Tag: 142.2

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers was written by Martini, Elisabetta;Salvicchi, Alberto;Ghelardini, Carla;Manetti, Dina;Dei, Silvia;Guandalini, Luca;Martelli, Cecilia;Melchiorre, Michele;Cellai, Cristina;Scapecchi, Serena;Teodori, Elisabetta;Romanelli, Maria Novella. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Electric Literature of C7H14N2O This article mentions the following:

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Electric Literature of C7H14N2O).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H14N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries was written by Baranczak, Aleksandra;Tu, Noah P.;Marjanovic, Jasmina;Searle, Philip A.;Vasudevan, Anil;Djuric, Stevan W.. And the article was included in ACS Medicinal Chemistry Letters in 2017.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone This article mentions the following:

The productivity of medicinal chem. programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, the authors describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small mol. libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chem. transformations with testing in a variety of biochem. assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chem. discovery cycles. In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers was written by Martini, Elisabetta;Salvicchi, Alberto;Ghelardini, Carla;Manetti, Dina;Dei, Silvia;Guandalini, Luca;Martelli, Cecilia;Melchiorre, Michele;Cellai, Cristina;Scapecchi, Serena;Teodori, Elisabetta;Romanelli, Maria Novella. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Electric Literature of C7H14N2O This article mentions the following:

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Electric Literature of C7H14N2O).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H14N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries was written by Baranczak, Aleksandra;Tu, Noah P.;Marjanovic, Jasmina;Searle, Philip A.;Vasudevan, Anil;Djuric, Stevan W.. And the article was included in ACS Medicinal Chemistry Letters in 2017.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone This article mentions the following:

The productivity of medicinal chem. programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, the authors describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small mol. libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chem. transformations with testing in a variety of biochem. assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chem. discovery cycles. In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers was written by Martini, Elisabetta;Salvicchi, Alberto;Ghelardini, Carla;Manetti, Dina;Dei, Silvia;Guandalini, Luca;Martelli, Cecilia;Melchiorre, Michele;Cellai, Cristina;Scapecchi, Serena;Teodori, Elisabetta;Romanelli, Maria Novella. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Electric Literature of C7H14N2O This article mentions the following:

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Electric Literature of C7H14N2O).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H14N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries was written by Baranczak, Aleksandra;Tu, Noah P.;Marjanovic, Jasmina;Searle, Philip A.;Vasudevan, Anil;Djuric, Stevan W.. And the article was included in ACS Medicinal Chemistry Letters in 2017.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone This article mentions the following:

The productivity of medicinal chem. programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, the authors describe a platform that consolidates synthesis, purification, quantitation, dissolution, and testing of small mol. libraries. The system was validated through the synthesis and testing of two libraries of binders of polycomb protein EED, and excellent correlation of obtained data with results generated through conventional approaches was observed The fully automated and integrated platform enables batch-supported compound synthesis based on a broad array of chem. transformations with testing in a variety of biochem. assay formats. A library turnaround time of between 24 and 36 h was achieved, and notably, each library synthesis produces sufficient amounts of compounds for further evaluation in secondary assays thereby contributing significantly to the shortening of medicinal chem. discovery cycles. In the experiment, the researchers used many compounds, for example, 1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone).

1-(1,4-Diazepan-1-yl)ethanone (cas: 61903-11-5) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Recommanded Product: 1-(1,4-Diazepan-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics