Tag: 100-200

SDS of cas: 34352-59-5On October 31, 1983 ,《Imidazole systems. I. Imidazo[2,1-b][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Della Vecchia, Laurence; Dellureficio, James; Kisis, Biruta; Vlattas, Isidoros. The article conveys some information:

Imidazo[2,1-b][1,3,5]benzothiadiazepine (I, R-R2 = H) constitutes a novel ring system, and I [R = H, Me; R1 = H, Cl, F, CF3, OMe; R2 = (un)substituted piperazino, imidazole, perhydro-1,4-diazepino] were synthesized to investigate their antipsychotic activity. The synthesis of I was achieved by reaction of 2-aminophenylthioimidazoles with COCl2 or CSCl2 or by ring closure of the 1-[2-(2-imidazolyl)thiophenyliminocarbonyl]-1-piperazines. An efficient method for the conversion of I (R2 = SH) to I (R2 = amino) via I (R2 = thiocyanato) was also developed. The results came from multiple reactions, including the reaction of 1-Methylpiperazine dihydrochloride(cas: 34352-59-5SDS of cas: 34352-59-5)

1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..SDS of cas: 34352-59-5

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SDS of cas: 109-01-3In 2019 ,《Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols》 was published in Journal of the American Chemical Society. The article was written by Laudadio, Gabriele; Barmpoutsis, Efstathios; Schotten, Christiane; Struik, Lisa; Govaerts, Sebastian; Browne, Duncan L.; Noel, Timothy. The article contains the following contents:

Sulfonamides are key motifs in pharmaceuticals and agrochems., spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, the authors report an environmentally benign electrochem. method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chems. The transformation is completely driven by electricity, does not require any sacrificial reagent or addnl. catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2011,Bioorganic & Medicinal Chemistry Letters included an article by Kim, Heung Jae; Kwak, Woo Young; Min, Jong Pil; Lee, Jae Young; Yoon, Tae Hyun; Kim, Ha Dong; Shin, Chang Yell; Kim, Mi Kyung; Choi, Song Hyen; Kim, Hae Sun; Yang, Eun Kyoung; Cheong, Ye Hwang; Chae, Yu Na; Park, Kyung Jin; Jang, Ji Myun; Choi, Soo Jung; Son, Moon Ho; Kim, Soon Hoe; Yoo, Moohi; Lee, Bong Jin. Application In Synthesis of 1-(Pyridin-2-yl)piperazin-2-one. The article was titled 《Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes》. The information in the text is summarized as follows:

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229, I) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clin. development. In addition to this study using 1-(Pyridin-2-yl)piperazin-2-one, there are many other studies that have used 1-(Pyridin-2-yl)piperazin-2-one(cas: 345310-98-7Application In Synthesis of 1-(Pyridin-2-yl)piperazin-2-one) was used in this study.

1-(Pyridin-2-yl)piperazin-2-one(cas: 345310-98-7) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Application In Synthesis of 1-(Pyridin-2-yl)piperazin-2-one

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chen, Jianyang; Peng, Haixia; He, Jinxue; Huan, Xiajuan; Miao, Zehong; Yang, Chunhao published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors》.Product Details of 534615-34-4 The author mentioned the following in the article:

The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biol. study of these compounds provided potent compounds I, II, III, and IV with low nanomolar IC50s against PARP-1 enzyme. In the experiment, the researchers used many compounds, for example, 1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4Product Details of 534615-34-4)

1-(Isopropylsulfonyl)piperazine(cas: 534615-34-4) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.Product Details of 534615-34-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《Synthesis and antifungal activity of 1-aminomethyl-3-[4′-(4”-fluorobenzyloxy)-benzohydrazono] isatins》 were Rastogi, Nisheeth. And the article was published in Indian Journal of Heterocyclic Chemistry in 2019. Category: piperazines The author mentioned the following in the article:

A new series of 1-aminomethyl-3-[4′-(4”-fluorobenzyloxy)benzohydrazono]isatins (Mannich bases) I [R = H, Me, morpholinomethyl, etc.] were synthesized and screened for their antifungal potential against human pathogenic fungi. The structures of the compounds were established by means of elemental anal. and spectral data (IR and 1H NMR). The experimental part of the paper was very detailed, including the reaction process of 1-Methylpiperazine(cas: 109-01-3Category: piperazines)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 109-01-3In 2021 ,《Facile and Cost-Effective Route for the Synthesis of Simmerafil》 was published in Organic Process Research & Development. The article was written by Odilov, Abdullajon; Liu, Yin; Hu, Tianwen; Jiang, Xiangrui; Suo, Jin; Tian, Guanghui; Yang, Feipu; Shen, Jingshan. The article contains the following contents:

An improved synthesis of simmerafil, a potent PDE5 inhibitor as a clin. candidate, is described with a 38.1% overall yield and 99.7% purity. Starting from the safe and inexpensive salicylamide, the key intermediate 2-propoxybenzimidamide, which is also a potential precursor for the preparation of pyrimidinone derivatives, was effectively and conveniently obtained. The subsequent process from 2-propoxybenzimidamide to simmerafil was optimized, which makes it more amenable to scale-up.1-Methylpiperazine(cas: 109-01-3HPLC of Formula: 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..HPLC of Formula: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Tabushi, Iwao; Shimokawa, Kazuhiro published an article in Journal of the American Chemical Society. The title of the article was 《Model approach to retinal pigments. Remarkable red shift due to proximal ammonium ion》.Name: 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:

Retinal derivs, I and II, were prepared and the absorption characteristics of a series of retinal derivatives (I, II, III, IV, and V) were investigated as a model study for the remarkable red shift observed for the native retinal pigments such as rhodopsins or bacteriorhodopsins. Remarkable red shifts observed in the following 2 derivatives were interpreted mechanistically; in retinal N’-methylpiperidinium perchlorate, 526 nm in CHCl3, as the electrostatic destabilization of the ground state by the proximal NH4 with a loose counter-anion in a less polar solvent; and in III chloride, 497 nm in water, as the balance between the electrostatic destabilization and the twist of the chromophore. In addition to this study using 1-Methylpiperazine dihydrochloride, there are many other studies that have used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Name: 1-Methylpiperazine dihydrochloride) was used in this study.

1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Name: 1-Methylpiperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dow, Robert L.; Paight, Ernest S.; Schneider, Steven R.; Hadcock, John R.; Hargrove, Diane M.; Martin, Kelly A.; Maurer, Tristan S.; Nardone, Nancy A.; Tess, David A.; DaSilva-Jardine, Paul published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Potent and selective, sulfamide-based human β3-adrenergic receptor agonists》.Name: 4-Methyl-1-piperazinesulfonyl Chloride The author mentioned the following in the article:

A series of sulfamide-based analogs, e.g., I, related to L-796568 were prepared and evaluated for their biol. activity at the human β3-adrenergic receptor (AR). This modification allows for a significant reduction in mol. weight, while maintaining single-digit nanomolar potencies at the β3-AR and high selectivities vs. the β1- or β2-AR.4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5Name: 4-Methyl-1-piperazinesulfonyl Chloride) was used in this study.

4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.Name: 4-Methyl-1-piperazinesulfonyl Chloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 1-MethylpiperazineIn 2021 ,《Discovery and optimization of novel pyrazole-benzimidazole CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3)》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yamani, Abdellah; Zdzalik-Bielecka, Daria; Lipner, Joanna; Stanczak, Aleksandra; Piorkowska, Natalia; Stanczak, Paulina Seweryna; Olejkowska, Patrycja; Hucz-Kalitowska, Joanna; Magdycz, Marta; Dzwonek, Karolina; Dubiel, Krzysztof; Lamparska-Przybysz, Monika; Popiel, Delfina; Pieczykolan, Jerzy; Wieczorek, Maciej. The article conveys some information:

The scaffolds hybridization approach, scaffold-hopping concept, has been employed to synthesize a series of novel pyrazole-benzimidazoles I [R1 = H, Cl; R2 = morpholin-4-yl, 4-methylpiperazin-1-ylcarbonyl, tetrahydropyran-4-ylcarbamoyl, etc.; R3 = H, F]. Compound I [R1 = R3 = H; R2 = 4-methylpiperazin-1-yl] (CPL304110) was identified as a selective and potent pan-FGFR inhibitor for FGFR1, FGFR2, FGFR3 with IC50 of 0.75 nM, 0.50 nM, 3.05 nM resp., and IC50 of 87.90 nM for FGFR4. Due to its favorable pharmacokinetic profile, low toxicity and potent anti-tumor activity in-vivo, this compound I is currently under evaluation in phase I clin. trial for the treatment of bladder, gastric and squamous cell lung cancers (01FGFR2018; NCT04149691). In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Safety of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Safety of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Synthesis, biological evaluation and molecular docking studies of some new 2-(2-(substituted piperazin-1-yl)-phenyl)-1H-benzo[d]imidazoles as potential antibacterial, anticancer and antifungal agents》 was written by Bhardwaj, Harsh; Sharma, C. S.. Name: 1-Methylpiperazine And the article was included in Indian Journal of Heterocyclic Chemistry in 2020. The article conveys some information:

Some new 2-(2-(substituted piperazin-1-yl)-phenyl)-1H-benzo[d]imidazoles I [R = H, 2-Me, 4-Et, etc.] were designed, synthesized and evaluated by the docking studies using glide tool for their antimicrobial and anticancer activities. The structures of these compounds I were characterized by IR, proton NMR, mass spectral data, and elemental anal. Each analog was tested in-vitro for various types of pharmacol. activities, including antibacterial, antifungal and anticancer activity. The compound I [R = 3-Me] was found to be most active against Escherichia coli and Pseudomonas aeruginosa and compound I [R = 2-Et] against Bacillus subtilis and Staphylococcus aureus. The derivative I [R = 4-Et] showed good activity against Candida albicans and Aspergillus niger. Among all the tested compounds, I [R = H, 2-Me] were found with significant anticancer activity in comparison to Adriamycin standard drug. The obtained results revealed that most of the synthesized compounds I exhibited significant antifungal, antibacterial and anticancer activity. It was deduced that these synthesized compounds I can be regarded as a promising starting point for developing a single mol. with multiple targets.1-Methylpiperazine(cas: 109-01-3Name: 1-Methylpiperazine) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Name: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics