Tag: 100-200

Identification of a 5-HT₄ receptor antagonist clinical candidate through side-chain modification was written by Clark, Robin D.;Jahangir, Alam;Alam, Muzaffar;Rocha, Cynthia;Lin, Lin;Bjorner, Bodil;Nguyen, Khanh;Grady, Carole;Williams, Timothy J.;Stepan, George;Tang, Hai Ming;Ford, Anthony P. D. W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Quality Control of 1-Propylpiperazine This article mentions the following:

Replacement of the N-Bu side-chain of lead 5-HT₄ receptor antagonist 2 with propanesulfonylpiperidinyl, morpholinyl, and piperazinyl groups led to higher affinity analogs 4-6. In vitro drug metabolism screens and cassette pharmacokinetic studies in the dog led to identification of the N-methylpiperazinyl analog (I), which displayed pharmacokinetic, selectivity, and safety parameters sufficient for advancement to the clinic for the treatment of urinary incontinence. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Quality Control of 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Quality Control of 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Discovery of 1,4-Dihydroxy-2-naphthoate Prenyltransferase Inhibitors: New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens was written by Kurosu, Michio;Narayanasamy, Prabagaran;Biswas, Kallolmay;Dhiman, Rakesh;Crick, Dean C.. And the article was included in Journal of Medicinal Chemistry in 2007.Application of 21867-64-1 This article mentions the following:

Since utilization of menaquinone in the electron transport system is a characteristic of Gram-pos. organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors (I) and (II) act as selective antibacterial agents against organisms such as methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-pos. organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-pos. organisms. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of substituted 2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]diazepine-7-sulfamides was written by Filimonov, S. I.;Kravchenko, D. V.;Khakhina, M. Yu.;Dorogov, M. V.;Tkachenko, S. E.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.Product Details of 21867-64-1 This article mentions the following:

Liquid-phase parallel synthesis of a combinatorial library of 320 2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-sulfonamides I (R¹, R² = H, Me; R³R⁴N = primary or secondary aliphatic, cycloaliphatic, aromatic or heterocyclic amine) was carried out by chlorosulfonylation of the corresponding benzodiazepines followed by reaction with primary and secondary amines. The pharmacol. important parameters of some of these compounds (mol. weight, lipophilicity and number of hydrogen bond donor and acceptors) have been calculated In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Structural Evolution and Photoluminescence Properties of Two-dimensional Lead Halide Perovskites was written by Ma, Yue-Yu;Pan, Hong-Mei;Li, Dong-Yang;Wu, Shuang;Jing, Zhihong. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2022.Computed Properties of C7H16N2 This article mentions the following:

Herein, by using different size of organic mols. as cation templates, we prepared four new two-dimensional (2D) lead halide perovskites, [PrPipz]PbBr₄ (1), [DMEDA]PbBr₄ (2), [TMEDA]₀.₅[DMA]PbCl₄ (3) and [TMA]₄Pb₃Cl₁₀ (4). Under the distinct structural directing effects of organic cations, compounds 1-4 present four different types of 2D inorganic layers. Remarkably, compounds 1, 3 and 4 exhibit broadband blue emissions, while compound 2 exhibits broadband yellow emission upon the excitation of UV light at room temperature This work paves a way to modulate the crystal structure and photoluminescent property of low-dimensional halide perovskite via structural modulation strategy from the mol. level. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Computed Properties of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Computed Properties of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at σ receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds was written by de Costa, Brian R.;He, Xiaoshu;Linders, Joannes T. M.;Dominguez, Celia;Gu, Zi Qiang;Williams, Wanda;Bowen, Wayne. And the article was included in Journal of Medicinal Chemistry in 1993.Computed Properties of C7H16N2 This article mentions the following:

As a continuation of an earlier study (J. Med. Chem. 1992, 35, 4334-4343) the σ-receptor ligand was conformationally restricted in 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylamine (I) by incorporating it into homologous piperazines and homopiperazines, diazabicyclononanes and decanes, bridgehead bicyclooctanes and nonanes as well as other miscellaneous compounds σ-Receptor binding affinities were obtained using [³H](+)-pentazocine in guinea pig brain membranes. Probably the N lone pair orientation found in the piperazines affords the strongest binding interaction. Other N lone pair orientations or compounds representing unlikely staggered conformations of I [as in 4-[2-(3,4-dichlorophenyl)ethyl]-1,4-diazabicyclo[3.2.2]nonane] show very weak σ interaction. Comparison of the binding data of different N-substituted homologs of I with those of the 1-[2-(3,4-dichlorophenyl)ethyl]-4-alkylpiperazines suggests that the 2 N atoms of I are working in opposition to one another in terms of their sensitivity to steric bulk. The high binding affinity of 1,4-diazabicyclo[4.3.0]nonanes suggests that these may approx. the Me and pyrrolidine ring conformations found in I when it is bound to the σ receptor. Binding data suggest that the conformation of I favors strong binding interaction at σ-receptors. σ-Receptor K_i‘s was 0.55 nM for 1-[2-(3,4-dichlorophenyl)ethyl]-4-n-butylpiperazine. Overall comparison of the results indicate that I is subject to considerable conformational freedom and suggests that the σ receptor is not subject to rigid stereochem. restraints with I. These results corroborate an earlier study where I was restrained using simple monocyclic heterocycles. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Computed Properties of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Computed Properties of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and Biological Evaluation of Novel 1H-Benzo[d]imidazole Derivatives as Potential Anticancer Agents Targeting Human Topoisomerase I was written by Pandey, Stuti;Tripathi, Pragya;Parashar, Palak;Maurya, Vikas;Malik, Zubbair Md.;Singh, Raja;Yadav, Pooja;Tandon, Vibha. And the article was included in ACS Omega in 2022.Reference of 21867-64-1 This article mentions the following:

Small mols. that modulate biol. functions are targets of modern-day drug discovery efforts. A new series of novel 1H-benzo[d]imidazoles (BBZs) were designed and synthesized with different functional groups at the Ph ring and variable lengths of the alkyl chain at the piperazine end as anticancer agents. We identified human topoisomerase I (Hu Topo I) as a probable target of these mols. through a computational study and DNA relaxation assay, a functional assay of the Hu Topo I enzyme. UV absorption, fluorescence, and CD spectroscopy were used to study interactions between BBZ and DNA. Out of 16 compounds, three substances showed strong binding affinity and thermal stabilization of AT sequence-specific DNA. BBZs were screened against a panel of 60 human cancer cell lines at National Cancer Institute, USA. Most potent mols. showed 50% growth inhibition (GI₅₀) in a concentration range from 0.16 to 3.6μM cancer cells. Moreover, one compound showed 50% inhibition of the relaxation of DNA by Hu Topo I at 16μM. Furthermore, flow cytometry revealed that the three substances cause prominent G2M arrest of cancer cells. In view of the above, we propose that I deserves to be further evaluated for its therapeutic use as an anticancer agent. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Reference of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Reference of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

New piperazine amidines and related compounds. Potential antihypertensives and diuretics was written by Areschka, Alex;Mahaux, Jean;Verbruggen, Francis;Houben, Christian;Descamps, Marcel;Heyndrickx, Jean P.;Beersaerts, Joseph;Colot, Michel;Charlier, Robert. And the article was included in European Journal of Medicinal Chemistry in 1976.Product Details of 21867-64-1 This article mentions the following:

Amidines I (R = 2-ethyl-3-benzothienyl, 2-butyl-3-benzothienyl, 2-methyl-3-benzothienyl, 3-methyl-5-chloro-2-benzothienyl, Ph, 2-ClC6H4, 4-ClC6H4, 4-MeOC6H4, 2-benzodioxanyl, H, Me, Et; R1 = Me, Et, Pr, 2-pyridyl, 4-pyridyl, H, CHMe2, Bu, 4-ClC6H4, 4-FC6H4, 3-F3CC6H4, CH2Ph) and II [X = CH2, CHMe, CHOH, O, (CH2)3, CH2NMe] were prepared by ethanolysis of RCH2CN and aminolysis of the product RCH2C(:NH)OEt. Some I and II displayed diuretic and antihypertensive activity in animal tests, which were not observed in clinical tests, however. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Product Details of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Syntheses of piperazines substituted on the nitrogen atoms with allyl, propyl, 2-hydroxypropyl and 3-hydroxypropyl groups was written by Kafka, Stanislav;Cermak, Jan;Novak, Tomas;Pudil, Frantisek;Viden, Ivan;Ferles, Miloslav. And the article was included in Collection of Czechoslovak Chemical Communications in 1985.Recommanded Product: 21867-64-1 This article mentions the following:

The piperazines I [R = allyl, Pr, HO(CH₂)₃, H, 2,3-epoxypropyl, MeCH(OH)CH₂, MeCOCH₂, EtCO, Bz; R¹ = allyl, Pr, 2,3-epoxypropyl, MeCOCH₂, EtCO₂(CH₂)₃, HO(CH₂)₃, MeCH(OH)CO, MeCH(OH)CH₂] were prepared Thus, piperazine was alkylated with allyl bromide to give 55% I (R = R¹ = allyl), mass spectra and gas-liq chromatog. indexes of I were reported. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Recommanded Product: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of N-(3-amino-2-hydroxy propyl)-N-sulfonylanilines derivatives. Potential antianginal activities was written by Goldenberg, Charles;Van Meerbeeck, Clement;Wandestrick, Raymond;Descamps, Marcel;Tornay, Chantal;Dirks, Michel;Colot, Michel;De Claviere, Michel. And the article was included in European Journal of Medicinal Chemistry in 1980.Category: piperazines This article mentions the following:

The title compounds I [R = 2-allyloxy, 4-AcNH, 4-H₂NCOCH₂, R¹ = H; R = 2-Cl, R¹ = 6-Cl; R = 3-Cl, R¹ = 4-Cl; R² = Me, 4-MeC₆H₄, 4-MeOC₆H₄, Ph; R³ = H, R⁴ = CHMe₂, CMe₃, CH₂CH₂OPh, (CH₂)₃Ph; NR³R⁴ = pyrrolidino, morpholino, 4-substituted piperazino] were prepared by sulfonylating RR¹C₆H₃NH₂, treating RR¹C₆H₃NHSO₂R² with epichlorohydrin, and aminolysis. I have both α- and β-sympatholytic activity. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Immobilized palladium nanoparticles on silica functionalized N-propylpiperazine sodium N-propionate (SBPPSP): catalytic activity evaluation in copper-free Sonogashira reaction was written by Niknam, Khodabakhsh;Deris, Abdollah;Panahi, Farhad;Reza Hormozi Nezhad, M.. And the article was included in Journal of the Iranian Chemical Society in 2013.Electric Literature of C7H16N2 This article mentions the following:

An efficient heterogeneous palladium catalyst system has been developed based on immobilization of Pd nanoparticles on silica-bonded N-propylpiperazine sodium N-propionate (SBPPSP) substrate. SBPPSP substrate can stabilize the Pd nanoparticles effectively so that it can improve their stability against aggregation. In addition, grafted piperazine species on to the silica backbone prevent the removing of Pd nanoparticles from the substrate surface. Transmission electron microscopy (TEM) of catalyst is shown the size of Pd nanoparticles, also it confirmed by particle size analyzer which shown the average size of 21 nm for Pd. The catalytic activity of these catalysts was investigated in the Sonogashira reaction. The catalyst could be recycled several times without appreciable loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Electric Literature of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Electric Literature of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics