; (ii) N ≈ CH > CF > COMe when N-1 was 2,4-difluorophenyl; (iii) N ≥ CH when N-1 was tert-butyl; and (i.v.) N > CH when N-1 was Et. In general, derivatives with piperazine substitutions at C-7 were slightly less active against mycobacteria than the analogs with pyrrolidine substitutions, regardless of the pattern of substitution at the 8 position. Several of the best compounds were evaluated for their potential side effects as well as their activities against Mycobacterium aurum, Mycobacterium avium-M. Intracellularle, and M. tuberculosis. These agents exhibited biol. profiles similar to or better than those of the pos. controls ciprofloxacin and sparfloxacin. In addition to this study using 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, there are many other studies that have used 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhang, Dou-Sheng’s team published research in Journal of Planar Chromatography–Modern TLC in 2013 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 182868-72-0

Zhang, Dou-Sheng; Liu, Wen; Li, Ya-Ping; Hu, Chang-Qin published an article in Journal of Planar Chromatography–Modern TLC. The title of the article was 《Establishment and optimization of an HPTLC method for the analysis of gatifloxacin and related substances by design of experiment》.Related Products of 182868-72-0 The author mentioned the following in the article:

The objective of this study was to establish and optimize high-performance thin-layer chromatog. (HPTLC) anal. of gatifloxacin and related substances by the method of design of experiment (DOE). First, preliminary screening of 22 solvents was performed using uniform design (UD) to establish the developing solvent proposed to be optimized. The optimal proportions of components in the developing solvent were established by central composite design (CCD) to establish and validate HPTLC anal. of gatifloxacin and related substances. Using DOE, it was found that the optimal proportions (by volume) of components in the developing solvent in the HPTLC anal. method were methanol-1,2-dichloroethane-concentrated ammonia solution-acetonitrile (2.8:7.2:0.5:0.5, ν/ν). Methodol. validation showed that the established HPTLC method could sep. gatifloxacin and 8 related substances with similar structures effectively. In particular, impurity pairs with the greatest separation difficulty (due to their similar polarities and dipole moments), e.g., impurity #3 (8-fluorogatifloxacin) and impurity #8 (gatifloxacin 2-methylpiperazine), impurity #3, and substance #9 (gatifloxacin), could also be separated effectively. The HPTLC method was simple, accurate, reliable, and suitable for rapid qual. anal. of gatifloxacin and related substances in routine tests. Addnl., the anal. results presented here may provide useful supplemental information on the current reversed phase high-performance liquid chromatog. (RP-HPLC) method, especially in terms of the mechanism of normal-phase separation In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0Related Products of 182868-72-0)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Renau, Thomas E.’s team published research in Antimicrobial Agents and Chemotherapy in 1996 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

SDS of cas: 182868-72-0On October 31, 1996 ,《Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position》 appeared in Antimicrobial Agents and Chemotherapy. The author of the article were Renau, Thomas E.; Gage, Jeffrey W.; Dever, Julie A.; Roland, Gregory E.; Joannides, E. Themis; Shapiro, Martin A.; Sanchez, Joseph P.; Gracheck, Stephen J.; Domagala, John M.. The article conveys some information:

A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relation between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedures described in the literature and were evaluated for their activities against Mycobacterium fortuitum and Mycobacterium smegmatis. The activities of the compounds against these two organisms were used as a measure of Mycobacterium tuberculosis activity. The results demonstrate that the contribution of the 8 position to antimycobacterial activity was dependent on the substituent at N-1 and was in the order (i) COMe ≈ CBr > CCl > CH ≈ CF ≈ COEt > N > CCF3 when N-1 was cyclopropyl; (ii) N ≈ CH > CF > COMe when N-1 was 2,4-difluorophenyl; (iii) N ≥ CH when N-1 was tert-butyl; and (i.v.) N > CH when N-1 was Et. In general, derivatives with piperazine substitutions at C-7 were slightly less active against mycobacteria than the analogs with pyrrolidine substitutions, regardless of the pattern of substitution at the 8 position. Several of the best compounds were evaluated for their potential side effects as well as their activities against Mycobacterium aurum, Mycobacterium avium-M. Intracellularle, and M. tuberculosis. These agents exhibited biol. profiles similar to or better than those of the pos. controls ciprofloxacin and sparfloxacin. In addition to this study using 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, there are many other studies that have used 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0) was used in this study.

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zhang, Dou-Sheng’s team published research in Journal of Planar Chromatography–Modern TLC in 2013 | CAS: 182868-72-0

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Zhang, Dou-Sheng; Liu, Wen; Li, Ya-Ping; Hu, Chang-Qin published an article in Journal of Planar Chromatography–Modern TLC. The title of the article was 《Establishment and optimization of an HPTLC method for the analysis of gatifloxacin and related substances by design of experiment》.SDS of cas: 182868-72-0 The author mentioned the following in the article:

The objective of this study was to establish and optimize high-performance thin-layer chromatog. (HPTLC) anal. of gatifloxacin and related substances by the method of design of experiment (DOE). First, preliminary screening of 22 solvents was performed using uniform design (UD) to establish the developing solvent proposed to be optimized. The optimal proportions of components in the developing solvent were established by central composite design (CCD) to establish and validate HPTLC anal. of gatifloxacin and related substances. Using DOE, it was found that the optimal proportions (by volume) of components in the developing solvent in the HPTLC anal. method were methanol-1,2-dichloroethane-concentrated ammonia solution-acetonitrile (2.8:7.2:0.5:0.5, ν/ν). Methodol. validation showed that the established HPTLC method could sep. gatifloxacin and 8 related substances with similar structures effectively. In particular, impurity pairs with the greatest separation difficulty (due to their similar polarities and dipole moments), e.g., impurity #3 (8-fluorogatifloxacin) and impurity #8 (gatifloxacin 2-methylpiperazine), impurity #3, and substance #9 (gatifloxacin), could also be separated effectively. The HPTLC method was simple, accurate, reliable, and suitable for rapid qual. anal. of gatifloxacin and related substances in routine tests. Addnl., the anal. results presented here may provide useful supplemental information on the current reversed phase high-performance liquid chromatog. (RP-HPLC) method, especially in terms of the mechanism of normal-phase separation In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0SDS of cas: 182868-72-0)

1-Cyclopropyl-8-ethoxy-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(cas: 182868-72-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 182868-72-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics