Tag: 200-300

On December 3, 2021, Zhao, Liang-Liang; Wu, Yixin; Huang, Shiqing; Zhang, Zengyu; Liu, Wei; Yan, Xiaoyu published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst. And the article contained the following:

Hydrogen isotope exchange reactions of phenols and benzyl alcs. was achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas d. functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to phenol regioselective deuterium exchange, deuterated phenol preparation, benzyl alc regioselective deuterium exchange, deuterium benzyl alc preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 15, 2014, Tang, Yan-feng; Mao, Jia-rong; Chen, Jiao; Sun, Tong-ming; Wang, Miao; Zhu, Jin-li published an article.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Synthesis of preladenant. And the article contained the following:

An intermediate, 1-(4′-methoxyethoxyl phenyl) piperazine (III), was synthesized from 1-(4′-hydroxylphenyl)-piperazinyl ethanone (I) via etherification and hydrolysis. Another intermediate (VII) with a nitrogen condensed ring was prepared from Me furan-2-carboxylate (IV) by acylation, ring-closure and halogenation. Finally, Preladenant was prepared from the two intermediates by condensation reaction. FTIR, 1HNMR and ESI-MS were employed to characterize these intermediates and the target compound Through common synthetic method, the yields of these 6 steps are 99.0%, 95.4%, 98.0%, 78.9%, 86.9% (calculated by Cl) and 52.5%, resp. To obtain a higher total yield, ultrasonic was used in the last condensation reaction. The results show that the condensation yield reached 85.4% when the reaction conditions were as follows: the ultrasonic power (150 W), the molar ratio of intermediate III to VII (1.2: 1), solvent (DMSO), acid-bonding agent (Na2CO3), reaction temperature (90°C) and reaction time (1.5 h). The yield of the condensation is greatly increased by ultrasonic method. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to preladenant condensation ultrasound, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 10, 2021, Patwardhan, Neeraj Narendra; Chhabra, Milloni Balwantkumar; Hamilton, Gregory Lawrence; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa published a patent.Recommanded Product: 59695-29-3 The title of the patent was Preparation of lipid nanoparticles for nucleic acid delivery to immune cells. And the patent contained the following:

Lipid nanoparticle compositions comprising a conformationally constrained ionizable lipids useful for delivery of nucleic acids without the need for a targeting ligand are described. Compounds of formula I [wherein R1 = C9-20alkyl or C9-20alkenyl with 1-3 units of unsaturation; X1 and X2 independently = absent, -O-, NR2, -(CH)a-, wherein R2 is C1-6alkyl, and wherein X1 and X2 are not both -O- or NR2; a = integer between 1 and 6; X3 and X4 independently = (un)substituted 4- to 7-membered heterocyclyl or (un)substituted 5- to 6-membered heteroaryl; X5 = -(CH2)b-, wherein b = integer between 0 and 6; X6 = H, C1-6alkyl, (un)substituted 5- to 6-membered heteroaryl] and compositions thereof, are claimed and exemplified. Example compound II was prepared from a multistep process (preparation given). Prepared lipid nanoparticles in which siCD45 had been encapsulated were characterized using high throughput dynamic light scattering (data provided). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Recommanded Product: 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid deliver immune cell, sirna cd45 lipid nanoparticle encapsulation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Recommanded Product: 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2021, Hamilton, Gregory Lawrence; Patwardhan, Neeraj Narendra; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa; Chhabra, Milloni Balwantkumar published a patent.Application of 59695-29-3 The title of the patent was Preparation of lipid nanoparticle compositions for delivery of nucleic acids to cells. And the patent contained the following:

Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the formula I [R1 = alkyl, alkenyl; X1, X2 = O, (substituted) NH, alkylene, etc.; X3, X4 = heterocyclyl, heteroaryl, aryl, cycloalkyl, etc.; X5 = absent, alkyl, alkylene; X6 = H, alkyl, heteroaryl, heterocyclyl, etc.; A1, A2 = haloalkyl, alkenyl, etc.; n = 1-4]. Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Application of 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Application of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 18, 2019, Miracle, Gregory Scot; Valenti, Dominick Joseph; Dey, Sanjeev Kumar; Qin, Haihu; Freund, Wesley A. published a patent.Formula: C13H16N2O2 The title of the patent was Leuco colorants as bluing agents in laundry care compositions. And the patent contained the following:

A laundry care composition including (a) at least one laundry care ingredient and (b) at least one fluorescent moiety covalently bound to at least one second moiety selected from the group consisting of leuco moieties and chromophore moieties. A method of treating a textile includes the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).Formula: C13H16N2O2

The Article related to leuco colorant bluing laundry care, Surface Active Agents and Detergents: Dry-Cleaning Solvents and Laundering Detergents (Cleaning Of Finished Garments) and other aspects.Formula: C13H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Mastuo, Kasumi; Kuriyama, Masami; Yamamoto, Kosuke; Demizu, Yosuke; Nishida, Koyo; Onomura, Osamu published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents. And the article contained the following:

The nickel-catalyzed hydrodeoxygenation of aryl sulfamates ROS(O)2R1 [R = 2-propanoylbenzen-1-yl, 1-ethyl-1H-indol-4-yl, 4-(4-acetylpiperazin-1-yl)benzen-1-yl, etc.; R1 = dimethylaminyl, piperidin-1-yl, bis(propan-2-yl)aminyl, etc.] has been developed with alcs. as mild reductants. A variety of functional groups and heterocycles were tolerated in this reaction system to give the desired products RH in high yields. In addition, the gram-scale process and stepwise cine-substitution were also achieved with high efficiency. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to aromatic hydrocarbon preparation, aryl sulfamate hydrodeoxygenation nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On February 28, 2014, Mghandef, Marwa; Boughzala, Habib published an article.COA of Formula: C12H16N2O2 The title of the article was 1-(4-Hydroxyphenyl)piperazine-1,4-diium tetrachloridocobalt(II) monohydrate. And the article contained the following:

The asym. unit of the title inorganic-organic hybrid compound, (C10H16N2O)[CoCl4]·H2O, consists of a tetrahedral [CoCl4]2- anion, together with a [C10H18N2O]2+ cation and a water mol. Crystal cohesion is achieved through N-H···Cl, O-H···Cl and N-H···O hydrogen bonds between organic cations, inorganic anions and the water mols., building up a three-dimensional network. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).COA of Formula: C12H16N2O2

The Article related to cobalt hydroxyphenylpiperazinedium tetrachloride monohydrate crystal structure, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.COA of Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On November 30, 2013, Kavitha, Channappa N.; Jasinski, Jerry P.; Anderson, Brian J.; Yathirajan, H. S.; Kaur, Manpreet published an article.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was 1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanone. And the article contained the following:

In the title compound, C12H16N2O2, the piperazine ring has a chair conformation. The dihedral angle between the mean planes of the benzene ring and the acetyl group is 48.7 (1)°. In the crystal, mols. are linked via O-H···O hydrogen bonds, forming chains propagating along [010]. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to hydroxyphenylpiperazinylethanone crystal structure, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 7, 2022, Huo, Changxin; Wang, Hexiang; Lv, Gang; Wang, Zhiwei; Liu, Huaqing published a patent.COA of Formula: C15H29N3O2 The title of the patent was Degradation of bruton’s tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use. And the patent contained the following:

Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof. The title compounds I [ring A and B = (independently) an aromatic ring comprising 0-3 heteroatoms selected from N, S and O as ring member(s); Z1-Z4 = (independently) N or CRz; L = (independently) a bond, alkylene, O, etc.; m, n and q = (independently) 0-4; t = 0-2; R1 and R2 = (independently) H, alkyl, cycloalkyl, etc.; R3, R5 and R6 = (independently) H, halo, alkyl, etc.; Rz = the bond between moiety and Linker-Degron moiety, H, halo, etc.; the Linker = a bond or a divalent linking group; and the Degron = E3 Ubiquitin ligase moiety] or pharmaceutically acceptable salts thereof, were prepared E.g., a multi-step synthesis of II, starting from 4-phenoxybenzaldehyde and 4-methylbenzenesulfonohydrazide, was described. Exemplified compounds I were evaluated for their activity as BTK degradation (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of tert-Butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate(cas: 1211568-27-2).COA of Formula: C15H29N3O2

The Article related to bifunctional compound preparation bruton’s tyrosine kinase btk degradation, targeted protein degrader btk e3 ubiquitin ligase bifunctional compound, btk inhibitor e3 ligase conjugation bifunctional compound preparation and other aspects.COA of Formula: C15H29N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2020, Ramesh, Deepthi; Joji, Annu; Vijayakumar, Balaji Gowrivel; Sethumadhavan, Aiswarya; Mani, Maheswaran; Kannan, Tharanikkarasu published an article.SDS of cas: 67914-60-7 The title of the article was Indole chalcones: Design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis. And the article contained the following:

Indole chalcones were designed and synthesized as a promising set of compounds against H37Rv strain of Mycobacterium tuberculosis. Within this library of compounds, (E)-1-(furan-3-yl)-3-(1H-indol-3-yl)prop-2-en-1-one (18), (E)-3-(1H-indol-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one (20) and (E)-2-((1H-indol-2-yl)methylene)cyclopentan-1-one (24) displayed high anti-tubercular activity at 50 μg/mL with MIC values of 210, 197 and 236 μM resp. The in-silico studies revealed that compound 18 exhibit binding modes similar to FAS-II inhibitors like INH or Thiolactomycin against KasA protein. Cytotoxicity assay results suggest that the compounds 18, 20 and 24 are non-cytotoxic to human megakaryocytes and murine B cells. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).SDS of cas: 67914-60-7

The Article related to indole chalcones tuberculostatics mycobacterium, anti-tubercular, cytotoxicity, h(37)rv strain, indole chalcones, kasa protein, luciferase reporter mycobacteriophages (lrp), mycobacterium tuberculosis, sars and other aspects.SDS of cas: 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics