Tag: 109-01-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

nitrobenzyl bromide and N- methyl piperazine after the substitutionreaction, and then get by stannous chloride reduction., 109-01-3

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; CHINA PHARMACEUTICAL UNIVERSITY; YANG, ZHAO; WANG, ZHIXIANG; FANG, ZHENG; GUO, KAI; WEI, PING; (23 pag.)CN103739550; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.,109-01-3

Add 10 g (46.3 mmol) of p-nitrobenzyl bromide and 100 mL of dichloromethane to a 500 mL single-necked flask. N-methylpiperazine 4.7 g (47.0 mmol) was slowly added dropwise under ice-water bath (0-5 C) And triethylamine 7.1g (70.3 mmol) 20 mL of dichloromethane, After heating and refluxing for 1 h, The disappearance of the starting material by TLC (ethyl acetate: petroleum ether = 1:2). 150 mL of chloroform and 100 mL of a saturated sodium hydrogencarbonate solution were added to the reaction solution. Stir vigorously for 30 min at room temperature. The reaction solution was extracted with chloroform (100 mL¡Á3). Combine the organic layers, Wash once with water and saturated sodium chloride (100 mL ¡Á 1). Dried over anhydrous magnesium sulfate, filter, The solvent was evaporated under reduced pressure to give 8.5 g of pale-yellow solid, The yield is 78.1%.. The product was directly fed to the next reaction without further purification.

As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Wang Yue; Lu Shuai; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (26 pag.)CN109970717; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 147Preparation of 2-[4-(4-methylpiperazin-1-yl)phenyl]-4,5,6,7-tetrahydro-1 ,3- benzothiazol-7-ol Step A: 4-(4-Methylpiperazin-1-yl)benzonitrile A mixture of 4-bromobenzonitrile (1.82 g, 10 mmol), 1 -methyl piperazine (2.0 g, 10 mmol), tris(dibenzylideneacetone)dipalladium(0) (50 mg), rac-2,2′-bis(diphenylphosphino)-1,1′- binaphthyl (50 mg), and sodium te/f-butoxide (1.92 g, 20 mmol) in 20 ml. of toluene is stirred at 80 C for 18 hours and then concentrated. The residue is chromatographed over silica gel, eluting with a gradient of ethyl acetate to 20% methyl alcohol in ethyl acetate. Concentration provides 4-(4-methylpiperazin-1-yl)benzonitrile as a tan solid (1.6 g).

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; WYETH; WO2009/120826; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the ionic liquid [TPA][Pro] (1 mL) was added amine (1-14; Table-1) (1 mmol) and di-tert-butyl dicarbonate (1.2 mmol). The reaction was stirred at room temperature for an appropriate time (Table-1). After completion of the reaction as monitored by TLC, water was added to the reaction mixture and the product was extracted into ethyl acetate (3 ¡Á 20 mL). The combined organic layer was washed with brine solution and concentrated under reduced pressure to give crude product, which was purified over silica gel column to afford corresponding N-tert-butylcarbamate. The ionic liquid [TPA][Pro] in aqueous solution was recovered by removing water under reduced pressure and dried. The recovered ionic liquid was reused for five times without loss of its activity. Finally, all the compounds confirmed by their m.p.?s, IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis wherever needed.

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Vijaya Durga; Rambabu; Srinivasa Reddy; Hari Babu; Asian Journal of Chemistry; vol. 29; 6; (2017); p. 1313 – 1316;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: These amines were required for the syntheses of 4 and 20 respectively. To a solution of 4-nitrobenzylchloride (1 mmol) in anhydrous THF (3 mL) was added 1-methylpiperazine or piperidine (1 mmol) and triethylamine (1.5 mmol, 0.21 mL). The solution was heated at 70 C overnight. The reaction mixture was then extracted with dichloromethane and water. The organic fractions were combined, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by column chromatography (hexane/EA 1:4) and characterized by 1H NMR (Supplementary Information). It was dissolved in 10 mL ethanol, PtO2 (0.01 g) was added under nitrogen. Hydrogenation was carried out on a Parr hydrogenator at 50 psi for 16 h. The catalyst was then removed by filtration and the filtrate was concentrated in vacuo to give the amine in quantitative yield.

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2917 – 2929;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics