Tag: 100-200

Reference of 1-MethylpiperazineIn 2021 ,《Experimental review of PEI electrodeposition onto copper substrates for insulation of complex geometries》 appeared in RSC Advances. The author of the article were Zirignon, J.-C.; Capezza, A. J.; Xiao, X.; Andersson, R. L.; Forslund, M.; Diner, P.; Olsson, R. T.. The article conveys some information:

Polyetherimide (PEI) was used for coating copper substrates via electrophoretic deposition (EPD) for elec. insulation. Different substrate preparation and elec. field application techniques were compared, demonstrating that the use of a pulsed voltage of 20 V allowed for the best formation of insulating coatings in the 2-6μm thickness range. The results indicate that pulsed EPD is the best technique to effectively coat conductive substrates with superior surface finish coatings that could pass a dielec. withstand test at 10 kV mm-1, which is of importance within the EV automotive industry. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Reference of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Reference of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wambua, Victor; Hirschi, Jennifer S.; Vetticatt, Mathew J. published an article in 2021. The article was titled 《Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects》, and you may find the article in ACS Catalysis.Formula: C5H12N2 The information in the text is summarized as follows:

A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a “”designed”” reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene with primary and secondary amines is investigated under synthetically relevant catalytic conditions using traditional intermol. 13C NMR methodol. at natural abundance. Switching to 1,4-dibromobenzene, a sym. bromoarene as the designed reactant, the same exptl. 13C KIEs are determined using an intramol. KIE approach. This rapid methodol. for KIE determination requires substantially less material and time compared to traditional approaches. Details of the Buchwald-Hartwig amination mechanism are investigated under varying synthetic conditions, namely a variety of halides and bases. The enantioselectivity-determining step of the L-proline catalyzed aldol reaction is also evaluated using this approach. We expect this mechanistic methodol. to gain traction among synthetic chemists as a practical technique to rapidly obtain high-resolution information regarding the transition structure of synthetically relevant reactions under catalytic conditions. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides》 was written by Brandes, Benjamin; Koch, Lukas; Hoenke, Sophie; Deigner, Hans-Peter; Csuk, Rene. Quality Control of 1-MethylpiperazineThis research focused onursolic acid piperazinylamide preparation antitumor structure activity; oleanolic acid piperazinylamide preparation antitumor structure activity; Amides; Cytotoxicity; N-oxide; Oleanolic acid; Ursolic acid. The article conveys some information:

3-O-Acetyl-ursolic acid and 3-O-acetyl-oleanolic acid were converted into piperazinylamides holding a distal NH, NMe or a NMe2 group. These compounds as well as the corresponding N-methyl-N-oxides were accessed. Their cytotoxicity was assessed in SRB assays employing a panel of human tumor cell lines and non-malignant fibroblasts (NIH 3T3). As a result, compounds holding a quaternary distal N-substituent were less cytotoxic that those holding a NH-moiety. Hence, the presence of a distal cationic center seems not to be a sufficient criterion for obtaining triterpenoids of high cytotoxicity and selectivity. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors》 was written by El-Abd, Azhar O.; Bayomi, Said M.; El-Damasy, Ashraf K.; Mansour, Basem; Abdel-Aziz, Naglaa I.; El-Sherbeny, Magda A.. Application of 109-01-3This research focused ontrimethoxyphenylthiazole preparation antitumor SAR tubulin polymerization inhibition mol docking. The article conveys some information:

A new series of 2,4-disubstituted thiazole derivatives I [R = 2-chloroacetyl, 2-(butylamino)acetyl, 2-piperazin-1-ylacetyl, etc.] containing 4-(3,4,5-trimethoxyphenyl) moiety was synthesized and evaluated for their potential anticancer activity as tubulin polymerization inhibitors. All designed compounds I were screened for cytotoxic activity against four human cancer cell lines, namely, HepG2, MCF-7, HCT116, and HeLa, using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay, with combretastatin A-4 as a reference drug. Compounds I [R = 2-(isopropylamino)acetyl, 2-[4-(4-fluorophenyl)piperazin-1-yl]acetyl, 2-(4-nitroanilino)acetyl, 2-hydrazinoacetyl, 2-[(2Z)-2-(5-chloro-2-oxo-indolin-3-ylidene)hydrazino]acetyl, 2-[(2Z)-2-(5-methyl-2-oxo-indolin-3-ylidene)hydrazino]acetyl] showed superior activity against the tested cell lines, with IC50 values ranging from 3.35 ± 0.2 to 18.69 ± 0.9 μM. Further investigation for the most active cytotoxic agents as tubulin polymerization inhibitors was also performed in order to explore the mechanism of their antiproliferative activity. The obtained results suggested that compounds I [R = 2-(isopropylamino)acetyl, 2-(4-nitroanilino)acetyl, 2-[(2Z)-2-(5-chloro-2-oxo-indolin-3-ylidene)hydrazino]acetyl] remarkably inhibit tubulin polymerization, with IC50 values of 2.95 ± 0.18, 2.00 ± 0.12, and 2.38 ± 0.14 μM, resp., which exceeded that of the reference drug combretastatin A-4 (IC50 2.96 ± 0.18 μM). Mol. docking studies were also conducted to investigate the possible binding interactions between the targeted compounds and the tubulin active site. The interpretation of the results showed clearly that compounds I [R = 2-(4-nitroanilino)acetyl, 2-[(2Z)-2-(5-chloro-2-oxo-indolin-3-ylidene)hydrazino]acetyl] were identified as the most potent tubulin polymerization inhibitors with promising cytotoxic activity and excellent binding mode in the docking study. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Application of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 109-01-3In 2020 ,《One-pot multicomponent synthesis and bioevaluation of tetrahydroquinoline derivatives as potential antioxidants, a-amylase enzyme inhibitors, anti-cancerous and anti-inflammatory agents》 was published in Molecules. The article was written by Farooq, Samra; Mazhar, Aqsa; Ghouri, Areej; Ihsan-Ul-Haq; Ullah, Naseem. The article contains the following contents:

Mankind has always suffered from multiple diseases. Therefore, there has been a rigorous need in the field of medicinal chem. for the design and discovery of new and potent mol. entities. In this work, thirteen tetrahydroquinoline derivatives were synthesized and evaluated biol. for their antioxidant, a-amylase enzyme inhibitory, anti-proliferative and anti-inflammatory activities. SF8 showed the lowest IC50 of 29.19 ± 0.25 microg/mL by scavenging DPPH free radicals. SF5 showed significant antioxidant activity in total antioxidant capacity (TAC) and total reducing power (TRP) assays. SF5 and SF9 showed the maximum inhibition of a-amylase enzyme i.e., 97.47% and 89.93%, resp., at 200 microg/mL concentration Five compounds were shortlisted to determine their anti-proliferative potential against Hep-2C cells. The study was conducted for 24, 48 and 72 h. SF8 showed significant results, having an IC50 value of 11.9 ± 1.04 microM at 72 h when compared with standard cisplatin (IC50 value of 14.6 ± 1.01 microM). An in vitro nitric oxide (NO) assay was performed to select compounds for in vivo anti-inflammatory activity evaluation. SF13 scavenged the NO level to a maximum of 85% at 50 microM concentration, followed by SF1 and SF2. Based on the NO scavenging assay results, in vivo anti-inflammatory studies were also performed and the results showed significant activity compared to the standard, acetylsalicylic acid (ASA). In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jiang, Feng; Gao, Donghui; Feng, Xi; Pan, Jiaming; Pu, Wanfen published an article in 2021. The article was titled 《W/O high internal phase emulsions (HIPEs) stabilized by a piperazinyl based emulsifier》, and you may find the article in Soft Matter.Recommanded Product: 1-Methylpiperazine The information in the text is summarized as follows:

In this study, a piperazinyl-based emulsifier (EA/AMPA) was synthesized to prepare water-in-oil (W/O) high internal phase emulsions (HIPEs). Using kerosene as the oil phase, stable HIPEs with internal phase fractions of up to 98% were prepared This enabled the EA/AMPA to have a high efficiency, as the HIPEs with a 90% internal phase fraction could be easily prepared with 0.1% of EA/AMPA. In addition, the formation of HIPEs was not affected by the addition of Na+. Because of the fact that EA/AMPA has a hydrophilic head with two tertiary amines, EA/AMPA could be easily recovered from the oil phase by adjusting the pH to acidic values. Moreover, the unique structure promoted the formation of stable HIPEs, even with crude oil used as the oil phase. The results indicate that EA/AMPA has the potential to significantly contribute to the preparation of W/O HIPEs and that the design of the hydrophilic head with two tertiary amines can provide a reference for the fabrication of new W/O emulsifiers. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Wormlike micelles with a unique ladder shape formed by a C22-tailed zwitterionic surfactant bearing a bulky piperazine group》 was written by Han, Yugui; Wang, Yefei; Meng, Xianghai; Wang, Qiuxia; Han, Xiaodong. Application In Synthesis of 1-MethylpiperazineThis research focused onzwitterionic surfactant wormlike micelle zero shear viscosity surface tension. The article conveys some information:

Wormlike micelles (WLMs) have been successfully constructed from many different C22-tailed surfactants. Here, we creatively introduced a bulky piperazine group onto a C22-tailed zwitterionic surfactant, N-erucamidopropyl-N,N-piperazine-N-Me ammonium propanesulfonate (EDPS), and investigated the micellar structure and properties of the EDPS WLMs via mol. dynamics simulation, cryo-TEM and rheol. techniques. It was found that 25 mM EDPS increased the zero-shear viscosity to as high as ~106 mPa s. Furthermore, abnormal rheol. behaviors, such as an inflection in the shear thinning region of steady rheol. and an abrupt decrease of the shear stress at a critical shear rate, were observed, which was attributed to the unique ladder shape micellar structure. The EDPS WLMs were superior to other C22-tailed surfactants in many aspects, such as a low overlapping concentration, higher viscosity, stable viscosity over the whole pH range, and great temperature and salt (NaCl, CaCl2 and MgCl2) tolerance. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Application In Synthesis of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application In Synthesis of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dubey, M.; Verma, V. K.; Shanker, K.; Sinha, J. N.; Bhargava, K. P.; Kishor, K. published an article on January 31 ,1979. The article was titled 《Synthesis of some newer piperazinoquinazolones as cardiovascular agents》, and you may find the article in Pharmazie.HPLC of Formula: 34352-59-5 The information in the text is summarized as follows:

Twenty-nine piperazinoquinazolones I (R1 = H, Cl, Br, I; R2 = H, Cl, Br; R3 = Me, Ph, 2- and 4-MeOC6H4, 3- and 4-ClC6H4) were prepared by Mannich reaction of II with HCHO and the appropriate piperazines. II were prepared in 40-60% yield by heating equimolar proportions of the appropriate acetanthranils with p-H2NC6H4COMe. Several I, e.g., I (R1 = R2 = H, R3 = Me, Ph, 2-MeOC6H4) elicited hypotensive activity. Several I elicited bradycardia and others produced tachycardia. Some others blocked the carotid occlusion response. In the experimental materials used by the author, we found 1-Methylpiperazine dihydrochloride(cas: 34352-59-5HPLC of Formula: 34352-59-5)

1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..HPLC of Formula: 34352-59-5

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker》 was written by Zhang, Guang-Yu; Zhang, Zhe; Li, Kang; Liu, Jie; Li, Bo; Jin, Zhen; Liu, Ya-Hong; Tang, You-Zhi. HPLC of Formula: 109-01-3 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

A series of novel pleuromutilin derivatives containing piperazine ring, 1,2,3-triazoles and secondary amines on side chain of C14 e.g., I were synthesized under mild conditions via click reaction. The in vitro antibacterial activities of synthesized derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, ATCC 29213,144 and AD3) and one strain of Escherichia coli (ATCC 25922) were evaluated by broth dilution method. Among these derivatives, 22-[2-(4-((4-nitrophenyl piperazine)methyl)-1,2,3-triazol-1-yl)-1-(piperazine-1-yl) ethyl-1-one] deoxy pleuromutilin I showed most prominent in vitro antibacterial effect against MRSA (MIC = 1μg/mL). Furthermore, compound I displayed more rapid bactericidal kinetic than tiamulin time-kill studies and possessed a longer PAE than tiamulin against MRSA in vitro. In addition, in vivo antibacterial activities of compound I against MRSA were further evaluated employing thigh infection model. And compound I (-8.89 log10 CFU/mL) displayed superior activities than tiamulin. Compound I was further evaluated in CYP450 inhibition assay and the results showed that it exhibited low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6 and CYP3A4 enzymes. The PK properties of compound I were then measured. The half-life (t1/2), clearance rate (Cl) and area under the plasma concentration time curve (AUC0→∞) of compound I were 0.74 h, 0.29 L/h/kg and 46.28μg·h/mL, resp.1-Methylpiperazine(cas: 109-01-3HPLC of Formula: 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..HPLC of Formula: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2022,Chen, Xiao-Xian; Liu, De-Xuan; Gong, Ya-Ping; Wang, Sha-Sha; Zhang, Wei-Xiong; Chen, Xiao-Ming published an article in Inorganic Chemistry. The title of the article was 《Above-Room-Temperature Ferroelastic Phase Transitions in Two Tetrafluoroborate-Based Hexagonal Molecular Perovskites》.Name: 1-Methylpiperazine The author mentioned the following in the article:

ABX3-type mol. perovskites provide an important platform to tune phase transitions, via judiciously choosing A-, B-, and X-site components, to approach advanced functional materials for applications. Although tetrafluoroborate can act as X-site component to assemble ten instances of ABX3 mol. perovskites, only two of them possess hexagonal perovskite structures. Herein, we report two tetrafluoroborate-based hexagonal mol. perovskites, A[Na(BF4)3], by judiciously choosing two different A-site cations: 1-methyl-1,4-diazabicyclo[2.2.2]octane-1,4-diium (Hmdabco2+) for 1 and 1-methylpiperazine-1,4-diium (H2mpz2+) for 2. They have high-temperature phases in the same space group (P63/mmc) revealing highly disordered A-site cations. Upon cooling, 1 undergoes two-step P63/mmc ↔ P3̅c1 ↔ P21/n transitions at 344 and 338 K, resp., including a ferroelastic one (3̅mF2/m) accompanied by a spontaneous strain of 0.013. In contrast, the smaller H2mpz2+ cation with more adoptable conformations induces a one-step sharp P63/mmc ↔ P21/c ferroelastic transition (6/mmmF2/m(s)) at 418 K in 2, leading to more significant symmetry breaking and a considerable spontaneous strain of 0.129. This study provides important clues to modulate structural phase transitions by tuning diverse components for the multicomponent dense hybrid crystals. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Name: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Name: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics