Behavior of 4-(-2-hydroxyethyl)-1-piperazineethanesulphonic acid under electrospray ionization mass spectrometry conditions was written by Saraiva, Marco A.;Borges, Carlos M.;Florencio, M. Helena. And the article was included in European Journal of Mass Spectrometry in 2010.Related Products of 75277-39-3 This article mentions the following:
The authors’ previous experiments on electrospray ionization mass spectrometry (ESI-MS) anal. of reaction mixtures containing 4-(-2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES, zwitterionic organic buffering agent), a commonly used buffer, indicated that HEPES species did not significantly suppress analyte species, even in reaction mixture solutions with significant amounts of HEPES. With the purpose of investigating the behavior of HEPES under ESI-MS conditions, HEPES aqueous solutions and HEPES aqueous solutions containing analyte with high polarity properties and low polarity properties and with different acid/base chem., were therefore investigated. For electrosprayed aqueous solutions of HEPES with concentrations above 10-5M, an enhanced formation of HEPES multimer ions, showing HEPES monomer ion formation, was observed This enhanced formation of HEPES multimer ions is much higher than those observed for other polar compounds, such as acetyl-arginine, acetyl-lysine and histidine. Information from solution behavior such as HEPES concentration, solution pH and instrumental factors, namely the capillary temperature, was related to information from mass spectra. The results obtained led us to conclude that the formation of HEPES ions is related to the initial solution composition The influence of analyte species on HEPES species formation, for electrosprayed HEPES solutions with analyte, was also investigated. The variations observed for HEPES monomer and multimer ion abundance, which were found to be consistent with those observed for analyte monomer ion abundance, were related to the type of analyte, i.e. to their acid/base nature. Strikingly, the variations observed between HEPES monomer and multimer ion abundance enable the discrimination of different influences of analyte species on HEPES species formation. The results obtained also provided an explanation for the observation that HEPES species do not significantly suppress analyte species ion signals when highly-concentrated HEPES solutions with analyte are electrosprayed. According to our results, the associated behavior between HEPES species seems to be preserved in the gas phase during electrospray ionization. This observation may provide some information that may be useful regarding the behavior involved in the gas-phase ion formation process from charged droplets during electrospray ionization or, at least, to differentiate between behaviors. In the experiment, the researchers used many compounds, for example, Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3Related Products of 75277-39-3).
Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Related Products of 75277-39-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics