Tag: 268.3568

Hong, Youji et al. published their research in Huadong Fangzhi Gongxueyuan Xuebao in 1985 | CAS: 7479-12-1

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Name: 4,4′-(Piperazine-1,4-diyl)dianiline

Synthesis of the third comonomer of Kevlar 1414, p,p’-diaminophenylpiperazine was written by Hong, Youji;Xiao, Ruojian;Ye, Xiuzhen. And the article was included in Huadong Fangzhi Gongxueyuan Xuebao in 1985.Name: 4,4′-(Piperazine-1,4-diyl)dianiline This article mentions the following:

Piperazine  [110-85-0] was treated with p-ClC6H4NO2  [100-00-5] in N-methylpyrolidone in the presence of CaH2 to give 1,4-bis(p-nitrophenyl)piperazine (I) [16264-05-4] with productivity <82.3%, compared with 57.9% without CaH2. I was refluxed with SnCl2, 95% EtOH, and concentrated HCl for 2 h to give 1,4-bis(p-aminophenyl)piperazine  [7479-12-1] in 80.6% yield. In the experiment, the researchers used many compounds, for example, 4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1Name: 4,4′-(Piperazine-1,4-diyl)dianiline).

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Name: 4,4′-(Piperazine-1,4-diyl)dianiline

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Stanicki, Dimitri et al. published their research in Pharmaceuticals in 2013 | CAS: 7479-12-1

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Diamidines versus monoamidines as anti-Pneumocystis agents: an in vivo study was written by Stanicki, Dimitri;Pottier, Muriel;Gantois, Nausicaa;Pincon, Claire;Forge, Delphine;Mahieu, Isabelle;Boutry, Sebastien;Vanden Eynde, Jean Jacques;Martinez, Ann;Dei-Cas, Eduardo;Aliouat, El-Moukhtar. And the article was included in Pharmaceuticals in 2013.Category: piperazines This article mentions the following:

Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, resp. The most efficient antifungal derivatives, namely N,N’-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a diamidine) and N-(benzamidine-4-yl)-N’-phenylethane-1,2-diamine (compound 7, a monoamidine), exhibited no cytotoxicity and were evaluated in vivo in a rat model. Only the diamidine 6 emerged as a promising hit for further studies. In the experiment, the researchers used many compounds, for example, 4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1Category: piperazines).

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Stanicki, Dimitri et al. published their research in Pharmaceuticals in 2013 | CAS: 7479-12-1

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Diamidines versus monoamidines as anti-Pneumocystis agents: an in vivo study was written by Stanicki, Dimitri;Pottier, Muriel;Gantois, Nausicaa;Pincon, Claire;Forge, Delphine;Mahieu, Isabelle;Boutry, Sebastien;Vanden Eynde, Jean Jacques;Martinez, Ann;Dei-Cas, Eduardo;Aliouat, El-Moukhtar. And the article was included in Pharmaceuticals in 2013.Category: piperazines This article mentions the following:

Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, resp. The most efficient antifungal derivatives, namely N,N’-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a diamidine) and N-(benzamidine-4-yl)-N’-phenylethane-1,2-diamine (compound 7, a monoamidine), exhibited no cytotoxicity and were evaluated in vivo in a rat model. Only the diamidine 6 emerged as a promising hit for further studies. In the experiment, the researchers used many compounds, for example, 4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1Category: piperazines).

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Stanicki, Dimitri et al. published their research in Pharmaceuticals in 2013 | CAS: 7479-12-1

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Diamidines versus monoamidines as anti-Pneumocystis agents: an in vivo study was written by Stanicki, Dimitri;Pottier, Muriel;Gantois, Nausicaa;Pincon, Claire;Forge, Delphine;Mahieu, Isabelle;Boutry, Sebastien;Vanden Eynde, Jean Jacques;Martinez, Ann;Dei-Cas, Eduardo;Aliouat, El-Moukhtar. And the article was included in Pharmaceuticals in 2013.Category: piperazines This article mentions the following:

Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, resp. The most efficient antifungal derivatives, namely N,N’-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a diamidine) and N-(benzamidine-4-yl)-N’-phenylethane-1,2-diamine (compound 7, a monoamidine), exhibited no cytotoxicity and were evaluated in vivo in a rat model. Only the diamidine 6 emerged as a promising hit for further studies. In the experiment, the researchers used many compounds, for example, 4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1Category: piperazines).

4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics