Tag: 200-300

On April 22, 2021, Berlin, Michael; Dong, Hanqing; Sherman, Dan; Snyder, Lawrence; Wang, Jing; Zhang, Wei published a patent.COA of Formula: C15H29N3O2 The title of the patent was Bifunctional molecules containing an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety and their preparation. And the patent contained the following:

Bifunctional compounds of formula I, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. Bifunctional compounds of formula I wherein ULM is a small E3 ubiquitin ligase binding moiety that bonds Von Hippel-Lindau, cereblon; PTM is a small mol. comprising a B-cell lymphoma 6 protein targeting moiety; L is a bond and a chem. linker; pharmaceutically acceptable salts, enantiomers, stereoisomers, solvates, and polymorphs thereof, are claimed. The bifunctional compounds of the disclosure exhibit a broad range of pharmacol. activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the disclosure. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their BCL6 protein degradation activity (some data given). The experimental process involved the reaction of tert-Butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate(cas: 1211568-27-2).COA of Formula: C15H29N3O2

The Article related to bifunctional mol preparation bcl6 protein degrader, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C15H29N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On November 20, 2019, Daneshyar, Anahita; Nematollahi, Davood; Varmaghani, Fahimeh; Goljani, Hamed; Alizadeh, Hojjat published an article.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Electrochemical synthesis of a new phosphonium betaine. Kinetic evaluation and antibacterial susceptibility. And the article contained the following:

Cyclic voltammetry, controlled-potential coulometry, chronoamperometry, chronocoulometry and chronopotentiometry methods were used for the electrochem. study of 1-acetyl-4-(4-hydroxyphenyl)piperazine (APIP) in the presence of PPh3 (TPP) as a nucleophile. Electrochem. generated APIPox can serve as a Michael acceptor for nucleophilic attack by TPP to yield a new phosphonium betaine (APTP). The authors prepared a new product in good yield and purity by reaction of TPP with APIPox in an undivided cell equipped with C anode. Based on an EC mechanism, the observed homogeneous rate constant (kobs) of the Michael addition reaction of APIPox with TPP were estimated by comparing the exptl. cyclic voltammograms with the digital simulated results. Also, electrochem. oxidation of APIP was studied both exptl. and theor. to provide insight into the influence of natural charge and thermodn. stability parameters on the type of chem. reaction which follows APIPox. The synthesized compound was evaluated for in vitro antibacterial. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to electrochem synthesis phosphonium betaine kinetics antibacterial susceptibility, antibacterial agents, chronoamperometry, chronopotentiometry, coulometry, cyclic voltammetry, glassy carbon electrodes, ir spectra, lumo (molecular orbital), mass spectra, nmr (nuclear magnetic resonance), reaction mechanism and other aspects.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Amani, Amene; Khazalpour, Sadegh; Nematollahi, Davood published an article in 2013, the title of the article was Electrochemical oxidation of acetaminophen and 4-(piperazin-1-yl)phenols in the presence of 4-hydroxy-1-methyl-2(1H)-quinolone.Electric Literature of 67914-60-7 And the article contains the following content:

A facile and 1-pot electrochem. method for the synthesis of mono and disubstituted 1,4-benzoquinones generated from the electrochem. oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1a), 4-(piperazin-1-yl)phenol (1b) and acetaminophen (8) in the presence of 4-hydroxy-1-methyl-2(1H)-quinolone (3) as nucleophile is reported. The electrochem. generated electrophiles derived from the oxidation of 1a, 1b and 8 participate in Michael-addition reactions with 3. The authors report the synthesis of mono and diquinolone substituted of 1,4-benzoquinone in good yields based on controlled potential condition at C electrode in a divided cell. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Electric Literature of 67914-60-7

The Article related to electrochem oxidation acetaminophen piperazinylphenol hydroxymethylquinolone, cyclic voltammetry, deprotonation (in electrochem. oxidation), electrochemical oxidation, glassy carbon electrodes, hydrolysis, michael reaction (electrochem.), nmr (nuclear magnetic resonance), reaction mechanism and other aspects.Electric Literature of 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Beiginejad, Hadi; Nematollahi, Davood; Varmaghani, Fahimeh; Bayat, Mehdi published an article in 2013, the title of the article was Efficient factors on the hydrolysis reaction rate of some para-aminophenol derivatives in acidic pHs.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone And the article contains the following content:

Electrochem. oxidation of some p-aminophenol derivatives (1-5) in acidic solutions was studied both exptl. and theor. to provide insight into the influence of some factors on the hydrolysis reaction rate. The result of this work shows that the electrogenerated p-quinoneimines participate in the hydrolysis reaction and are converted to the p-benzoquinone. The hydrolysis reaction rate strongly depends on the structure of the p-aminophenols and solution’s pH. The observed homogeneous rate constants of hydrolysis (kobshyd) of p-quinoneimines were determined using digital simulation technique. The effect of different parameters such as: change of Gibbs free energy (ΔG) of the electrochem. oxidation of para-aminophenol derivatives (1-5), charge of reaction site, N-C4 bond order (Wiberg Bond Indexes, WBIs) and the nature of substituted group, on the hydrolysis rate constant were also studied. All calculations were performed using D. Functional Theory (DFT) both BP86 and B3LYP levels of theory and 6-311G (p,d) basis set. The N-C4 bond order and charge on the reaction site play significant roles in hydrolysis reaction’s rate. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to hydrolysis electrochem oxidation aminophenol derivative acidic medium, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 31, 2016, Bayrak, Riza; Akcay, Hakki Turker; Biyiklioglu, Zekeriya; Degirmencioglu, Ismail published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Substituted phthalocyanines and their electropolymerization properties. And the article contained the following:

New metal-free and metallo-phthalocyanine complexes (Co, TiO) were synthesized using a piperazine-substituted phthalonitrile derivative All proposed structures were supported by instrumental methods. Electrochem. studies of H2-Pc, TiIVOPc, and CoIIPc were examined using cyclic voltammetry (CV) and square-wave voltammetry (SWV) techniques. Voltammetric analyses of phthalocyanines supported the proposed structure of the synthesized complexes. All studied phthalocyanines were oxidatively electropolymerized on the working electrode during the repetitive anodic potential scans. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to phthalocyanine electropolymerization oxidation reduction property, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Amani, Amene; Khazalpour, Sadegh; Nematollahi, Davood published an article in 2012, the title of the article was Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone And the article contains the following content:

The electrochem. oxidation of 4-(piperazin-1-yl)phenols were studied in the presence of indole derivatives as nucleophiles in H2O/MeCN mixture by cyclic voltammetry and controlled-potential coulometry. The reaction mechanism is believed to be oxidation of 4-(piperazin-1-yl)phenols, Michael addition reaction, oxidation of the formed adduct, another Michael addition reaction, oxidation of new adduct and hydrolysis (ECECEC). Bisindolyl-p-quinones were synthesized through the regioselective addition of indoles to electrochem. generated quinone imines in good yields at C electrode in a divided cell. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to electrooxidation piperazinylphenol indole derivative regioselectivity electrosynthesis conjugated bisindolyl quinone, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Goodarzi, Hassan; Asghari, Alireza; Amani, Ameneh; Rajabi, Maryam; Nematollahi, Davood; Khazalpour, Sadegh published an article in 2018, the title of the article was Electrochemical Synthesis of a New Derivative of 1,4-Dihydroxybenzene: Embedded Nucleophile in the Structure of Electrophile.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone And the article contains the following content:

The electrochem. oxidation of 4-(Piperazin-1-yl)phenols (1a,b) was studied in the H2O, MeCN and nitromethan by cyclic voltammetry and controlled-potential coulometry. P-quinone-imines generated of oxidation 4-(Piperazin-1-yl)phenols after the hydrolysis reaction participate in Michael-addition reactions with released piperazine of hydrolysis reaction of p-quinone imines. The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of a new derivative of 1,4-dihydroxybenzene under green conditions. The effect of H2O as a solute on the electrochem. response of 4-(Piperazin-1-yl)phenols (1a,b) was examined in the MeCN (AN) and nitromethane (NM) solvent. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to electrosynthesis derivative dihydroxybenzene embedded nucleophile structure electrophile, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On January 15, 2011, Nematollahi, Davood; Amani, Amene published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Electrochemical synthesis of the new substituted phenylpiperazines. And the article contained the following:

Electrochem. oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1) has been studied in the presence of arylsulfinic acids (3a-c) as nucleophiles in aqueous solutions using cyclic voltammetry and controlled-potential coulometry methods. The results revealed that quinone-imine derived from oxidation of 1 participates in Michael type addition reaction with arylsulfinic acids and via an EC mechanism converts to the corresponding new phenylpiperazine derivatives The present work has led to the development of a facile and environmentally friendly reagent-less electrochem. method for synthesis of some new phenylpiperazine derivatives in aqueous solutions with high atom economy and safe waste under ambient conditions and in an undivided cell using a carbon electrode. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to phenylpiperazine derivative electrooxidation electrosynthesis arylsulfinic acid, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On November 20, 2014, Nematollahi, Davood; Momeni, Shima; Khazalpour, Sadegh published an article.Formula: C12H16N2O2 The title of the article was Different strategies in electrochemical synthesis of new mono and di-substituted hydroquinone and benzoquinone. And the article contained the following:

Electrochem. syntheses of 2-indolyl-5-arylsulfonyl-p-benzoquinone derivatives were carried out in two successive oxidation steps. The 1st involves the oxidation of hydroquinone, 4-(piperazin-1-yl)-phenol and 1-(4-(4-hydroxyphenyl)-piperazin-1-yl) ethanone in the presence of arylsulfinic acids as nucleophiles. The authors’ voltammetric data indicate that electrochem. generated p-benzoquinone participates in Michael addition reaction with arylsulfinic acids leading to the 2-(arylsulfonyl) benzene-1,4-diols. The 2nd consists of the oxidation of 2-(arylsulfonyl) benzene-1,4-diols in the presence of 1,2-dimethylindole and the formation of 2-indolyl-5-arylsulfonyl-p-benzoquinone derivatives as the final products. A plausible mechanism for the synthesis of 2-indolyl-5-arylsulfonyl-p-benzoquinone derivatives is also presented. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Formula: C12H16N2O2

The Article related to strategy electrochem synthesis mono di hydroquinone benzoquinone derivative, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Amani, Amene; Nematollahi, Davood published an article in 2012, the title of the article was Electrochemical synthesis of new coumarin derivatives of potential biological significance.SDS of cas: 67914-60-7 And the article contains the following content:

Electrochem. synthesis of some new coumarin derivatives was carried out via the electrochem. oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1) in the presence of 4-hydroxycoumarin and 4-hydroxy-6-methylcoumarin (2a,b). Electrogenerated p-quinone imine, participated in Michael type reaction with 2a,b and after hydrolysis reaction is converted to the corresponding coumarin derivatives This method provides a 1-pot procedure for the synthesis of new coumarin derivatives of potential biol. significance. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).SDS of cas: 67914-60-7

The Article related to electrochem synthesis coumarin derivative biol application, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.SDS of cas: 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics