Tag: 300-400

On June 9, 2022, Banipal, Tarlok S.; Kaur, Sandeep; Beri, Aashima; Banipal, Parampaul K. published an article.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures. And the article contained the following:

The interaction of drugs with nucleic acids is one of the most essential parts of biol. research in the drug discovery and pharmaceutical development processes. Furthermore, physicochem. studies of the solution behavior of such systems are extremely desirable to elucidate the various interactions in aqueous solutions So, in this context, measurements of d. (ρ), speed of sound (u), viscosity (η) and enthalpy of dilution (q) for uracil, thymine, uridine, and thymidine in water and in aqueous solutions of ciprofloxacin hydrochloride monohydrate (Cfx) at mB (molality of Cfx in water) = (5, 10, 15, 20, 25) mmol·kg-1 across the temperature range T = (288.15 to 318.15) K and at p = 1 x 105 Pa were performed. Further, these data were utilized to evaluate partial molar volumes, partial molar isentropic compressions, viscosity B-coefficients, standard molar enthalpy of dilution, and their corresponding transfer parameters (ΔtrV2,Φ0, ΔtrKs,2,Φ0, ΔtrB and ΔtrΔdilH°). These properties were used to elucidate the presence of solute-solvent interactions. The solute-Cfx interactions are exothermic in nature, according to calorimetry studies. Furthermore, the UV-visible studies show that the interactions between the pyrimidine based mols. and drug result in shift in wavelength (λ) as well as change in absorption. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to elucidation interactions ciprofloxacin hydrochloride monohydrate, constituent nucleic acid aqueous solution, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 12, 2019, Beri, Aashima; Kaur, Rupinder; Banipal, Parampaul K.; Banipal, Tarlok S. published an article.Electric Literature of 86393-32-0 The title of the article was Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/L-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15-323.15 K and at Pressure p = 1 × 105 Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies. And the article contained the following:

Like the drug-salt interactions, drug-amino acid interaction in the aqueous medium is dependent upon different physiol. events occurring in the body. In this context, investigations on the interactions of ciprofloxacin hydrochloride (CFX) being a second-generation antibiotic with both nonessential amino acid and essential amino acid have been done. The physicochem. properties like apparent molar volume (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ) of drug, CFX in water and in the presence of glycine (GLY), and L-isoleucine (ILU) at mB (molality of GLY or ILU) = 10, 20, 35, 50, and 75 mmol·kg-1 have been determined over the temperature range of 288.15-323.15 K and at p = 1 × 105 Pa. These data have further been used to calculate different parameters, which help to obtain valuable information corresponding to the distinct kinds of interactions present in the ternary systems. The volumes and compressibility studies have shown that the predominant interactions are hydrophilic-hydrophilic and hydrophilic-ionic in the studied systems. It may be postulated that the effect of CFX prevails through the hydrophilic groups of the constituents of proteins. Dehydration behavior of drug is also observed using hydration number and calorimetry at higher mB values. Both hyperchromic and hypsochromic changes have been observed from the absorption spectra for the CFX/ILU system. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0

The Article related to volumetric calorimetric property ciprofloxacin hydrochloride glycine isoleucine aqueous mixture, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Electric Literature of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On August 24, 2007, Yagneskumar, Trivedi Amit; Pandurang, Gaitonde Shrikant; Anant, Shrikhande Atul; Pravichandra, Mehta Bharat published a patent.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Preparation methodology of piperazinylquinolones as antibacterial agents. And the patent contained the following:

The invention relates to the methodol. of reacting halogenated quinolinones with piperazine derivatives in a chem. system comprising of alkali salts of aromatic acids and a ternary mixture of (alkyl)pyridine, polar solvent represented by hydrophobic alkanols or DMSO, and N,N-dimethylglyoxime or biacetyl. Quinolinones reacted in this way with even equimolar of piperazines, good yields of the products were achieved. Another innovation is achieved by the use of moistured piperazines, including recycling of the unreacted piperazine solution in pyridine with substantial presence of water by adding dialkylsulfosuccinate , which has a surprisingly beneficial effect to the process. Example compound I•HCl•H2O (ciprofloxacin) was prepared by N-arylation of piperazine with 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to piperazinyl quinolone preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 15, 2005, Liu, Yong; Wang, Jingkang; Yin, Qiuxiang published an article.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was The crystal habit of ciprofloxacin hydrochloride monohydrate crystal. And the article contained the following:

Crystals with two different habits (e.g. needle-like and plate-like) of ciprofloxacin hydrochloride monohydrate (CPFX) were prepared from aqueous solution by varied methods. These crystals were identified by various means such as scanning electron microscope (SEM), DSC, TG, and x-ray powder diffraction (XRPD). According to the anal. of crystals by DSC, TG and XRPD, it is concluded that CPFX crystals produced in cooling or dilution crystallization experiment should have the same crystal structure. Using the XRPD data, the unit cell parameters were calculated by software TREOR90. Systematic absence and statistics of reflexion indicate that CPFX crystals in this work have a high possibility of being the space group P21/c. The crystal habit transition was observed in the salting-out crystallization when 0.2M KCl solution works as precipitant. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride hydrate crystal morphol structure, Crystallography and Liquid Crystals: Crystal Morphology (Habit), Orientation, Crystallinity and other aspects.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 9, 2022, Banipal, Tarlok S.; Kaur, Sandeep; Beri, Aashima; Banipal, Parampaul K. published an article.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures. And the article contained the following:

The interaction of drugs with nucleic acids is one of the most essential parts of biol. research in the drug discovery and pharmaceutical development processes. Furthermore, physicochem. studies of the solution behavior of such systems are extremely desirable to elucidate the various interactions in aqueous solutions So, in this context, measurements of d. (ρ), speed of sound (u), viscosity (η) and enthalpy of dilution (q) for uracil, thymine, uridine, and thymidine in water and in aqueous solutions of ciprofloxacin hydrochloride monohydrate (Cfx) at mB (molality of Cfx in water) = (5, 10, 15, 20, 25) mmol·kg-1 across the temperature range T = (288.15 to 318.15) K and at p = 1 x 105 Pa were performed. Further, these data were utilized to evaluate partial molar volumes, partial molar isentropic compressions, viscosity B-coefficients, standard molar enthalpy of dilution, and their corresponding transfer parameters (ΔtrV2,Φ0, ΔtrKs,2,Φ0, ΔtrB and ΔtrΔdilH°). These properties were used to elucidate the presence of solute-solvent interactions. The solute-Cfx interactions are exothermic in nature, according to calorimetry studies. Furthermore, the UV-visible studies show that the interactions between the pyrimidine based mols. and drug result in shift in wavelength (λ) as well as change in absorption. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to elucidation interactions ciprofloxacin hydrochloride monohydrate, constituent nucleic acid aqueous solution, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 12, 2019, Beri, Aashima; Kaur, Rupinder; Banipal, Parampaul K.; Banipal, Tarlok S. published an article.Electric Literature of 86393-32-0 The title of the article was Expliciting the {Ciprofloxacin Hydrochloride + (Glycine/L-Isoleucine)} Interactions in Aqueous Solution over the Temperature range T = 288.15-323.15 K and at Pressure p = 1 × 105 Pa: Volumetric, Acoustic, Calorimetric, and Absorption studies. And the article contained the following:

Like the drug-salt interactions, drug-amino acid interaction in the aqueous medium is dependent upon different physiol. events occurring in the body. In this context, investigations on the interactions of ciprofloxacin hydrochloride (CFX) being a second-generation antibiotic with both nonessential amino acid and essential amino acid have been done. The physicochem. properties like apparent molar volume (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ) of drug, CFX in water and in the presence of glycine (GLY), and L-isoleucine (ILU) at mB (molality of GLY or ILU) = 10, 20, 35, 50, and 75 mmol·kg-1 have been determined over the temperature range of 288.15-323.15 K and at p = 1 × 105 Pa. These data have further been used to calculate different parameters, which help to obtain valuable information corresponding to the distinct kinds of interactions present in the ternary systems. The volumes and compressibility studies have shown that the predominant interactions are hydrophilic-hydrophilic and hydrophilic-ionic in the studied systems. It may be postulated that the effect of CFX prevails through the hydrophilic groups of the constituents of proteins. Dehydration behavior of drug is also observed using hydration number and calorimetry at higher mB values. Both hyperchromic and hypsochromic changes have been observed from the absorption spectra for the CFX/ILU system. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0

The Article related to volumetric calorimetric property ciprofloxacin hydrochloride glycine isoleucine aqueous mixture, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Electric Literature of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cao, Ling-feng; Zhang, Yong-tang; Zhang, Jing-zheng published an article in 2011, the title of the article was Improved process of the piperazine condensation for preparation of ciprofloxacin hydrochloride.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate And the article contains the following content:

Ciprofloxacin hydrochloride I complying with CP, EP and USP standard was prepared via substitution of cyclopropanecarboxylic acid with anhydrous piperazine. A novel reaction system was developed effectively to reduce the amount of two main byproducts and to increase product yield and quality. Based on the reaction system, other factors were investigated such as the equivalent of piperazine, the reaction temperature and reaction time to determine the optimal parameters of piperazine: the n-pentanol:2-Me pyrrolidone (v:v = 1:1) mixed solvent, 4 mol/L of anhydrous piperazine, 125°C∼130°C and reaction of 8 h, the total yield can reach 81.9%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride preparation cyclopropanecarboxylic acid piperazine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 1, 1989, Lopez Molina, Isidro; Palomo Coll, Alberto; Domingo Coto, Antonio published a patent.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Preparation of ciprofloxacin hydrochloride monohydrate from ciprofloxacin hydrates. And the patent contained the following:

The antibacterial title compound (I.HCl.H2O) is prepared by acidification of I.xH2O (x = 1-4) with an oxonium acid RR1O+H Cl- (R, R1 = aliphatic or aromatic alkyl, alkoxyalkyl; or RR1 may form heterocyclic ring) in the presence of ≥1 lower aliphatic alc. and an ether R2OR3 (R2, R3 = as given for R, R1). The acid is prepared, possibly in situ, from HCl and ROR1. Thus, a suspension of 2 g I.2.5H2O (preparation given) in 15 mL dioxane and 5 mL MeOH was bubbled with HCl at 15-20° until acidic, followed by stirring, cooling to 5°, filtration, washing with dioxane, and air drying at 60° to give I.HCl.H2O in 99% yield. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride monohydrate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 1, 1989, Lopez Molina, Isidro; Palomo Coll, Alberto; Domingo Coto, Antonio published a patent.HPLC of Formula: 86393-32-0 The title of the patent was Preparation of ciprofloxacin hydrochloride monohydrate from higher hydrates. And the patent contained the following:

The antibacterial title compound(I.HCl.H2O) is prepared by treating higher hydrates I.HCl.xH2O (x > 1) with an aliphatic or aromatic alc., an N,N-dialkyl aliphatic amide, or a mixture, at moderate temperatures for ≤3 h. Thus, 4.51 g I.HCl.2.5H2O (preparation given) was refluxed in 45 mL iso-PrOH for 30 min, followed by hot filtration, washing and drying in air at 50° to give I.HCl.H2O in 99% yield. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).HPLC of Formula: 86393-32-0

The Article related to ciprofloxacin hydrochloride monohydrate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cao, Ling-feng; Zhang, Yong-tang; Zhang, Jing-zheng published an article in 2011, the title of the article was Improved process of the piperazine condensation for preparation of ciprofloxacin hydrochloride.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate And the article contains the following content:

Ciprofloxacin hydrochloride I complying with CP, EP and USP standard was prepared via substitution of cyclopropanecarboxylic acid with anhydrous piperazine. A novel reaction system was developed effectively to reduce the amount of two main byproducts and to increase product yield and quality. Based on the reaction system, other factors were investigated such as the equivalent of piperazine, the reaction temperature and reaction time to determine the optimal parameters of piperazine: the n-pentanol:2-Me pyrrolidone (v:v = 1:1) mixed solvent, 4 mol/L of anhydrous piperazine, 125°C∼130°C and reaction of 8 h, the total yield can reach 81.9%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride preparation cyclopropanecarboxylic acid piperazine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics