Heterocyclic Building Blocks-piperazine

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the chloro compounds (1.00 mmol) in toluene, were added piperazines 8a-j (1.0 mmol) at room temperature. The reaction mixture was heated at 110 oC for overnight. After completion (TLC), the reaction mixture was extracted with ethyl acetate and water. The organic layer was separated and dried over anhydrous Na2SO4, evaporated to dryness. The residue was purified with column chromatography using an eluent of 25% ethyl acetate in hexane to furnish the compounds with moderate to good yields (64-82%)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Naseema, Mohammad; Gomedhika, P. Mary; Nagarapu, Lingaiah; Sirisha; Kumar, C. Ganesh; Gundasw, Shravan Kumar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 7; (2018); p. 1166 – 1170;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

To a suspension OF 4-METHYLPIPERAZINE-1-CARBONYL chloride hydrochloride (19.9 g 0.1 mol) and piperidone monohydrate hydrochloride (15.3 g 0.1 mol), in 200 ML of dichloromethane, dry triethylamine (45 mL, 0.33 mol) was added dropwise. The mixture was stirred for 2 hours. The organic phase was washed with brine (2 x 20 mL) and dried over sodium sulfate. After filtration, the solvent was evaporated in vacuo and the crude product was dissolved in ETOH (50 mL) and diethylether (100 mL) and treated with HCl 4N in dioxane (25 mL). After 1 hour, the precipitate was filtered and dried in oven to give 13 g (yield 50%) of the title compound. 1 H NMR (400 MHz, DMSO-D6) 8 ppm 2.40 (t, J=6. 16 Hz, 4 H) 2.81 (s, 3 H) 3.00- 3.11 (m, 2 H) 3.12-3. 23 (m, 2 H) 3.28-3. 42 (m, 2 H) 3.51 (t, J=6. 16 Hz, 4 H) 3.73 (d, J=14. 27 Hz, 2 H) 10.12 (s, 1 H), 55112-42-0

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 0.332/0.36885 g (0.001 mol) of 1-(6-bromohexyl)-1,8-naphthosultam(3a)/lactam (3b), 0.00095 mol of the corresponding arylpiperazine(4), 0.414/0.120 g (0.003 mol) K2CO3/NaOH and 0.032 g(0.0001 mol) of TBAB were triturated in a mortar. The triturated mixturewas transferred to a round bottom flask. In the case of the reactionin the presence of the solvent, 0.2 cm3 of acetonitrile, DMF or water wasadded to the reaction mixture. The reactions were carried out for 50 s ina CEM Discover microwave reactor at a 100W output power. Theprogress of the reaction was monitored by TLC (CHCl3:MeOH 9:1).After completion of the reaction, 40 cm3 of water was added to themixture and placed in the refrigerator overnight. After cooling, thecrude product was filtered off. In the absence of the required purity, thecrude product was crystallized from methanol or methanol-water. Afterobtaining a minimum of 90% purity, the ligands were dissolved inacetone, then converted to 4M HCl hydrochloride in dioxane. The reactionyields for individual ligands were calculated based on the weightof the obtained pure hydrochloride.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zar?ba, Przemys?aw; Ja?kowska, Jolanta; Czekaj, Izabela; Sata?a, Grzegorz; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3396 – 3407;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To a 250 mL round bottom flask was added 7.5 g (36.6 mmol) of crude I-a ‘4-nitro-1H-pyrazole-3-carboxylic acid 6.3 g(40.1 mmol),EDC ¡¤ HCl 8.4 g (44.0 mmol)HOBt 6.0 g (44.4 mmol) and dry DMF 100 mL,Stir at room temperature for 24 h TLC detects the disappearance of the starting material (methanol: chloroform = 1:10).The reaction solution was poured into 200 mL of ice water,Precipitation of a large number of light yellow solid, standing, take the yellow solid,The crude product was recrystallized from a mixed solvent of ethyl acetate and methanol to give 11.1 g of (I-e)Yield 88.2%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
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67455-41-8,67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Argon was passed through the suspension of bis-chloride (1) (0.419 g, 1 mmol) in dry pyridine(15 mL) at room temperature over 15 min. Amine (2.5 mmol) was added and the reaction mixture wasbubbled with argon for a further 15 min. The mixture was then stirred at room temperature for 7 days.The solid product was filtered off and washed with dry ether. The raw product was purified throughrecrystallization from ethanol.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stuffed solution of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HC1, 575 mg, 3.0 mmol) in DMF at 0 C,2-picolinic acid (246 mg, 2.0 mmol) was added followed by addition of hydroxybenzotriazole(HOBt, 405 mg, 3.0 mmol) and the final reaction mixture was stuffed at 0C. After 30 mm 6-fluoro-1- methyl-4-oxo-7-(piperazin- 1 -yl)- 1 H,4H- [1,3] thiazeto[3 ,2-a] -quinoline-3 -carboxylic acid (700 mg, 2.01 mmol) and N,N-diisopropylethylamine(0.53 ml, 3 mmol) were added and reaction mixture was allowed to stir at room temperature for overnight. After completion, the reaction mixture wasevaporated, remaining mass was triturated 2-3 times and dried to obtain compound 3las an off white solid (250 mg, 28%). 1H NMR (DMSO-d6): oe 14.61 (brs, 1H, COOH), 8.62 (d, 1H, JAB = 4.5 Hz, ArH), 7.96 (t, 1H, JAB = 7.5 Hz, ArH), 7.82 (d, 1H, JAB = 13.5 Hz, ArH), 7.64 (d, 1H, JAB = 7.5 Hz, ArH), 7.52 (dd, 1H, JAB = 7.0 Hz, Jm = 5.0 Hz, ArH), 6.98 (d, 1H, JAB = 7.0 Hz, ArH), 6.36 (q, 1H, JAB = 6.0 Hz,SCHN), 3.89-3.81 (m, 2H, CH2N), 3.66-3.52 (m, 2H, C?H2N), 2.11 (d, 3H, JAB = 6.5Hz, CH3). ESI-MS (mlz): 454.92 (M+H)., 112984-60-8

As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.

Reference£º
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

Example 7 N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-indole-2-carboxamide To 85 mg (0.25 MM) 6-Hydroxy-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide in 5 ml dichloromethane at 0¡ã C. was added 144 mg (1 MM) 2-(4-Methyl-piperazin-1-yl)-ethanol, 262 mg (1 MM) triphenylphosphine and 131 mg (0.75 MM) DEAD. After several hours the mixture was allowed to warm to room temperature and stir overnight.The reaction mixture was purified directly on a preparative TLC plate and eluted with 10percent methanol/dichloromethane.The product was then partitioned between 1 M HCl and ethyl acetate, the aqueous layer was neutralized and extracted with ethyl acetate, dried over magnesium sulfate and stripped to give 18.9 mg 6-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide. Similarly prepared were: N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-1-methyl-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-Morpholin-4-yl-ethanol. N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-morpholin-4-yl-ethanol., 5464-12-0

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
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109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 29 2-(4-Chlorophenoxy)ethyl 3-(3-methyl-1-piperazinyl)-2-pyrazinyl Ether The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and 2-methylpiperazine (256 mg, 2.56 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 143 mg (77%) of the title product. HRMS m/z calcd for C17H21ClN4O2 (M)+348.1353, found 348.1370. Anal. (C17H21ClN4O2) C, H, N. *Prepared according to the procedure described in Example 4, Step 1., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US6465467; (2002); B1;,
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Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 [0116] 0.61 g (1.29 mmol) of betulonic acid chloride was dissolved in 40 mL of anhydrous dichloromethane (CH2Cl2), and then 0.72 mL (5.16 mmol) of anhydrous triethylamine and 0.60 g (2.58 mmol) of 1-(4-trifluoromethylphenyl)piperazine were added thereto, and then stirred at 25 C. for 48 hours. The resulting product was washed with 10% HCl (40 mL¡Á3), further washed with pure water (40 mL¡Á3), and then a solvent layer was dried by 10 g of anhydrous Na2SO4. A dichloromethane (DCM) layer was evaporated and dried to obtain 0.85 g of light brown solids. These light brown solids were dissolved in ethanol to prepare a sample, and then this sample was fractionated by RP C18 semi-prep HPLC, and then completely evaporated and dried to obtain 0.64 g (yield: 74.9%) of 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid. [0117] 1H NMR (600 MHz, CDCl3): [0118] A white crystalline solid, m.p. 229-230 C. IR (ATR) umax cm-1: 2944, 1704 (C?O), 1616 (CONH), 1525, 1458, 1332, 1230, 1112, 1073, 1023, 885, 830. 1H NMR (600 MHz, CDCl3): 0.93 (3H, s, Me-25), 0.96 (1H, m, H-12), 0.97 (3H, s, Me-27), 0.98 (3H, s, Me-26), 1.02 (3H, s, Me-24), 1.06 (3H, s, Me-23), 1.19 (1H, m, H-15), 1.30-1.52 (12H, m, H-1, 5, 6, 6, 7, 7, 9, 11, 11, 15, 16, 21), 1.59 (2H, m, H-12, 18), 1.69 (3H, s, Me-30), 1.75 (1H, m, H-22), 1.89 (2H, m, H-1, 21), 2.01 (1H, m, H-22), 2.16 (1H, m, H-16), 2.39 (1H, m, H-2), 2.49 (1H, m, H-2), 2.92 (1H, m, H-13), 3.00 (1H, dt, J1=11.4 Hz, J2=4.2 Hz, H-19), 3.41 (4H, m, H-3?, 3?, 5?, 5?), 3.78 (4H, m, H-2?, 2?, 6?, 6?), 4.74 and 4.60 (2H, both br. s, H-29), 6.94 (2H, d, J=8.4 Hz, H-2?, 6?), 7.51 (2H, d, J=8.4 Hz, H-3?, 5?). [0119] C41H59N2O2F3, 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid 7, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF ENERGY RESEARCH; Chue, Kuck-Tack; Kim, Tae-Hwan; Ten, Leonid; US2014/243527; (2014); A1;,
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381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (1) (1.65 g, 0.005 mol), C2H5OH (30 mL) and N(C2H5)3 (3 mL), 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (2) (1.65 g, 0.006 mol) was added and heated at 70-80 C for 5 h. The reaction was monitored by TLC. After filtration, the filtrate was evaporated under reduced pressure. Water (30 mL) was added to the residue, which was then extracted with ethyl acetate (80 mL ¡Á 3). The extract was washed with saturated NaCl solution (20 mL ¡Á 3), dried over anhydrous Na2SO4 and evaporated. The residue was crystallized from C2H5OH to afford a white solid 3 1.92 g, in 75% yield: m.p. 115-117 C. 1H NMR (DMSO-d6): 6.80-8.48 (6H, m, Ar-H), 7.81, 8.13 (2H, ss, triazole-H), 4.51-4.60 (2H, dd, J = 15 Hz, triazole-CH2-), 2.50-3.01 (8H, m, piperazine-H), 2.73-3.17 (2H, dd, J = 15 Hz, CH2-piperazine-), 5.10 (1H, s, OH). IR (KBr): 3200, 2940, 2893, 1605, 1514, 1338, 1257, 1136, 918 cm-1. LC-MS, m/z Calcd. for C22H21F5N6O3, 512.2, found [M + H]+ 513.3., 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

Reference£º
Article; Chai, Xiaoyun; Zhang, Jun; Cao, Yongbing; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3167 – 3176;,
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