Tag: 171504-98-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171504-98-6,Methyl 1,4-Bis(Boc)-2-piperazinecarboxylate,as a common compound, the synthetic route is as follows.

To a dry flask were added 1, 4-di-tert-butyl 2-methyl piperazine-1, 2, 4-tricarboxylate (10 g, 29.04 mmol) , anhydrous tetrahydrofuran (100 mL) in turn, the mixture was cooled to -78 under N 2, and then LiHDMS (35 mL, 35 mmol, 1 mol/L) was added dropwise slowly. The mixture was keeped at -78 and stirred for 2 hours, then iodomethane (3.7 mL, 59 mmol) was added. The mixture was further stirred for 1 hour, and warmed to rt and stirred for 12 hours. The reaction was quenched with saturated ammonium chloride aqueous solution (50 mL) in an ice bath, and the mixture was extracted with EtOAc (100 mL ¡Á 2) . The combined organic layers were washed with saturated brine (80 mL) , dried over anhydrous sodium sulfate, and concentrated in vacuo, and the residue was purified by silica gel column chromatography (PE/EA (V/V) =10/1) to give the title compound as a colorless oil (8.2 g, 79%) . MS (ESI, pos. ion) m/z: 381.2 [M+Na] +., 171504-98-6

The synthetic route of 171504-98-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Xinchang; REN, Qingyun; YAN, Guanghua; GOLDMANN, Siegfried; ZHANG, Yingjun; (253 pag.)WO2019/76310; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171504-98-6,Methyl 1,4-Bis(Boc)-2-piperazinecarboxylate,as a common compound, the synthetic route is as follows.

Step 2: To a solution of Compound All (13.4 g, 38.9 mmol) in 200 mL of anhydrous THF was added freshly prepared LDA (2M in THF, 38 mL) at -78 C. The reaction mixture was stirred for 30 minutes at -78 C. and then warmed to room temperature for 30 minutes. The mixture was cooled down to -78 C. and a solution of allyl bromide (6.7 mL, 77.9 mmol) in 10 mL of THF was added. After the mixture was warmed to room temperature and stirred overnight, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography to afford Compound AI (yield 13.6 g, 91%)., 171504-98-6

As the paragraph descriping shows that 171504-98-6 is playing an increasingly important role.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Kou, Buyu; Lin, Xianfeng; Shen, Hong; Shi, Houguang; Yan, Shixiang; Zhang, Weixing; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2015/252057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics