Tag: 100-200

Microarrays of over 2000 hydrogels – Identification of substrates for cellular trapping and thermally triggered release was written by Zhang, Rong;Liberski, Albert;Sanchez-Martin, Rosario;Bradley, Mark. And the article was included in Biomaterials in 2009.Application of 21867-64-1 This article mentions the following:

In this paper we describe an approach whereby over 2000 individual polymers were synthesized, in situ, on a microscope slide using inkjet printing. Subsequent biol. anal. of the entire library allowed the rapid identification of specific polymers with the desired properties. Herein we demonstrate how this array of new materials could be used for the identification of polymers that allow cellular adherence, proliferation and then mild thermal release, for multiple cell lines, including mouse embryonic stem (mES) cells. The optimal, identified hydrogels were successfully scaled-up and demonstrated excellent cell viability after thermal detachment for all cell lines tested. We believe that this approach offers an avenue to the discovery of a specific thermal release polymer for every cell line. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SAR of the arylpiperazine moiety of obeline somatostatin sst₁ receptor antagonists was written by Hurth, Konstanze;Enz, Albert;Floersheim, Philipp;Gentsch, Conrad;Hoyer, Daniel;Langenegger, Daniel;Neumann, Peter;Pfaeffli, Paul;Sorg, Dieter;Swoboda, Robert;Vassout, Annick;Troxler, Thomas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Synthetic Route of C10H12N4 This article mentions the following:

The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst₁ receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst₁ affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst₁ affinities and >10,000-fold selectivities over the sst₂ receptor subtype as well as promising pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Synthetic Route of C10H12N4).

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C10H12N4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors was written by Zlatoidsky, P.;Maliar, T.. And the article was included in European Journal of Medicinal Chemistry in 1996.Safety of 1-Propylpiperazine This article mentions the following:

Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 μM. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Safety of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A therapeutic approach to pantothenate kinase associated neurodegeneration was written by Sharma, Lalit Kumar;Subramanian, Chitra;Yun, Mi-Kyung;Frank, Matthew W.;White, Stephen W.;Rock, Charles O.;Lee, Richard E.;Jackowski, Suzanne. And the article was included in Nature Communications in 2018.Safety of 6-(Piperazin-1-yl)nicotinonitrile This article mentions the following:

Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular CoA (CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 lead to pantothenate kinase associated neurodegeneration (PKAN). Here we performed a library screen followed by chem. optimization to produce PZ-2891, an allosteric PANK activator that crosses the blood brain barrier. PZ-2891 occupies the pantothenate pocket and engages the dimer interface to form a PANK.ATP.Mg²⁺.PZ-2891 complex. The binding of PZ-2891 to one protomer locks the opposite protomer in a catalytically active conformation that is refractory to acetyl-CoA inhibition. Oral administration of PZ-2891 increases CoA levels in mouse liver and brain. A knockout mouse model of brain CoA deficiency exhibited weight loss, severe locomotor impairment and early death. Knockout mice on PZ-2891 therapy gain weight, and have improved locomotor activity and life span establishing pantazines as novel therapeutics for the treatment of PKAN. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Safety of 6-(Piperazin-1-yl)nicotinonitrile).

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Safety of 6-(Piperazin-1-yl)nicotinonitrile

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis, biological evaluation, and molecular docking study of thiophene-, piperazine-, and thiazolidinone-based hybrids as potential antimicrobial agents was written by Desai, Nisheeth C.;Rupala, Yogesh M.;Khasiya, Ashvinkumar G.;Shah, Keyur N.;Pandit, Unnat P.;Khedkar, Vijay M.. And the article was included in Journal of Heterocyclic Chemistry in 2022.Reference of 21867-64-1 This article mentions the following:

Antibiotic resistance in bacteria exacerbates the issue of antimicrobial resistance. Bacteria that cause common or serious infections have evolved resistance to every new antibiotic that has been introduced into the market, to varying degrees, over several decades. Faced with this reality, one of societys most urgent needs is for new antimicrobial drugs with novel mechanisms of action. With this objective, we describe here the development of a novel set of compounds including piperazine- and thiophene-based thiazolidinones (5a-i) and thiophene-thiazolidinones (6a-i). Compounds (5a-i) and (6a-i) were developed, synthesized, and tested for their antimicrobial activity, and their structures were elucidated with the help of various anal. techniques. Compounds 5a and 5d showed excellent antibacterial efficacy against Pseudomonas aeruginosa, with MICs of 50 μg/mL, whereas compounds 6c and 6e showed similar potency against Staphylococcus aureus and Escherichia coli, resp. The antifungal efficacy of compounds 5e and 6i against Candida albicans was outstanding (MIC = 50 μg/mL). The only compound that had excellent antifungal efficacy against Aspergillus niger was compound 5e (MIC = 50 μg/mL). The chemico-in silico-biol. approach could provide valuable insights into the potential of this novel hybridized scaffold for the development of promising antimicrobial agents. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Reference of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids was written by Hayakawa, Isao;Hiramitsu, Tokiyuki;Tanaka, Yoshiaki. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Computed Properties of C7H16N2 This article mentions the following:

Title compounds I [R = H, Me; R¹ = F, Cl; R² = (substituted) piperazino, piperidino, diazepino, pyrrolidino, etc.] (44 compounds) were prepared from nitrobenzenes II (R¹, R³, R⁴ = F, F, F; Cl, F, Cl; F, Cl, F) via benzoxazines III. I (R = Me, R¹ = F, R² = 4-methyl-1-piperazinyl) (DL-8280) showed potent antibacterial activity against Gram-pos. and -neg. pathogens, including Pseudomonas aeruginosa, and its metabolic disposition was shown in sep. experiments to be favorable. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Computed Properties of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Computed Properties of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Protein binding in a congeneric series of antibacterial quinolone derivatives was written by Zlotos, Gabriele;Bucker, Annegret;Jurgens, Jens;Holzgrabe, Ulrike. And the article was included in International Journal of Pharmaceutics in 1998.HPLC of Formula: 21867-64-1 This article mentions the following:

The extent of plasma protein binding was determined in a series of gyrase inhibitors characterized either by a varying substitution on the Ph ring in position N-1 or by an increasing alkyl chain at the N-4′ of the piperazine moiety. An attempt was made to derive QSARs. Especially substituents at the m-position of the N-1-Ph ring influenced the extent of protein binding; an optimum of size was determined The increase of the alkyl group at the outer piperazine nitrogen which is combined with an augmented lipophilicity resulted in an increase in the degree of protein binding. So it can be concluded that the N-1-Ph ring as well as the piperazine ring take part in the interaction with the plasma protein. Both substituents can be used to regulate the extent of protein binding in new gyrase inhibitors. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1HPLC of Formula: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.HPLC of Formula: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and optimization of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors was written by Ryu, Je Ho;Kim, Shinae;Lee, Jung A.;Han, Hye Young;Son, Hyun Joo;Lee, Hyun Jung;Kim, Yong Hyuk;Kim, Jae-Sun;Park, Hyeung-geun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile This article mentions the following:

The synthesis and structure-activity relationship of a series of 6-substituted picolinamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1 are described. The optimization of the left-hand side of lead compound I resulted in the discovery of the highly potent, selective, and orally available inhibitor II, which demonstrated an excellent activity in a mouse ex vivo pharmacodynamic model. Moreover, II reduced the blood glucose and improved the lipid profiles in ob/ob mice after oral administration. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile).

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of 6-(Piperazin-1-yl)nicotinonitrile

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics