Tag: 300-400

Prioritized antibiotics screening based on comprehensive risk assessments and related management strategy in various animal farms was written by Liu, Zhong;Zou, Huiyun;Lan, Zouran;Li, Xuewen. And the article was included in Journal of Environmental Management in 2022.Application In Synthesis of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Antibiotic pollution in the environment caused by animal breeding has become a serious issue. The persistent release of antibiotics with animal waste may lead to antibiotic resistances in the environment, which poses a threat to human health. This study tries to provides a practical method for screening prioritized antibiotics via a comprehensive risk assessment and determination of their major sources, and put forward corresponding regulatory measures for animal industries. We investigated the occurrence and distribution of 20 antibiotics belonging to eight classes, spanning the areas of animal feed, drinking water, and animal feces on 59 animal farms in Shandong Province, China. The results showed that antibiotic contamination was prevalent in different environmental mediums (feed, feces, and drinking water) on these farms. Tetracyclines typically exhibited higher concentrations than the other classes in all samples, and the majority of antibiotics had greater concentrations in cattle feces than in pig- or chicken feces. For the antibiotic ecol. risks in feces, doxycycline, tetracycline, and enrofloxacin exhibited much more toxic effects on terrestrial organisms (e.g., wheat, cucumber, and rice). Ciprofloxacin, enrofloxacin, ofloxacin, and tetracycline levels in drinking water samples can lead to high risk of antibiotic resistance, while no antibiotic posed obvious risks to human health. Based on compressive risk assessments, 11 antibiotics were prioritized to control in the animal breeding environment. Based on the survey of feeds, drinking water and animal waste from the farm, roxithromycin in the feces mainly originated from the feeds, while most prioritized antibiotics, were from extra addition in the animal breeding process (including injection and other oral routes). The key point of local antibiotic management in animal farms should be adjusted from the feed factory to the extra addition of antibiotics in animal breeding processes. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Application In Synthesis of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application In Synthesis of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The antibiotic resistance and risk heterogeneity between urban and rural rivers in a pharmaceutical industry dominated city in China: The importance of social-economic factors was written by Zhang, Lulu;Ju, Zejia;Su, Zhiguo;Fu, Yu;Zhao, Bo;Song, Yuanmeng;Wen, Donghui;Zhao, Yu;Cui, Jiansheng. And the article was included in Science of the Total Environment in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

Rivers are important environmental sources of human exposure to antibiotic resistance. Many factors can change antibiotic resistance in rivers, including bacterial communities, human activities, and environmental factors. However, the systematic comparison of the differences in antibiotics resistance and risks between urban rivers (URs) and rural rivers (RRs) in a pharmaceutical industry dominated city is still rare. In this study, Shijiazhuang City (China) was selected as an example to compare the differences in antibiotics resistance and risks between URs and RRs. The results showed higher concentrations of total quinolones (QNs) antibiotics in both water and sediment samples collected from URs than those from RRs. The subtypes and abundances of antibiotic resistance genes (ARGs) in URs were significantly higher than those in RRs, and most emerging ARGs (including OXA-type, GES-type, MCR-type, and tet(X)) were only detected in URs. The ARGs were mainly influenced by QNs in URs and social-economic factors (SEs) in RRs. The composition of the bacterial community was significantly different between URs and RRs. The abundance of antibiotic-resistant pathogenic bacteria (ARPBs) and virulence factors (VFs) were higher in URs than those in RRs. Therein, 371 and 326 pathogen types were detected in URs and RRs, resp. Most emerging ARGs showed a significantly pos. correlation with priority ARPBs. Variance partitioning anal. revealed that SEs were the main driving factors of ARGs (80 %) and microbial communities (92 %) both in URs and RRs. Structural equation models indicated that antibiotics (QNs) and microbial communities were the most direct influence of ARGs in URs and RRs, resp. The cumulative resistance risk of QNs was high in URs, but relatively low in RRs. Enrofloxacin and flumequine posed the highest risk in water and sediment, resp. This study could help us to better manage and control the risk of antibiotic resistance in different rivers. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Effects of dissolved organic matter on the adsorption of norfloxacin on a sandy soil (fraction) from the Yellow River of Northern China was written by Wang, Yuting;Yu, Wenfei;Chang, Zhaofeng;Gao, Chanjuan;Yang, Yanni;Zhang, Bei;Wang, Yanhua;Xing, Baoshan. And the article was included in Science of the Total Environment in 2022.Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Dissolved organic matter (DOM), which exists widely in the environment, coming from different sources, may greatly affect the adsorption of antibiotics. However, the adsorption mechanisms of antibiotics in a sandy soil and the effects of DOM from different sources on the adsorption remain poorly understood. This study systematically investigated the adsorption characteristics of norfloxacin (NOR) onto a sandy soil obtained from the banks of Xi′an in Yellow River and in the presence of three DOM including HDOM (com. available humic acids), LDOM (derived from fallen leaves) and MDOM (derived from cattle manure). Elemental anal., UV-vis spectroscopy, 3D-EEM, XPS, TOC, SEM, and FTIR were used to analyze the adsorption mechanism. It was found that all the DOM sources we used could reduce the adsorption of NOR on sandy soil and prolong the reaction time to reach adsorption equilibrium The decreasing adsorption capacities of NOR by the three types of DOM (10 mg/L) followed the order as: HDOM < LDOM < MDOM, which was related to their aromaticity, polarity and hydrophobicity. These adsorption processes of NOR on sandy soil in the presence of DOM were well fitted by Double-chamber first-order kinetics, Linear model and Freundlich models. Besides, the adsorption reaction was endothermic and spontaneous. Adsorption competition of DOM mols. with NOR, or formation of DOM-NOR complexes in solution resulted in a decrease of sandy soil adsorption capacity. Correspondingly, co-adsorption and cumulative adsorption were also considered to be the key processes that determined NOR adsorption towards sandy soil after adding DOM. Moreover, the adsorption of NOR onto sandy soil exhibited strong pH-dependent characteristic and NOR might be more easily leached from sandy soil in the aquifer at an alk. pH. High-ion strength suppressed the adsorption. These results would help to understand the fate and risk of NOR under the action of different DOM. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The TetR-type regulator AtsR is involved in multidrug response in Corynebacterium glutamicum was written by Su, Tao;Che, Chengchuan;Han, Jiyu;Zhao, Yuying;Zhang, Zihan;An, Guangdi;Si, Meiru;Chen, Can. And the article was included in Microbial Cell Factories in 2022.Computed Properties of C16H18FN3O3 The following contents are mentioned in the article:

The TetR (tetracycline repressor) family is one of the major transcription factor families that regulate expression of genes involved in bacterial antimicrobial resistance systems. NCgl0886 protein, designated as AtsR, is a member of the TetR family identified in Corynebacterium glutamicum, which is conserved in several species of the genera Corynebacterium, also including the well-known pathogen C. diphtheriae. AtsR is located at no far upstream of the identically oriented ncgl0884 gene, encoding a putative multidrug efflux pump protein, and in the same operon with ncgl0887, encoding a resistance, nodulation and cell division (RND) superfamily drug exporter. However, the role of AtsR is not clearly understood. Here we showed that dimeric AtsR directly repressed the expression of the ncgl0887-atsR operon, as well as indirectly controlled the ncgl0884 transcription. Antibiotics and toxic compounds induced the expression of ncgl0887-atsR operon. A perfect palindromic motif (5′-TGCAA-N2-TTGCA-3′; 12 bp) was identified in the upstream region of ncgl0887-atsR operon. Electrophoretic mobility shift assays (EMSAs) demonstrated specific binding of AtsR to this motif, and hydrogen peroxide (H2O2) blocked binding. H2O2 oxidized cysteine residues to form Cys123-Cys187 intermol. disulfide bonds between two subunits in AtsR dimer, which altered its DNA-binding characteristics and caused its dissociation, thereby leading to derepression of the drug efflux protein. Deletion of ncgl0884 and ncgl0887 increased the susceptibilities of C. glutamicum for several toxic compounds, but overexpression of atsR decreased the drug tolerance of C. glutamicum. Our study revealed that AtsR was a redox regulator that sensed oxidative stress via thiol modification. The results obtained here will contribute to our understanding of the drug response mechanism not only in C. glutamicum but also in the related bacteria C. diphtheriae. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Computed Properties of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Computed Properties of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quinolone distribution, trophodynamics, and human exposure risk in a transit-station lake for water diversion in east China was written by Liu, Yuanyuan;Hua, Zulin;Lu, Ying;Gu, Li;Luan, Chengmei;Li, Xiaoqing;Wu, Jianyi;Chu, Kejian. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.Related Products of 70458-96-7 The following contents are mentioned in the article:

Quinolone antibiotics (QNs) pollution in lake environments is increasingly raising public concern due to their potential combined toxicity and associated risks. However, the spatiotemporal distribution and trophodynamics of QNs in transit-station lakes for water diversion are not well documented or understood. In this study, a comprehensive investigation of QNs in water, sediment, and aquatic fauna, including norfloxacin (NOR), ciprofloxacin (CIP), enrofloxacin (ENR), and ofloxacin (OFL), was conducted in Luoma Lake, a major transit station for the eastern route of the South-to-North Water Diversion Project in China. The target QNs were widely distributed in the water (∑QNs: 70.12 ± 62.79 ng/L) and sediment samples (∑QNs: 13.35 ± 10.78 ng/g dw) in both the non-diversion period (NDP) and the diversion period (DP), where NOR and ENR were predominant. All the QNs were detected in all biotic samples in DP (∑QNs: 80.04 ± 20.59 ng/g dw). The concentration of ∑QNs in the water in NDP was significantly higher than those in DP, whereas the concentration in the sediments in NDP was comparable to those in DP. ∑QNs in the water-sediment system exhibited decreasing trends from northwest (NW) to southeast (SE) in both periods; however, the Koc (organic carbon normalized partition coefficients) of individual QNs in DP sharply rose compared with those in NDP, which indicated that water diversion would alter the environmental fate of QNs in Luoma Lake. In DP, all QNs, excluding NOR, were all biodiluted across the food web; whereas their bioaccumulation potentials in the SE subregion were higher than those in the NW subregion, which was in contrast to the spatial distribution of their exposure concentrations The estimated daily QN intakes via drinking water and aquatic products suggested that residents in the SE side were exposed to greater health risks, despite less aquatic pollution in the region. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Related Products of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Anti-inflammatory effect, antibiotic potentiating activity against multidrug-resistant strains of Escherichia coli and Staphylococcus aureus, and evaluation of antibiotic resistance mechanisms by the ibuprofen derivative methyl 2-(-4-isobutylphenyl)propanoate was written by Xavier, Maria R.;Freitas, Thiago S.;Pereira, Raimundo L. S.;Marinho, Emanuelle M.;Bandeira, Paulo N.;de Sousa, Amanda P.;Oliveira, Larissa S.;Bezerra, Lucas Lima;Neto, Jose B. A.;Silva, Maria M. C.;Cruz, Beatriz G.;Rocha, Janaina E.;Barbosa, Cristina R. S.;da Silva, Antonio W.;de Menezes, Jane E. S. A.;Coutinho, Henrique D. M.;Marinho, Marcia M.;Marinho, Emmanuel S.;dos Santos, Helcio S.;Teixeira, Alexandre M. R.. And the article was included in Microbial Pathogenesis in 2022.Category: piperazines The following contents are mentioned in the article:

The prevalence of multidrug-resistant (MDR) bacteria and the limited efficacy of current available antibiotics cause every year approx. 700 000 deaths per yr. This study aimed to evaluate the anti-inflammatory effect and antibacterial potential of the ibuprofen derivative Me 2-(-4-isobutylphenyl)propanoate (MET-IBU). The mol. structure of MET-IBU was confirmed by NMR (NMR) and, Attenuated Total Reflectance Fourier Transform IR spectroscopy (ATR-FTIR) spectroscopy. Our in vivo study using adult zebrafish model demonstrated that the ibuprofen derivative MET-IBU also possesses anti-inflammatory effect, and in vitro antibacterial activity assays showed that in the association of ampicillin, norfloxacin, and gentamicin with MET-IBU occurred reduction in the min. inhibitory concentration (MIC) for MDR bacterial strains of Escherichia coli 06 and Staphylococcus aureus 10, indicating a potentiating in the growth inhibition of these pathogenic bacteria. Regarding the strain of Staphylococcus aureus K2068 (overexpressing mepA gene), a potentiation of ethidium bromide was found in the association with MET-IBU, indicating the action of this compound on the efflux pump mechanism present in this strains. This result corroborates the mol. docking study that indicated a high affinity of the MET-IBU with the MepA efflux pump. It was also noticed an antibiotic potentiating activity in the association MET-IBU with norfloxacin against strains of Staphylococcus aureus 1199B (overexpressing norA gene) when compared to the norfloxacin control. This enhanced antibiotic effect of MET-IBU is associated with a second resistance mechanism, which is due to the modification in the topoisomerase enzyme. These results bring attention to the ibuprofen derivative MET-IBU as possible candidate for the development of new options for the treatment of bacterial infections with protective anti-inflammatory action. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Magnetically separatable CoFe2O4/BiOCl of controllable synthesis, superior photocatalytic performance and mechanism towards decomposing RhB, NOR and Cr(VI) under visible light was written by Liu, Jun;Wang, Hui;Chang, Meng-Jie;Sun, Meng;He, Zhi-Wei;Zhang, Cong-Miao;Zhu, Wen-Yao;Chen, Jia-Liang;Du, Hui-Ling;Peng, Long-Gui;Luo, Zhen-Min;Zhang, Li. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

Magnetically separatable CoFe₂O₄/BiOCl (CFO/BOC) fibers were facilely prepared by solvothermal growth of BiOCl on hollow electrospun CoFe₂O₄ nanofibers in a weak reduction ethylene glycol (EG) solvent for visible light photocatalytic degradation of various contaminants. Due to the defect level resulted from the oxygen vacancies (OVs), evident visible light response and enhanced charge transfer are achieved both for the solo BiOCl spheres and nanosheets on the CoFe₂O₄ fibrous support. The optimum CFO/BOC synthesized at 160°C with a precursor concentration of 50 mM shows outstanding photocatalytic activity to degrade different pollutants of Rhodamine B (RhB, 92.9%), Norfloxacin (NOR, 75.5%), and Cr(VI) (78.0%) within 2 h under visible light. The CoFe₂O₄ nanofibers are not pivotal for the photocatalytic process, but mainly contribute to the photocatalysis as magnetic support, ensuring the CFO/BOC no aggregation and easy collection under an external magnet. In contrast, the OVs play an important role in the visible light absorption, reactive oxygen species generation and redox process during the photocatalytic process. In detail, both photosensitization of RhB and species of h⁺ and·O-2 contribute to the degradation of RhB, while NOR decomposition is accomplished by three species (h⁺,·O-2,·OH). In addition, electrons are the main reactive species for the photoreduction of Cr(VI). Compared to current reported CoFe₂O₄/BiOI photocatalysts, significant advances for the CFO/BOC are obtained not only for the cheap BiOCl with OVs for the photocatalytic application, but also much clearer investigation of more details of CFO/BOC photocatalysts such as light absorption, charge transfer and active species for the degradation of various pollutants. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Antibiotic resistance genes in Chishui River, a tributary of the Yangtze River, China: Occurrence, seasonal variation and its relationships with antibiotics, heavy metals and microbial communities was written by Wu, Tianyu;Zhang, Yuntao;Wang, Bin;Chen, Chao;Cheng, Zhentao;Li, Yancheng;Li, Jiang. And the article was included in Science of the Total Environment in 2022.Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

The large-scale use and release of antibiotics may create selective pressure on antibiotic resistance genes (ARGs), causing potential harm to human health. River ecosystems have long been considered repositories of antibiotics and ARGs. Therefore, the distribution characteristics and seasonal variation in antibiotics and ARGs in the surface water of the main stream and tributaries of the Chishui River were studied. The concentrations of antibiotics in the dry season and rainy season were 54.18-425.74 ng/L and 66.57-256.40 ng/L, resp., gradually decreasing along the river direction. The results of antibiotics in the dry season and rainy season showed that livestock and poultry breeding were the main sources in the surface water of the Chishui River basin. Risk assessments indicated high risk levels of OFL in both seasons. In addition, anal. of ARGs and microbial community diversity showed that sul1 and sul3 were the main ARGs in the two seasons. The highest abundance of ARGs was 7.70 x 107 copies/L, and intl1 was significantly pos. correlated with all resistance genes (p< 0.01), indicating that it can significantly promote the transmission of ARGs. Proteobacteria were the dominant microorganisms in surface water, with a higher average abundance in the dry season (60.64%) than in the rainy season (39.53%). Finally, correlation analyses were performed between ARGs and antibiotics, microbial communities and heavy metals. The results showed that there was a significant pos. correlation between ARGs and most microorganisms and heavy metals (p< 0.01), indicating that occurrence and transmission in the environment are influenced by various environmental factors and cross-selection. In conclusion, the persistent residue and transmission of ARGs and their transfer to pathogens are a great threat to human health and deserve further study and attention. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Seasonal occurrence of multiple classes of antibiotics in East China rivers and their association with suspended particulate matter was written by Wang, Kun;Su, Zhaoxin;Reguyal, Febelyn;Bian, Rongxing;Li, Weihua;Yu, Haofeng;Sun, Yingjie;Zhuang, Ying;Shang, Wan. And the article was included in Science of the Total Environment in 2022.Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Understanding the occurrence and fate of antibiotics from different categories is vital to predict their environmental exposure and risks. This study presents the spatiotemporal occurrence of 45 multi-class antibiotics and their associations with suspended particulate matter (SPM) in Xiaoqing River (XRB) and Yellow River (YRB) via 10-mo monitoring in East China. Thirty-five and 31 antibiotics were detected in XRB and YRB, resp. Among them, fluoroquinolones (FQs) had the highest total mean concentration (up to 24.8μg/L in XRB and 15.4μg/L in YRB), followed by sulfonamides (SAs) (14.0μg/L and 15.4μg/L) and macrolides (MLs) (1.1μg/L and 1.6μg/L). Significant spatial-temporal variations were found in both rivers where higher concentrations of antibiotics were observed in urban and densely populated areas during winter and spring. Hydrol. factors such as river flow and water volume, instream attenuation and antibiotic usage may cause the observed variabilities in the seasonal patterns of antibiotic pollution. Using linear regression anal., for the first time, this study confirmed that the total concentrations of MLs (p < 0.05), FQs (p < 0.001) and SAs (p < 0.001) were strongly correlated with the turbidity/total suspended solids in the studied rivers (except MLs in YRB). It is thus suggested that partitioning processes onto SPM might affect the distribution of detected antibiotics in rivers, which are largely dependent on SPM composition and characteristics. The risk quotient (RQ) determined for up to 87% of individual compound was below 0.1 in both rivers; however, the high joint toxicity reflected by the mixed RQs of detected antibiotics may rise risk alarm for aquatic species. Further aspects regarding active mechanisms of SPM-antibiotic interactions and ecol. risks of coexistence of multiple antibiotics need to be investigated. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Antibiotics and antimycotics in waste water treatment plants: Concentrations, removal efficiency, spatial and temporal variations, prediction, and ecological risk assessment was written by Yang, Yi;Ji, Yaqin;Gao, Yuzong;Lin, Zi;Lin, Yu;Lu, Yuan;Zhang, Liwen. And the article was included in Environmental Research in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

For investigating the spatial, temporal variations and assessing ecol. risk of 10 antibiotics and 6 antimycotics, influent sewage water and treated effluent were collected during three different seasons in 19 waste water treatment plants of Tianjin. High performance liquid chromatog. tandem mass spectrometry was used to analyze 16 substances. The concentration range of influent samples was not detected (nd) -547.94 ng/L and the concentration range of effluent samples was nd-52.97 ng/L. By calculating the removal efficiency, it was found that Ciprofloxacin (CIP), Ofloxacin (OFL) and Clotrimazole (CTR) were effectively removed. There were significant spatial and temporal differences, the concentration in the dry season was evidently higher than that in the wet and normal seasons, and the northeast was lower than that in the northwest and southeast. By establishing a data set of influent and effluent, the priority features were extracted by feature engineering, which were temperature and NH₃-N. Under the condition of ensuring the best performance of the models, the influent model with 9 features and the effluent model with 4 features were established, and the quant. relationship between the above features and concentration was obtained through partial dependence anal. Except for Moxifloxacin (MOX), Norfloxacin (NOR) and OFL in the influent samples, the RQ values for other antibiotics and antimycotics were less than 0.1. Among the effluent samples, only NOR had an RQ value greater than 0.1, and OFL, MOX, and Pefloxacin (PEF) had RQ values between 0.01 and 0.1. Comparing the observations and predictions individual RQ values, the predictions were ideal and matched the observations. This work effectively assessed environmental impact and provided a valuable reference for evaluating antibiotics and antimycotics ecol. toxicity. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics