Tag: 300-400

Rispal, P; Grellet, J; Celerier, C; Breilh, D; Dorian, M; Pellegrin, J L; Saux, M C; Leng, B published an article in 1996, the title of the article was Comparative uptake of sparfloxacin and ciprofloxacin into human THP 1 monocytic cells..Related Products of 86393-32-0 And the article contains the following content:

The uptake of sparfloxacin (CAS 11542-93-9) by human monocytes was studied by comparison with ciprofloxacin (CAS 86393-32-0). The human monocytic THP 1 cells were incubated with the antibiotics for 2 h. Entry of antimicrobials into the cells was determined by means of a velocity gradient centrifugation technique and HPLC assay. Antibiotic uptake was expressed as the ratio of the intracellular to the extracellular drug concentration (IC/EC). Quinolones enter readily in monocytic cells but sparfloxacin is taken up more rapidly than ciprofloxacin. At steady-state the IC/EC ratio of sparfloxacin (9.07) is higher than IC/EC of ciprofloxacin (4.29). Characterization of quinolone uptake suggests that these drugs penetrate throughout the THP 1 membrane by passive diffusion. However, the results of the present study indicate that additional mechanisms may contribute to intracellular accumulation of ciprofloxacin and sparfloxacin. Gemfibrozil, an inhibitor of organic anion transport, increases the accumulation of ciprofloxacin but does not modify IC/EC of sparfloxacin. It can be concluded that human monocyte-like cells have functional organic anion transporters and that this way of secretion is quinolone selective. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Related Products of 86393-32-0

The Article related to anti-infective agents: metabolism, cell line, chromatography, high pressure liquid, ciprofloxacin: metabolism, fluoroquinolones, gemfibrozil: pharmacology, humans, hydrogen-ion concentration, hypolipidemic agents: pharmacology, monocytes: metabolism, quinolones: metabolism and other aspects.Related Products of 86393-32-0

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On November 30, 2021, Sarwar, M. Sohail; Ghaffar, Abdul; Huang, Qingrong published an article.Computed Properties of 86393-32-0 The title of the article was Development and characterization of sodium alginate/poly(sodium 4-styrenesulfonate) composite films for release behavior of ciprofloxacin hydrogen chloride monohydrate. And the article contained the following:

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochem. properties, mol. interactions, and drug release behavior. The possible intermol. hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (weight/weight). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (crosslinked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution In SGF, around 90% of the model drug was released in 110 min that was approx. 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Computed Properties of 86393-32-0

The Article related to sodium alginate polysodiumstyrenesulfonate composite film ciprofloxacin hydrogen chloride monohydrate, Pharmaceuticals: Drug Standards and other aspects.Computed Properties of 86393-32-0

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Piperazine – Wikipedia,
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Akdag, Yagmur; Sahin, Selma; Nemutlu, Emirhan; Oner, Levent published an article in 2019, the title of the article was Determination of N-acetylcysteine in the presence of ciprofloxacin or levofloxacin in microparticulate dry powder inhalers.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate And the article contains the following content:

A fast and easy method was validated for simultaneous determination of ciprofloxacin hydrochloride monohydrate (CP), levofloxacin hemihydrate (LV), and N-acetylcysteine (NAC) in samples. The anal. was performed on a C18 column (250 × 4.6 mm, 5μm) (Inertsil ODS-3V) using an isocratic elution method with a mobile phase composed of 25 mM KH2 PO4 (pH 3.0) and methanol (72:28, volume/volume) at a flow rate of 1 mL/min. UV detection was performed at 214 nm for NAC and 293 nm for CP and LV. The method was validated for linearity, accuracy, precision (repeatability and reproducibility), specificity, sensitivity, and stability. The calibration study using several media demonstrated that the calibration curves were linear for all compounds in all media (R2 >0.9993). The limit of detection was 0.098μg/mL for CP, 0.049μg/mL for LV, and 0.487μg/mL for NAC. The limit of quantification was 0.328μg/mL for CP, 0.165μg/mL for LV, and 1.624μg/mL for NAC. Precision and accuracy values of the method fulfilled the required limits. All these outcomes demonstrate that the validated HPLC method is appropriate for simultaneous anal. of CP, LV, and NAC in samples for content uniformity of dry powder inhaler and permeability studies. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to lung adenocarcinoma cell dry powder inhaler ciprofloxacin levofloxacin, Pharmaceuticals: Pharmaceutics and other aspects.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On January 31, 1992, Lin, Guoquan; Lu, Zhufen; Xu, Jiemei; Ouyang, Weiying published an article.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Facile salt formation of ciprofloxacin hydrochloride monohydrate. And the article contained the following:

Crude cirpofloxacin hydrochloride monohydrate was dissolved in water containing 0.09 mol concentrated HCl, decolorized with active carbon, crystallized on cooling, and recrystallized from 85% EtOH after filtration and washing with absolute EtOH; the yield was 80.7%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin hydrochloride monohydrate recrystallization, Pharmaceuticals: Pharmaceutics and other aspects.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On September 30, 2004, Weyenberg, W.; Vermeire, A.; D’Haese, E.; Vanhaelewyn, G.; Kestelyn, P.; Callens, F.; Nelis, H. J.; Remon, J. P.; Ludwig, A. published an article.Formula: C17H21ClFN3O4 The title of the article was Effect of different sterilisation methods on the properties of bioadhesive powders and ocular minitablets, and clinical evaluation. And the article contained the following:

The purpose of this study was to evaluate the influence of gamma-irradiation and dry heat sterilization on the properties of a bioadhesive powder mixture containing ciprofloxacin and its corresponding ocular minitablets. The mol. weight characteristics of drum dried waxy maize starch (DDWM), employed as major component of the bioadhesive formulation, the decay kinetics of radicals, the rheol. properties of the bioadhesive polymers and the microbial activity of ciprofloxacin were studied. The influence of the different sterilization methods on the characteristics of the ocular minitablets was investigated by measuring the crushing strength, the friability, and the in vitro release of ciprofloxacin from the minitablets. Finally, the clin. value of the selected sterilized minitablets was evaluated in seven healthy volunteers. Both sterilization methods similarly affected the properties of the bioadhesive formulation by inducing stable radicals and decreasing the mol. weight of DDWM, although no changes in the microbiol. activity of ciprofloxacin were measured. An obvious influence of both sterilization methods was observed in the in vitro release study. The crushing strength and friability of the minitablets were not significantly influenced by gamma-irradiation Based on these data, gamma-irradiation was more adequate as sterilization method for the bioadhesive ocular minitablets than dry heat sterilization, because it affected the least the phys. properties of the minitablets. Therefore, the gamma-sterilized minitablets were selected for an in vivo evaluation in seven volunteers. The concentration of ciprofloxacin in the tear film remained above its MIC value for the most common ocular pathogens for at least 8 h. Consequently, the gamma-irradiated minitablets containing ciprofloxacin can be considered as a promising formulation to treat bacterial keratitis and conjunctivitis. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4

The Article related to bioadhesive powder ocular minitablet sterilization, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C17H21ClFN3O4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 1, 1996, Turel, Iztok; Bukovec, Peter published an article.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Comparison of the thermal stability of ciprofloxacin and its compounds. And the article contained the following:

The thermal behavior of ciprofloxacin, its hydrochloride and 2 copper (II) compounds of ciprofloxacin was studied by thermogravimetry, DSC, evolved gas anal. and IR spectroscopy. In all the compounds studied, profound differences in the carboxylic (C:O) absorption were found after heating, which can be explained by the rearrangement of the hydrogen bonds. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to ciprofloxacin copper complex thermal stability, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 2, 2004, Faour, Joaquina; Vergez, Juan A. published a patent.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Breakable, controlled-release tablets comprising a preformed passage. And the patent contained the following:

The invention relates to a simple and improved osmotic device for the controlled release of an active agent from the core into the use environment. According to the invention, the active agent is first released through a preformed passage and, subsequently, through a second passage which is formed in situ. Optionally, the size of one or both of the passages increases during the use of the osmotic device. Moreover, the preformed passage and/or the second passage increases the release speed of the active agent and enables the release of larger particles containing the active agent and/or the release of active agents which are essentially insoluble in the use environment. Owing to the in situ formation of the second opening, the device can release a greater percentage of active agent than that which would be released without said second opening. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

The Article related to drug delivery tablet controlled release, Pharmaceuticals: Pharmaceutics and other aspects.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On May 31, 2002, Liu, Yong; Wang, Jing-kang; Yin, Qiu-xiang published an article.Related Products of 86393-32-0 The title of the article was Study on the thermodynamics of crystallization of ciprofloxacin hydrochloride monohydrate. And the article contained the following:

The melting temperature, the melting heat and the solubility of ciprofloxacin hydrochloride monohydrate in water/ethanol solution are measured in this paper. The solubility model and the expression of the relationship between the activity coefficient and the solvation constant K of ciprofloxacin hydrochloride monohydrate have been established. The dissolution heat and the solvation energy of ciprofloxacin hydrochloride monohydrate in water/ethanol solution have been estimated using the exptl. solubility data. This study aims at supplying valuable thermodn. data for the industrial manufacture of ciprofloxacin hydrochloride monohydrate. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Related Products of 86393-32-0

The Article related to ciprofloxacin thermodn crystallization, Pharmaceuticals: Pharmaceutics and other aspects.Related Products of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 4, 2008, Souza, Fabio Eduardo Silva; Oudenes, Jan; Gorin, Boris Ivanovich published a patent.Formula: C17H21ClFN3O4 The title of the patent was Anhydrous ciprofloxacin hydrochloride. And the patent contained the following:

The present invention provides a new anhydrous crystalline form of ciprofloxacin-HCl that is substantially free from solvent mols., and processes of preparation thereof. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4

The Article related to ciprofloxacin hydrochloride anhydrous, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C17H21ClFN3O4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2007, Raina, R.; Prawez, S.; Dimitrova, D. J.; Verma, P. K.; Pankaj, N. K. published an article.Product Details of 86393-32-0 The title of the article was Pharmacokinetics of ciprofloxacin following intravenous administration in WLH chickens (Gallus domesticus). And the article contained the following:

Pharmacokinetics of ciprofloxacin was studied in WLH chicken after single i.v. dose @ 4 mg.kg-1 body weight Plasma ciprofloxacin concentrations were analyzed by microbiol. assay technique using E. coli ATCC-25922 as test organisms grown. The determination of the best-fit compartment model and initial estimates of the model-dependent pharmacokinetics was analyzed for each bird by Top-Fit v. 2.0 computer program. The three compartment open model was the best fit for i.v. injection of ciprofloxacin. Statistical moments were also used to compute the noncompartmental pharmacokinetic anal. The elimination half life (t1/2β), volume of distribution from central compartment (Vc) and total body clearance (ClB) were 5.79±1.14 h, 0.85±0.07 L.kg-1 and 16.27±1.87mL.min-1.kg-1, resp. The mean residence time (MRT) and area under the plasma concentration vs time curve from 0 to ∞ (AUC0→ ∞) were 7.05±1.34 h and 4.54±0.59 μg.h.ml-1, resp. The variation coefficient of the technique for the intraassay and interassay precission was less than 10% in the range of standard concentration The lower limit of sensitivity of the ciprofloxacin assay was 0.015 μg.ml-1. The serum concentration at time zero (Cp°) and area under the curve from 0 to 24h (AUC0-24) were applied in the calculation of predictors of efficacy for concentration-dependent antibiotics. Ciprofloxacin concentration in plasma of chickens, maintaining min. inhibitory concentration (MIC <1 μg.ml-1) for upto 12 h after i.v. administration @ 4mg.kg-1, would be adequate for controlling avian bacterial diseases. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Product Details of 86393-32-0

The Article related to antimicrobial pharmacokinetics pharmacodynamics ciprofloxacin hydrochloride monohydrate escherichia pasteurella gallus, Pharmacology: Drug Metabolism and other aspects.Product Details of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics