Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors was written by Cumming, J. N.;Le, T. X.;Babu, S.;Carroll, C.;Chen, X.;Favreau, L.;Gaspari, P.;Guo, T.;Hobbs, D. W.;Huang, Y.;Iserloh, U.;Kennedy, M. E.;Kuvelkar, R.;Li, G.;Lowrie, J.;McHugh, N. A.;Ozgur, L.;Pan, J.;Parker, E. M.;Saionz, K.;Stamford, A. W.;Strickland, C.;Tadesse, D.;Voigt, J.;Wang, L.;Wu, Y.;Zhang, L.;Zhang, Q.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.COA of Formula: C16H22N2O3 This article mentions the following:
Guided by structure-based design two series of potent inhibitors of BACE1, were synthesized and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2′ pocket. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate (cas: 78551-60-7COA of Formula: C16H22N2O3).
tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate (cas: 78551-60-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.COA of Formula: C16H22N2O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics